Unyango olutsha kunye noNyango lwe-Ulcerative Colitis

Umxholo

• Unyango lwangoku
• Aminosalicylates
• ICorticosteroids
• Amagciwane omzimba
• Iibhlokhi ze-TNF
• Ugqirha
• Amachiza amatsha
• Tofacitinib (Xeljanz)
• Ibhayoloji
• Unyango oluphantsi kophando
• Ukufakelwa kwe-Fecal
• Unyango lwesitem
• Uvavanyo lwezonyango
• Yise kude

Ushwankathelo

Xa une-ulcerative colitis (UC), injongo yonyango kukumisa amajoni akho omzimba ekuhlaseleni ulusu lwamathumbu akho. Oku kuyakuhlisa ukudumba okubangela iimpawu zakho, kwaye kukufake uxolelo. Ugqirha wakho unokukhetha kwiindidi ezahlukeneyo zamayeza ukukunceda ufezekise ezi njongo.

Kule minyaka imbalwa idlulileyo, inani leziyobisi ezisetyenziselwa ukunyanga i-UC lenyukile. Abaphandi bafunda olunye unyango olutsha kwaye kunokwenzeka ukuba luphuculwe kuvavanyo lweklinikhi.

Unyango lwangoku

Iindidi ezimbalwa zamayeza ziyafumaneka ukunyanga i-UC. Ugqirha wakho uya kukunceda ukhethe olunye lonyango ngokusekelwe:

• ubungqongqo besifo sakho (ubumnene, ukumodareyitha, okanye ubukhali)
• zeziphi iziyobisi osele uzithathile
• uphendule kakuhle kangakanani kula mayeza
• impilo yakho iyonke

Aminosalicylates

Eli qela lamachiza liqukethe isithako se-5-aminosalicylic acid (5-ASA). Ziquka:

• sulfasalazine (Azulfidine)
• iMesalamine (Canasa)
• i-olsalazine (iDipentum)
• balsalazide (iColazal, iGiazo)

Xa usela la machiza ngomlomo okanye njenge-enema, ayanceda ukwehlisa ukudumba emathunjini akho. I-Aminosalicylates isebenza kakuhle kwi-UC enobulali, kwaye inokunceda ukukhusela ii-flares.

ICorticosteroids

I-Corticosteroids (iziyobisi ze-steroid) icinezela amajoni omzimba ukuzisa ukudumba. Imizekelo ibandakanya:

• ubume
• yingca
• imethylprednisolone
• mfumomfi

Ugqirha wakho unokumisela elinye lala mayeza ixesha elifutshane ukuthomalalisa uphawu. Akungombono olungileyo ukuhlala kwi-steroids ixesha elide, kuba zinokubangela iingxaki ezinje ngeswekile yegazi, ukuzuza ubunzima, usulelo kunye nokulahleka kwethambo.

Amagciwane omzimba

La machiza acinezela amajoni akho omzimba ukukhusela ekubangeleni ukudumba. Ungaqala ukuthatha elinye lala mayeza ukuba ii-aminosalicylates khange zincede kwiimpawu zakho. Imizekelo yama-immunomodulators ibandakanya:

• azathioprine (Azasan)
• I-6-mercaptopurine (6MP) (iPurinethol)
• i-cyclosporine (iSandimmune, iNeoral, ezinye)

Iibhlokhi ze-TNF

I-block block ye-TNF luhlobo lweziyobisi ze-biologic. I-Biologics yenziwe ngeeproteni zobunjineli okanye ezinye izinto zendalo. Zisebenza kumacandelo athile omzimba wakho aqhuba ukudumba.

Iziyobisi ezichasene ne-TNF zivimba inkqubo yomzimba yokuzikhusela ebizwa ngokuba yi-tumor necrosis factor (TNF) ebangela ukudumba. Banokunceda abantu abane-UC ukumodareyitha ukuya kwiimpawu ezinzima iimpawu ezingakhange ziphuculwe ngelixa bezisebenzisa ezinye iziyobisi.

Iibhlokhi ze-TNF zibandakanya:

• adalimumab (Humira)
• igolimumab (iSimponi)
• infliximab (I-Remicade)
• vedolizumab (Entyvio)

Ugqirha

Ukuba unyango oluzamile aluzange luzilawule iimpawu zakho okanye uyeke ukusebenza, unokufuna utyando. Inkqubo ebizwa ngokuba yi-proctocolectomy isusa yonke ikholoni kunye ne-rectum ukuthintela ukudumba okungaphezulu.

Emva kotyando, awuyi kuba nekholoni yokugcina inkunkuma. Ugqirha wakho uza kwenza isikhwama ngaphandle komzimba wakho obizwa ngokuba yi-ileostomy, okanye ngaphakathi komzimba wakho kwinxalenye yamathumbu akho amancinci (ileum).

Utyando linyathelo elikhulu, kodwa liya kuzikhupha iimpawu ze-UC.

Amachiza amatsha

Kule minyaka imbalwa idlulileyo, kuye kwavela iindlela zonyango ezintsha ze-UC.

Tofacitinib (Xeljanz)

IXeljanz ikudidi lwamayeza abizwa ngokuba yiJanus kinase (JAK) inhibitors. La machiza abhloka i-enzyme JAK, eyenza iiseli zomzimba zikwazi ukuvelisa ukudumba.

I-Xeljanz ivunyiwe ukusukela ngo-2012 ukunyanga isifo samathambo (RA), kwaye ukusukela ngo-2017 ukunyanga isifo samathambo (PsA). Kwi-2018, i-FDA iyivumile ukuba inyange abantu abane-UC yokumodareyitha ukuya kubukhali abangaphendulanga kwi-block blockers ye-TNF.

Eli liyeza lonyango lokuqala lwexesha elide lomlomo kwi-UC yokumodareyitha. Amanye amachiza afuna ukumiliselwa okanye inaliti. Iziphumo ebezingalindelekanga ezivela kwiXeljanz zibandakanya i-cholesterol ephezulu, intloko ebuhlungu, urhudo, ukubanda, irhashalala, kunye neentsimbi.

Ibhayoloji

Ii-Biosimilars ziludidi olutsha lweziyobisi ezenzelwe ukulinganisa iziphumo zebhayoloji. Njenge-biologics, la machiza ajolise kwiiproteni zamajoni omzimba anegalelo kukudumba.

Ii-Biosimilars zisebenza ngendlela efanayo ne-biologics, kodwa zinokubiza imali encinci. Oonobumba abane bongezwa esiphelweni segama ukunceda ukwahlula ichiza le-biosimilar kwi-biologic yoqobo.

I-FDA ivume ii-biosimilars ezininzi ze-UC kule minyaka imbalwa idlulileyo, kubandakanya:

• infliximab-abda (Renflexis)
• I-infliximab-dyyb (Inflectra)
• infliximab-qbtx (Ixifi)
• iadalimumab-adbm (Cyltezo)
• i-adalimumab-atto (Amjevita)

Unyango oluphantsi kophando

Abaphandi bahlala bekhangela iindlela ezingcono zokulawula i-UC. Nazi iindlela zonyango ezimbalwa eziphantsi kophando.

Ukufakelwa kwe-Fecal

Ukufakelwa kwe-fecal, okanye ukutshintshwa kwesitulo, yindlela yokulinga ebeka ibhaktheriya enempilo ukusuka kwisitulo somnikeli kwikholoni yomntu one-UC.Umbono unokuvakala ungathandeki, kodwa ibhaktiriya elungileyo inceda ukuphilisa umonakalo kwi-UC kwaye ibuyisele impilo eseleyo kwiintsholongwane.

Unyango lwesitem

Iiseli zestem ziiseli ezincinci ezikhula ziye kwiiseli ezahlukeneyo kunye nezicubu emizimbeni yethu. Banokubanakho ukuphilisa zonke iintlobo zomonakalo ukuba siyazisebenzisa kwaye sizisebenzisa ngokuchanekileyo. Kwi-UC, iiseli ezi-stem zinokutshintsha amajoni omzimba ngendlela enceda ukwehlisa ukudumba kunye nokuphilisa umonakalo.

Uvavanyo lwezonyango

Oogqirha banoluhlu olubanzi lweendlela zonyango ze-UC kunanini na ngaphambili. Ngaphandle kweziyobisi ezininzi, abanye abantu banengxaki yokuzifumana zisebenzelayo.

Abaphandi bahlala befunda iindlela ezintsha zonyango kuvavanyo lweklinikhi. Ukujoyina olunye lwezi zifundo kunokukunika ukufikelela kwichiza ngaphambi kokuba lifumaneke eluntwini. Buza ugqirha ophatha i-UC yakho ukuba ulingo lweklinikhi kwindawo yakho lunokuba lulungele wena.

Yise kude

Imbonakalo yabantu abane-UC ibhetele kakhulu namhlanje, ngenxa yamachiza amatsha anokuthomalalisa ukudumba kwamathumbu. Ukuba uzame ichiza kwaye khange likuncede, yazi ukuba ezinye iindlela zinokuphucula iimpawu zakho. Zingisa, kwaye sebenza ngokusondeleyo kunye nogqirha wakho ukufumana unyango olukusebenzelayo ekugqibeleni.