Uzipho lukaMtyholi: Izibonelelo, Iziphumo ebezingalindelekanga kunye nedosi

Umxholo

• Yintoni iClaw's Devil?
• Ngamana unokunciphisa ukuvuvukala
• Ngamana unokuphucula iOsteoarthritis
• Ngamana zinokunciphisa iimpawu zeGout
• Ngamana Unokudambisa Ubuhlungu Bokubuyela
• Ngamana bangakhuthaza ukunciphisa umzimba
• Iziphumo ebezingalindelekanga kunye nonxibelelwano
• Imilinganiselo ekhuthaziweyo
• Umgca osezantsi

Uzipho lukaMtyholi, ngokwenzululwazi olwaziwa njenge IHarpagophytum procumbens, sisityalo esizalelwa eMzantsi Afrika. Inetyala elinegama elothusayo kwisiqhamo sayo, esiqulatha uqikelelo oluncinci olunje ngeheyiphu.

Ngokwesiko, iingcambu zesi sityalo bezisetyenziselwa ukunyanga uluhlu lwezigulo, ezinje ngomkhuhlane, iintlungu, isifo samathambo kunye nokugaya (1).

Eli nqaku liphonononga izibonelelo ezinokubakho zenzipho yomtyholi.

Yintoni iClaw's Devil?

Uzipho lukaMtyholi sisityalo esidubula iintyatyambo kusapho lwesame. Iingcambu zayo zipakisha iikhompawundi zezityalo ezisebenzayo kwaye zisetyenziswa njengesongezo semifuno.

Ngokukodwa, uzipho lukaSathana luqukethe i-iridoid glycosides, iklasi yeekhompawundi ezibonise iziphumo ezichasayo ().

Ezinye kodwa ayizizo zonke izifundo ezibonisa ukuba i-iridoid glycosides inokuba nefuthe lokulwa ne-antioxidant. Oku kuthetha ukuba isityalo sinokubanakho ukukhusela isiphumo esonakalisa iiseli kwiimolekyuli ezingazinzanga ezibizwa ngokuba ziiradical radicals (3,,).

Ngenxa yezi zizathu, izongezo zikaSathana zenzipho ziye zafundwa njengesixhobo esinokubakho seemeko ezinxulumene nokudumba, ezinje ngesifo samathambo kunye negawuthi. Ukongeza, kucetyisiwe ukunciphisa iintlungu kwaye kunokuxhasa ukunciphisa umzimba.

Unokufumana i-devil's claw supplements ngendlela ye-extracts kunye neepilisi, okanye umhlaba ube ngumgubo ocolekileyo. Isetyenziswe njengesithako kwiitayi ezahlukeneyo zemifuno.

Uzipho lukaMtyholi sisongezo semifuno esetyenziswa ikakhulu njengolunye unyango lwe-arthritis kunye neentlungu. Iza ngeendlela ezininzi, kubandakanya izicatshulwa ezixineneyo, iicapsule, umgubo kunye neti yemifuno.

Ngamana unokunciphisa ukuvuvukala

Ukuvuvukala kukuphendula kwendalo komzimba wakho ekonzakaleni kunye nosulelo. Xa usika umnwe, bamba idolo okanye wehle nomkhuhlane, umzimba wakho uphendula ngokwenza amajoni akho omzimba ().

Ngelixa ukudumba kuyimfuneko ukukhusela umzimba wakho kwingozi, ukudumba okungapheliyo kunokuba yingozi kwimpilo. Ngapha koko, uphando oluqhubekayo luye lwadibanisa ukudumba okungapheliyo nesifo sentliziyo, isifo seswekile kunye nokuphazamiseka kwengqondo (,,).

Ewe kunjalo, kukho iimeko ezichazwe ngokuthe ngqo kukudumba, ezinje ngesifo samathumbu esivuthayo (IBD), isifo samathambo kunye negout (, 11,).

Uzipho lukaMtyholi luye lwacetyiswa njengesixhobo esinokubakho sokudumba imeko kuba iqulethe izixube zezityalo ezibizwa ngokuba yi-iridoid glycosides, ngakumbi i-harpagoside. Kwityhubhu yovavanyo kunye nezifundo zezilwanyana, iharpagoside iye yathintela iimpendulo zokukrala ().

Umzekelo, uphononongo kwiimpuku lubonise ukuba iharpagoside icinezele ngokubonakalayo isenzo se cytokines, eziyimolekyuli emzimbeni wakho ezaziwayo ukukhuthaza ukudumba ().

Nangona inzipho kasathana ingakhange ifundwe kakhulu ebantwini, ubungqina bokuqala bucebisa ukuba inokuba lolunye unyango lweemeko zokudumba.

Uzipho lukaMtyholi luqulathe iikhompawundi zezityalo ezibizwa ngokuba yi-iridoid glycosides, eziye zaboniswa ukucinezela ukudumba kwi-tube-test nakwizifundo zezilwanyana.

Ngamana unokuphucula iOsteoarthritis

I-Osteoarthritis yeyona ndlela ixhaphakileyo yesifo samathambo, ichaphazela abantu abadala abangaphezu kwezigidi ezingama-30 e-US ().

Kwenzeka xa isigqubuthelo esikhuselayo esiphelweni samathambo akho adibeneyo- abizwa ngokuba yi-cartilage-ayaphela. Oku kubangela ukuba amathambo ahlikihle kunye, okukhokelela kukudumba, ukuqina kunye neentlungu (16).

Izifundo ezikumgangatho ophezulu ziyafuneka, kodwa uphando lwangoku lubonisa ukuba uzipho lwedemon lusenokusebenza ukunciphisa iintlungu ezinxulunyaniswa ne-osteoarthritis.

Umzekelo, olunye uphando lweklinikhi olubandakanya abantu abayi-122 abane-osteoarthritis yamadolo kunye ne-hip bacebisa ukuba i-2,610 mg ye-devil's claw yonke imihla inokusebenza ngokunciphisa iintlungu ze-osteoarthritis njenge-diacerein, iyeza eliqhele ukusetyenziselwa ukunyanga le meko ().

Ngokufanayo, isifundo seenyanga ezi-2 kubantu abangama-42 abane-osteoarthritis engapheliyo bafumanisa ukuba ukongeza yonke imihla nge-claw's devil ngokudibanisa ne-turmeric kunye ne-bromelain, ekucingelwa ukuba ineziphumo ezichasayo, kwaye kunciphisa iintlungu nge-avareji ye-46% ().

Uphando lubonisa ukuba uzipho lukaSathana lunokunceda ekuthomalaliseni iintlungu ezidibeneyo ezinxulunyaniswa ne-osteoarthritis kwaye zinokusebenza ngokuchanekileyo njenge-diacerein yokuthomalalisa iintlungu.

Ngamana zinokunciphisa iimpawu zeGout

Igawuthi lolunye uhlobo oluqhelekileyo lwesifo samathambo, esibonakala ngokudumba okubuhlungu nokubomvu kumalungu, ihlala iinzwane, amaqatha namadolo ().

Kubangelwa kukwakheka kwe-uric acid egazini, ethi yenziwe xa i-purines - iikhompawundi ezifumaneka kukutya okuthile-zidiliza ().

Amayeza, anjengee-nonsteroidal anti-inflammatory drugs (ii-NSAIDs), aqhele ukusetyenziselwa ukunciphisa iintlungu kunye nokudumba okubangelwa yintsholongwane.

Ngenxa yeempembelelo ezichasayo ezichasayo kunye nokukwazi ukunciphisa intlungu, i-devil's claw iye yacetyiswa njengolunye unyango kulabo abane-gout (20).

Kwakhona, abanye abaphandi bacebisa ukuba inganciphisa i-uric acid, nangona ubungqina besayensi bunqunyelwe. Kwisifundo esinye, iidosi eziphezulu zedisk's claw zinciphise amanqanaba e-uric acid kwiimpuku (21, 22).

Nangona ityhubhu yovavanyo kunye nophando lwezilwanyana lubonisa ukuba uzipho lwedemoni lunokuthintela ukudumba, izifundo zeklinikhi zokuxhasa ukusetyenziswa kwe-gout ngokukodwa azifumaneki.

Ngokusekwe kuphando olunqongopheleyo, inzipho yomtyholi iye yacetyiswa ukunciphisa iimpawu ze-gout ngenxa yeempembelelo zayo ezichasayo kunye nokukwazi ukunciphisa amanqanaba e-uric acid.

Ngamana Unokudambisa Ubuhlungu Bokubuyela

Iintlungu ezisezantsi ngumthwalo kwabaninzi. Ngapha koko, kuqikelelwa ukuba i-80% yabantu abadala bayayifumana ngamanye amaxesha okanye kwelinye (23).

Kanye kunye neempembelelo ezichasayo, i-devil's claw ibonisa amandla okunciphisa intlungu, ngokukodwa kwiintlungu ezisezantsi. Abaphandi bathi le nto yi-harpagoside, isityalo esisebenzayo kwi-claw's devil.

Kwesinye isifundo, isicatshulwa se-harpagoside sibonakala sisebenza ngokufanayo njenge-nonsteroidal anti-inflammatory drug (NSAID) ebizwa ngokuba yiVioxx. Emva kweeveki ezi-6, iintlungu ezisezantsi zabathathi-nxaxheba zancitshiswa ngama-23% aphakathi kunye ne-harpagoside kunye ne-26% nge-NSAID ().

Kwakhona, izifundo ezimbini zeklinikhi zifumanise ukuba i-50-100 gram ye-harpagoside ngosuku yayisebenza ngakumbi ekunciphiseni iintlungu ezisezantsi xa kuthelekiswa nonyango, kodwa kufuneka izifundo ezingaphezulu ukuqinisekisa ezi ziphumo (,).

Uzipho lukaMtyholi lubonisa ukubakho njengokuthomalalisa iintlungu, ngakumbi iintlungu ezisezantsi. Abaphandi bathi le nto yenziwe sisityalo esikwinzipho kasathana ebizwa ngokuba yi-harpagoside. Nangona kunjalo, uphando oluninzi luyafuneka ukuqinisekisa ezi ziphumo.

Ngamana bangakhuthaza ukunciphisa umzimba

Ngaphandle kokunciphisa iintlungu kunye nokudumba, uzipho lukaSathana lunokucinezela ukutya ngokusebenzisana nehommone yendlala ghrelin ().

IGhrelin ifihliwe sisisu sakho. Omnye wemisebenzi yayo ephambili kukubonisa ingqondo yakho ukuba lixesha lokutya ngokwandisa umdla wokutya ().

Kwisifundo seempuku, izilwanyana ezifumene inzipho yomtyholi yeengcambu zomgubo zitye ukutya okuncinci kwezi yure zine zilandelayo kunalezo ziphathwe nge-placebo ().

Nangona ezi ziphumo zinomdla, ezi ziphumo zokunciphisa ukutya azikaze zifundwe ebantwini. Ke ngoko, ubungqina obubambekayo bokuxhasa ukusebenzisa inzipho yomtyholi yokunciphisa umzimba ayifumaneki ngeli xesha.

Uzipho lukaMtyholi lunokucinezela isenzo se-ghrelin, ihomoni emzimbeni wakho eyonyusa ukutya kwaye ibonakalise ingqondo yakho ukuba lixesha lokutya. Nangona kunjalo, uphando olusekwe ebantwini kwesi sihloko alufumaneki.

Iziphumo ebezingalindelekanga kunye nonxibelelwano

Uzipho lukaMtyholi lubonakala lukhuselekile xa luthathwa ngeedosi ukuya kuthi ga kwi-2,610 mg yonke imihla, nangona iziphumo zexesha elide zingakhange ziphandwe (29).

Iziphumo ebezingalindelekanga ezichaziweyo azithambile, olona luqhelekileyo lurhudo. Iziphumo ezibi kakhulu ezibandakanya ukungahambelani komzimba, intloko kunye nokukhohlela ().

Nangona kunjalo, ezinye iimeko zinokukubeka emngciphekweni omkhulu wokuphendula okunzulu (31):

• Ukuphazamiseka kwentliziyo: Izifundo zibonise ukuba uzipho lukaSathana lunokuchaphazela ukubetha kwentliziyo, ukubetha kwentliziyo kunye noxinzelelo lwegazi.
• Seswekile: Uzipho lukaMtyholi lunokwehlisa amanqanaba eswekile yegazi kwaye luqinise iziphumo zamayeza eswekile.
• Ilitye: Ukusetyenziswa kweenzipho zikamtyholi kunokunyusa ukwakheka kwenyongo kwaye kubangele iingxaki ngakumbi kwabo banezinyongo.
• Izilonda esiswini: Ukuveliswa kweasidi esiswini kunokwanda ngokusetyenziswa kweenzipho zikamtyholi, ezinokukhulisa izilonda ezinamachiza.

Amayeza aqhelekileyo anokuphinda asebenzisane kakubi neenzipho zedemon, kubandakanya iziyobisi ezichasayo (i-NSAID), amayeza egazi kunye nesinciphisi sesisu esiswini (31):

• Ii-NSAID: Uzipho lukaMtyholi lunokucothisa ukufunxwa kweeNSAID ezidumileyo, ezinjengeMotrin, iCelebrex, iFeldene kunye neVoltaren.
• Abacoci begazi: Uzipho lukaMtyholi lunokuphucula iziphumo zeCoumadin (ekwabizwa ngokuba yi-warfarin), enokuthi ikhokelele ekwandeni kokopha kunye nokugruzuka.
• Isinciphisi seasis esiswini: Uzipho lukaMtyholi lunokunciphisa iziphumo zokuncipha kwesisu esiswini, njengePepcid, Prilosec kunye nePrevacid.

Olu ayilo luhlu lubandakanya konke ukusebenzisana kwamayeza. Ukuze ube kwicala elikhuselekileyo, soloko uxoxa ngokusebenzisa kwakho izongezo kunye nogqirha wakho.

Kubantu abaninzi, umngcipheko weziphumo ebezingalindelekanga zenzipho yomtyholi iphantsi. Nangona kunjalo, isenokungafaneleki kubantu abaneemeko ezithile zempilo kunye nabo bathatha amayeza athile.

Imilinganiselo ekhuthaziweyo

Uzipho lukaMtyholi lunokufunyanwa njengesicatshulwa esixineneyo, icapsule, itablet okanye umgubo. Ikwasetyenziswa njengesithako kwiitayi zemifuno.

Xa ukhetha isongezelelo, jonga ukugxila kwe-harpagoside, ikhompawundi esebenzayo kwinzipho kasathana.

Imithamo ye-600-2,610 mg ye-slaw's claw mihla le isetyenzisiwe kwizifundo ze-osteoarthritis kunye nentlungu yomqolo. Ngokuxhomekeke kwingxinano yokukhupha, oku kuhambelana ne-50-100 mg ye-harpagoside ngosuku (,,,).

Ukongeza, isongezelelo esibizwa ngokuba yi-AINAT sisetyenzisiwe njengeyeza lokunyanga kwamathambo. I-AINAT iqulethe i-300 mg ye-devil's claw, kunye ne-200 mg ye-turmeric kunye ne-150 mg ye-bromelain - ezinye izicatshulwa zezityalo ezimbini ezikholelwa ukuba zineziphumo ezichasayo ().

Kwezinye iimeko, izifundo ezaneleyo zokufumanisa iidosi ezifanelekileyo azifumaneki.Ukongeza, uzipho lukaSathana lusetyenziswe kuphela ukuya kunyaka omnye kwizifundo. Nangona kunjalo, uzipho lomtyholi lubonakala lukhuselekile kubantu abaninzi ngeedosi ukuya kuthi ga kwi-2,610 mg ngosuku (29).

Gcina ukhumbula ukuba iimeko ezithile, ezinjengesifo sentliziyo, isifo seswekile, amatye ezintso kunye nezilonda zesisu, zinokunyusa umngcipheko weziphumo ezibi xa uthatha uzipho lukaSathana.

Kwakhona, nayiphi na idosi yeclaw's devil's cake inokuphazamisa amayeza onokuthi uwathathe. Oku kubandakanya iziyobisi ezichasayo (ii-NSAID), ii-thinner zegazi kunye nesinciphisi seasis esiswini.

Uzipho lukaMtyholi lubonakala luncedo ngeedosi ezingama-600-2610 mg ngosuku. Izifundo ezingaphezulu ziyafuneka ukumisela ukuba ngaba la madosi ayasebenza kwaye akhuselekile ixesha elide.

Umgca osezantsi

Uzipho lukaMtyholi lunokuthomalalisa iintlungu ezibangelwa ziimeko ezidumbayo ezifana nesifo samathambo kwaye zinokucinezela iihomoni zendlala.

Imithamo yemihla ngemihla ye-600-2,610 mg ibonakala ikhuselekile, kodwa akukho ngcebiso yaseburhulumenteni ikhona.

Iziphumo ebezingalindelekanga zihlala ziphakathi, kodwa uzipho lukaSathana lunokuba mandundu kwimicimbi ethile yezempilo kwaye asebenzisane namayeza athile.

Njengazo zonke izongezo, inzipho kasathana kufuneka isetyenziswe ngononophelo. Qiniseka ukuba uthethe nogqirha wakho ngaphambi kokuba uthathe.