Uhlaselo lweLobular Carcinoma: Iimpawu, unyango kunye nokunye

Umxholo

• Yintoni i-invasive lobular carcinoma (ILC)?
• Iimpawu zomhlaza webele we-lobular
• Oonobangela bomhlaza webele lobular
• Imiba yomngcipheko
• I-Lobular carcinoma in situ (LCIS)
• Ufumanisa njani umhlaza webele webele?
• Iimpawu
• Ukulinganisa i-ILC
• Unyangwa njani umhlaza webele webele?
• Unyango olongezelelweyo nolunye
• Ndingawuthintela njani umhlaza webele lobular?
• I-LCIS
• Ndingafumana phi amaqela enkxaso?
• Imbonakalo

Yintoni i-invasive lobular carcinoma (ILC)?

Invasive lobular carcinoma (ILC) ngumhlaza kumadlala avelisa ubisi. Abantu abane-ILC akunakwenzeka ukuba bazive izigaxa ze-telltale. Kukwaziwa nangokuthi kukufaka i-lobular carcinoma okanye umhlaza webele we-lobular.

I-ILC ikhula kwaye isasazeka ngokwahlukileyo kwezinye iintsholongwane zomhlaza webele ezinje nge-ductal carcinoma (IDC), okanye umhlaza kwimibhobho yobisi.

Xa umhlaza usasazeka, ubizwa ngokuba yi-metastatic. Kwi-ILC, umhlaza uqala kwi-lobules yebele kwaye uhambele kwizicubu zebele ezikufutshane. Inokuhamba iye kwii-lymph node kunye namanye amalungu emzimbeni.

Ngaphezulu kwabafazi abayi-180,000 e-United States minyaka le baya kufumana isifo somhlaza wamabele. I-ILC yenza malunga neepesenti ezili-10 zeso sifo.

Iimpawu zomhlaza webele we-lobular

I-ILC ikhula ngokwahlukileyo kwiindidi eziqhelekileyo zomhlaza wamabele. Kunqabile ukuba kubekho izigaqa ezicacileyo. Kumanqanaba okuqala, akunakubakho miqondiso okanye mpawu. Kodwa njengoko umhlaza ukhula, ungawaqaphela amabele akho:

• ukuqina okanye ukuqina kwindawo ethile
• ukudumba okanye ukuziva ugcwele kwindawo ethile
• ukutshintsha kokubonakala okanye ukubonakala kolusu, njengokuncipha
• ukwenza ingono esandula ukujika
• ukutshintsha ngobukhulu okanye ukumila

Ezinye iimpawu zingabandakanya:

• iintlungu zebele
• Ingono yengono
• Ukukhutshwa ngaphandle kobisi lwebele
• iqhuma elijikeleze indawo engaphantsi kwekhwapha

Ezi zihlala ziyimpawu zokuqala zomhlaza wamabele, kubandakanya i-ILC. Yiya kugqirha wakho ukuba uyazibona ezi mpawu.

Oonobangela bomhlaza webele lobular

Yintoni ebangela ukuba i-ILC ingacaci. Kodwa olu hlobo lomhlaza luqala xa iiseli ezikumadlala akho avelisa ubisi zenza utshintsho lwe-DNA olulawula ukukhula kweseli kunye nokufa.

Iiseli zomhlaza ziqala ukwahlula kwaye zisasazeke njengamasebe, yiyo loo nto kungenakulindeleka ukuba uve iqhuma.

Imiba yomngcipheko

Amathuba okufumana ukwanda kwe-ILC ukuba:

• umntu obhinqileyo
• kubudala obudala, ngaphezulu kwezinye iintlobo zomhlaza wamabele
• Umfazi kunyango olubuyisela i-hormone (HRT), ngesiqhelo emva kokuyeka ukuya exesheni
• ethwele izakhi zofuzo zomhlaza

I-Lobular carcinoma in situ (LCIS)

Umngcipheko wakho wokuphuhlisa i-ILC unokunyuka ukuba ngaba une-LCIS diagnostic. I-LCIS kuxa i-atypical okanye iiseli ezingaqhelekanga zifunyanwa, kodwa ezi seli zixinaniswe kwi-lobules kwaye azange zihlasele izicubu zebele ezingqonge.

I-LCIS ayiyena umhlaza kwaye ithathwa njengesiqhelo.

Ufumanisa njani umhlaza webele webele?

Oogqirha bakho baya kusebenzisa iimvavanyo zokucinga ezahlukeneyo ukunceda ukufumanisa isifo somhlaza webele. Olu vavanyo lubandakanya:

• Ultrasound
• IMRI
• yovavanyo
• ibele biopsy

ILC inee-subtypes ezimbalwa, ezisekwe kwinkangeleko yeeseli eziphantsi kwemicroscope. Kuhlobo lweklasikhi ye-ILC, iiseli zilandelelana kwifayile enye.

Ezinye iintlobo eziqhelekileyo zokukhula zibandakanya oku kulandelayo:

• yomelele: zikhule ngamashiti amakhulu
• I-alveolar: zikhula ngamaqela eeseli ezingama-20 okanye nangaphezulu
• tubulolobular: ezinye iiseli ziyifayile enye yokwakheka kwaye ezinye zenza ifomathi efana nezakhiwo
• ukuguquguquka: inkulu kune-ILC yakudala ene-nuclei ekhangeleka yahlukile enye kwenye
• iseli yomsesane wophawu: Iiseli zizele yincindi

Iimpawu

Iimammograms zinokunika iziphumo ezingezizo zobuxoki zomhlaza we-lobular. Kungenxa yokuba, kwi-X-ray, umhlaza we-lobular ujongeka ngokufana nezicubu eziqhelekileyo.

I-ILC isasazeka ngezicubu zamabele ngokwahlukileyo kwi-IDC.

Amathumba abunjwe kakuhle kunye needipozithi zekhalsiyam azifane ziqheleke, zisenza nzima kwi-radiologist ukwahlula i-ILC kwizicubu zesifuba esiqhelekileyo kwi-mammogram.

Kwakhona kunokwenzeka ukuba kuphuculwe ngaphezu kweyodwa kwindawo yesifuba okanye kumabele omabini. Ukuba ibonwa kwimammogram, isenokubonakala incinci kunokuba injalo.

Ukulinganisa i-ILC

Ukubeka isifuba kuxa ugqirha wakho emisela ukuba umhlaza uqhubele phambili kangakanani okanye usasazeke kangakanani ukusuka ebeleni.

Isiteji sisekwe:

• ubungakanani bethumba
• zingaphi ii-lymph node ezichaphazelekayo
• ingaba umhlaza unwenwele nakwamanye amalungu omzimba

Kukho amanqanaba amane e-ILC, ukusuka kwi-1 ukuya kwi-4.

Njenge-IDC, ukuba i-ILC isasazeka, ihlala ibonakalisa kwi:

• ithumba
• amathambo
• isibindi
• imiphunga
• ingqondo

Ngokungafaniyo ne-IDC, i-ILC kunokwenzeka ukuba isasazeke kwiindawo ezingaqhelekanga ezinje:

• isisu namathumbu
• ulusu esiswini
• amalungu okuzala

Ukuchonga ukuba ngaba iiseli zomhlaza zisasazekile, ugqirha wakho unokuyalela iimvavanyo zokujonga i-lymph node, igazi kunye nokusebenza kwesibindi.

Unyangwa njani umhlaza webele webele?

Olona khetho lwakho lonyango luya kuxhomekeka kwinqanaba lakho lomhlaza, ubudala, kunye nempilo ngokubanzi. Ukunyanga i-ILC kuhlala kubandakanya utyando kunye nonyango olongezelelekileyo.

Ukukhetha ugqirha wakho ngocoselelo kubaluleke ngakumbi ngenxa yendlela engaqhelekanga yokukhula kwe-ILC. Ugqirha onamava ekunyangeni abaguli abane-ILC ngundoqo.

Utyando oluncinci olunolunya njenge-lumpectomy luneziphumo ezifanayo kunyango olunoburharha njenge-mastectomy.

I-lumpectomy inokuba lukhetho olufanelekileyo ukuba inxenye encinci yesifuba inomhlaza (kolu tyando, ugqirha osusa ugqirha ususa kuphela izicwili zomhlaza).

Ukuba kubandakanyeka ezinye izicubu zamabele, ugqirha wakho unokucebisa nge-mastectomy (ukususwa ngokupheleleyo kwebele).

Ezinye iindlela zibandakanya ukususa i-lymph node kufutshane nebele lakho, inkqubo ebizwa ngokuba yi-sentinel lymph node biopsy, kunye ne-armpit, ebizwa ngokuba yi-axillary lymph node dissection.

Unokufuna unyango olongezelelekileyo, olunje ngemitha, unyango lwehomoni, okanye ichemotherapy, ukunciphisa umngcipheko womhlaza okhulayo emva kotyando.

Unyango olongezelelweyo nolunye

Ngelixa unyango olongezelelweyo kunye nolunye unyango (i-CAM) alwaziwa ukunyanga umhlaza webele, banokukunceda ukukhulula ezinye zeempawu kunye neziphumo ebezingalindelekanga zomhlaza kunye nonyango lwayo.

Umzekelo, abantu abathatha unyango lwehomoni kumhlaza wamabele banokuba namava ashushu, okanye ngequbuliso, ukufudumala okukhulu kunye nokubila.

Unokufumana isiqabu ngoku:

• ukucamngca
• izongezo zeevithamini
• umthambo wokuphumla
• iyoga

Soloko uthetha nogqirha wakho ngaphambi kokuzama amayeza amatsha okanye isongezelelo. Banokudibana nonyango lwakho lwangoku kwaye babangele iziphumo ebezingalindelekanga.

Unyango lweHormone (HT) lunokucetyiswa ukuba iiseli zomhlaza wakho zi-ethe-ethe kwiihomoni ezinje nge-estrogen kunye neprogesterone.

Oku kuhlala kunjalo kumhlaza webele lobular. I-HT inokuthintela iihomoni zomzimba wakho ekuboniseni iiseli zomhlaza ukuba zikhule.

Ndingawuthintela njani umhlaza webele lobular?

I-Lobular carcinoma, njengamanye umhlaza wamabele, inokukhula kubantu abaphilileyo. Unokuwunciphisa umngcipheko ngoku:

• ukusela utywala ngokumodareyitha, ukuba kunjalo
• ukwenza iimviwo zakho
• ukufumana uvavanyo lonyaka, kubandakanya ii-mammograms
• ukugcina ubunzima obunempilo
• ukutya ukutya okunezondlo kunye nokwenza umthambo rhoqo

Ukuba ucinga nge-HRT, xoxa ngengozi kunye nezibonelelo zolu nyango nogqirha wakho. I-HRT inokuphakamisa umngcipheko we-lobular carcinoma kunye nezinye iintlobo zomhlaza wamabele.

Ukuba ukhetha ukuthatha i-HRT, kuya kufuneka uthathe eyona idosi iphantsi esebenzayo kwelona xesha lifutshane.

I-LCIS

Ndingafumana phi amaqela enkxaso?

Ukufumana isifo somhlaza wamabele naluphi na uhlobo kunokuba nzima. Ukufunda ngomhlaza wamabele kunye nokhetho kunyango kunokukunceda uzive ukhululeke ngakumbi njengoko uhamba kuhambo lwakho.

Iindawo onokujikela kuzo xa ufuna ukuxilongwa ngumhlaza wamabele zibandakanya:

• iqela lakho lokhathalelo lwempilo
• abahlobo kunye nosapho
• uluntu online
• amaqela enkxaso asekuhlaleni

Kukho umngcipheko okhulayo wokuba nomhlaza webele ongenayo ukuba ufumene ukuba une-LCIS. Unokuthatha amayeza, njenge-tamoxifen, ukunciphisa umngcipheko.

Ugqirha wakho usenokucebisa nge-mastectomy ukuba unembali yosapho yomhlaza webele.

Uluntu lomhlaza webele luyabonakala kwaye luthetha. Amaqela enkxaso asekuhlaleni angaluncedo ekunxibelelaneni nabanye abahlangabezana namava afanayo.

Imbonakalo

Ukuchongwa kwangoko kunye nenkqubela phambili kunyango kunceda ukwandisa amathuba akho okuphila ubomi obude kunye nobunempilo. Umbono wexesha elide we-ILC uxhomekeke kwizinto ezininzi, ezinje:

• inqanaba lomhlaza
• ibakala kunye ne-subtype
• imida yoqhaqho, okanye ukuba iiseli zomhlaza zisondele kangakanani kwizicwili ezisuswe ebeleni
• iminyaka yakho
• impilo yakho iyonke
• uphendula njani kunyango

Enye into echaphazela isiphumo kwi-ILC kukuba ingaba i-estrogen, iprogesterone, okanye i-HER2 (i-human epidermal ukukhula factor receptor 2) ii-receptors ziyafumaneka kumphezulu weeseli zomhlaza.