I-lymphoid leukemia engapheliyo: yintoni, iimpawu kunye nonyango

Umxholo

• Iimpawu ze-LLC
• Uxilongo lwenziwa njani
• Unyango lwe-LLC

I-lymphoid leukemia engapheliyo, ekwabizwa ngokuba yi-LLC okanye i-lymphocytic leukemia, luhlobo lwe-leukemia olubonakaliswa ngokwanda kwenani lee-lymphocyte ezivuthiweyo kwigazi lomda, ukongeza kwi-lymph node, ukunciphisa umzimba kunye nokudinwa kakhulu, umzekelo .

I-LLC ihlala ifunyaniswa ineminyaka yobudala engama-65, kuba esi sifo sinokuvela kancinci, kwaye iimpawu zihlala ziqwalaselwa xa isifo sele sikwinqanaba eliphambili. Ngenxa yokulibaziseka kokubonakala kweempawu, esi sifo sihlala sibonwa ngexesha lovavanyo lwegazi oluqhelekileyo, ngakumbi ukubalwa kwegazi, apho ukonyuka kwenani lee-lymphocyte kunokuchongwa.

Iimpawu ze-LLC

I-LLC ikhula ngaphezulu kweenyanga okanye iminyaka kwaye, ke, iimpawu zibonakala ngokuthe ngcembe, kwaye isifo sihlala sibonwa xa sele sikwisigaba esiphambili. Iimpawu ezibonisa i-LLC zezi:

• Ukonyuka kwe-lymph node kunye ne-lymph node;
• Ukudinwa;
• Ukuphefumla kancinci ngexesha lomsebenzi womzimba;
• Ukwandiswa kwesleen, ekwabizwa ngokuba yi-splenomegaly;
• I-hepatomegaly, eyokukhulisa isibindi;
• Izifo ezenzeka rhoqo kolusu, umchamo nemiphunga;
• Ukuhla ukusinda.

Njengokuba esi sifo singazivezi iimpawu kwisigaba saso sokuqala, i-LLC inokuchongwa emva kokwenza uvavanyo oluqhelekileyo, apho ukonyuka kwenani lee-lymphocyte kunye nee-leukocyte kunokubonwa kuvavanyo lwegazi.

Uxilongo lwenziwa njani

Ukuchongwa kwesifo seLymphoid Leukemia kwenziwa ngohlalutyo lweeseli zegazi ngesiphumo sobalo lwegazi olupheleleyo, olwenziwa kuhlalutyo lwesampulu yegazi. Kwigazi elipheleleyo le-LLC kunokwenzeka ukuba kuchongwe i-leukocytosis, ihlala ngaphezulu kwe-25,000 iiseli / mm³ yegazi, kunye ne-lymphocytosis eqhubekayo, ihlala ngaphezulu kwe-5000 lymphocyte / mm / yegazi. Ukongeza, abanye abaguli bane-anemia kunye ne-thrombocytopenia, oko kukuthi, kunciphisa inani leeplatelets egazini. Jonga ukuba zithini ixabiso lesalathiso segazi elimhlophe.

Ngaphandle kokuvuthwa, ii-lymphocyte ezikhoyo kwigazi elisecaleni zincinci kwaye zibuthathaka kwaye, ke, ngexesha lokwenza i-smear yegazi zinokuqhekeka kwaye zivelise izithunzi zenyukliya, ekwabizwa ngokuba zizithunzi zeGumprecht, nazo ezithathelwa ingqalelo epheleleyo ukuxilongwa.

Nangona inani legazi lanele ukugqiba ukuxilongwa kwe-lymphocytic leukemia engapheliyo, iimvavanyo ze-immunophenotyping ziyimfuneko ukuchonga ubukho beempawu zokuqinisekisa ukuba yi-leukemia enxulumene nokwanda kohlobo lwe-lymphocyte kunye nokuba yinto engapheliyo. I-Immunophenotyping ithathwa njengomgangatho wegolide wokuchonga kungekuphela kwe-LLC kodwa kunye nezinye iintlobo zegazi.

Ngamanye amaxesha, ugqirha unokucela i-myelogram, oluvavanyo olwenziwe ukuhlalutya iiseli ezikhoyo kumongo wethambo, kwimeko ye-LLC ene-lymphocyte engaphezulu kwama-30%. Olu vavanyo, nangona kunjalo, alucelwa kakhulu ukuba luchaze isifo, kodwa kukuqinisekisa ubukho bendalo, ipatheni yokungena yeelemphocyte kunye nokuchaza isifo. Qonda ukuba yenziwa njani i-myelogram.

Unyango lwe-LLC

Unyango lwe-LLC lwenziwa ngokwenqanaba lesi sifo:

• Umngcipheko omncinci: apho kuchongwa kuphela i-leukocytosis kunye ne-lymphocytosis, ngaphandle kwazo naziphi na ezinye iimpawu. Ke, ugqirha uhamba nesigulana kwaye akuyomfuneko ukwenza unyango;
• Umngcipheko ophakathi: apho i-lymphocytosis, ukwandiswa kwee-lymph node kunye nesibindi okanye i-splenomegaly iqinisekiswa, efuna ukulandelelwa kwezonyango ukujonga ukuvela kwesi sifo kunye nonyango nge-chemo okanye i-radiotherapy;
• Umngcipheko omkhulu: apho kuchongwa iimpawu ze-CLL, ukongeza kwi-anemia kunye ne-thrombocytopenia, kwaye unyango kufuneka luqale kwangoko. Olona nyango lucetyiswayo kakhulu kulo mzekelo kukufakelwa umnatha wethambo, kwaye kunyanzelekile ukuba wenze i-chemo kunye ne-radiotherapy.

Ngokukhawuleza ukuba ukonyuka kwesixa se-lymphocyte kwigazi elisecaleni, kubalulekile ukuba ugqirha avavanye imeko yesigulana ngokubanzi ukuze kuqinisekiswe ukuxilongwa kwe-CLL kwaye unyango lungaqaliswa kwaye ukuqhubela phambili kwesifo kunokuthintelwa.

Zombini i-radiotherapy kunye ne-chemotherapy zinokuphazamisa kwaye ziphazamise umgangatho wobomi bomntu. Ke, kuyanomdla ukuba nokutya okusempilweni kunye nokulinganisela ukuqinisekisa imvakalelo yempilo kunye nokunciphisa iimpawu ezinxulumene nolu hlobo lonyango. Jonga le vidiyo ilandelayo malunga nokutya okungcono ukukhulula iziphumo ebezingalindelekanga zekhemotherapy: