Unyango lwe-RA: Ii-DMARD kunye ne-TNF-Alpha Inhibitors

Umxholo

• Intshayelelo
• Ii-DMARD: Kubalulekile kunyango lwakwangoko
• Ii-DMARDs ngeepilisi zentlungu
• ICorticosteroids
• Ii-NSAID ezingaphezulu kwe-counter
• IiNSAID ezimiselweyo
• Ii-DMARD kunye nosulelo
• I-TNF-alpha inhibitors
• Thetha nogqirha wakho
• Q:
• A:

Intshayelelo

I-rheumatoid arthritis (RA) sisifo esingapheliyo sokuzimela. Ibangela ukuba amajoni akho omzimba ahlasele izicwili ezisempilweni kumalungu akho, okukhokelela kwintlungu, ukudumba, kunye nokuqina. Ngokungafaniyo ne-osteoarthritis, ebangelwa kukunxiba okuqhelekileyo kunye nokukrazula njengoko uneminyaka yobudala, i-RA inokuchaphazela nabani na nangaliphi na ubudala. Akukho mntu waziyo kakuhle ukuba ibangelwa yintoni.

I-RA ayinanyango, kodwa amayeza anokunceda ekunciphiseni iimpawu. La mayeza abandakanya iziyobisi ezichasayo, ii-corticosteroids, kunye neziyobisi ezicinezela amajoni omzimba. Olunye lonyango olusebenzayo lonyango lwezifo lutshintsho lweziyobisi ezichasene ne-rheumatic (DMARDs), ezibandakanya i-TNF-alpha inhibitors.

Ii-DMARD: Kubalulekile kunyango lwakwangoko

Ii-DMARD ngamayeza e-rheumatologists ahlala ewachaza kanye emva kokuchongwa kwe-RA. Uninzi lomonakalo odibeneyo osisigxina ovela kwiRA wenzeka kwiminyaka emibini yokuqala, ke la machiza angenza impembelelo enkulu kwangethuba kwesi sifo.

Ii-DMARD zisebenza ngokwenza buthathaka amajoni akho omzimba. Eli nyathelo linciphisa uhlaselo lweRA kumalungu akho ukunciphisa umngcipheko opheleleyo.

Imizekelo yee-DMARD zibandakanya:

• imethotrexate (iOtrexup)
• ihydroxychloroquine (iPlaquenil)
• leflunomide (Arava)

Ii-DMARDs ngeepilisi zentlungu

Eyona nto iphambili ekusebenziseni i-DMARD kukuba bayacotha ukwenza. Kungathatha iinyanga ezininzi ukuziva nayiphi na intlungu evela kwi-DMARD. Ngesi sizathu, i-rheumatologists zihlala zichaza iipilisi zentlungu ezisebenza ngokukhawuleza ezinje nge-corticosteroids okanye ii-nonsteroidal anti-inflammatory (NSAIDs) ukuba zithathe ngexesha elinye. La machiza anokunceda ukunciphisa iintlungu ngelixa ulinde i-DMARD ukuba iqale ukusebenza.

Imizekelo ye-corticosteroids okanye ii-NSAID ezinokusetyenziswa nee-DMARD zibandakanya:

ICorticosteroids

• i-prednisone (iRayos)
• imethylprednisolone (iDepo-Medrol)
• triamcinolone (Aristospan)

Ii-NSAID ezingaphezulu kwe-counter

• Iasprini
• ibuprofen
• naproxen isodiyam

IiNSAID ezimiselweyo

• mzantsiweb
• iselecoxib (Celebrex)
• ipiroxicam (Feldene)

Ii-DMARD kunye nosulelo

Ii-DMARD zichaphazela onke amajoni akho omzimba. Oku kuthetha ukuba bakubeka emngciphekweni omkhulu wokosuleleka.

Ezona zifo zixhaphakileyo abanazo abaguli beRA zezi:

• usulelo lolusu
• izifo eziphezulu zokuphefumula
• ukukrala kwemiphunga
• usulelo lomchamo

Ukunceda ukuthintela usulelo, kuya kufuneka wenze ucoceko olulungileyo, kubandakanya ukuhlamba izandla rhoqo kunye nokuhlamba yonke imihla okanye yonke imihla. Kufuneka uhlale kude nabantu abagulayo.

I-TNF-alpha inhibitors

I-tumor necrosis factor alpha, okanye i-alpha ye-TNF, yinto eyenzeka ngokwendalo emzimbeni wakho. Kwi-RA, iiseli zomzimba zokuhlasela ezihlasela amalungu zidala amanqanaba aphezulu e-alfa ye-TNF. La manqanaba aphezulu abangela iintlungu kunye nokudumba. Ngelixa ezinye izinto ezininzi zongeza kumonakalo weRA kumalungu, i-alfa ye-TNF ngumdlali ophambili kwinkqubo.

Ngenxa yokuba i-alfa ye-TNF yingxaki enkulu kwi-RA, i-TNF-alpha inhibitors yenye yezona ntlobo zibalulekileyo ze-DMARD kwintengiso ngoku.

Kukho iintlobo ezintlanu ze-TNF-alpha inhibitors:

• adalimumab (Humira)
• I-etanercept (i-Enbrel)
• isatifikethi sepgol (Cimzia)
• igolimumab (iSimponi)
• infliximab (I-Remicade)

La machiza abizwa ngokuba zii-block blockers ze-TNF kuba athintela ukusebenza kwe-alpha ye-TNF. Banciphisa amanqanaba e-alfa e-TNF emzimbeni wakho ukunceda ukunciphisa iimpawu ze-RA. Baqala ukusebenza ngokukhawuleza kunezinye ii-DMARD. Baqala ukusebenza kwisithuba seeveki ezimbini ukuya kwinyanga.

Thetha nogqirha wakho

Uninzi lwabantu abane-RA baphendula kakuhle kwi-TNF-alpha inhibitors nakwezinye ii-DMARD, kodwa kwabanye abantu, olu khetho alunakusebenza konke konke. Ukuba azisebenzi kuwe, xelela i-rheumatologist yakho. Banokumisela i-TNF-alpha inhibitor eyahlukileyo njengenyathelo elilandelayo, okanye banokucebisa uhlobo olwahlukileyo lwe-DMARD ngokupheleleyo.

Qiniseka ukuba uhlaziya i-rheumatologist yakho malunga nendlela oziva ngayo kunye nendlela ocinga ngayo ukuba iyeza lakho lisebenza. Ngokudibeneyo, wena nogqirha wakho unokufumana isicwangciso sonyango RA esiza kukusebenzela.

Q:

Ngaba ukutya kwam kunokuchaphazela iRA yam?

A:

Ewe. Kukho ukutya okuninzi okunokunceda ukunciphisa ukudumba emzimbeni wakho. Ukuba ufuna ukuzama utshintsho kwindlela yokutya ukuze uphucule iimpawu zakho zeRA, qala ngokutya ukutya okuninzi okune-omega-3 fatty acids, antioxidants, kunye nefayibha, ezinje ngamandongomane, intlanzi, amajikijolo, imifuno, kunye neti eluhlaza. Enye indlela elungileyo yokuzisa oku kutya kwindlela yakho yemihla ngemihla kukulandela ukutya kweMeditera. Ngolwazi oluthe kratya malunga nokutya kunye nokunye ukutya okunokunceda ukunciphisa iimpawu ze-RA, jonga ukutya okuchasayo okuchasayo kweRA.