IHarvoni (ledipasvir / sofosbuvir)

Umxholo

• Yintoni iHarvoni?
• IHarvoni generic
• Iziphumo ebezingalindelekanga zeHarvoni
• Iziphumo eziqhelekileyo ezichaphazelekayo
• Iziphumo ebezingalindelekanga ezimandundu
• Uthintelo lokuzibulala
• Iziphumo ebezingalindelekanga zexesha elide
• Iziphumo ebezingalindelekanga emva konyango
• Ukwehla kobunzima okanye ukutyeba
• Iimpawu zokurhoxa
• Intlungu edibeneyo
• Iziphumo zamehlo
• Ukulahleka kweenwele
• Irhashalala / ukurhawuzelela
• Urhudo
• Uxinzelelo
• Ukudinwa
• Ukuphuthelwa (kunzima ukulala)
• Intloko ebuhlungu
• Umhlaza wesibindi / umhlaza
• Iindleko zeHarvoni
• Uncedo lwezezimali kunye neinshurensi
• IHarvoni isebenzisa
• Umthamo weHarvoni
• Iifom zamachiza kunye namandla
• Isisombululo se-hepatitis C
• Ubude bonyango
• Kuthekani ukuba ndiphose idosi?
• Ukuncamathela kwisicwangciso sakho sonyango lweHarvoni
• IHarvoni kunye notywala
• IHarvoni ene-ribavirin
• Iziphumo ebezingalindelekanga zeRibavirin
• Ribavirin kunye nokukhulelwa
• IRibavirin kunye nokuncancisa
• Ukudibana kweHarvoni
• Harvoni kunye namanye amayeza
• IHarvoni kunye ne-ribavirin
• IHarvoni kunye ne-omeprazole okanye ezinye ii-PPI
• IHarvoni kunye nemifuno kunye nezongezo
• IHarvoni kunye nekofu
• Enye indlela eya eHarvoni
• IHarvoni vs. nezinye iziyobisi
• IHarvoni vs Epclusa
• IHarvoni vs Mavyret
• IHarvoni vs Sovaldi
• IHarvoni vs iZepatier
• Uyithatha njani iHarvoni
• Ixesha
• Ukuthatha iHarvoni ngokutya
• Ngaba iHarvoni inokutyunyuzwa?
• Usebenza njani uHarvoni
• Malunga nehepatitis C
• I-Harvoni inyanga njani i-hepatitis C?
• Kuthatha ixesha elingakanani ukusebenza?
• Harvoni kunye nokukhulelwa
• IHarvoni kunye nokuncancisa
• Imibuzo eqhelekileyo malunga neHarvoni
• Ngaba kufuneka ndilandele ukutya okukhethekileyo ngelixa ndithatha iHarvoni?
• Uza kuthatha ixesha elingakanani uHarvoni ukususa i-hepatitis C yam?
• Lithini inqanaba lokunyanga iHarvoni?
• Ngaba i-hepatitis C ingabuya emva kokuthatha iHarvoni?
• Yintoni i-hepatitis C genotype?
• Ukugqithisa kweHarvoni
• Iimpawu libanda
• Kufuneka wenze ntoni xa uthe wagqithisa?
• Izilumkiso zikaHarvoni
• Isilumkiso se-FDA: Ukuvuselelwa kwentsholongwane ye-hepatitis B
• Ezinye izilumkiso
• Ukuphela kweHarvoni
• Ulwazi lobungcali lweHarvoni
• Indlela yokusebenza
• I-Pharmacokinetics kunye ne-metabolism
• Ukungqinelana
• Ukugcina

Yintoni iHarvoni?

IHarvoni ligama elichaza amayeza elisetyenziselwa ukunyanga i-hepatitis C. IHarvoni inamachiza amabini: i-ledipasvir kunye ne-sofosbuvir. Kuza njengethebhulethi ethathwa kanye yonke imihla kwiiveki ezili-12.

IHarvoni luhlobo lweziyobisi olubizwa ngokuba yi-antiviral esebenza ngokuthe ngqo (DAA). Kwavunywa yi-FDA ngo-2014 ukunyanga ii-genotypes ezahlukeneyo, okanye iifom, ze-hepatitis C.

I-Harvoni yamkelwe ukunyanga i-hepatitis C:

• kubantu abane-hepatitis C genotypes 1, 4, 5, no-6
• kubantu abane-cirrhosis okanye ngaphandle kwayo
• kubantu abaye bafakelwa isibindi
• kubantu abadala okanye abantwana abaneminyaka eyi-12 okanye ngaphezulu okanye abanobunzima beepawundi ezingama-77 ubuncinci

Uninzi lwezifundo zeklinikhi zeHarvoni, inqanaba lempumelelo lokunyanga i-hepatitis C lalilikhulu kune-90 yeepesenti. Oku kuthetha ukuba phantse bonke abantu abathathe iHarvoni bafumane impendulo eqhubekayo ye-virologic (SVR). I-SVR ithetha ukuba babengenayo intsholongwane efunyenwe emzimbeni wabo kwiiveki ezili-12 okanye ngaphezulu emva kokuba unyango luphelile.

IHarvoni generic

IHarvoni iqulethe iziyobisi ezibini kwithebhulethi enye: ledipasvir kunye nesofosbuvir. Okwangoku azikho iifom zohlobo oluqhelekileyo zendibaniselwano yeziyobisi okanye iziyobisi ezizezinye. IHarvoni ifumaneka kuphela njengegama eligunyazisiweyo lonyango.

Nangona kunjalo, uhlobo oluqhelekileyo lweHarvoni kulindeleke ukuba lukhutshwe kwangoko kwi-2019.

Iziphumo ebezingalindelekanga zeHarvoni

IHarvoni inokubangela iziphumo ebezingalindelekanga ezinobulali okanye ezinobuzaza. Olu luhlu lulandelayo luqulathe ezinye zeziphumo ebezingalindelekanga ezinokubakho ngelixa uthatha iHarvoni. Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga ezinokubakho.

Ngolwazi oluthe kratya malunga neziphumo ebezingalindelekanga zeHarvoni okanye iingcebiso ngendlela yokujongana nefuthe elibi, thetha nogqirha wakho okanye usokhemesti.

Ukuba ugqirha wakho ukumisela i-ribavirin ukuba uyithathe kunye neHarvoni, unokuba neziphumo ebezingalindelekanga ezongezelelweyo. (Jonga "iHarvoni kunye ne-ribavirin" apha ngezantsi.)

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo zeHarvoni zingabandakanya:

• ukudinwa
• intloko ebuhlungu
• isicaphucaphu
• urhudo
• ukulala (kunzima ukulala)
• ukukhohlela
• ubuthathaka
• iintlungu zemisipha
• iDyspnea (ukuphefumla okufutshane)
• ukucaphuka
• isiyezi

Ngamanye amaxesha, iHarvoni inokubangela ukuphendula kancinci. Iimpawu zingabandakanya ukukhawuleza kwesikhumba, ukukhawuleza, kunye nokutshiza (ukufudumala kwesikhumba nokubomvu, ngokuqhelekileyo ebusweni nasentanyeni).

Uninzi lweziphumo ebezingalindelekanga zinokuhamba zingaphelanga iintsuku okanye iiveki ezimbalwa. Ukuba zinzima kakhulu okanye azihambi, thetha nogqirha wakho okanye usokhemesti.

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ezibi kakhulu ezivela eHarvoni aziqhelekanga, kodwa zinokwenzeka. Shayela ugqirha wakho ngokukhawuleza ukuba unemiphumo emibi. Tsalela umnxeba ku-911 ukuba iimpawu zakho ziziva zisongela ubomi okanye ukuba ucinga ukuba unempilo kaxakeka.

Iziphumo ebezingalindelekanga ezimandundu kunye neempawu zazo zinokubandakanya oku kulandelayo:

• Ukuvuselelwa kwe-Hepatitis B kubantu abane-hepatitis C kunye ne-hepatitis B. Abanye abantu abane-hepatitis C kunye ne-hepatitis B baye bafumana ukuvuselelwa kwintsholongwane ye-hepatitis B xa beqala unyango kunye noHarvoni. Ukuphinda usebenze kwakhona kuthetha ukuba intsholongwane iyasebenza kwakhona. Ukuvuselelwa kwentsholongwane ye-hepatitis B kunokukhokelela kumonakalo wesibindi, ukusilela kwesibindi, okanye ukufa. Ngaphambi kokuba uqale unyango kunye noHarvoni, ugqirha wakho uya kuvavanya i-hepatitis B. Kuya kufuneka uthathe amayeza ukunyanga i-hepatitis B.
• Impendulo enkulu. Kwiimeko ezinqabileyo, iHarvoni inokubangela ukusabela okubi kakhulu. Iimpawu zingabandakanya:
• i-angioedema (ukudumba phantsi kolusu lwakho, ubukhulu becala kwiinkophe zakho, imilebe, izandla, okanye iinyawo)
• ukudumba komqala wakho, umlomo nolwimi
• ingxaki yokuphefumla
• Iingcinga zokuzibulala. Kwiimeko ezinqabileyo, iHarvoni inokubangela iingcinga zokuzibulala okanye isenzo xa sithathwa ngokudibanisa ne-ribavirin okanye i-pegylated interferon / ribavirin.

Uthintelo lokuzibulala

• Ukuba uyazi umntu osemngciphekweni wokuzenzakalisa, ukuzibulala, okanye ukwenzakalisa omnye umntu:
• Tsalela u-911 okanye inombolo yongxamiseko yendawo.
• Hlala naloo mntu de kufike uncedo lobungcali.
• Susa naziphi na izixhobo, amayeza, okanye ezinye izinto ezinokuba yingozi.
• Mamela umntu ngaphandle komgwebo.
• Ukuba wena okanye umntu omaziyo uneengcinga zokuzibulala, umnxeba wokuthintela unokunceda. I-National Suicide Prevention Lifeline ifumaneka iiyure ezingama-24 ngosuku ngo-1-800-273-8255.

Iziphumo ebezingalindelekanga zexesha elide

Iziphumo ebezingalindelekanga zexesha elide khange zixelwe ngokusetyenziswa kweHarvoni.

Nangona kunjalo, abantu abane-cirrhosis (ukusilela kwesibindi) banokuqhubeka nokuba neempawu zomonakalo wesibindi emva kokuba i-hepatitis C yabo iphilisiwe. Ukuba une-cirrhosis, ugqirha wakho uya kufuna ukujonga ukusebenza kwesibindi rhoqo ngexesha nasemva konyango kunye neHarvoni.

Iziphumo ebezingalindelekanga emva konyango

Iziphumo ebezingalindelekanga emva konyango lweHarvoni khange zixelwe kwizifundo zeklinikhi.

Nangona kunjalo, emva kokugqiba unyango kunye neHarvoni, abanye abantu banokuba neempawu ezinje ngomkhuhlane, ezinje ngezihlunu zemithambo, ukugodola, ukudinwa kunye nengxaki yokulala. Iziphumo ebezingalindelekanga zibangelwa kukuchacha komzimba wakho emva kokuba intsholongwane ye-hepatitis C icociwe.

Ukuba uneempawu ezinje ngomkhuhlane emva kokugqiba unyango kunye noHarvoni, thetha nogqirha wakho.

Ukwehla kobunzima okanye ukutyeba

Utshintsho kubunzima ngexesha lonyango lweHarvoni aluzange luxelwe kwizifundo zeklinikhi. Nangona kunjalo, abanye abantu balahle ubunzima njengophawu lwe-hepatitis C. Ukuba uneenguqu ezinzima kubunzima, thetha nogqirha wakho.

Iimpawu zokurhoxa

Ukuyeka unyango kunye neHarvoni akubanga zimpawu zokurhoxa kwizifundo zeklinikhi.

Abanye abantu banokuba neempawu ezifana nokurhoxa, ezinje ngomkhuhlane-njengomkhuhlane, intloko ebuhlungu, kunye neentlungu zemisipha. Nangona kunjalo, akucaci ukuba ngaba ezi mpawu zihambelana nokumisa unyango lweHarvoni.

Intlungu edibeneyo

Intlungu edibeneyo yayingenguye umphumo weHarvoni kwizifundo zeklinikhi.

Abantu abaninzi abane-hepatitis C banamava ngokudibeneyo njengophawu lwentsholongwane, nangona kunjalo. Oku kunokuba sisiphumo sokudumba okungapheliyo okanye inkqubo yokuzenzekelayo ehlasela amalungu akho.

Ukuba unentlungu kumalungu akho, thetha nogqirha wakho malunga neendlela zokuzilawula.

Iziphumo zamehlo

Kwizifundo zeklinikhi zaseHarvoni, abantu abathatha ichiza khange bafumane ngxaki yamehlo. Kodwa kukho ingxelo enye yokulahleka kombono okwethutyana emva kokusebenzisa iHarvoni ngesiyobisi i-ribavirin. Kwaye omnye umntu uxele ukudumba kwamehlo kunye nombono ongacacanga emva kokusebenzisa i-sofosbuvir (elinye lamayeza eHarvoni) kunye ne-ribavirin.

Nangona kunjalo, akucaci ukuba iHarvoni okanye izithako zayo zibangele iingxaki zamehlo kwezi meko. Kwakhona, isifundo se-2019 safumanisa ukuba la mayeza afanayo awakhange abangele iingxaki zamehlo kubantu abane-hepatitis C.

Ngayiphi na imeko, ukuba ufumana naziphi na iimpembelelo zamehlo ngelixa uthatha iHarvoni, thetha nogqirha wakho ngoko nangoko.

Ukulahleka kweenwele

Ukulahleka kweenwele akuzange kuchazwe njengempembelelo yecala kwizifundo zeklinikhi zaseHarvoni. Abanye abantu baye baxela ukulahleka kweenwele ngelixa besebenzisa ichiza, kodwa akucaci ukuba ngaba uHarvoni wayengunobangela wokulahleka kweenwele zabo.

Kubalulekile ukuba uqaphele ukuba ukulahleka kweenwele kunokuba luphawu lwe-hepatitis C. Intsholongwane ye-hepatitis C (HCV) ithintela isibindi sakho ekusebenzeni kakuhle. Udinga isibindi esisempilweni ukuze ufumane izakhamzimba kukutya okutyayo. Ke ukuba awukwazi ukufumana izakhamzimba ezifunwa ngumzimba wakho, unokufumana ilahleko yeenwele.

Ukuba unenkxalabo malunga nokulahleka kweenwele, thetha nogqirha wakho.

Irhashalala / ukurhawuzelela

Ukuqubuka kolusu kwaxelwa kwabanye abantu abathathe iHarvoni kwizifundo zeklinikhi, kodwa akucaci ukuba babeqheleke kangakanani. Ngamanye amaxesha, abantu babenamadyungudyungu kunye nokudumba kolusu, nabo. Oku kunokubangelwa kukungaziphathi kakuhle kwiHarvoni.

Ukurhawuzelela ulusu kunye nerhashalala kukwimpawu zentsholongwane ye-hepatitis C. Ukongeza, banokuba ziimpawu zomonakalo omkhulu wesibindi. Thetha nogqirha wakho ukuba ufumana irhashalala okanye ulusu olukhathazayo.

Urhudo

Kwizifundo zeklinikhi zaseHarvoni, phakathi kweepesenti ezintathu kunye neepesenti ezisi-7 zabantu abanesifo sohudo ngexesha lonyango. Urhudo lunokuhamba kunye nokuqhubeka nokusebenzisa iziyobisi.

Ukuba unesifo sohudo esibuhlungu, okanye isifo sohudo esihlala ngaphezu kweentsuku ezimbalwa, xela ugqirha wakho kwangoko.

Uxinzelelo

Uxinzelelo sisiphumo esingaqhelekanga seHarvoni. Kwizifundo zeklinikhi, ngaphantsi kweepesenti ezintlanu zabantu abathathe uHarvoni bafumana uxinzelelo. Ukongeza, iingcinga zokuzibulala zenzeka ngaphantsi kwe-1 yepesenti yabantu abathathe iHarvoni nge-ribavirin okanye i-pegylated interferon / ribavirin.

Abantu abaninzi abane-hepatitis C banokuziva bedandathekile ngenxa yokufumanisa isifo. Ukuba uziva uxinezelekile, thetha nogqirha wakho ngeendlela zokuphucula imeko yakho. Kwaye ukuba uneengcinga zokuzenzakalisa, biza ugqirha wakho kwangoko.

Ukudinwa

Ukukhathala, okanye ukunqongophala kwamandla, sisiphumo esibi secala likaHarvoni. Kwizifundo zeklinikhi, ukuya kuthi ga kwiipesenti ze-18 zabantu abathathe uHarvoni bafumana ukudinwa.

Ukukhathala kunokuhamba kunye nokusetyenziswa okuqhubekayo kweHarvoni. Nangona kunjalo, ukuba ukudinwa kwakho kunzima kwaye kuchaphazela ubomi bakho, thetha nogqirha wakho.

Ukuphuthelwa (kunzima ukulala)

Kwizifundo zeklinikhi, ukuqaqanjelwa sisisu kwenzeka ukuya kuthi ga kwiipesenti ezi-6 zabantu abathathe iHarvoni. Iziphumo ebezingalindelekanga zinokuhamba nokusetyenziswa gwenxa kweziyobisi.

Iindlela zokuphucula ukulala kwakho zibandakanya ukulandela ishedyuli yokulala rhoqo kunye nokugcina i-elektroniki, ezinje ngee-smartphones, kwigumbi lakho lokulala. Ukuba ukulala kwakho kuyakukhathaza kwaye akupheli, thetha nogqirha wakho ngezinye iindlela zokukunceda ulale.

Intloko ebuhlungu

Intloko yiphumo eliqhelekileyo laseHarvoni. Kwizifundo zeklinikhi, ukuya kuthi ga kwiipesenti ezingama-29 zabantu abathathe iHarvoni abanamava entloko. Ukuba uneentloko ngelixa uthatha iHarvoni, thetha nogqirha wakho malunga neendlela zokukunceda uzilawule.

Umhlaza wesibindi / umhlaza

IHarvoni sisiyobisi esibizwa ngokuba yi-antiviral esebenza ngokuthe ngqo (DAA). Ukunyanga i-hepatitis C nee-DAA kunceda ukuthintela iziphumo zexesha elide, njengomhlaza wesibindi. Nangona kunjalo, kukho iingxelo zomhlaza wesibindi kubantu abaye baphiliswa kwi-hepatitis C ngonyango lwe-Harvoni.

Olunye uphononongo lweklinikhi lufumanise ukuba abantu abane-cirrhosis abanyangwa nge-DAA babenomngcipheko omkhulu wokuba nomhlaza wesibindi xa kuthelekiswa nezo zingenasibindi. Nangona kunjalo, abantu abangenayo i-cirrhosis banokufumana umhlaza wesibindi.

Ukuba unomdla malunga nomngcipheko wokuba nomhlaza wesibindi, thetha nogqirha wakho.

Iindleko zeHarvoni

Njengawo onke amayeza, indleko zeHarvoni ziyahluka.

Ixabiso lakho liya kuxhomekeka kwi-inshurensi yakho.

Uncedo lwezezimali kunye neinshurensi

Ukuba ufuna inkxaso yemali ukuhlawula iHarvoni, okanye ukuba ufuna uncedo lokuqonda i-inshurensi yakho, uncedo luyafumaneka.

Isayensi yaseGiliyadi, Inc., umenzi weHarvoni, unikezela ngenkqubo ebizwa ngokuba yiHarvoni Support Path. Ngolwazi oluthe kratya kunye nokufumanisa ukuba uyilungele na inkxaso, tsalela umnxeba ku-855-769-7284 okanye undwendwele iwebhusayithi yenkqubo.

IHarvoni isebenzisa

Ulawulo lokutya kunye neziyobisi (i-FDA) livuma amayeza amiselweyo anje ngeHarvoni ukunyanga iimeko ezithile.

IHarvoni yamkelwe yi-FDA kunyango lwe-hepatitis C (HCV). IHarvoni inokumiselwa:

• Abantu abadala kunye nabantwana (abaneminyaka eli-12 nangaphezulu okanye abanobunzima obungama-77 eepawundi):
• une-HCV genotype 1, 4, 5, okanye 6. Ii-genotypes ziintlobo ezahlukeneyo zentsholongwane.
• ndinayo okanye andiyibhatalanga i-cirrhosis. I-Cirrhosis inobungozi obukhulu kwisibindi esithintela ukuba isebenze ngokufanelekileyo. I-cirrhosis ehlawulwayo yi-cirrhosis engabangeli zimpawu.
• Abantu abadala aba:
• ndine-genotype 1 kunye ne-cirrhosis ebolileyo. Ukuqina kwesibindi kuxa isibindi sisilela kwaye sibangela imiba yezempilo. Abantu abane-cirrhosis ebolaweyo kuya kufuneka bathathe iHarvoni ngesiyobisi sesibini, i-ribavirin (iRebetol).
• ndine-genotype 1 okanye 4 kwaye ndafakelwa isibindi.

Le theyibhile ibonisa ukuba ngubani olungeleyo unyango lweHarvoni:

Umthamo weHarvoni

I-Harvoni imiselwe njengedosi enye: Ithebhulethi equlathe i-90 mg ye-ledipasvir kunye ne-400 mg yesofosbuvir, ethathwa kube kanye ngemini.

Kwiimeko ezithile, ugqirha wakho unokumisela ichiza lesibini ukuba ulithathe kunye noHarvoni. Umzekelo, unokumiselwa i-ribavirin (iRebetol) ngokudibanisa neHarvoni.

Oku kunokwenzeka ukuba unokubola kwesibindi (iimpawu ezinzima ezivela kwisifo sesibindi) okanye ukuba uthathe amayeza athile ukunyanga i-hepatitis C ngaphambili. Idosi ye-ribavirin yakho iya kuxhomekeka kubunzima bakho, ukusebenza kwezintso, kunye nezinye iimeko zempilo.

Olu lwazi lulandelayo luchaza idosi ecetyiswayo yeHarvoni.

Iifom zamachiza kunye namandla

IHarvoni ifumaneka ngamandla omnye. Iza kwithebhulethi yokudibanisa equlathe i-90 mg ye-ledipasvir kunye ne-400 mg yesofosbuvir.

Isisombululo se-hepatitis C

Umthamo wokunyanga i-hepatitis C yicwecwe elinye (90 mg ledipasvir / 400 mg sofosbuvir), ithathwa kube kanye ngemini.

Ubude bonyango

Kuthatha ixesha elingakanani ukuba i-Harvoni ixhomekeke kuhlobo lwakho lwe-hepatitis C (uhlobo lwentsholongwane). Kuya kuxhomekeka ekusebenzeni kwesibindi, kunye naluphi na unyango lwe-hepatitis C oluzamile ngaphambili.

Uninzi lwabantu luthatha iHarvoni iiveki ezili-12, kodwa unyango lunokuhlala iiveki ezisibhozo okanye ezingama-24. Ugqirha wakho uya kumisela ixesha elifanelekileyo lonyango lwakho.

Kuthekani ukuba ndiphose idosi?

Kubalulekile ukuthatha iHarvoni yonke imihla ixesha elipheleleyo ugqirha ugqirha. Ukulahleka okanye ukweqa iidosi kunokubangela ukuba intsholongwane ixhathise iHarvoni. Ukuxhathisa kuthetha ukuba iyeza alisasebenzi kuwe.

Sebenzisa isixhobo sokukhumbuza kunokukunceda ukhumbule ukuthatha iHarvoni yonke imihla.

Ukuba uphosa idosi, yithathe ngokukhawuleza ukuba uyakhumbula. Ukuba awukhumbuli kude kube lusuku olulandelayo, ungathathi idosi ezimbini zeHarvoni ngaxeshanye. Oku kunokunyusa umngcipheko weziphumo ebezingalindelekanga. Thatha nje idosi yakho eqhelekileyo yeHarvoni.

Ukuncamathela kwisicwangciso sakho sonyango lweHarvoni

Kubaluleke kakhulu ukuba uthathe iipilisi zakho zeHarvoni ngokuchanekileyo njengoko ugqirha ugqirha. Kungenxa yokuba ukulandela isicwangciso sakho sonyango kunyusa amathuba akho okunyanga i-hepatitis C (HCV) yakho. Kwakhona kunceda ukunciphisa umngcipheko wexesha elide le-HCV, elibandakanya i-cirrhosis kunye nomhlaza wesibindi.

Iidosi ezingekhoyo zinokwenza iHarvoni ingasebenzi kakuhle ekunyangeni i-HCV yakho. Ngamanye amaxesha, ukuba uphosa idosi, i-HCV yakho ayinakunyangeka.

Qiniseka ukuba ulandela imiyalelo kagqirha wakho kwaye uthathe ipilisi enye yeHarvoni yonke imihla ngobude obupheleleyo bonyango lwakho. Sebenzisa isixhobo sokukhumbuza kunokukunceda uqiniseke ukuba uthatha iHarvoni yonke imihla.

Ukuba unemibuzo okanye unenkxalabo ngonyango lwakho, thetha nogqirha wakho. Banokukunceda ukusombulula nayiphi na imicimbi kunye nokukunceda ufumane olona nyango lusebenzayo kwi-hepatitis C.

IHarvoni kunye notywala

Ukusela utywala ngelixa uthatha iHarvoni kunokunyusa umngcipheko weziphumo ebezingalindelekanga ezivela eHarvoni. Ezi ziphumo zibandakanya:

• ukudinwa
• intloko ebuhlungu
• isicaphucaphu
• urhudo

Ukongeza, zombini hepatitis C kunye nokusetyenziswa gwenxa kotywala kubangela amanxeba kunye nokudumba esibindini sakho. Ukudibanisa ezi zimbini kwandisa umngcipheko we-cirrhosis kunye nokusilela kwesibindi.

Utywala bunokukwenza ukuba ungabinakho ukuthatha amayeza akho njengoko kuyalelwa ngugqirha. Umzekelo, kunokubangela ukuba ulibale ukuthatha amayeza akho ngexesha elifanelekileyo. Iidosi ezingekhoyo zeHarvoni zinokuyenza ingasebenzi kakuhle ekunyangeni i-HCV yakho.

Kuzo zonke ezi zizathu, kuya kufuneka uphephe ukusela utywala xa une-hepatitis C. Oku kuyinyani ngakumbi xa unyangwa noHarvoni. Ukuba unengxaki yokuphepha utywala, thetha nogqirha wakho.

IHarvoni ene-ribavirin

I-Harvoni ihlala ithathwa iyodwa ukunyanga i-hepatitis C. Nangona kunjalo, kwezinye iimeko, ithathwa nelinye ichiza elibizwa ngokuba yi-ribavirin (i-Rebetol).

Ugqirha wakho unokumisela i-ribavirin kunye neHarvoni ukuba:

• unesifo sokuqina kwesibindi
• utyando lwesibindi
• khange baphumelele kunyango ngamanye amayeza e-hepatitis C ngaphambili

IHarvoni kunye ne-ribavirin zisetyenziswa kunye ebantwini kwezi meko kuba izifundo zeklinikhi zibonise inqanaba eliphezulu lokunyanga ngonyango oludibeneyo kuneHarvoni yodwa.

Unyango lwe-ribavirin luhlala iiveki ezili-12. IRibavirin iza njengepilisi oyisela kabini ngemini. Idosi oyithathayo iya kusekelwa kubunzima bakho. Inokusekwa kwakhona ekusebenzeni kwezintso kunye namanqanaba e-hemoglobin.

Iziphumo ebezingalindelekanga zeRibavirin

I-Ribavirin inokubangela iziphumo ebezingalindelekanga ezininzi nezibi. Kuza nezilumkiso ezibalulekileyo.

Isilumkiso esibhokisiweyo

I-Ribavirin inesilumkiso esibhokisiweyo esivela kwi-FDA. Isilumkiso esinebhokisi lolona hlobo lomeleleyo lwesilumkiso esifunwa yi-FDA. Isilumkiso esinebhokisi kaRibavirin sicebisa ukuba:

• I-Ribavirin akufuneki isetyenziswe yodwa ukunyanga i-hepatitis C kuba ayisebenzi yodwa.
• I-Ribavirin inokubangela uhlobo lwesifo segazi esibizwa ngokuba yi-hemolytic anemia. Le meko inokukhokelela ekuhlaselweni yintliziyo okanye ekufeni. Ngenxa yalo mngcipheko, abantu abanesifo sentliziyo esinzulu okanye esingazinzanga akufuneki bathathe i-ribavirin.
• Xa i-ribavirin isetyenziswa kwabasetyhini abakhulelweyo, inokubangela ingozi enkulu okanye ukufa kwimveku engekazalwa. I-Ribavirin akufuneki ithathwe ngabafazi abakhulelweyo okanye amaqabane abo esini ngexesha lokukhulelwa. Ukukhulelwa kufuneka kuthintelwe ubuncinci iinyanga ezintandathu emva kokuba unyango lwe-ribavirin luphelile. Ngeli xesha, cinga ukusebenzisa indlela yogcino (inzala).

Ezinye iziphumo ebezingalindelekanga

I-Ribavirin inokubangela iziphumo ebezingalindelekanga eziqhelekileyo, ezinje:

• ukudinwa
• ndiziva ndixhalabile
• ifiva
• intloko ebuhlungu
• ndiziva ndicaphukile
• Ukuphelelwa ngumdla wokutya
• iintlungu zemisipha okanye ubuthathaka
• isicaphucaphu
• ukugabha

Iziphumo ezinqabileyo kodwa ezinzulu ezibonwe kwizifundo zeklinikhi zibandakanya i-anemia, isifo semiphunga kunye nepancreatitis. Babandakanya iingxaki zamehlo, ezinjengosulelo kunye nokungaboni kakuhle.

Ribavirin kunye nokukhulelwa

Jonga "isilumkiso esibhokisiweyo" ngasentla.

IRibavirin kunye nokuncancisa

Ayaziwa ukuba i-ribavirin idlula kubisi lomntu lwebele. Izifundo kwizilwanyana zibonisa ukuba i-ribavirin ethathwe ngumama inokuba yingozi kubongikazi abancinci. Nangona kunjalo, izifundo zezilwanyana azihlali ziqikelela ukuba kuya kwenzeka ntoni ebantwini.

Ukuba ucinga unyango lwe-ribavirin ngelixa uncancisa, thetha nogqirha wakho. Basenokucebisa ukuba uyeke ukuncancisa okanye uphephe unyango lwe-ribavirin.

Ukudibana kweHarvoni

IHarvoni inokusebenzisana namanye amayeza. Iyakwazi ukusebenzisana nezibonelelo ezithile kunye nokutya.

Unxibelelwano olwahlukileyo kunokubangela iziphumo ezahlukeneyo. Umzekelo, ezinye zinokuphazamisa ukusebenza kakuhle kwesiyobisi, ngelixa ezinye zinokubangela ukwanda kweempembelelo.

Harvoni kunye namanye amayeza

Apha ngezantsi luluhlu lwamayeza anokusebenzisana noHarvoni. Olu luhlu alunazo zonke iziyobisi ezinokuthi zidibane noHarvoni.

Ngaphambi kokuba uthathe iHarvoni, qiniseka ukuxelela ugqirha wakho kunye nosokhemesti ngayo yonke into emiselweyo, ekhawuntareni, kunye nezinye iziyobisi ozithathayo. Baxelele malunga nazo naziphi na iivithamini, amayeza esintu kunye nezixhasi ozisebenzisayo. Ukwabelana ngolu lwazi kunokukunceda uphephe unxibelelwano olunokubakho.

Ukuba unemibuzo malunga nokunxibelelana kweziyobisi okunokuchaphazela, buza ugqirha wakho okanye usokhemesti.

IiAntacids

Ukuthatha iHarvoni ngee-antacids, ezinje ngeMylanta okanye iiTum, kunokunciphisa inani leHarvoni elifunxwa ngumzimba wakho. Oku kunokwenza iHarvoni ingasebenzi kakuhle. Ukuthintela oku kunxibelelana, hlula idosi yeHarvoni kunye nee-antacids ubuncinci iiyure ezine.

Iibhloko ze-H2

Ukuthatha iHarvoni ngeziyobisi ekuthiwa zii-H2 blockers kunokunciphisa isixa seHarvoni esifakwe emzimbeni wakho. Oku kunokubangela ukuba iHarvoni ingasebenzi kakuhle ekulweni nentsholongwane ye-hepatitis C.

Ukuba ufuna ukuthatha i-H2 blocker ngeHarvoni, kuya kufuneka ubathathe ngaxeshanye okanye ubathabathe iiyure ezili-12. Ukuwathatha ngaxeshanye kuvumela amachiza ukuba anyibilike kwaye afunxwe ngumzimba wakho ngaphambi kokuba i-H2 blocker ingene. Ukuwathatha ngaphandle iiyure ezili-12 kukwavumela ichiza ngalinye ukuba lifunxwe ngumzimba wakho ngaphandle kokunxibelelana nelinye ichiza.

Imizekelo ye-H2 blocker ibandakanya i-famotidine (Pepcid) kunye ne-cimetidine (Tagamet HB).

Amiodarone

Ukuthatha iHarvoni kunye ne-amiodarone (iPacerone, Nexterone) kunokubangela ukubetha kwentliziyo okucothayo okuyingozi, okubizwa ngokuba yi-bradycardia. Ezinye iingxelo zichaze ukuba abantu abathathe i-amiodarone kunye ne-Harvoni kunye badinga i-pacemaker ukugcina ukubetha kwentliziyo rhoqo. Baye baxela ukuba abanye abantu babulawa sisifo sentliziyo.

Ukuthatha i-amiodarone kunye neHarvoni kunye ayikhuthazwa. Ukuba kufuneka uthathe iHarvoni kunye ne-amiodarone kunye, ugqirha wakho uya kujonga ngokusondeleyo ukusebenza kwentliziyo yakho.

I-Digoxin

Ukuthatha iHarvoni nge-digoxin (Lanoxin) kunokunyusa inani le-digoxin emzimbeni wakho. Amanqanaba e-Digoxin aphezulu kakhulu anokukhokelela kwiziphumo ebezingalindelekanga eziyingozi.

Ukuba ufuna ukuthatha iHarvoni kunye ne-digoxin kunye, ugqirha wakho uya kujonga ngononophelo amanqanaba akho e-digoxin. Banokutshintsha idosi yakho yedigoxin ukunciphisa umngcipheko weziphumo ebezingalindelekanga.

Amayeza okuhlutha

Ukuthatha iHarvoni ngamayeza athile okuthimba umzimba kunganciphisa inani leHarvoni elifunxwa ngumzimba wakho. Oku kunokunciphisa ukusebenza kweHarvoni. Ngesi sizathu, akufuneki uthathe iHarvoni ngala mayeza okuthimba.

Imizekelo yokuthatha amayeza okuthintela ngelixa uthatha iHarvoni ibandakanya:

• icarbamazepine (iCarbatrol, i-Equetro, iTegretol)
• I-phenytoin (iDilantin, iPhenytek)
• ifumanobarbital
• oxcarbazepine (iTrileptal)

Amayeza okubulala iintsholongwane

Amanye amayeza e-antibiotic anokunciphisa amanqanaba e-Harvoni emzimbeni wakho. Oku kunokwenza iHarvoni ingasebenzi kakuhle. Ukuthintela olu nxibelelwano, thintela ukuthatha iHarvoni ngezi ntsholongwane zilandelayo:

• irifabutin (Mycobutin)
• irifampin (Rifadin, Rimactane)
• irifapentine (Priftin)

Amayeza e-HIV

Ukuthatha iHarvoni ngamayeza athile e-HIV kunokutshintsha amanqanaba omzimba wakho nokuba nguHarvoni okanye amayeza e-HIV. Oku kunxibelelana kunokwenza amayeza angasebenzi kakuhle okanye kwandise umngcipheko weziphumo ebezingalindelekanga.

I-Tenofovir disoproxil fumarate

Ukuthatha iHarvoni ngamayeza aqukethe i-tenofovir disoproxil fumarate kunokunyusa amanqanaba e-tenofovir emzimbeni wakho. Oku kuyonyusa umngcipheko weziphumo ebezingalindelekanga ezivela kwi-tenofovir, ezinjengokonakala kwezintso. Ukuba ufuna ukuthatha iHarvoni ngamayeza aqukethe i-tenofovir disoproxil fumarate, ugqirha wakho uya kukujonga ngokusondeleyo kwiziphumo ebezingalindelekanga.

Imizekelo yamayeza aqulathe i-tenofovir disoproxil fumarate ibandakanya:

• tenofovir (IViread)
• i-tenofovir kunye ne-emtricitabine (iTruvada)
• i-tenofovir, i-elvitegravir, i-cobicistat, kunye ne-emtricitabine (Stribild)
• i-tenofovir, i-emtricitabine, kunye ne-rilpivirine (Complera)

I-Tipranavir kunye ne-ritonavir

Ukuthatha iHarvoni ngamayeza e-HIV i-tipranavir (Aptivus) okanye i-ritonavir (i-Norvir) inganciphisa amanqanaba e-Harvoni emzimbeni wakho. Oku kunokwenza iHarvoni isebenze kancinci. Ukuthatha iHarvoni nge-tipranavir kunye ne-ritonavir ayikhuthazwa.

Amayeza eecholesterol

Ukuthatha iHarvoni ngamayeza e-cholesterol abizwa ngokuba zii-statins kunokunyusa amanqanaba e-statins emzimbeni wakho. Oku kwandisa umngcipheko weziphumo ebezingalindelekanga ze-statin, ezinjengeentlungu zomzimba kunye nomonakalo.

Iitatins zibandakanya iziyobisi ezinjenge rosuvastatin (Crestor), atorvastatin (Lipitor), kunye ne simvastatin (Zocor). Ukuba uthatha iHarvoni nge-statin, ugqirha wakho uya kukujonga ngokusondeleyo kwiimpawu ze-rhabdomyolysis (ukuphazamiseka kwemisipha).

I-Rosuvastatin kunye neHarvoni akufuneki zithathwe kunye. Eminye imimiselo kufuneka isetyenziswe ngononophelo kunye neHarvoni.

IWarfarin

IHarvoni inokuchaphazela ukubanakho komzimba wakho wokwenza amahlwili egazi. Ukuba ufuna ukuthatha i-warfarin (Coumadin) ngelixa uphathwa ngeHarvoni, ugqirha wakho unokuvavanya igazi lakho rhoqo. Banokufuna ukonyusa okanye ukunciphisa ithamo lakho lemfazwe.

IHarvoni kunye ne-ribavirin

Akukho nxibelelwano phakathi kweHarvoni kunye ne-ribavirin (iRebetol). IHarvoni ikhuselekile ukuthatha kunye ne-ribavirin. Ngapha koko, iHarvoni yamkelwe yi-FDA ukuba ithathwe nge-ribavirin kubantu abaneembali ezithile zonyango.

Ugqirha wakho unokumisela i-ribavirin ukuba uyithathe kunye neHarvoni ukuba:

• unesifo sokuqina kwesibindi
• utyando lwesibindi
• baye basilela kunyango ngamanye amayeza e-hepatitis C ngaphambili

IHarvoni kunye ne-ribavirin zisetyenziswa kunye kubantu abanezi meko kuba izifundo zeklinikhi zibonise inqanaba eliphezulu lokunyanga ngonyango oludibeneyo.

IHarvoni kunye ne-omeprazole okanye ezinye ii-PPI

Ukuthatha iHarvoni nge-omeprazole (Prilosec) okanye enye iproton pump inhibitors (ii-PPIs) kunokunciphisa inani leHarvoni emzimbeni wakho. Oku kunokwenza iHarvoni ingasebenzi kakuhle.

Ukuba kunokwenzeka, thintela ukuthatha iHarvoni kunye noluhlu lweziyobisi. Ukuba ufuna i-PPI ngelixa uthatha iHarvoni, kuya kufuneka uthathe iHarvoni kunye ne-PPI ngaxeshanye kwisisu esingenanto.

Imizekelo yezinye ii-PPIs ibandakanya:

• esomeprazole (Nexium)
• I-lansoprazole (Prevacid)
• I-pantoprazole (iProtonix)

IHarvoni kunye nemifuno kunye nezongezo

Ukuthatha iHarvoni nge-St. John's wort kunganciphisa inani leHarvoni emzimbeni wakho. Oku kunokwenza iHarvoni ingasebenzi kakuhle. Ukuthintela oku kunxibelelana, musa ukuthatha iHarvoni kunye neSt.

Amanye amayeza okanye izongezo ezinokunciphisa isixa seHarvoni emzimbeni wakho zibandakanya:

• kava kava
• inkunkuma yobisi
• ikhala
• iglucomannan

Ngexesha lokunyanga kwakho noHarvoni, jonga kugqirha wakho ngaphambi kokuba uthathe nayiphi na imifuno okanye izongezo.

IHarvoni kunye nekofu

Akukho nxibelelwano luchaziweyo phakathi kweHarvoni kunye nekofu. Nangona kunjalo, ezinye zeziphumo ebezingalindelekanga zikaHarvoni zinokuba mandundu ukuba utya kakhulu ikofu okanye icaffeine. Umzekelo, ukusela ikofu emva kwemini okanye ngokuhlwa kunokwenza iingxaki zokulala kwakho zibe mandundu. Kwaye icaffeine inokuzenza mandundu iintlungu.

Ukuba usela ikofu okanye uyitya rhoqo icaffeine, thetha nogqirha wakho malunga nokuba ikhuselekile na kuwe ngexesha lonyango kunye noHarvoni.

Enye indlela eya eHarvoni

Ezinye iziyobisi ziyafumaneka ezinokunyanga i-hepatitis C. Ezinye zinokulungela wena kunabanye. Ukuba unomdla ekufumaneni enye indlela yeHarvoni, thetha nogqirha wakho ukuze ufunde ngakumbi ngamanye amayeza anokukusebenzela.

I-Hepatitis C inokunyangwa kusetyenziswa ezinye iziyobisi okanye indibaniselwano yeziyobisi. Unyango olukhethwe ngugqirha lwakho luya kuxhomekeka kuhlobo lwe-hepatitis C, ukusebenza kwesibindi, nokuba sele ulufumene unyango lwe-hepatitis C ngaphambili.

Imizekelo yezinye iziyobisi ezingasetyenziselwa ukunyanga i-hepatitis C zibandakanya:

• I-Epclusa (velpatasvir, sofosbuvir)
• Imavyret (glecaprevir, pibrentasvir)
• IViekira Pak (paritaprevir, ombitasvir, ritonavir, dasubuvir)
• I-Vosevi (velpatasvir, sofosbuvir, voxilaprevir)
• UZepatier (elbasvir, grazoprevir)
• I-Rebetol (ribavirin), esetyenziswa ngokudibanisa namanye amachiza

Ii-interferon ngamayeza amadala awayekade esetyenziswa ukunyanga i-hepatitis C. Nangona kunjalo, amayeza amatsha anjengeHarvoni abangela iziphumo ebezingalindelekanga ezimbalwa kwaye anezinga eliphezulu lokunyanga kunee-interferon. Ngenxa yezi zizathu, namhlanje ii-interferon azisetyenziselwa ukunyanga i-hepatitis C.

IHarvoni vs. nezinye iziyobisi

Unokuzibuza ukuba iHarvoni ithelekiswa njani namanye amayeza anikwe ukusetyenziswa okufanayo. Apha ngezantsi kuthelekiswa phakathi kweHarvoni kunye namayeza aliqela.

IHarvoni vs Epclusa

IHarvoni iqulethe amachiza amabini kwipilisi enye: ledipasvir kunye nesofosbuvir. I-Epclusa ikwanamachiza amabini kwipilisi enye: velpatasvir kunye nesofosbuvir.

Omabini la mayeza aqulathe iyeza lesofosbuvir, elithathwa ngokuba "ngumqolo" wonyango. Oku kuthetha ukuba isicwangciso sonyango sisekwe kwichiza lomqolo, kunye namanye amachiza ongezwe ngokudibeneyo.

Sebenzisa

IHarvoni kunye ne-Epclusa bobabini bavunyelwe yi-FDA ukunyanga i-hepatitis C. IHarvoni inokunyanga i-hepatitis C genotypes 1, 4, 5, kunye ne-6, ngelixa i-Epclusa inganyanga zonke ii-genotypes ezintandathu.

Omabini la machiza avunyiwe ukuba anyange abantu ngaphandle kwesibindi, okanye ahlawulelwe okanye aphulukane nesibindi. Kukho umahluko omncinci ukuba ngubani omiselwe bona, kuxhomekeke kuhlobo lwe-genotype, ukusebenza kwesibindi, kunye nembali yezonyango.

I-Harvoni ivunyiwe yi-FDA ukunyanga i-hepatitis C kubantwana abaneminyaka eli-12 nangaphezulu okanye abanobunzima obungama-77 eepawundi. I-Epclusa ayivunyelwanga ukunyanga i-hepatitis C ebantwaneni.

Iifom zeziyobisi kunye nolawulo

IHarvoni kunye ne-Epclusa bobabini bathathwa njengecwecwe elinye kube kanye yonke imihla. Bangathathwa kunye nokutya okanye kwisisu esingenanto.

Ubude bonyango lweHarvoni zii-8, 12, okanye iiveki ezingama-24. Uthatha ixesha elingakanani iHarvoni iya kuxhomekeka kuhlobo lwakho, okanye uhlobo lwe-hepatitis C kunye nokusebenza kwesibindi. Kuya kuxhomekeka kunyango lwakho lwangaphambili lwe-hepatitis C.

Ixesha lonyango lwe-Epclusa ziiveki ezili-12.

Iziphumo kunye neengozi

IHarvoni kunye ne-Epclusa zozibini iziyobisi ezibizwa ngokuba zi-antivirals ezisebenza ngokuthe ngqo kwaye zineempembelelo ezifanayo emzimbeni. Ngenxa yoku, zibangela uninzi lweempembelelo ezifanayo. Apha ngezantsi kukho imizekelo yeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo ebezingalindelekanga ezinokubakho ngeHarvoni kunye ne-Epclusa zibandakanya:

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezinokubakho ngeHarvoni kunye ne-Epclusa zibandakanya:

• Ukuphinda kusebenze i-hepatitis B (xa usulelo lwangaphambili luphinda lusebenze kwakhona), olunokukhokelela ekusileleni kwesibindi okanye ekufeni (jonga "Izilumkiso ezibhokisiweyo" ngezantsi)
• iimpendulo ezimbi, ezinempawu ezinokubandakanya ukuphefumla kunye ne-angioedema (ukudumba phantsi kolusu lwakho, ikakhulu kwiinkophe zakho, imilebe, izandla, okanye iinyawo)

Izilumkiso zebhokisi

UHarvoni kunye no-Epclusa bobabini banesilumkiso esibhokisi esivela kwi-FDA. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA.

Isilumkiso sichaza umngcipheko wokuphinda kusebenze i-hepatitis B emva kokuqalisa unyango ngalo naliphi na ichiza. Ukuvuselelwa kwakhona kwe-hepatitis B kunokukhokelela kumonakalo omkhulu wesibindi, ukusilela kwesibindi, okanye ukufa.

Ugqirha wakho uya kuvavanya i-hepatitis B ngaphambi kokuba uqale ukuthatha iHarvoni okanye i-Epclusa. Ukuba uvavanya ukuba une-hepatitis B, kungafuneka uthathe amayeza ukuyinyanga.

Ukusebenza ngempumelelo

Ngokwezikhokelo zonyango, iHarvoni kunye ne-Epclusa zombini iindlela zonyango ezinokukhethwa kunyango lwe-hepatitis C 1, 4, 5, kunye no-6. Iingcebiso ezongezelelweyo zibandakanya oku kulandelayo:

• IHarvoni lukhetho lokuqala lokunyanga ii-genotypes 1, 4, 5, kunye no-6 kubantwana abaneminyaka eli-12 nangaphezulu (okanye ubunzima beepawundi ezingama-77 nangaphezulu).
• I-Epclusa lukhetho lokuqala lokunyanga ii-genotypes 2 kunye 3.

IHarvoni kunye ne-Epclusa zithelekisiwe kwizifundo zeklinikhi. Zombini zifunyenwe zisebenza kakhulu ekunyangeni i-hepatitis C. Nangona kunjalo, i-Epclusa inokuphilisa ipesenti enkulu yabantu kuneHarvoni.

Kwisifundo seklinikhi, ngaphezulu kweepesenti ezingama-93 zabantu abafumene i-ledipasvir kunye ne-sofosbuvir, izinto ze-Harvoni, baphiliswa kwi-hepatitis C. Iqondo lokunyanga abantu abafumene i-velpatasvir kunye ne-sofosbuvir, izinto ze-Epclusa, zazingaphezulu kweepesenti ezingama-97.

Isifundo sesibini sifumene iziphumo ezifanayo kubantu abane-cirrhosis yesibindi. Olunye uphononongo lufumanise ukuba i-Epclusa yanyanga i-hepatitis C kwipesenti enkulu yabantu kuneHarvoni.

Kuzo zontathu izifundo, i-SVR yayiphezulu kancinci kwi-Epclusa kuneHarvoni. I-SVR imele impendulo eqhubekayo ye-virologic, oko kuthetha ukuba intsholongwane ayinakufunyanwa emzimbeni wakho.

Iindleko

IHarvoni kunye ne-Epclusa bobabini bangamayeza anegama lophawu. Okwangoku azikho iintlobo zohlobo oluthile lwamayeza. Amayeza egama leBrand ngokubanzi axabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iHarvoni ibiza kakhulu kune-Epclusa. Elona xabiso uhlawula ngalo naliphi na ichiza lixhomekeke kwisicwangciso sakho seinshurensi nakwikhemesti oyisebenzisayo.

Phawula: Iinguqulelo eziqhelekileyo zala machiza kulindeleke ukuba zikhutshwe ekuqaleni kuka-2019. Umvelisi uqikelela ukuba indleko zekhosi nganye iya kuba ngama- $ 24,000. Eli xabiso lingaphantsi kakhulu kunexabiso leenguqulelo zegama legama.

IHarvoni vs Mavyret

IHarvoni iqulethe amachiza amabini kwipilisi enye: ledipasvir kunye nesofosbuvir. IMavyret ikwanamachiza amabini kwipilisi enye: glecaprevir kunye nepibrentasvir.

Sebenzisa

IHarvoni kunye neMavyret zombini zivunyiwe yi-FDA ukunyanga i-hepatitis C. Nangona kunjalo, zisetyenziselwa ukunyanga ii-genotypes ezahlukeneyo kwiimeko ezahlukeneyo:

• I-Harvoni ivunyiwe ukuba inyange i-hepatitis C genotypes 1, 4, 5, kunye no-6. I-Mavyret yamkelwe ukunyanga zonke i-genotypes eziphambili.
• Omabini la mayeza asetyenziselwa ukunyanga abantu abathe bahlawula i-cirrhosis. IHarvoni inokusetyenziselwa abantu abane-cirrhosis ebolileyo, kodwa uMavyret akakwazi.
• Zombini zinokusetyenziswa kubantu abaye bafakelwa isibindi.
• I-Mavyret ingasetyenziselwa abantu abanesifo esibi sezintso okanye emva kokufakelwa kwezintso, kodwa iHarvoni ayivunyelwanga kwezi zinto zisetyenziswayo.
• I-Harvoni ivunyelwe ukunyanga i-hepatitis C kubantwana abaneminyaka eli-12 nangaphezulu okanye abanobunzima obungama-77 eepawundi. I-Mavyret ivunyiwe kuphela ukuba isetyenziswe kubantu abadala.
• Omabini la mayeza avunyelwe ukunyanga abantu abazame amayeza athile e-hepatitis C ngaphambili.

Iifom zeziyobisi kunye nolawulo

IHarvoni kunye neMavyret bobabini beza njengeetafile ozithatha kanye ngemini. Nangona kunjalo, ngelixa uthatha ithebhulethi enye yeHarvoni ngosuku, uthatha iipilisi ezintathu zeMavyret ngosuku.

IHarvoni ingathathwa kunye okanye ngaphandle kokutya, kodwa iMavyret kufuneka ithathwe ngokutya.

IHarvoni inokumiselwa iinyanga ezi-8, 12, okanye ezingama-24 zonyango. Ixesha lokunyanga likaMavyret linokuba zii-8, 12, okanye iiveki ezili-16. Ubude bonyango ugqirha ocacisayo buya kusekelwa kuhlobo lwakho lwe-hepatitis C, ukusebenza kwesibindi, kunye nembali yonyango oludlulileyo lwe-hepatitis C.

Iziphumo kunye neengozi

IHarvoni kunye neMavyret baneziphumo ezifanayo emzimbeni. Oku kuthetha ukuba zikwabangela iziphumo ebezingalindelekanga ezifanayo. Ngezantsi yimizekelo yezinye zeziphumo ebezingalindelekanga.

Iziphumo eziqhelekileyo ezichaphazelekayo

Iziphumo eziqhelekileyo eziqhelekileyo ezinokuthi zenzeke kunye neHarvoni kunye neMavyret ziquka:

Iziphumo ebezingalindelekanga ezimandundu

Iziphumo ebezingalindelekanga ezinokubakho ngeHarvoni kunye neMavyret zibandakanya:

• Ukuphinda kusebenze i-hepatitis B (xa usulelo lwangaphambili luphinda lusebenze kwakhona), olunokukhokelela kumonakalo omkhulu wesibindi, ukusilela kwesibindi, okanye ukufa (jonga "Izilumkiso ezibhokisiweyo" ngezantsi)
• ukuphendula kakubi, kunye neempawu ezinokubandakanya ukuphefumula kunye ne-angioedema (ukuvuvukala phantsi kwesikhumba sakho, ngokuqhelekileyo kwiinkophe zakho, imilebe, izandla, okanye iinyawo)

Izilumkiso zebhokisi

UHarvoni kunye noMavyret bobabini baneebhokisi zezilumkiso ezivela kwi-FDA. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA.

Isilumkiso sichaza umngcipheko wokuphinda kusebenze i-hepatitis B emva kokuqalisa unyango ngalo naliphi na ichiza. Ukuvuselelwa kwe-Hepatitis B kunokukhokelela kumonakalo omkhulu wesibindi, ukusilela kwesibindi, okanye ukufa.

Ugqirha wakho uya kuvavanya i-hepatitis B ngaphambi kokuba uqale ukuthatha iHarvoni okanye iMavyret. Ukuba uvavanya ukuba une-hepatitis B, kungafuneka uthathe amayeza ukuyinyanga.

Ukusebenza ngempumelelo

IHarvoni kunye neMavyret khange zithelekiswe kwizifundo zeklinikhi, kodwa zombini ziyasebenza kunyango lwe-hepatitis C.

Ngokwezikhokelo zonyango, uHarvoni kunye noMavyret bobabini ukhetho lokuqala lonyango lwe-hepatitis C genotypes 1, 4, 5, kunye no-6. iimeko ezithile zonyango apho ichiza elinye liya kucetyiswa ngaphezulu kwelinye:

• Abantwana abaneminyaka eyi-12 nangaphezulu okanye abanobunzima beepawundi ezingama-77 okanye nangaphezulu: I-Harvoni lukhetho lokuqala lokunyanga aba bantwana nge-genotypes 1, 4, 5, kunye ne-6. I-Mavyret ayikhuthazwa ukuba isetyenziswe ebantwaneni.
• Isifo sezintso kakhulu: I-Mavyret lukhetho lokuqala lokunyanga i-hepatitis C kubantu abakule meko. I-Harvoni ayikhuthazwa kubantu abanesifo esibi sezintso.
• Ukuqina kwesibindi: Kubantu abane-cirrhosis ebolaweyo, iHarvoni iyacetyiswa ukuba isetyenziswe ne-ribavirin. I-Mavyret ayikhuthazwa kubantu abakule meko.
• Ukutshintshwa kwezintso: Kubantu abafumene ukufakelwa kwezintso, omabini la machiza anconyelwa njengolukhetho lokuqala kubantu abane-genotypes 1 okanye 4. (IHarvoni isetyenzisiwe ngaphandle kwelebheli ukulungiselela le njongo.) I-Mavyret ikwacetyiswa kubantu abane-genotypes 2 , 3, 5, okanye 6 oye wafakelwa izintso, kodwa uHarvoni akakho.
• Ukufakelwa kwesibindiIingcebiso zonyango malunga nokusetyenziswa kweHarvoni kunye neMavyret zahlukile kubantu abanesibindi sokufakelwa isibindi. Zisekwe kwi-genotype kunye nokusebenza kwesibindi.

Iindleko

IHarvoni kunye neMavyret bobabini bangamayeza anegama lophawu. Okwangoku azikho iindlela zohlobo oluthile lwamayeza akhoyo. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iHarvoni ibiza kakhulu kuneMavyret. Indleko ozihlawulela iziyobisi ziya kuxhomekeka kwisicwangciso sakho seinshurensi nakwikhemesti oyisebenzisayo.

PhawulaInguqulelo yohlobo oluqhelekileyo lweHarvoni kulindeleke ukuba ikhutshwe ekuqaleni konyaka ka-2019. Eli xabiso lingaphantsi kakhulu kunexabiso lenguqulelo yegama legama.

IHarvoni vs Sovaldi

IHarvoni kunye ne-Sovaldi zombini zisetyenziselwa ukunyanga i-hepatitis C. IHarvoni yicwecwe lokudibanisa elinamachiza amabini: i-ledipasvir kunye ne-sofosbuvir. I-Sovaldi inelinye ichiza: i-sofosbuvir.

Sebenzisa

I-Harvoni ivunyiwe yi-FDA ukunyanga i-hepatitis C kubantu abadala abane-genotypes 1, 4, 5, okanye 6. Ingasetyenziselwa ukuphatha abantwana abanezi genotypes abaneminyaka eli-12 nangaphezulu okanye abanobunzima obungama-77 eepawundi.

I-Sovaldi ikwavunyiwe ukuba inyange i-hepatitis C, kodwa isetyenziswa kubantu abadala abane-genotypes 1, 2, 3, okanye 4. Ingasetyenziswa nakubantwana abane-genotypes 2 okanye 3 abaneminyaka eyi-12 okanye ngaphezulu okanye abanobunzima beepawundi ezingama-77 okanye ngaphezulu .

I-Sovaldi isetyenziswa ngokudibene namanye amayeza ukunyanga i-hepatitis C. Ayivunyelwanga yi-FDA ukuba isetyenziselwe yona.

Iifom zeziyobisi kunye nolawulo

IHarvoni kunye neSovaldi bobabini beza njengeetafile ozithatha ngomlomo. I-Harvoni ithathwa kanye yonke imihla i-8, 12, okanye iiveki ezingama-24. I-Sovaldi nayo ithathwa kanye yonke imihla, kodwa iiveki ezili-12 okanye ezingama-24.

Omabini la mayeza aqukethe i-sofosbuvir, kodwa iHarvoni yindibaniselwano yamayeza enokusetyenziselwa yona yedwa kwabanye abantu. I-Sovaldi ayisetyenziswanga yodwa ukunyanga i-hepatitis C. Imiselwe ngamanye amachiza, kubandakanya i-pegylated interferon kunye ne-ribavirin (i-Rebetol). Ifom yesiqhelo ye-Sovaldi ikwafumaneka nakwezinye iindlela zokudibanisa i-hepatitis C.

Iziphumo kunye neengozi

Omabini la mayeza ane-sofosbuvir, ke aya kubangela iziphumo ebezingalindelekanga ezininzi ezifanayo. Nangona kunjalo, uSovaldi uhlala ethathwa ngokudibanisa namanye amayeza, anokusebenza ngokwahlukileyo kwiHarvoni. Ngenxa yoku, iziphumo ebezingalindelekanga ezibonwe kunyango lwe-Sovaldi zixhomekeke kwichiza elisetyenzisiweyo.

Iziphumo eziqhelekileyo kunye nezibi zeHarvoni kunye neSovaldi ziboniswe ngezantsi. Iziphumo ebezingalindelekanga ezichazwe nguSovaldi zibonwa xa iSovaldi isetyenziswa kunye nezinye iziyobisi ze-hepatitis C ezinje nge-ribavirin kunye ne-pegylated interferon.

* UHarvoni kunye noSovaldi bobabini banesilumkiso esibhokisi esivela kwi-FDA sokuvuselelwa kwesifo se-hepatitis B. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

I-Harvoni kunye ne-Sovaldi zinokusetyenziswa okuvunyiweyo kwe-FDA, kodwa zombini zisetyenziselwa ukunyanga i-hepatitis C. IHarvoni iyasebenza ngokuchasene nentsholongwane xa isetyenziswa yodwa okanye i-ribavirin. I-Sovaldi iyasebenza ekunyangeni i-hepatitis C kuphela xa isetyenziswa ngokudibanisa namanye amachiza, njenge-ribavirin kunye ne-pegylated interferon.

Ngokwezikhokelo zonyango, i-Harvoni lukhetho lokuqala lokunyanga i-hepatitis C kubantu abane-genotypes 1, 4, 5, okanye 6. Kukokhetho lokuqala kubantwana abaneminyaka eli-12 nangaphezulu okanye abanobunzima obungama-77 eepawundi.

I-Sovaldi ayisaphakanyiswa sisikhokelo sonyango njengokhetho lokuqala lokunyanga i-hepatitis C. Kungenxa yokuba amachiza amatsha anje ngeHarvoni athathelwa ingqalelo ukuba asebenza ngakumbi. Amachiza amatsha nawo abangela iziphumo ebezingalindelekanga ezimbalwa.

Nangona kunjalo, uSovaldi ngamanye amaxesha uyacetyiswa njengonyango lwesibini kubantu abathile, kodwa kufuneka isetyenziswe ngokudibeneyo namanye amayeza.

Iindleko

IHarvoni kunye neSovaldi ngamagama egama lonyango. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza.

Ngokwengqikelelo yeGoodRx.com, iHarvoni ixabisa ngaphezulu kuneSovaldi. Elona xabiso uhlawula ngalo naliphi na ichiza liya kuxhomekeka kwi-inshurensi nakwikhemesti oyisebenzisayo.

PhawulaInguqulelo yohlobo oluqhelekileyo lweHarvoni kulindeleke ukuba ikhutshwe ekuqaleni konyaka ka-2019. Eli xabiso lingaphantsi kakhulu kunexabiso lenguqulelo yegama legama.

IHarvoni vs iZepatier

IHarvoni iqulethe ichiza ledipasvir kunye nesofosbuvir kwipilisi enye. I-Zepatier ikwanamachiza amabini kwipilisi enye: i-elbasvir kunye ne-grazoprevir.

Sebenzisa

I-Harvoni kunye ne-Zepatier bobabini bavunyelwe yi-FDA ukunyanga intsholongwane ye-hepatitis C kubantu abadala abane-genotypes 1 okanye 4. IHarvoni ikwamkelwe ukunyanga ii-genotypes 5 kunye no-6 kubantu abadala, kunye ne-genotypes 1, 4, 5, okanye 6 kubantwana abaneminyaka eli-12 okanye ngaphezulu. okanye ngubani onobunzima obungama-77 eepawundi ubuncinci. I-Zepatier ayivunyelwanga ukuba isetyenziswe ebantwaneni.

I-Harvoni ivunyiwe ukuba inyange intsholongwane ye-hepatitis C kubantu abadala abane-cirrhosis ebolileyo okanye abanotyando lwesibindi. Ngale miqathango, ugqirha wakho uya kuthi amisele i-ribavirin kunye neHarvoni.

I-Zepatier ayivunyelwanga ukuba isetyenziswe kubantu abanezifo zesibindi okanye ezomeleleyo, ezinesibindi, okanye emva kokufakelwa kwesibindi.

I-Zepatier ivunyiwe yi-FDA ukuba isetyenziswe kubantu abane-genotypes 1 kunye ne-4 abanemeko ebizwa ngokuba yi-polymorphism. Ngale meko, umntu uneenguqu ezithile zofuzo ezenza intsholongwane ukuba inganyangeki kumayeza athile. Xa intsholongwane iyanyangeka, kunzima ukunyanga ngamayeza athile.

Ugqirha wakho uya kwenza uvavanyo lwegazi ukuze abone ukuba unayo enye yezi zinto zahlukileyo. Ukuba uyakwenza oko, kuya kufuneka uthathe i-ribavirin kunye neZepatier.

Iifom zeziyobisi kunye nolawulo

IHarvoni kunye neZepatier bobabini beza njengepilisi enye ethathwa kanye yonke imihla. Nganye inokuthathwa kunye okanye ngaphandle kokutya.

Unyango lweHarvoni luhlala iiveki ezi-8, 12, okanye ezingama-24. Unyango lweZepatier luhlala iiveki ezili-12 okanye ezili-16. Ixesha lokunyanga ugqirha wakho elimiselweyo liya kusekelwa kuhlobo lwakho, ukusebenza kwesibindi, kunye nembali yonyango oludlulileyo lwe-hepatitis C.

Iziphumo kunye neengozi

IHarvoni kunye neZepatier ngamayeza afanayo kwaye iziphumo zawo emzimbeni ziyafana. Ke ngoko, zibangela uninzi lweempembelelo ezifanayo. Apha ngezantsi kukho imizekelo yeziphumo ebezingalindelekanga.

* UHarvoni kunye noZepatier bobabini banesilumkiso esibhokisi esivela kwi-FDA sokuphinda kusebenze i-hepatitis B. Isilumkiso sebhokisi sisilumkiso esomeleleyo esifunwa yi-FDA. Yazisa oogqirha kunye nezigulana malunga neziphumo zeziyobisi ezinokuba yingozi.

Ukusebenza ngempumelelo

IHarvoni kunye neZepatier khange zithelekiswe kwizifundo zeklinikhi, kodwa zombini ziyasebenza kunyango lwe-hepatitis C.

Ngokwezikhokelo zonyango, bobabini uHarvoni kunye noZepatier bayacetyiswa njengokhetho lokuqala lokunyanga i-hepatitis C kubantu abadala abane-genotypes 1 kunye ne-4. IHarvoni lukhetho lokuqala lokunyanga ii-genotypes 5 kunye ne-6, kodwa uZepatier akayona.

Izindululo zesikhokelo seHarvoni kunye neZepatier ziyahluka kwezi meko zilandelayo:

• Abantwana abaneminyaka eyi-12 nangaphezulu okanye abanobunzima beepawundi ezingama-77 okanye nangaphezulu: I-Harvoni lukhetho lokuqala lokunyanga aba bantwana bane-genotypes 1, 4, 5, kunye ne-6. I-Zepatier ayikhuthazwa ukuba isetyenziswe ebantwaneni.
• Isifo sezintso kakhulu: I-Zepatier icetyiswa njengokhetho lokuqala lokukhetha kubantu abakule meko, ngelixa iHarvoni ingekho.
• Ukuqina kwesibindi: Kubantu abane-cirrhosis ebolaweyo, iHarvoni iyacetyiswa njengokhetho lokuqala. I-Zepatier ayikhuthazwa kubantu abakule meko.
• Ukufakelwa kwesibindi okanye izintso: I-Harvoni lukhetho lokuqala lokunyanga i-hepatitis C kubantu abanesibindi okanye ukufakelwa kwezintso. I-Zepatier ayikhuthazwa kubantu abanezi meko.

Iindleko

IHarvoni kunye neZepatier ngamagama egama lonyango. Okwangoku azikho iifom zohlobo oluthile ezifumaneka nakweliphi na ichiza. Amayeza egama leBrand ahlala exabisa ngaphezu kwegeneric.

Ngokwengqikelelo yeGoodRx.com, iHarvoni ixabisa ngaphezulu kweZepatier. Indleko ozihlawulela iziyobisi ziya kuxhomekeka kwisicwangciso sakho seinshurensi nakwikhemesti oyisebenzisayo.

PhawulaInguqulelo yohlobo oluqhelekileyo lweHarvoni kulindeleke ukuba ikhutshwe ekuqaleni konyaka ka-2019. Eli xabiso lingaphantsi kakhulu kunexabiso lenguqulelo yegama legama.

Uyithatha njani iHarvoni

Kuya kufuneka uthathe iHarvoni ngokwemiyalelo kagqirha wakho.

Ixesha

IHarvoni ingathathwa ngalo naliphi na ixesha losuku. Nangona kunjalo, kuya kufuneka uzame ukuthatha iHarvoni ngexesha elifanayo yonke imihla. Oku kunokukunceda ukhumbule ukuyithatha kwaye uncede ukugcina inani elilinganayo leziyobisi kwinkqubo yakho.

Ukuba ufumana ukudinwa ngexesha lonyango kunye noHarvoni, zama ukuthatha iyeza ebusuku. Oko kunokukunceda ukuba uphephe iziphumo ebezingalindelekanga.

Ukuthatha iHarvoni ngokutya

IHarvoni ingathathwa kunye okanye ngaphandle kokutya. Ukuba ufumana isicaphucaphu emva kokuthatha iHarvoni, unokuyiphepha lempembelelo ngokuthatha ichiza kunye nokutya.

Ngaba iHarvoni inokutyunyuzwa?

Ayaziwa nokuba kukhuselekile na ukutyumza iipilisi zeHarvoni, ke kungcono ukuba ungazityumzi. Ukuba unengxaki yokuginya iipilisi zeHarvoni, thetha nogqirha wakho ngamanye amayeza anokusebenza ngcono kuwe.

Usebenza njani uHarvoni

IHarvoni isetyenziselwa ukunyanga usulelo lwentsholongwane ye-hepatitis C (HCV).

Malunga nehepatitis C

I-HCV idluliselwa ngegazi okanye ulwelo lomzimba. Intsholongwane ihlasela ikakhulu iiseli kwisibindi sakho kwaye ibangele ukudumba. Oku kukhokelela kwiimpawu ezinje:

• iintlungu esiswini sakho (isisu)
• ifiva
• umchamo omnyama-mnyama
• intlungu edibeneyo
• i-jaundice (tyheli kolusu lwakho okanye abamhlophe bamehlo akho)

Eminye imizimba yabantu inokulwa i-HCV ngaphandle konyango. Nangona kunjalo, abantu abaninzi bafuna amayeza okucoca intsholongwane kunye nokunciphisa iziphumo zexesha elide. Iziphumo ezibi, zexesha elide ze-hepatitis C zibandakanya i-cirrhosis (ukusilela kwesibindi) kunye nomhlaza wesibindi.

I-Harvoni inyanga njani i-hepatitis C?

IHarvoni yi-antiviral esebenza ngokuthe ngqo (DAA). Ezi ndidi zamachiza zinyanga i-HCV ngokunqanda intsholongwane ekubeni ivelise kwakhona (ukuzenzela iikopi zayo). Iintsholongwane ezingenakwenza iikopi ekugqibeleni zife kwaye zicocwe emzimbeni.

Ukucoca intsholongwane emzimbeni wakho kuya kunciphisa ukudumba kwesibindi kunye nokuthintela ukonakala kwesibindi.

Kuthatha ixesha elingakanani ukusebenza?

Abanye abantu baqala ukuziva bhetele kwiintsuku ezimbalwa okanye kwiiveki zokuqala unyango ngoHarvoni. Nangona kunjalo, kuya kufuneka uthabathe iHarvoni ngalo lonke ixesha elimiselwe ngugqirha wakho.

Kwizifundo zeklinikhi, ngaphezulu kweepesenti ezingama-86 zabantu abathathe iHarvoni baphiliswa emva kweenyanga ezintathu zonyango.

Ugqirha wakho uza kuvavanya igazi lakho ukuze abonakalise intsholongwane ngaphambi nangexesha lonyango. Baza kuvavanya iiveki ezili-12 emva kokuba ulugqibile unyango. Ukuba akukho ntsholongwane ifumanekayo emzimbeni wakho kwiiveki ezili-12 emva kokuba unyango lwakho luphelile, uphumelele ukuphendula ngokuqhubekayo kwe-virologic (SVR). Ukufezekisa i-SVR kuthetha ukuba uthathwa njengonyango lwe-hepatitis C.

Harvoni kunye nokukhulelwa

Khange kubekho zifundo zaneleyo ebantwini ukuba bazi ukuba iHarvoni ikhuselekile na ngexesha lokukhulelwa. Kwizifundo zezilwanyana, kwakungekho monakalo kwimveku ebonwayo xa umama wamkela uHarvoni. Nangona kunjalo, izifundo zezilwanyana azihlali ziqikelela ukuba kuya kwenzeka ntoni ebantwini.

Ukuba ukhulelwe okanye uceba ukukhulelwa, thetha nogqirha wakho malunga nokuba iHarvoni ikulungele na.

Qaphela: Ukuba uthatha iHarvoni nge-ribavirin, olo nyango alukhuselekanga xa ulusebenzisa xa ukhulelwe (jonga "iHarvoni kunye ne-ribavirin" apha ngasentla).

IHarvoni kunye nokuncancisa

Ayaziwa ukuba iHarvoni idlula kubisi lomntu lwebele. Kwizifundo zezilwanyana, iHarvoni yafunyanwa kubisi lwebele kodwa ayibanga ziphumo zenzala kwinzala. Nangona kunjalo, izifundo zezilwanyana azihlali ziqikelela ukuba kuya kwenzeka ntoni ebantwini.

Ukuba uncelisa okanye uceba ukuncelisa, thetha nogqirha wakho malunga nobungozi kunye neenzuzo zokuthatha iHarvoni ngelixa uncelisa.

Qaphela: Ukuba uthatha iHarvoni nge-ribavirin, kuya kufuneka uthethe nogqirha wakho malunga nokuba ungaqhubeka nokuncancisa ngokukhuselekileyo (jonga "iHarvoni kunye ne-ribavirin" apha ngasentla).

Imibuzo eqhelekileyo malunga neHarvoni

Nazi iimpendulo kwimibuzo ebuzwa rhoqo malunga neHarvoni.

Ngaba kufuneka ndilandele ukutya okukhethekileyo ngelixa ndithatha iHarvoni?

Hayi, akukho kutya okhethekileyo okufunekayo ngelixa uthatha iHarvoni.

Nangona kunjalo, ukuba ufumana isicaphucaphu okanye iintlungu zesisu njengempembelelo esecaleni yeHarvoni, kunokuba luncedo ukutya ukutya okuncinci kunye nokuthintela ukutya okunamafutha, okubabayo, okanye okune asidi. Ukuthatha iHarvoni ngesinekhi esincinci kunokunciphisa isicaphucaphu.

Uza kuthatha ixesha elingakanani uHarvoni ukususa i-hepatitis C yam?

IHarvoni izakuqala ukusebenza kwangoko ukulwa intsholongwane. Nangona kunjalo, ukuze ulahle i-hepatitis C, kuya kufuneka uthabathe iHarvoni ixesha elipheleleyo elimiselwe ngugqirha wakho. Oku kunokuba zi-8, 12, okanye iiveki ezingama-24, kuxhomekeke kwimbali yakho yonyango.

Kwizifundo zeklinikhi, phantse bonke abantu abathathe iHarvoni baphumelele ngokuzinzileyo kwempendulo ye-virologic SVR) emva konyango olupheleleyo. I-SVR ithetha ukuba intsholongwane yayingasabonakali kwigazi labo. Xa umntu efezekisa i-SVR, bathathelwa ingqalelo njengonyango lwe-hepatitis C.

Lithini inqanaba lokunyanga iHarvoni?

Izinga lokunyanga i-Harvoni lixhomekeke kwimiba ethile ye-hepatitis C. Oku kubandakanya ukuba unayo okanye awunayo i-cirrhosis, loluphi unyango lwe-hepatitis C ozamile ngaphambili, kwaye loluphi uhlobo lwe-virus onalo.

Umzekelo, kwizifundo zeklinikhi zaseHarvoni, iipesenti ezingama-96 zabantu abadibana nale nkcazo ilandelayo baphiliswa kwi-hepatitis C emva kweeveki ezili-12:

• Ndine-genotype 1
• wayengenaso isifo sokuqina kwesibindi
• wayengenayo nembali yolunye unyango lwe-hepatitis C

Kwizifundo ezifanayo zeklinikhi, phakathi kweepesenti ezingama-86 kunye neepesenti ezili-100 zabantu abaneembali ezahlukeneyo zonyango baphiliswa kwi-hepatitis C.

Ngaba i-hepatitis C ingabuya emva kokuthatha iHarvoni?

Ukuba uthatha iHarvoni yonke imihla njengokuyalelwa ngugqirha wakho kwaye ugcina indlela yokuphila esempilweni, intsholongwane ayifanelanga ukubuya.

Nangona kunjalo, kunokwenzeka ukuba uphinde uphinde (usulelo luphinde luvele). Oku kwenzeka xa iyeza linyange umntu kwi-hepatitis C, kodwa kuvavanyo lwegazi lubhaqa intsholongwane kwakhona kwiinyanga ukuya kwiminyaka emva konyango. Kuvavanyo lweklinikhi, ukuya kuthi ga kwiipesenti ezi-6 zabantu abaphathwe ngeHarvoni babuyela umva.

Kwakhona, ukuba uphinde wachaphazeleka kwi-hepatitis C emva kokuba uthathe naliphi na iyeza le-hepatitis C, kubandakanya iHarvoni, unokuphinda ubenentsholongwane. Ukuphinda uphinde usuleleke kwenzeka ngendlela efanayo nosulelo lwantlandlolo olwafunyanwa ngalo.

Ukwabelana ngeenaliti ezisetyenziselwa ukutofa iziyobisi kunye nokuba neentlobano zesini ngaphandle kwekhondom ziindlela ezinokubangela ukosuleleka kwakhona. Ukuphepha ezi ndlela zokuziphatha kunokunceda ukuthintela ukosuleleka kwakhona yi-hepatitis C.

Yintoni i-hepatitis C genotype?

Kukho iintlobo ezintandathu ezahlukeneyo, okanye iintlobo, zeentsholongwane ze-hepatitis C ezaziwayo ukuba ziyosulela abantu. Ezi ntlobo zibizwa ngokuba ziigenotypes.

IiGenotypes zichongwa ngokwahluka kwikhowudi yemfuza yentsholongwane. Uhlobo oluqhelekileyo lwe-hepatitis C e-United States luhlobo lwe-genotype 1, kodwa ezinye iintlobo zikwabonwa apha.

Ugqirha wakho uya kukunika uvavanyo lwegazi ukumisela ukuba loluphi uhlobo onalo. Uhlobo lwakho lwe-hepatitis C luya kukunceda ugqirha wakho athathe isigqibo sokuba leliphi iyeza elifanelekileyo kuwe.

Ukugqithisa kweHarvoni

Ukuba uthatha iHarvoni eninzi, wonyusa umngcipheko weziphumo ebezingalindelekanga ezibi.

Iimpawu libanda

Iimpawu zokugqithisa kweHarvoni zingabandakanya:

• ukudinwa
• intloko ebuhlungu
• isicaphucaphu nokugabha
• ubuthathaka bemisipha
• ukulala (kunzima ukulala)
• ukucaphuka

Kufuneka wenze ntoni xa uthe wagqithisa?

Ukuba ucinga ukuba uthathe kakhulu eli chiza, biza ugqirha wakho okanye ufune isikhokelo kuMbutho waseMelika wamaZiko oLawulo lweTyhefu e800-222-1222 okanye ngesixhobo sabo se-Intanethi. Kodwa ukuba iimpawu zakho zinzima, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka elikufutshane ngoko nangoko.

Izilumkiso zikaHarvoni

Eli chiza liza nezilumkiso ezininzi.

Isilumkiso se-FDA: Ukuvuselelwa kwentsholongwane ye-hepatitis B

Eli chiza linesilumkiso esibhokisiweyo. Esi sisilumkiso esibi kakhulu esivela kuLawulo lokutya kunye noLawulo lweziyobisi (FDA). Isilumkiso esinebhokisi silumkisa oogqirha kunye nezigulana malunga neziyobisi ezinokuba yingozi.

• Xa abantu abanesifo semali sobabini be-hepatitis C kunye ne-hepatitis B beqala ukuthatha iHarvoni, kukho umngcipheko wokuvuselelwa kwentsholongwane ye-hepatitis B (HBV). Ukuphinda usebenze kwakhona kuthetha ukuba intsholongwane iyasebenza kwakhona. Ukuvuselelwa kwe-HBV kunokukhokelela ekusileleni kwesibindi okanye ekufeni. Ugqirha wakho uya kuvavanya i-HBV ngaphambi kokuba uqale unyango kunye neHarvoni. Ukuba ufunyaniswe une-HBV, kusenokufuneka ukuba uthathe amayeza ukuze unyange.

Ezinye izilumkiso

Ngaphambi kokuba uthathe uHarvoni, thetha nogqirha wakho malunga nembali yakho yezempilo. IHarvoni isenokungakulungeli ukuba uneemeko ezithile zonyango.

Ayaziwa ukuba iHarvoni ikhuselekile okanye iyasebenza kubantu abanesifo esibi sezintso. Oku kubandakanya abantu abanokukhubazeka okukhulu kwezintso okanye abanesifo sezintso sokugqibela esidinga i-hemodialysis. Nangona kunjalo, abantu abanesifo sezintso ezinzima abathathe iHarvoni kwisifundo sonyango se-2018 baphathwa ngokufanelekileyo kwaye babengenayo imiphumo emibi.

Ukuba unesifo esibi sezintso, thetha nogqirha wakho malunga nokuba iHarvoni ikulungele na.

Ukuphela kweHarvoni

Xa iHarvoni ikhutshwa kwikhemesti, usokhemesti uya kongeza umhla wokuphelelwa kwileyibhile esebhotileni. Lo mhla uqhele ukuba ngunyaka omnye ukusukela kumhla wokukhutshwa kwamayeza.

Injongo yale mihla yokuphelelwa lixesha kukuqinisekisa ukusebenza kweyeza ngeli xesha. Isimo sangoku soLawulo lwezoKutya kunye noLawulo lweziyobisi (i-FDA) kukuphepha ukusebenzisa amayeza aphelelwe lixesha.

Kuhlala ixesha elingakanani iyeza lihlala lilungile kunokuxhomekeka kwizinto ezininzi, kubandakanya nokuba ligcinwa njani kwaye liphi iyeza. Iipilisi zeHarvoni kufuneka zigcinwe ngaphantsi kwe-86⁰F (30⁰C) kwaye zigcinwe kwisikhongozeli esize nazo.

Ukuba awusebenzisanga iyeza elidlulileyo, thetha nosokhemesti malunga nokuba unganako na ukuyisebenzisa.

Ulwazi lobungcali lweHarvoni

Olu lwazi lulandelayo lubonelelwe ngoochwephesha kunye nabanye abaqeqeshi bezempilo.

Indlela yokusebenza

IHarvoni iqulethe iziyobisi ezibini: ledipasvir kunye nesofosbuvir.

I-Ledipasvir inqanda iprotein ye-HCV NS5A, efunekayo ukuze iphosphorylation esebenzayo ye-RNA yentsholongwane. Ukuthintela i-NS5A kuthintela ukuphindaphindeka kwe-RNA kunye nokudibana.

I-Sofosbuvir yi-HCV NS5B polymerase inhibitor ene-metabolite esebenzayo (i-nucleoside analog triphosphate) efakwe kwi-HCV RNA. I-metabolite esebenzayo isebenza njenge-terminator terminator, imisa ukuphindaphinda kwe-HCV.

IHarvoni inomsebenzi ngokuchasene neHCV genotypes 1, 4, 5, kunye 6.

I-Pharmacokinetics kunye ne-metabolism

IHarvoni iqulethe izinto ezimbini ezisebenzayo: ledipasvir kunye nesofosbuvir.

I-Ledipasvir ifikelela kwincopho yoxinzelelo malunga neeyure ezine kwaye iphantse yabotshwa ngokupheleleyo kwiiproteni zeplasma. I-Metabolism yenzeka nge-oxidation ngendlela engaziwayo. Isiqingatha sobomi malunga neeyure ezingama-47. Ichiza engatshintshiyo kunye nemetabolites yayo ene-oxidative isuswe ikakhulu kwilindle.

Ukuxinana okuphezulu kweSofosbuvir kwenzeka kwimizuzu engama-45 ukuya kweyure enye. I-akhawunti ebopha iproteni yePlasma malunga neepesenti ezingama-65 zeziyobisi ezijikelezayo. I-Sofosbuvir yiprodrug eguqulwa ibe yimetabolite esebenzayo (GS-461203) yi-hydrolysis kunye ne-phosphorylation esibindini. I-GS-461203 iphinda yenziwe dephosphorylated kwimetabolite engasebenziyo.

Ukuya kuthi ga kwiipesenti ezingama-80 zedosi isuswe kumchamo. Isiqingatha-seziyobisi somzali yimizuzu engama-30, kwaye isiqingatha sobomi se-metabolite esingasebenziyo sijikeleze iiyure ezingama-27.

Ukungqinelana

Akukho zichasene nokusetyenziswa kweHarvoni. Jonga i-ribavirin echaza ulwazi ngokuchasene nabantu abafumana iHarvoni nge-ribavirin.

Ukugcina

IHarvoni kufuneka igcinwe kwisitya sayo sokuqala kumaqondo obushushu angaphantsi kwe-86 thanF (30⁰C).

Ukuziphendulela: I-MedicalNewsToday yenze yonke imizamo yokuqinisekisa ukuba yonke ingcaciso ichanekile, ibanzi kwaye ihlaziyiwe. Nangona kunjalo, eli nqaku akufuneki lisetyenziswe endaweni yolwazi kunye nobuchule bengcali yezempilo enelayisensi. Kuya kufuneka usoloko uqhagamshelana nogqirha wakho okanye nolunye uqeqesho kwezonyango ngaphambi kokuba uthathe nawaphi na amayeza. Ulwazi lweziyobisi oluqulethwe apha luyakwazi ukutshintsha kwaye alujoliswanga ekusetyenzisweni konke okunokwenzeka, imikhombandlela, izilumkiso, izilumkiso, ukuhlangana kweziyobisi, ukungahambelani komzimba, okanye iziphumo ezibi. Ukungabikho kwezilumkiso okanye olunye ulwazi ngesiyobisi esinikiweyo akubonisi ukuba indibaniselwano yeziyobisi ikhuselekile, iyasebenza, okanye ifanelekile kuzo zonke izigulana okanye konke ukusetyenziswa okuthile.