Yintoni i-mosaicism kunye neziphumo zayo eziphambili

Umxholo

• Iimpawu eziphambili
• Iziphumo zokuphambuka

I-Mosaicicism ligama elinikwe kuhlobo lokungaphumeleli kwemfuzo ngexesha lokukhula kwesibeleko ngaphakathi kwesibeleko soomama, apho umntu aqala khona ukuba nezinto ezimbini zemvelo, ezenziwa kukuhlangana kweqanda kunye nedlozi labazali. , kunye nenye evelayo ngenxa yokutshintsha kweseli ngexesha lokukhula kombungu.

Ke, umntu uya kukhulisa umxube weeseli, ngepesenti yeeseli eziqhelekileyo kunye nenye ipesenti yeeseli ezinokutshintsha, njengoko kubonisiwe kumfanekiso olandelayo:

Iimpawu eziphambili

I-Mosaicicism yenzeka xa utshintsho lwenzeka kwiseli engekazalwa, ihlala ilahleko okanye iphinda-phinda ye-chromosome, ebangela ukuba umntu aphuhlise umzimba wakhe aneentlobo ezimbini zeeseli, kunye neentlobo ezi-2 zezinto zemvelo. Olu tshintsho lunokuba ziindidi ezimbini:

• Ukuhluma okanye uGonadal: ichaphazela isidoda okanye amaqanda, notshintsho olunokudluliselwa ebantwaneni. Eminye imizekelo yezifo ezibangelwe lutshintsho kwiiseli zentsholongwane yi-Turner's syndrome, i-osteogenesis engagqibelelanga kunye neDuchenne muscular dystrophy;
• Somatics: apho iiseli ezivela kulo naliphi na elinye ilungu lomzimba zithwala olu tshintsho, nokuba umntu angalwenza na utshintsho lomzimba olubangelwa koko. Ke, ukubonakaliswa kokutshintsha komzimba kuxhomekeke ekubeni zingaphi kwaye zingaphi iiseli zomzimba ezichaphazelekayo. I-Somatic mosaicism inokudluliselwa isuka kubazali iye ebantwaneni, kwaye eminye imizekelo yezifo ezibangelwa yi-Down's syndrome kunye ne-neurofibromatosis.

Ngakolunye uhlangothi, i-mosaicism exubekileyo yenzeka xa umntu eneentlobo zombini ze-mosaicism, zombini ukukhula kunye ne-somatic.

I-mosaicism yahlukile kwi-chimerism kuba, kule meko, izinto zemfuza zombungu ziyaphindwa ngokuhlanganiswa kweembumba ezimbini ezahlukileyo, eziba nye. Funda ngakumbi ngale meko kwi-chimerism.

Iziphumo zokuphambuka

Nangona iimeko ezininzi ze-mosaicism zingabangeli zimpawu okanye nasiphi na isiphumo kwimpilo yomntu, le meko inokubangela ukubonakala kweengxaki ezininzi kunye nezifo zomntu ophetheyo, kwaye eminye imizekelo yile:

• I-predisposition kumhlaza;
• Utshintsho ekukhuleni;
• Ukubekwa kwangaphambili kwisisu sokukhupha isisu;
• Utshintsho kwipateni yombala wesikhumba;
• I-heterochromia ye-Ocular, apho umntu anokuba neliso elinye lombala ngamnye;
• I-Down's syndrome;
• I-Turner syndrome;
• IOsteogenesis imperfecta;
• IDuchenne muscular dystrophy;
• McCune-Albright syndromes;
• Isifo sePallister-Killian;
• Isifo seProteus.

Ukongeza, kuye kwaqatshelwa ukuba i-mosaicism yonyusa imeko yezifo zemithambo-luvo, ezinje nge-Alzheimer's okanye iParkinson, umzekelo.