Dermatitis Herpetiformis kunye nokunganyamezelani kweGluten

Umxholo

• Imifanekiso yedermatitis herpetiformis
• Yintoni ebangela i-dermatitis herpetiformis?
• Ngubani osemngciphekweni wedermatitis herpetiformis?
• Zithini iimpawu zedermatitis herpetiformis?
• Ichongwa njani i-dermatitis herpetiformis?
• Luluphi unyango olufumanekayo kwi-dermatitis herpetiformis?
• Zeziphi iingxaki zedermatitis herpetiformis?
• Yintoni imbonakalo yexesha elide yedermatitis herpetiformis?

Yintoni i-dermatitis herpetiformis?

Ukurhawuzelela, ukutshiza, ukutshisa isikhumba, i-dermatitis herpetiformis (i-DH) imeko enzima ukuhlala nayo. Irhashalala kunye nokurhawuzelela kwenzeka kwiingqiniba, emadolweni, entlonzeni, ngasemva nasezimpundu. Oku kungxamiseka kubonisa ukunganyamezelani kwe-gluten, enokuthi inxulumene nemeko ebaluleke kakhulu eyaziwa ngokuba sisifo se-celiac. I-DH ngamanye amaxesha ibizwa ngokuba sisifo sikaDuhring okanye isifo se-gluten. Abantu abanayo le meko kufuneka bagcine ukutya okungqongqo okungahambisani ne-gluten.

Imifanekiso yedermatitis herpetiformis

Yintoni ebangela i-dermatitis herpetiformis?

Ukusuka kwisandi segama, abantu abaninzi bacinga ukuba olu rhashalala lubangelwa luhlobo oluthile lwentsholongwane ye-herpes. Oku akunjalo, njengoko kungenanto enxulumene ne-herpes. I-Dermatitis herpetiformis yenzeka kubantu abanesifo se-celiac. Isifo seCeliac (esikwabizwa ngokuba yi-celiac sprue, ukunganyamezelani kwe-gluten, okanye i-enteropathy e-gluten-sensitive) sisifo sokuzimela komzimba esibonisa ukunganyamezelani kwi-gluten. IGluten yiprotein efumaneka kwingqolowa, irye nerhasi. Kwakhona ngamanye amaxesha kufumaneka kwi-oats esele iqhutyelwe kwizityalo eziphethe ezinye iinkozo.

NgokweZiko leSizwe lezeMpilo (NIH), iipesenti ezili-15 ukuya kwezi-25 zabantu abanesifo se-celiac bane-DH. Isifo seCeliac sinokubangela ukuba iintlungu zesisu, ukuqunjelwa, isicaphucaphu kunye nokugabha. Abantu abane-DH ngokwesiqhelo abanazo naziphi na iimpawu zamathumbu. Nangona kunjalo, nangona bengafumani naziphi na iimpawu zamathumbu, iipesenti ezingama-80 okanye ngaphezulu zabantu abane-DH basenomonakalo wamathumbu, ngakumbi ukuba batya ukutya okuphezulu kwi-gluten, ngokweNational Foundation for Celiac Awareness (NFCA).

Umonakalo wamathumbu kunye nerhashalala zibangelwa kukusabela kweeproteni zegluten ngohlobo olukhethekileyo lwe-antibody ebizwa ngokuba yi-immunoglobulin A (IgA). Umzimba wakho wenza ii-antibodies ze-IgA zihlasele iiproteni ze-gluten. Xa ii-antibodies ze-IgA zihlasela i-gluten, zonakalisa iinxalenye zamathumbu ezikuvumela ukuba ufumane iivithamini kunye nezakha mzimba. Olu luvo kwi-gluten luhlala luhamba kwiintsapho.

Ulwakhiwo olwenziwe xa i-IgA incamathele kwi-gluten emva koko ingena kwigazi, apho baqala khona ukuvala imithambo yegazi encinci, ngakumbi leyo yolusu. Iiseli ezimhlophe zegazi ziyatsaleleka kwezi clogs. Iiseli ezimhlophe zegazi zikhupha imichiza ebizwa ngokuba yi "complement" ebangela ukurhawuzelela, irhashalala.

Ngubani osemngciphekweni wedermatitis herpetiformis?

Isifo seCeliac sinokuchaphazela nabani na, kodwa sihlala siqhelekile kubantu abanelinye ilungu losapho elinesifo se-celiac okanye i-DH.

Nangona abafazi abaninzi kunamadoda bafumanisa ukuba banesifo se-celiac, amadoda kunokwenzeka ukuba aphuhlise i-DH kunabasetyhini, ngokwe-NIH. Ukugqithisa ngokuqhelekileyo kuqala kwi-20s okanye kwi-30s, nangona ingaqala ebuntwaneni. Le meko ixhaphake kakhulu kubantu abanemvelaphi yaseYurophu. Ayichaphazeli kangako abantu abanemvelaphi yaseAfrika okanye yaseAsia.

Zithini iimpawu zedermatitis herpetiformis?

I-DH yenye yezona ngxaki zinqabileyo zinokwenzeka. Iindawo eziqhelekileyo zokukhawuleza ziquka:

• iingqiniba
• amadolo
• umva ongezantsi
• iinwele
• umva wentamo
• amagxa
• iimpundu
• ulusu

Irhashalala lihlala lilingana ngokufanayo kunye nokumila kumacala omabini omzimba kwaye kuhlala kuza kuhamba.

Phambi kokuba kuqhambuke irhashalala ngokupheleleyo, unokuziva ulusu kwindawo e-rash-prone etshisayo okanye ukurhawuzelela. Amaqhuma abonakala ngathi ngamaqhakuva azaliswe lulwelo olucacileyo aqala ukwenza. Ezi zikrwitshiwe ngokukhawuleza. Amaqhuma ayaphola kwiintsuku nje ezimbalwa kwaye ashiye uphawu olubomvu oluhlala iiveki. Kodwa amaqhuma amatsha ayaqhubeka ukwenzeka njengoko abadala bephilisa. Le nkqubo ingaqhubeka kangangeminyaka, okanye ingene kuxolelo kwaye ibuye.

Ngelixa ezi mpawu zihlala zinxulunyaniswa ne-dermatitis herpetiformis, zinokubangelwa zezinye iimeko zolusu ezinje nge-atopic dermatitis, i-irritant okanye i-allergic contact dermatitis, i-psoriasis, i-pemphigoid, okanye ukhwekhwe.

Ichongwa njani i-dermatitis herpetiformis?

I-DH ifunyaniswa ngcono ukuba ine-biopsy yolusu. Ugqirha uthatha isampulu encinci yesikhumba kwaye uyivavanya phantsi kwemicroscope. Ngamanye amaxesha, kuvavanyo lwe-immunofluorescence ngqo lwenziwa, apho ulusu olujikeleze irhashalala ludyojwe nedayi eya kubonisa ubukho be-IgA antibody deposits. I-biopsy yolusu inokukunceda ukumisela ukuba iimpawu zibangelwa yenye imeko yolusu.

Uvavanyo lwegazi ukukhangela la machiza egazini nawo angenziwa. I-biopsy yamathumbu ingenziwa ukuze kuqinisekiswe ubukho bomonakalo ngenxa yesifo se-celiac.

Ukuba isifo asiqinisekanga, okanye olunye uvavanyo lunokwenzeka, olunye uvavanyo lunokwenziwa. Ukuvavanywa kwepatch yeyona ndlela ilungileyo yokufumanisa isifo soqhakamshelwano lwe-dermatitis, esisizathu esivakalayo seempawu ezifana ne-dermatitis herpetiformis.

Luluphi unyango olufumanekayo kwi-dermatitis herpetiformis?

I-DH inokunyangwa nge-antibiotic ebizwa ngokuba yi-dapsone. I-Dapsone liyeza elinamandla elinemiphumo emibi. Idosi kufuneka inyuswe kancinci ngaphezulu kweenyanga ezininzi ngaphambi kokuba isebenze ngokupheleleyo.

Uninzi lwabantu lubona isiqabu ekuthatheni i-dapsone, kodwa iziphumo ebezingalindelekanga zinokubandakanya:

• iingxaki zesibindi
• uvakalelo elangeni
• ianemia
• ubuthathaka bemisipha
• peripheral neuropathy

I-Dapsone inokuba nonxibelelwano olubi namanye amayeza, anje nge-aminobenzoate potassium, i-clofazimine, okanye i-trimethoprim.

Ezinye iziyobisi ezinokusetyenziswa zibandakanya i-tetracycline, i-sulfapyridine, kunye nezinye iziyobisi ezikhuselayo. Oku akusebenzi kangako kune-dapsone.

Olona nyango lusebenzayo olungenaziphumo zecala kukunamathela ngokungqongqo kukutya okungahambisani ne-gluten. Oku kuthetha ukuba kuya kufuneka uphephe ngokupheleleyo ukutya, isiselo, okanye amayeza aqukethe oku kulandelayo:

• ingqolowa
• rye
• irhasi
• ioats

Nangona oku kutya kunokuba nzima ukulandela, kuya kuba nefuthe eliluncedo kwimpilo yakho ukuba unesifo se-celiac. Nakuphi na ukuncitshiswa kokutya kwe-gluten kunokunceda ekunciphiseni isixa samayeza oza kuwathatha.

Zeziphi iingxaki zedermatitis herpetiformis?

Abantu abane-DH enganyangekiyo kunye nesifo se-celiac banokuba semngciphekweni omkhulu womhlaza wamathumbu ngenxa yokudumba okungapheliyo emathunjini. Ukusilela kweVitamin kunye ne-anemia nako kunokuba yingxaki ukuba amathumbu awathathi izondlo ngokufanelekileyo.

Kuba i-DH sisifo esizimele, ifumanise ukuba ikwanxulunyaniswa nezinye iintlobo zezifo ezizimele. Oku kubandakanya:

• hypothyroidism
• vitiligo
• uhlobo 1 seswekile
• imysthenia gravis
• Isifo sikaSjögren
• irheumatoid Arthritis

Yintoni imbonakalo yexesha elide yedermatitis herpetiformis?

I-DH sisifo sobomi bonke. Unokungena ekuxolelweni, kodwa naliphi na ixesha xa uvezwa kwi-gluten, unokuba nokuqhuma kwe-rash. Ngaphandle konyango, i-DH kunye nesifo se-celiac sinokubangela iziphumo ezininzi zempilo, kubandakanya ukusilela kweevithamini, i-anemia, kunye nomhlaza wamathumbu.

Unyango nge-dapsone lunokulawula iimpawu zokukhawuleza ngokukhawuleza. Nangona kunjalo, umonakalo wamathumbu obangelwa sisifo se-celiac unokunyangwa kuphela ngokugcina ukutya okungqongqo okungahambelani ne-gluten. Qiniseka ukuba uxoxa ngogqirha okanye isazi sezondlo malunga naziphi na iindlela zokutya.