Izibonelelo ezili-10 zeNzululwazi yeMbewu yamaDiliya, ngokusekwe kwinzululwazi

Umxholo

• 1. Ngaba unokunciphisa uxinzelelo lwegazi
• 2. Ngaba unokuphucula ukuhamba kwegazi
• 3. Ngaba ukunciphisa umonakalo oxidative
• 4. Ngamana unokuphucula amanqanaba e-collagen kunye nokomelela kwethambo
• 5. Ixhasa ingqondo yakho njengoko indala
• 6. Ngaba unokuphucula ukusebenza kwezintso
• 7. Ngaba kuthintela ukukhula esosulelayo
• 8. Ngamana unokunciphisa umngcipheko womhlaza
• 9. Ngamana ungasikhusela isibindi sakho
• 10. Kwandisa ukuphola kwenxeba nokubonakala
• Iziphumo ebezingalindelekanga ezinokwenzeka
• Umgca wezantsi

Ukukhutshwa kwembewu yamagilebhisi (GSE) sisongezo sokutya esenziwe ngokususa, ukomisa, kunye nokucola imbewu ekrakra yeediliya.

Imbewu yamagilebhisi ityebile kwii-antioxidants, kubandakanya i-phenolic acid, anthocyanins, flavonoids, kunye ne-oligomeric proanthocyanidin complexes (OPCs).

Ngapha koko, i-GSE ngomnye wemithombo eyaziwa kakhulu yeproanthocyanidins (,).

Ngenxa yomxholo wayo ophakamileyo we-antioxidant, i-GSE inokunceda ekuthinteleni izifo kwaye ikhusele nxamnye noxinzelelo lwe-oxidative, ukonakala kwethishyu kunye nokudumba ().

Qaphela ukuba isicatshulwa sembewu yamagilebhisi kunye nokukhutshwa kwembewu yegrapefruit zombini zithengiswa njengezongezo kwaye zifinyezwe sisichazi se-GSE. Eli nqaku lixoxa ngokutsalwa kwembewu yeediliya.

Nazi izibonelelo zezempilo ezili-10 zokukhutshwa kwembewu yamagilebhisi, konke kusekwe kwisayensi.

1. Ngaba unokunciphisa uxinzelelo lwegazi

Izifundo ezininzi ziphande iziphumo ze-GSE kuxinzelelo lwegazi oluphezulu.

Ukuphononongwa kwezifundo ezili-16 kubantu abayi-810 abanexinzelelo oluphezulu lwegazi okanye umngcipheko ophakamileyo wokufumanisa ukuba ukuthatha i-100-2,000 mg ye-GSE yonke imihla kunciphise kakhulu uxinzelelo lwegazi lwe-systolic kunye ne-diastolic (inani eliphezulu nelisezantsi) nge-avareji ye-6.08 mmHg kunye ne-2.8 mmHg, ngokulandelelana.

Abo bangaphantsi kweminyaka engama-50 ngokutyeba kakhulu okanye ukuphazamiseka emzimbeni babonisa ezona mpucuko zinkulu.

Iziphumo ezithembisayo kakhulu zivela kwiidosi ezisezantsi ze-100-800 mg yonke imihla kwiiveki ze-8-16, kunokuba idosi enye ye-800 mg okanye nangaphezulu ().

Olunye uphononongo kubantu abadala abangama-29 abanexinzelelo oluphezulu lwegazi bafumanise ukuba ukuthatha i-300 mg ye-GSE mihla le kwehlisa uxinzelelo lwegazi lwe-systolic nge-5.6% kunye noxinzelelo lwegazi lwe-diastolic nge-4.7% emva kweeveki ezi-6 ().

Isishwankathelo I-GSE inokunceda ukunciphisa uxinzelelo lwegazi, ngakumbi kubantu abancinci ukuya kuthi ga kubantu abadala kunye nakwabo banobunzima obugqithisileyo.

2. Ngaba unokuphucula ukuhamba kwegazi

Olunye uphononongo lubonisa ukuba i-GSE inokuphucula ukuhamba kwegazi.

Kwisifundo seeveki ezisi-8 kwabafazi abayi-17 abasempilweni emva kokuyeka ukuya exesheni, ukuthatha i-400 mg ye-GSE ineziphumo zokuncipha kwegazi, ezinokuthi zinciphise umngcipheko wamahlwili egazi ().

Isifundo esongeziweyo kwabasetyhini abasibhozo abasempilweni kuvavanywa iziphumo zedosi enye ye-400-mg yeproanthocyanidin evela kwi-GSE kwangoko ilandelwa ziiyure ezingama-6 zokuhlala. Kwaboniswa ukunciphisa ukudumba komlenze kunye ne-edema ngama-70%, xa kuthelekiswa nokungathathi i-GSE.

Kwakweso sifundo sinye, abasibhozo abasetyhini abasempilweni abathathe idosi yemihla ngemihla ye-133-mg ye-proanthocyanidins ukusuka kwi-GSE kangangeentsuku ezili-14 bafumana i-40% engaphantsi kokudumba komlenze emva kweeyure ezingama-6 behleli ().

Isishwankathelo I-GSE ibonakalisiwe ukuphucula ukuhamba kwegazi kunye nokunciphisa umngcipheko wokuqunjelwa kwegazi, okunokunceda abo baneengxaki zokujikeleza kwegazi.

3. Ngaba ukunciphisa umonakalo oxidative

Inqanaba legazi eliphakamileyo le-LDL (embi) ye-cholesterol yinto eyaziwayo yesifo sentliziyo.

I-oxidation ye-LDL ye-cholesterol inyusa kakhulu lo mngcipheko kwaye idlala indima ephambili kwi-atherosclerosis, okanye i-plaque ye-fatty plaque kwimithambo yakho ().

Izongezo ze-GSE zifunyenwe ukunciphisa i-LDL oxidation ebangelwa kukutya okunamafutha aphezulu kwizifundo ezininzi zezilwanyana (,,).

Olunye uphando ebantwini lubonisa iziphumo ezifanayo (,).

Xa abantu abasibhozo abasempilweni betya ukutya okunamafutha aphezulu, ukuthatha i-300 mg ye-GSE kuthintele i-oxidation yamafutha egazini, xa kuthelekiswa nokunyuka kwe-150% kubonwe kwabo bangakhange bathathe i-GSE ().

Kwesinye isifundo, abantu abadala abangama-61 abasempilweni babone ukwehla nge-13.9% kwi-LDL ene-oxidized emva kokuthatha i-400 mg ye-GSE. Nangona kunjalo, isifundo esifanayo asikwazanga ukuphinda-phinda ezi ziphumo (,).

Ukongeza, isifundo kubantu abangama-87 abenziwa utyando lwentliziyo bafumanisa ukuba ukuthatha i-400 mg ye-GSE kusuku olungaphambi kotyando kunciphise uxinzelelo lwe-oxidative. Ke ngoko, i-GSE inokuthi ikhuselwe ekuqhubekeni nomonakalo wentliziyo ().

Isishwankathelo I-GSE inokunceda ukunciphisa umngcipheko wesifo sentliziyo ngokuthintela i-oxidation ye-LDL (embi) ye-cholesterol kunye nokunciphisa i-oxidation kwinyama yentliziyo ngexesha loxinzelelo.

4. Ngamana unokuphucula amanqanaba e-collagen kunye nokomelela kwethambo

Ukonyusa ukusetyenziswa kwe-flavonoid kunokuphucula ukuhlanganiswa kwe-collagen kunye nokwenziwa kwethambo.

Njengomthombo otyebileyo we-flavonoids, i-GSE inokunceda ukwandisa uxinano lwethambo kunye namandla.

Ngapha koko, izifundo zezilwanyana zifumanise ukuba ukongeza i-GSE nokuba yicalcium esezantsi, esemgangathweni, okanye ukutya okune-calcium ephezulu kunokunyusa uxinano lweethambo, umxholo wezimbiwa, kunye nokomelela kwethambo (,).

I-rheumatoid arthritis yimeko yokuzimela komzimba ebangela ukuvuvukala okukhulu kunye nokutshatyalaliswa kwethambo kunye namalungu.

Izifundo zezilwanyana zibonise ukuba i-GSE inokucinezela ukubhujiswa kwethambo kwi-autoimmune arthritis (,,).

I-GSE ikwanciphise kakhulu ukuqaqanjelwa, i-bony spurs, kunye nomonakalo odibeneyo kwiimpuku ze-osteoarthritic, ukuphucula amanqanaba e-collagen kunye nokunciphisa ukulahleka kwe-cartilage ().

Ngaphandle kweziphumo ezithembisayo zophando lwezilwanyana, izifundo zabantu ziyasilela.

Isishwankathelo Izifundo zezilwanyana zibonisa iziphumo ezithembisayo malunga nokukwazi kwe-GSE ukunceda ukunyanga iimeko ze-arthritic kunye nokukhuthaza impilo ye-collagen. Nangona kunjalo, uphando olusekwe ebantwini luyasilela.

5. Ixhasa ingqondo yakho njengoko indala

Indibaniselwano ye-Flavonoids ye-antioxidant kunye ne-anti-inflammatory iipropathi kucingelwa ukuba ziyalibazisa okanye zinciphise ukuqala kwezifo ze-neurodegenerative ezifana nesifo se-Alzheimer's ().

Elinye lamacandelo e-GSE yi-gallic acid, ethi ibonakalise ukuba izilwanyana kunye neelebhu zinokuthintela ukwenziwa kweefayibrari yi-beta-amyloid peptides ().

Izihloko zeeproteni ze-beta-amyloid kwingqondo ziimpawu zesifo se-Alzheimer's ().

Izifundo zezilwanyana zifumanise ukuba i-GSE inokuthintela ukulahleka kwememori, iphucule imeko yokuqonda kunye nenqanaba le-antioxidant yengqondo, kunye nokunciphisa izilonda zobuchopho kunye namaqela e-amyloid (,,,).

Isifundo esinye seeveki ezili-12 kubantu abadala abangama-111 abasempilweni bafumanisa ukuba ukuthatha i-150 mg ye-GSE mihla le kuphuculwe ingqwalaselo, ulwimi, kunye nememori ekhawulezileyo kunye nokulibaziseka ().

Nangona kunjalo, izifundo zabantu ngokusetyenziswa kwe-GSE kubantu abadala abanememori esele ikho okanye ukusilela kwengqondo kuyasilela.

Isishwankathelo I-GSE ibonisa ukubanakho ukuthintela uninzi lweempawu eziwohlokayo zobuchopho kunye nokwehla kwengqondo. Nangona kunjalo, kufuneka kwenziwe izifundo ezingakumbi zabantu.

6. Ngaba unokuphucula ukusebenza kwezintso

Izintso zakho zichaphazeleka ikakhulu kumonakalo we-oxidative, odla ngokungenakuguqulwa.

Izifundo zezilwanyana zibonise ukuba i-GSE inokunciphisa umonakalo wezintso kunye nokuphucula ukusebenza ngokunciphisa uxinzelelo lwe-oxidative kunye nomonakalo wokudumba (,,).

Kwisifundo esinye, abantu abangama-23 abafunyaniswe benesifo esinganyangekiyo sezintso banikwa iigram ezi-2 ze-GSE yonke imihla iinyanga ezi-6 emva koko bathelekiswa neqela le-placebo. Iprotheyini ye-Urinary yehle nge-3% kwaye ukuhluza izintso kuphuculwe nge-9%.

Oku kuthetha ukuba izintso zalabo bakwiqela lokuvavanya babekwazi kangcono ukucoca umchamo kunezintso zalabo bakwiqela le-placebo ().

Isishwankathelo I-GSE inokubonelela ngokhuseleko kumonakalo woxinzelelo lwe-oxidative kunye nokudumba, oko ke kukhuthaza impilo yezintso.

7. Ngaba kuthintela ukukhula esosulelayo

I-GSE ibonisa ukuthembisa iipropathi zokulwa neentsholongwane kunye nokubola.

Izifundo zibonise ukuba i-GSE inqanda ukukhula kweentsholongwane eziqhelekileyo zokutya, kubandakanya Ubunjani benkampu kwaye E. coli, zombini ezi zinto zihlala zinoxanduva lokutya okunesifo kunye nesisu esiswini (33, 34).

Kwizifundo zelebhu, i-GSE ifunyenwe inhibit iintlobo ezingama-43 zokunganyangeki ngamayeza IStaphylococcus aureus iintsholongwane ().

I-Candida yintsholongwane eqhelekileyo enjengegwele enokuthi ngamanye amaxesha ibangele ukwanda kwe-candida, okanye i-thrush. I-GSE isetyenziswa ngokubanzi kumayeza emveli njengeyeza lecandida.

Kwisifundo esinye, iimpuku ezine-candidiasis yelungu lobufazi zanikwa isisombululo se-GSE sangaphakathi qho ngeentsuku ezimbini kwiintsuku ezisi-8. Usulelo lwathintelwa emva kweentsuku ezintlanu kwaye lwasemva ko-8 ().

Ngelishwa, izifundo zabantu kubuchule be-GSE bokunceda ukunyanga usulelo zisasilela.

Isishwankathelo I-GSE inokuthintela iintlobo ezahlukeneyo zeentsholongwane kwaye inikeze ukhuseleko ngokuchasene nentsholongwane enganyangekiyo yintsholongwane, izifo ezibangelwa kukutya ezibangelwa ziibhakteriya, kunye nosulelo lokungunda olufana necandida.

8. Ngamana unokunciphisa umngcipheko womhlaza

Unobangela womhlaza unzima, nangona umonakalo we-DNA luphawu oluphambili.

Ukutya okuphezulu kwee-antioxidants, ezinje nge-flavonoids kunye neproanthocyanidins, zinxulunyaniswa nomngcipheko omncinci wee-cancer ezahlukeneyo ().

Umsebenzi we-antioxidant we-GSE ubonakalise ukubanakho ukuthintela isifuba somntu, imiphunga, isisu, iseli yomlomo egcobayo, isibindi, iprostate, kunye nemigca yeseli yepancreatic kuseto lwelebhu (,,,).

Kwizifundo zezilwanyana, i-GSE ibonakalisiwe ukuba inyuse isiphumo seentlobo ezahlukeneyo zekhemotherapy (,,).

I-GSE ibonakala ikhusela ngokuchasene noxinzelelo lwe-oxidative kunye nobutyhefu besibindi ngelixa ujolise kwisenzo se-chemotherapy kwiiseli ezinomhlaza (,,).

Uphengululo lwezifundo zezilwanyana ezingama-41 lufumanise ukuba i-GSE okanye iproanthocyanidins inciphise umhlaza obangelwe ngumhlaza kunye nomonakalo kuzo zonke kodwa izifundo ().

Gcina ukhumbula ukuba i-GSE kunye ne-proanthocyanidins yayo ayinakudluliselwa ngqo kubantu abanomhlaza. Izifundo ezingakumbi ebantwini ziyafuneka.

Isishwankathelo Kwizifundo zelebhu, i-GSE ibonakalisiwe ukuba inqanda umhlaza kwiindidi ezahlukeneyo zeseli zabantu. I-GSE ikwabonakala iyanciphisa ityhefu ebangelwe yichemotherapy kwizifundo zezilwanyana ngaphandle kokuchaphazela kakubi unyango. Uphando olwenziwe ngabantu luyafuneka.

9. Ngamana ungasikhusela isibindi sakho

Isibindi sakho sidlala indima ebalulekileyo ekutshatyalaliseni izinto ezinobungozi ezifakwe emzimbeni wakho ngokusebenzisa iziyobisi, ukusuleleka kwintsholongwane, ukungcola, utywala kunye nokunye.

I-GSE ibonakala inefuthe elikhuselayo kwisibindi sakho.

Kwizifundo zetyhubhu yovavanyo, i-GSE inciphise ukudumba, iphinde yaphinda yasebenza i-antioxidants, kwaye ikhuselwe kumonakalo omkhulu wasimahla ngexesha lokuvezwa kwetyhefu (,,).

I-enzyme yesibindi i-alanine aminotransferase (ALT) sisalathiso esiphambili setyhefu yesibindi, oko kuthetha ukuba amanqanaba ayo anyuka xa isibindi sinomonakalo ().

Kwisifundo esinye, abantu abali-15 abanezifo zesibindi ezinamafutha ezingatyisiyo kunye namanqanaba aphezulu e-ALT anikwa i-GSE iinyanga ezintathu. I-enzyme zesibindi zajongwa qho ngenyanga, kwaye iziphumo zazithelekiswa nokuthatha i-2 gram ye-vitamin C ngosuku.

Emva kweenyanga ezi-3, iqela le-GSE lafumana ukunciphisa i-46% kwi-ALT, ngelixa iqela le-vitamin C labonisa utshintsho oluncinci ().

Isishwankathelo I-GSE ibonakala ikhusela isibindi sakho kwityhefu kunye nomonakalo obangelwe ziziyobisi. Nangona kunjalo, kufuneka kwenziwe izifundo ezingakumbi zabantu.

10. Kwandisa ukuphola kwenxeba nokubonakala

Izifundo ezininzi zezilwanyana zifumene ukuba i-GSE inokunceda ukuphilisa amanxeba (,, 52).

Izifundo zabantu zibonisa isithembiso ngokunjalo.

Kolu phando lunye, abantu abadala abangama-35 abasempilweni abaye benziwa utyando oluncinci banikwa i-2% ye-GSE cream okanye i-placebo. Abo basebenzisa i-GSE cream bafumana ukuphola kwenxeba ngokupheleleyo emva kweentsuku ezisi-8, ngelixa iqela le-placebo lithathe iintsuku ezili-14 ukuphilisa.

Ezi ziphumo zinokwenzeka ngenxa yamanqanaba aphezulu eproanthocyanidins kwi-GSE ebangela ukukhutshwa kwezinto zokukhula kulusu ().

Kwesinye isifundo seeveki ezisi-8 kumadoda aselula asempilweni ali-110, i-2% ye-GSE cream iphucule ukubonakala kolusu, ukutyeba, kunye nomxholo we-sebum, onokunceda ukunciphisa iimpawu zokwaluphala ().

Isishwankathelo Iikhrim ze-GSE zibonakala ngathi zonyusa ukukhula kwesikhumba. Kananjalo, banokunceda ukuphilisa amanxeba kunye nokunceda ukunciphisa iimpawu zokwaluphala kolusu.

Iziphumo ebezingalindelekanga ezinokwenzeka

I-GSE ngokubanzi ithathwa njengekhuselekileyo ngeziphumo ebezingalindelekanga ezimbalwa.

Imilinganiselo ejikeleze i-300-800 mg ngosuku ngemizuzu ye-8-16 iiveki ifunyenwe ikhuselekile kwaye inyamezeleke ebantwini ().

Abo bakhulelweyo okanye abancancisayo kufuneka bayiphephe, kuba akukho datha yaneleyo kwiziphumo zayo kwaba bantu.

I-GSE inokuhlisa uxinzelelo lwegazi, inciphise igazi lakho, kwaye inyuse ukuhamba kwegazi, ke isilumkiso siyacetyiswa kwabo bathatha ukunciphisa igazi okanye amayeza oxinzelelo lwegazi (,,).

Ngapha koko, inokunciphisa ukufunxwa kwentsimbi, kunye nokuphucula ukusebenza kwesibindi kunye nokusetyenziswa kweziyobisi. Nxibelelana nomboneleli wakho wezempilo ngaphambi kokuba uthathe ii-GSE supplements (,).

Isishwankathelo I-GSE ibonakala inyamezeleka kakuhle. Nangona kunjalo, abafazi abakhulelweyo nabancancisayo kufuneka bayiphephe. Kananjalo, abo bathabatha amayeza athile kufuneka baxoxe ngokuthatha olu ncedo kunye nomboneleli wabo wezempilo.

Umgca wezantsi

Ukukhupha imbewu yeediliya (GSE) sisongezo sokutya esenziwe ngembewu yeediliya.

Ngumthombo onamandla wee-antioxidants, ngakumbi iproanthocyanidins.

Ii-antioxidants kwi-GSE zinokunceda ukunciphisa uxinzelelo lwe-oxidative, ukudumba, kunye nokonakala kwethishu okunokwenzeka ecaleni kwezifo ezingapheliyo.

Ngokuxhasa nge-GSE, uya kuvuna izibonelelo zentliziyo ebhetele, ingqondo, izintso, isibindi kunye nempilo yolusu.