I-Biologics ye-AS: Zithini izinto onokukhetha kuzo?

Umxholo

• Yintoni i-biologics ye-AS?
• 1. I-tumor necrosis factor (TNF) blocker
• 2. I-Interleukin 17 (IL-17) inhibitors
• Inikwa njani i-biologics ye-AS?
• Iindleko zebhayoloji ze-AS
• Iziphumo ebezingalindelekanga zebhayoloji ye-AS
• Ulufumana njani unyango oluchanekileyo lwe-biologic ye-AS
• Yise kude

I-Ankylosing spondylitis (AS) sisifo esingapheliyo sokuzimela komzimba esichaphazela ikakhulu amalungu omqolo, kodwa amalungu amakhulu, anjengezinqe kunye namagxa, nawo angabandakanyeka.

Ukuvuvukala, okubangelwa ngumsebenzi wamajoni omzimba, kubangela ukudityaniswa ngokudibeneyo kumacandelo omqolo, okuhlala kukhokelela kwintlungu, ukudumba, kunye nokuqina.

Oku kunokunciphisa ukushukumiseka, kubenzima ukugqibezela imisebenzi yemihla ngemihla.

Akukho lunyango lwesi sifo, kodwa unyango olwahlukeneyo lunokucothisa ukuqhubela phambili kwaye luncede uphile ubomi obusebenzayo. Umboneleli wakho wezempilo uya kuphuhlisa isicwangciso sonyango emva kokuxilongwa.

Ngenxa yokuba iimpawu ze-AS zinokuthamba ukusuka kubunzulu ukuya kubunzima, abanye abantu banokulawula iimpawu zabo ngamachiza angenayo i-nonsteroidal anti-inflammatory (NSAIDs), anje nge-ibuprofen (Motrin, Advil) kunye ne-naproxen sodium (Aleve).

Ukuba iimpawu zakho aziphenduli kula machiza, amayeza amiselweyo yindlela elandelayo yokuzikhusela.

Amachiza amayeza asetyenziselwa i-AS abandakanya ukuguqula isifo iziyobisi ezichasene ne-rheumatic (i-DMARDs) ukunciphisa ukosuleleka komzimba okwenzakalayo.

Nangona bengakwazi ukujolisa ngqo kwisizathu sayo, ii-NSAID kunye nee-DMARD zombini ziyilelwe ukuyeka ukudumba.

Ngamanye amaxesha iintlungu kunye nokuqina AS kuzisa akuphenduli kula mayeza amiselweyo. Ukukunceda ulawule iimpawu, ugqirha wakho unokucebisa uhlobo oluthile lonyango olubizwa ngokuba yi-biologics.

Yintoni i-biologics ye-AS?

I-Biologics ziiprotein zobunjineli zemvelo ezenziwe kwizinto eziphilayo ezilinganisa imisebenzi eqhelekileyo yebhayoloji.

Zijolise kunyango olujolise kwiiproteni ezithile kwinkqubo yomzimba yokuzikhusela evelisa ukudumba, oko kukuthi:

• ithumba necrosis factor (TNF)
• I-interleukin 17 (IL-17)

Ulawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) livume i-biologic yokuqala ngo-1988 ukunyanga isifo samathambo. Ukusukela ngoko, ezinye izinto zebhayoloji ziye zaphuhliswa.

Okwangoku, zisixhenxe iintlobo zebhayoloji ezivunyiweyo kunyango lwe-AS. Oku kubandakanya:

1. I-tumor necrosis factor (TNF) blocker

• adalimumab (Humira)
• isatifikethi sepgol (Cimzia)
• I-etanercept (i-Enbrel)
• igolimumab (iSimponi, iSimponi Aria)
• infliximab (I-Remicade)

2. I-Interleukin 17 (IL-17) inhibitors

• secukinumab (iCosentyx)
• ixekizumab (iTaltz)

Inikwa njani i-biologics ye-AS?

I-Biologics kufuneka ihanjiswe kwizicubu phantsi kolusu okanye nzulu kwimisipha. Azifumaneki kwipilisi okanye kwifom yomlomo. Ubafumana ngenaliti okanye ngokufakwa.

Ukuhamba rhoqo kwenaliti okanye ukufakwa okufunekayo kuya kwahluka ngokuxhomekeka kunyango oluthile lwebhayoloji.

Unokufumana ukumiliselwa rhoqo kwiinyanga ezimbalwa. Okanye, unokufuna iinaliti ezininzi zokuqalisa kwaye emva koko ulandele inaliti unyaka wonke.

Umzekelo, i-biologic Simponi ifuna inaliti ezintathu zokuqala:

• iinaliti ezimbini kusuku lokuqala lonyango
• inaliti enye kwiiveki ezi-2 kamva

Emva koko, uya kuzinika inaliti enye qho kwiiveki ezi-4.

Kwelinye icala, ukuba uthatha u-Humira, uya kuzinika inaliti enye qho ngeveki emva kwamayeza amane okuqalisa.

Ugqirha wakho uya kukuxelela ukuba uza kuyidinga kangaphi unyango lwe-biologic, kwaye baya kukunika imiyalelo ngendlela yokufaka inaliti yakho.

I-Biologics ayiziphuculi iimpawu ze-AS ngobusuku, kodwa kuya kufuneka uqale uzive ungcono malunga ne-4 ukuya kwi-12 iiveki, ngamanye amaxesha ngokukhawuleza.

Injongo yonyango kukucinezela iimpawu zakho ukuze imeko ingaphazamisi ubomi bakho. Kubalulekile ukuba uqaphele ukuba i-biologics ayizukuyinyanga i-AS.

Iindleko zebhayoloji ze-AS

I-Biologics ihlala isebenza, kodwa iyabiza kakhulu eMelika. Ngokomndilili, indleko zebhayoloji ngamanye amaxesha zingaphezulu kakhulu kwiiarhente ezibiza kakhulu.

I-inshurensi iyakuthi igubungele inxenye yeendleko, nangona iya kuxhomekeka kukhuseleko lwakho.

Thetha nogqirha wakho malunga nokukhetha ii-biosimilars (ukwenziwa okufanayo kwi-biologics) kunye nazo naziphi na iinkqubo zoncedo lwesigulana ngabavelisi beziyobisi.

Iziphumo ebezingalindelekanga zebhayoloji ye-AS

Kukho umngcipheko weziphumo ebezingalindelekanga okanye uguquko kwiindlela ezininzi zamayeza, kwaye iibhayoloji azikho ngaphandle.

Iziphumo ebezingalindelekanga zonyango lwe-biologic zinokubandakanya:

• iintlungu, ukuba bomvu, irhashalala, okanye ukugruzuka kwindawo yenaliti
• intloko ebuhlungu
• urhashalala okanye irhashalala
• isisu esibuhlungu
• umqolo obuhlungu
• isicaphucaphu
• ukukhohlela okanye umqala obuhlungu
• umkhuhlane okanye ukubanda
• ubunzima bokuphefumla
• uxinzelelo lwegazi oluphantsi

Iziphumo ebezingalindelekanga zihlala zinobulali kwaye zihlala zithomalalisa kwaye ekugqibeleni zihambe.

Nangona kunjalo, kuya kufuneka ubize ugqirha wakho ukuba uneempawu ezinje ngemingci, ukudumba, okanye ukuphefumla nzima. Ezi zinokuba ziimpawu zokuphendula okungafunekiyo.

Ngenxa yokuba i-biologics icinezela amajoni akho omzimba, anokunyusa umngcipheko wosulelo kunye nomhlaza.

Ugqirha wakho unoku-odola uvavanyo lweelebhu ngaphambi kwenaliti yakho yokuqala okanye ukumiliselwa ukuze ujonge:

• isifo sephepha
• hepatitis B no-C
• ezinye izifo

Jonga ugqirha wakho ukuba uvelisa iimpawu zosulelo emva kokuqala unyango, njenge:

• ifiva
• Ukugodola
• ukuqhawukelwa ngumphefumlo
• ukukhohlela

Kwakhona, yazisa ugqirha wakho ukuba awuchazanga:

• ukugruzuka
• ukuhla ukusinda
• ukudinwa okungaqhelekanga

I-Biologics inokunyusa umngcipheko wokukhula komhlaza wegazi njenge-lymphoma.

Ulufumana njani unyango oluchanekileyo lwe-biologic ye-AS

Nangona zonke i-biologics ze-AS zenzelwe ukunciphisa ukuqhubela phambili kwesi sifo kunye nokuyeka ukuvuvukala, i-biologics ayisebenzi ngokufanayo kuwo wonke umntu.

Ukuba uqala unyango lwe-biologic, ugqirha wakho unokukuqala ngohlobo olunye kwaye ujonge imeko yakho kwiinyanga ezi-3 ezizayo ukuze ubone ukuba akukho phuculo.

Musa ukuziva udimazekile ukuba iimpawu zakho azinciphi emva kokungeniswa okanye inaliti yakho yokuqala. Ukuba i-AS yakho ayiphuculanga, ugqirha wakho unokucebisa ukuba utshintshele kwi-biologic eyahlukileyo evunyiweyo ye-AS.

Unyango lwe-Biologic kuphela ayisiyiyo kuphela ukhetho.

Akufanele uthathe ngaphezu kweyodwa i-biologic ngexesha ngenxa yengozi yokusuleleka, kodwa ungathatha i-biologics kunye namanye amayeza e-AS. Ukufumana isiqabu kwi-AS ngamanye amaxesha kungumcimbi wolingo kunye nephutha.

Linda. Kungathatha ixesha ukufumana indibaniselwano efanelekileyo yamachiza.

Ngokomzekelo, nangona iimpawu zakho zingazange ziphuculwe ngelixa zithatha ii-NSAID okanye ii-DMARD, ukudibanisa i-biologic nala mayeza anokusebenza.

Yise kude

Ngaphandle konyango olululo, i-AS inokuqhubela phambili ngokuthe ngcembe kwaye ibangele ukwanda kwentlungu, ukuqina, kunye nokuthintela ukuhamba.

Thetha nogqirha wakho ukuba uziva ngathi unyango lwakho lwangoku alusebenzi. Unokuba ngumgqatswa we-biologics.

Kodwa ngaphambi kokuba uqale unyango lwe-biologic (njengalo naluphi na unyango), qiniseka ukuba uyazi izinto ozikhethayo kwaye ubuze imibuzo.