Izibonelelo ezi-9 eziphezulu ze-NAC (N-Acetyl Cysteine)

Umxholo

• 1. Kubalulekile ekwenzeni i-Antioxidant Glutathione enamandla
• 2. Unceda nge-Detoxification ukukhusela okanye ukunciphisa i-kidney kunye nomonakalo wesibindi
• 3. Ngamana angaphucula ukuphazamiseka kwengqondo kunye nokuziphatha okuluthayo
• 4. Inceda ukuNqanda iZimpawu zeMeko zokuphefumla
• 5.Yandisa impilo yeBongo ngokuLawula iGlutamate kunye nokuzalisa iGlutathione
• 6. Ngamana angakuphucula ukuchuma kumadoda nabafazi
• 7. Ngamana ungazinzisa iGazi leSwekile ngokuThoba ukuDumba kwiiFat Cell
• 8. Ngamana unganciphisa ubungozi besifo sentliziyo ngokuthintela ukonakaliswa kweoksijini
• 9. Amandla okunyusa amanqanaba eGlutathione anokuphucula ukusebenza kwamajoni omzimba
• Ubungakanani
• Imiphumela
• Umgca osezantsi

ICysteine ​​yi-amino acid ebaluleke kakhulu.

Ithathelwa ingqalelo ibalulekile kuba umzimba wakho unokuyivelisa kwezinye ii-amino acid, ezizezi, i-methionine kunye ne-serine. Iya ibalulekile kuphela xa indlela yokutya yokutya kwe-methionine kunye ne-serine iphantsi.

ICysteine ​​ifumaneka kuninzi lokutya okuneprotein ephezulu, njengenkukhu, iturkey, iyogathi, itshizi, amaqanda, imbewu kajongilanga kunye nemidumba.

I-N-acetyl cysteine ​​(NAC) yifom yokongeza yecysteine.

Ukusebenzisa i-cysteine ​​eyaneleyo kunye ne-NAC kubalulekile kwizizathu ezahlukeneyo zempilo-kubandakanya ukuzalisa eyona antioxidant inamandla emzimbeni wakho, glutathione. Ezi amino acid zikwanceda kwiimeko zokuphefumla ezingapheliyo, ukuchuma kunye nempilo yengqondo.

Nazi izibonelelo ezi-9 eziphezulu zezempilo ze-NAC.

1. Kubalulekile ekwenzeni i-Antioxidant Glutathione enamandla

I-NAC ixabiswa ikakhulu ngendima yayo kwimveliso ye-antioxidant.

Kunye nezinye ii-amino acid ezimbini- i-glutamine kunye ne-glycine-NAC iyafuneka ukwenza kunye nokuzalisa i-glutathione.

I-Glutathione yenye yezona zinto zibaluleke kakhulu emzimbeni, ezinceda ukunciphisa i-radicals yamahhala engonakalisa iiseli kunye nezicubu emzimbeni wakho.

Kubalulekile kwimpilo yomzimba kunye nokulwa nomonakalo weselula. Abanye abaphandi bakholelwa ekubeni inokuba negalelo kubomi obude ().

Iimpawu zayo ze-antioxidant zikwabalulekile ekulweni ezinye izifo ezininzi ezibangelwa luxinzelelo lwe-oxidative, ezinjengesifo sentliziyo, ukungachumi kunye neemeko ezithile zengqondo ().

Isishwankathelo I-NAC inceda ukuzalisa i-glutathione, ngokungathandabuzekiyo yeyona nto inamandla emzimbeni. Ke ngoko, inokuphucula iimeko ezahlukeneyo zempilo.

2. Unceda nge-Detoxification ukukhusela okanye ukunciphisa i-kidney kunye nomonakalo wesibindi

I-NAC idlala indima ebalulekileyo kwinkqubo yokukhutshwa komzimba.

Inokukunceda ukunqanda iziphumo ebezingalindelekanga zeziyobisi kunye neetyhefu zokusingqongileyo ().

Ngapha koko, oogqirha bahlala benika i-intravenous (IV) NAC kubantu abane-acetaminophen overdose ukunqanda okanye ukunciphisa ukonzakala kwezintso kunye nesibindi ().

I-NAC ikwanazo nezinye izifo zesibindi ngenxa ye-antioxidant kunye ne-anti-inflammatory benefits ().

Isishwankathelo I-NAC inceda ukukhupha umzimba emzimbeni kwaye inokunyanga i-acetaminophen overdoses.

3. Ngamana angaphucula ukuphazamiseka kwengqondo kunye nokuziphatha okuluthayo

I-NAC inceda ukulawula amanqanaba e-glutamate-eyona neurotransmitter ibaluleke kakhulu kwingqondo yakho ().

Ngelixa i-glutamate iyimfuneko kwisenzo esiqhelekileyo sobuchopho, i-glutamate egqithileyo edityaniswe nokudodobala kwe-glutathione kunokubangela ukonakala kwengqondo.

Oku kunokuba negalelo kwiimeko zempilo yengqondo, ezinje ngengxaki yokuphazamiseka kwengqondo, isifo sengqondo, ukuphazamiseka okungafunekiyo (OCD) kunye nokuziphatha okuluthayo (7,).

Kubantu abanesifo se-bipolar kunye noxinzelelo, i-NAC inokunceda ukunciphisa iimpawu kunye nokuphucula amandla akho okusebenza. Ngaphezulu, uphando lubonisa ukuba inokudlala indima ekunyangeni i-OCD ephakathi (,).

Kwangokunjalo, isifundo sezilwanyana sichaza ukuba i-NAC inokunciphisa imiphumo emibi yeschizophrenia, njengokurhoxa ekuhlaleni, ukungakhathali kunye nokunciphisa ixesha lokujonga ().

Izongezo ze-NAC zikwanokunceda ukunciphisa iimpawu zokurhoxa kunye nokuthintela ukubuyela kwizidakamizwa ze-cocaine (,).

Ukongeza, izifundo zokuqala zibonisa ukuba i-NAC inokunciphisa intsangu kunye nokusetyenziswa kwe-nicotine kunye neminqweno (, 15).

Uninzi lwezi ngxaki luthintelwe okanye ngoku alwenziwanga kunyango. I-NAC inokuba luncedo olusebenzayo kubantu abanezi meko ().

Isishwankathelo Ngokulawula amanqanaba e-glutamate kwingqondo yakho, i-NAC inokunciphisa iimpawu zokuphazamiseka kwengqondo okuninzi kunye nokunciphisa isimilo.

4. Inceda ukuNqanda iZimpawu zeMeko zokuphefumla

I-NAC inokukhupha iimpawu zokuphefumla ngokusebenza njenge-antioxidant kunye ne-expectorant, ikhulule i-mucus kwiindlela zakho zomoya.

Njenge-antioxidant, i-NAC inceda ukuzalisa amanqanaba e-glutathione kwimiphunga yakho kwaye inciphise ukuvuvukala kwimibhobho yakho ye-bronchial kunye nakwizicubu zemiphunga.

Abantu abanesifo esinganyangekiyo se-pulmonary disease (COPD) abanamava okonakalisa i-oxidative yexesha elide kunye nokudumba kwethishu yemiphunga, ebangela ukuba i-airways inyanzelise-ekhokelela ekuphefumlweni nokuphefumla.

Izongezo ze-NAC zisetyenziselwe ukuphucula iimpawu zeCOPD, ukunyusa kunye nokwehla kwemiphunga (,, 19).

Kwisifundo sonyaka omnye, i-600 mg ye-NAC kabini ngemini iphucule kakhulu ukusebenza kwemiphunga kunye neempawu kwabo bane-COPD ezinzileyo ().

Abo bane-bronchitis engapheliyo banokuxhamla kwi-NAC.

I-bronchitis yenzeka xa inwebu yangaphakathi kwimiphunga yakho i-bronchial pathways idumbe, idumbe kwaye ivale iindlela zomoya kwimiphunga yakho (,).

Ngokucoca i-mucus kwimibhobho yakho ye-bronchial kunye nokunyusa amanqanaba e-glutathione, i-NAC inokunceda ukunciphisa ubungqongqo kunye nokuphindaphindeka kwempumlo, ukukhohlela kunye nokuhlaselwa kwemiphunga (23).

Ukongeza ekupheliseni i-COPD kunye ne-bronchitis, i-NAC inokuphucula ezinye iimeko zemiphunga kunye nokuphefumla njengecystic fibrosis, asthma kunye ne-pulmonary fibrosis, kunye neempawu zempumlo kunye nokuxinana kwesono ngenxa yesifo okanye isifo ().

Isishwankathelo I-NAC's antioxidant kunye ne-expectorant capacity inokuphucula ukusebenza kwemiphunga ngokunciphisa ukudumba kunye nokuqhekeza i-mucus.

5.Yandisa impilo yeBongo ngokuLawula iGlutamate kunye nokuzalisa iGlutathione

Ukukwazi kwe-NAC ukuzalisa i-glutathione kunye nokulawula amanqanaba e-glutamate yengqondo kunokunyusa impilo yengqondo.

Ingqondo ye-neurotransmitter glutamate ibandakanyeka kuluhlu olubanzi lokufunda, isimilo kunye nezenzo zememori, ngelixa i-antioxidant glutathione inceda ukunciphisa umonakalo we-oxidative kwiiseli zengqondo ezinxulumene nokwaluphala ().

Ngenxa yokuba i-NAC inceda ukulawula amanqanaba e-glutamate kunye nokuzalisa i-glutathione, inokunceda abo banengqondo kunye nezifo zememori ().

Ukuphazamiseka kwemithambo-luvo Isifo se-Alzheimer kunciphisa ukufunda komntu kunye namandla ememori. Izifundo zezilwanyana zibonisa ukuba i-NAC inokucothisa ilahleko yokuqonda kwengqondo kubantu abane-Alzheimer's (,).

Enye imeko yobuchopho, isifo sikaParkinson, sibonakaliswa kukuwohloka kweeseli ezenza i-neurotransmitter dopamine. Zombini umonakalo we-oxidative kwiiseli kunye nokuhla kwamandla e-antioxidant kunegalelo kwesi sifo.

Izongezo ze-NAC zibonakala ziphucula ukusebenza kwe-dopamine kunye neempawu zesifo ezinjengokungcangcazela ().

Ngelixa i-NAC inokuyiphucula impilo yengqondo, uphando olongezelelekileyo lomntu luyafuneka ukwenza izigqibo ezinamandla.

Isishwankathelo Ngokunceda ukuzalisa i-antioxidant glutathione kunye nokulawula i-glutamate, i-NAC inamandla okunyanga izifo ezifana ne-Alzheimer's kunye ne-Parkinson.

6. Ngamana angakuphucula ukuchuma kumadoda nabafazi

Phantse i-15% yazo zonke izibini ezizama ukukhulelwa zichaphazeleka ngokungachumi. Phantse kwisiqingatha samatyala, ukungachumi kwendoda yeyona nto inegalelo ().

Imiba emininzi yamadoda yokungachumi iyakhula xa amanqanaba e-antioxidant engonelanga ukulwa ukubunjwa okukhululekileyo kwenkqubo yakho yokuzala. Uxinzelelo lwe-oxidative lunokubangela ukufa kweseli kunye nokunciphisa ukuchuma ().

Ngamanye amaxesha, i-NAC ibonakalisiwe ukuphucula ukuzala kwamadoda.

Imeko enye enegalelo kukungazali kwabesilisa yi-varicocele- xa imithambo ngaphakathi kweproteum inyuka ngenxa yomonakalo omkhulu wasimahla. Utyando lolona nyango luphambili.

Kwisifundo esinye, amadoda angama-35 ane-varicocele anikwa i-600 mg ye-NAC ngosuku ngeenyanga ezintathu emva kotyando. Indibaniselwano yotyando kunye nokongezwa kwe-NAC kuphuculwe ukuthembeka kwesidoda kunye nenqanaba lokukhulelwa kweqabane nge-22% xa kuthelekiswa neqela lolawulo ().

Olunye uphononongo kumadoda angama-468 ngokungafumani bantwana kufumanise ukuba ukongeza nge-600 mg ye-NAC kunye ne-200 mcg ye-selenium iiveki ezingama-26 ziphucule umgangatho wobudoda ().

Abaphandi bacebise ukuba esi songezelelo sidityanisiweyo kufuneka sithathelwe ingqalelo njengonyango kunyango lokungachumi kwamadoda.

Ukongeza, i-NAC inokuphucula ukuchuma kwabasetyhini abane-polycystic ovary syndrome (i-PCOS) ngokunciphisa okanye ukwandisa umjikelezo we-ovulation ().

Isishwankathelo I-NAC inokunceda ukuphucula ukuzala emadodeni ngokunciphisa uxinzelelo lwe-oxidative olonakalisa okanye lubulale iiseli zokuzala. Inokunceda nasekuchumeni kwabasetyhini abane-PCOS.

7. Ngamana ungazinzisa iGazi leSwekile ngokuThoba ukuDumba kwiiFat Cell

Iswekile yegazi ephezulu kunye nokutyeba kakhulu kunegalelo ekuvukeleni kwizicwili ezinamanqatha.

Oku kungakhokelela ekonakaleni okanye ekutshatyalalisweni kwee-insulin receptors kwaye zikubeke emngciphekweni ophezulu wohlobo lweswekile 2).

Izifundo zezilwanyana zibonisa ukuba i-NAC inokuzinzisa iswekile yegazi ngokunciphisa ukudumba kwiiseli ezinamafutha kwaye ngaloo ndlela kuphuculwe ukunganyangeki kwe-insulin (,).

Xa ii-insulin receptors zihambelana kwaye zisempilweni, zisusa ngokufanelekileyo iswekile egazini lakho, zigcina amanqanaba kwimida eqhelekileyo.

Nangona kunjalo, gcinani engqondweni ukuba uphando lomntu kwi-NAC luyafuneka ukuqinisekisa ezi ziphumo kulawulo lweswekile yegazi.

Isishwankathelo Ngokunciphisa ukudumba kwizihlunu ezinamafutha, i-NAC inokunciphisa ukunganyangeki kwe-insulin kunye nokuphucula ukulawulwa kweswekile yegazi, kodwa uphando olusekwe ebantwini luyasilela.

8. Ngamana unganciphisa ubungozi besifo sentliziyo ngokuthintela ukonakaliswa kweoksijini

Umonakalo we-oxidative kwizicubu zentliziyo uhlala ukhokelela kwisifo sentliziyo, esibangela ukubetha, isifo sentliziyo kunye nezinye iimeko ezinzulu.

I-NAC inokunciphisa ingozi yesifo sentliziyo ngokunciphisa umonakalo we-oxidative kwizicubu entliziyweni yakho ().

Kukwabonakalisiwe ukwandisa imveliso ye-nitric oxide, enceda imithambo ukuba yande kwaye iphucule ukuhamba kwegazi. Oku kukhawulezisa ukuhanjiswa kwegazi ukubuyela entliziyweni yakho kwaye kunokuwunciphisa umngcipheko wokuhlaselwa sisifo sentliziyo ().

Okubangela umdla kukuba, uvavanyo lweetyhubhu zovavanyo lubonise ukuba - xa idityaniswe neti eluhlaza - i-NAC ibonakala inciphisa umonakalo ovela kwi-cholesterol "embi" ye-LDL, enye igalelo lesifo sentliziyo ().

Isishwankathelo I-NAC inokunciphisa umonakalo we-oxidative entliziyweni yakho, enokuthi yona-inciphise umngcipheko wesifo sentliziyo.

9. Amandla okunyusa amanqanaba eGlutathione anokuphucula ukusebenza kwamajoni omzimba

I-NAC kunye ne-glutathione zikwanyusa impilo yomzimba.

Uphando ngezifo ezithile ezinxulunyaniswa ne-NAC kunye nokusilela kwe-glutathione lubonisa ukuba ukusebenza komzimba kungaphuculwa- kwaye kungabuyiselwa - ngokuxhasa i-NAC ().

Le nto ifundwe kakhulu kubantu abanentsholongwane kaGawulayo (i-HIV).

Kwizifundo ezibini, ukuxhasa i-NAC kukhokelele kukonyuka okukhulu ekusebenzeni kwamajoni omzimba- phantse ukubuyiselwa ngokupheleleyo kweeseli zombulali zendalo (,,).

Amanqanaba aphezulu e-NAC emzimbeni wakho anokucinezela ukuzala kwakhona kwe-HIV-1 ().

Uvavanyo lwe-tube-test lubonise ukuba kwezinye iimeko ezikhuselwe ngamajoni omzimba, ezinjengomkhuhlane, i-NAC inokuthintela intsholongwane ekuphenduleni. Oku kunokunciphisa iimpawu kunye nexesha lokugula ().

Kwangokunjalo, olunye uvavanyo lweetyhubhu zovavanyo ludibanise i-NAC nokufa kweseli yomhlaza kunye nokuthintela ukuphindaphinda kweseli yomhlaza (,).

Ngokubanzi, izifundo ezingaphezulu zabantu ziyafuneka. Ke ngoko, qiniseka ukuba uthethe nogqirha wakho ngaphambi kokuba uthathe i-NAC ngexesha lonyango lomhlaza ().

Isishwankathelo Ukukwazi kwe-NAC ukunyusa amanqanaba e-glutathione kunokuphucula ukusebenza kwamajoni omzimba kwizifo ezahlukeneyo.

Ubungakanani

Akukho ngcebiso malunga nokutya kwi-cysteine ​​kuba umzimba wakho unokuvelisa imali encinci.

Ukuze umzimba wakho wenze i-amino acid cysteine, udinga inani elaneleyo le-folate, ivithamini B6 kunye nevithamini B12. Ezi zinongo zingafumaneka kwiimbotyi, iilentile, isipinatshi, iibhanana, isalmon kunye netyhuna.

Ngelixa ukutya okuninzi okuneprotein, njengenkukhu, iturkey, iyogathi, itshizi, amaqanda, imbewu kajongilanga kunye nemidumba, ine-cysteine, abanye abantu bakhetha ukongeza nge-NAC ukonyusa ukutya kwabo i-cysteine.

I-NAC ine-bioavailability ephantsi njengesongezelelo somlomo, okuthetha ukuba ayifunxwanga kakuhle. Ingcebiso eyamkelweyo yemihla ngemihla yonyango yi-600-1,800 mg ye-NAC (,).

I-NAC inokulawulwa njenge-IV okanye ithathwe ngomlomo, njenge-aerosol spray okanye kwifom engamanzi okanye ye powder.

Isishwankathelo Ukutya ukutya okuneproteni ephezulu kunokunika umzimba wakho i-amino acid cysteine, kodwa i-NAC inokuthathwa njengesongezelelo ukunceda ukunyanga iimeko ezithile.

Imiphumela

I-NAC inokuba ikhuselekile kubantu abadala xa ibonelelwa njengeyeza lonyango.

Nangona kunjalo, amanani aphezulu anokubangela isicaphucaphu, ukugabha, urhudo kunye nokuqhinwa ().

Xa uphefumlelwe, kunokubangela ukudumba emlonyeni, ukuphuma empumlweni, ukozela kunye nokuqina kwesifuba.

Abantu abaneengxaki zokopha okanye ukuthatha amayeza okucoca igazi akufuneki bathathe i-NAC, kuba inokucothisa igazi ().

I-NAC inevumba elingathandekiyo elenza kube nzima ukulisebenzisa. Ukuba ukhetha ukuyithatha, qhagamshelana nogqirha wakho kuqala.

Isishwankathelo Ngelixa i-NAC ithathwa njengekhuselekileyo njengamayeza kagqirha, inokubangela isicaphucaphu, ukugabha, ukuphazamiseka kwamathumbu, kunye nemicimbi yomlomo xa uphefumla.

Umgca osezantsi

I-NAC idlala indima ebalulekileyo kwimpilo yabantu.

Idume ngokukwazi kwayo ukuzalisa amanqanaba e-antioxidant glutathione, ikwalawula ubuchopho be-neurotransmitter glutamate. Ukongeza, i-NAC inceda inkqubo ye-detoxification yomzimba.

Le misebenzi yenza ukuba i-NAC yongeze ukhetho lonyango olunokubakho kwiingxaki ezininzi zempilo.

Nxibelelana nogqirha wakho ukuze ubone ukuba i-NAC inokuyonyusa impilo yakho.