I-Prednisone ye-Asthma: Ngaba iyasebenza?

Umxholo

• Isebenza njani i-prednisone yesifo sombefu?
• Zithini iziphumo ebezingalindelekanga?
• Ndizakuthatha malini?
• Imibuzo yokubuza ugqirha wakho
• Olunye ukhetho
• Ukurhoxa kwiicorticosteroids
• Isistim sokuqinisa iiseli
• Iinguqu zeLeukotriene
• Umgca wezantsi

Ushwankathelo

I-Prednisone yicorticosteroid eza kwifom yomlomo okanye engamanzi. Isebenza ngokusebenza kumajoni omzimba ukunceda ukunciphisa ukudumba kwindlela yomoya yabantu abanesifuba.

I-Prednisone inikwa ixesha elifutshane, ngokungathi kufuneka uye kwigumbi likaxakeka okanye ulaliswe esibhedlele ngenxa yokuhlaselwa sisifuba. Funda izicwangciso zokuthintela uhlaselo lwesifuba.

I-Prednisone inokunikwa njengonyango lwexesha elide ukuba isifo sakho sombefu sinzima okanye kunzima ukusilawula.

Isebenza njani i-prednisone yesifo sombefu?

Inqaku lokuphononongwa kwiAmerican Journal of Medicine kuvavanywe izilingo ezintandathu ezahlukeneyo kubantu abadala abaneziqendu zesifuba. Kwezi zilingo, abantu bafumana unyango lwe-corticosteroid ngaphakathi kwemizuzu engama-90 befika kwigumbi likaxakeka. Abaphandi bafumanise ukuba la maqela anezinga eliphantsi lokungeniswa esibhedlele kunabantu abafumene i-placebo endaweni yoko.

Ukongeza, uphononongo kulawulo lokuhlaselwa sisifo se-asthma kubugqirha bosapho baseMelika kufunyaniswe ukuba abantu bathumele ekhaya nge-5- kwiintsuku ezili-10 zokumiselwa nge-50 ukuya kwi-100 milligrams (mg) ye-oral prednisone yomngcipheko wokunciphisa ukubuyela kwakhona kweempawu zesifuba. Uphononongo olufanayo luthi kubantwana abaneminyaka emi-2 ukuya kweli-15 ubudala, iintsuku ezintathu zonyango lwe-prednisone kwi-1 mg ngekhilogram yesisindo somzimba sinokusebenza njengeentsuku ezintlanu zonyango lwe-prednisone.

Zithini iziphumo ebezingalindelekanga?

Imiphumo emibi ye-prednisone ingabandakanya:

• ukugcinwa kolwelo
• ukwanda kwesidlo
• ukutyeba kwakho
• isisu esimoshakele
• imo okanye utshintsho kwindlela yokuziphatha
• igazi elonyukayo
• ukwanda kokuchaphazeleka kusulelo
• osteoporosis
• utshintsho lwamehlo, njenge-glaucoma okanye i-cataract
• ifuthe elibi ekukhuleni nasekukhuleni (xa kumiselwe abantwana)

Kubalulekile ukuba uqaphele ukuba uninzi lweziphumo ebezingalindelekanga, ezinje nge-osteoporosis kunye nokutshintsha kwamehlo, kwenzeka emva kokusetyenziswa kwexesha elide. Aqhelekanga kwi-prednisone yexesha elifutshane. Jonga le mifanekiso ihlekisayo ineziphumo ebezingalindelekanga ze-prednisone.

Ndizakuthatha malini?

I-Prednisone iyafumaneka njengecwecwe lomlomo okanye isisombululo samanzi e-United States. Ngelixa kunjalo, i-prednisone ayifani ne-methylprednisolone, efumaneka njengesisombululo esinokujova kunye necwecwe lomlomo. Ngokwesiqhelo, i-prednisone yomlomo isetyenziswa njengonyango lodidi lokuqala lwesifuba esibuhlungu kuba zombini kulula ukuzithatha kwaye akubizi mali ininzi.

Ubude obuqhelekileyo bemithi ye-corticosteroids enje nge-prednisone ziintsuku ezi-5 ukuya kwezi-10. Kubantu abadala, idosi eqhelekileyo kunqabile ukuba idlule i-80 mg. Idosi ephezulu eqhelekileyo yi-60 mg. Iidosi ezinkulu kune-50 ukuya kwi-100 mg ngosuku aziboniswanga ukuba ziluncedo ngakumbi kuncedo.

Ukuba uphosa idosi ye-prednisone, kuya kufuneka uthathe idosi ephosiweyo kwangoko xa ukhumbula. Ukuba phantse lixesha ledosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uthathe idosi elandelayo ehleliweyo.

Awusoze uthathe idosi eyongezelelweyo ukwenza idosi oyiphosileyo. Ukuthintela isisu esibuhlungu, kungcono ukuthatha i-prednisone ngokutya okanye ubisi.

Imibuzo yokubuza ugqirha wakho

I-Prednisone ayikhuselekanga ukuyithatha ngexa ukhulelwe. Kufuneka kwangoko uxelele ugqirha wakho ukuba ukhulelwe ngelixa uthatha i-prednisone.

Ngenxa yokuba i-prednisone isebenza kumajoni omzimba, usenokuba sengozini yosulelo. Kuya kufuneka uthethe nogqirha wakho ukuba unosulelo oluqhubekayo okanye usandula kufumana isitofu sokugonya.

Kukho inani lamayeza anokusebenzisana kakubi ne-prednisone. Kubalulekile ukuba ugqirha wakho aziswe ngawo onke amayeza owathathayo. Kuya kufuneka uthethe nogqirha wakho ukuba ngoku uthatha naluphi na olu hlobo lonyango lulandelayo:

• abacoci gazi
• amayeza seswekile
• amayeza anti-isifo sephepha
• I-macrolide-type antibiotics, njenge-erythromycin (EES) okanye i-azithromycin (iZithromax)
• icyclosporine (iSandimmune)
• i-estrogen, kubandakanya amayeza olawulo lokuzalwa
• ii-nonsteroidal anti-inflammatory drugs (ii-NSAID), ezinjenge-aspirin
• womchamo
• i-anticholinesterases, ngakumbi kubantu abane-myasthenia gravis

Olunye ukhetho

Kukho ezinye iziyobisi ezichasayo ezinokusetyenziswa njengenxalenye yonyango lwesifuba. Oku kubandakanya:

Ukurhoxa kwiicorticosteroids

I-corticosteroids e-Inhaled iyasebenza kakhulu ekunciphiseni inani lokudumba kunye ne-mucus kwindlela yomoya. Zithathwa njengemihla ngemihla. Ziza ngeendlela ezintathu: inhaler yedosi yokulinganisa inhaler, inhaler eyomileyo ye-inhaler, okanye isisombululo se-nebulizer.

La mayeza anceda ukukhusela iimpawu zesifuba, anganyangi iimpawu.

Xa kuthathwa iidosi eziphantsi, ii-corticosteroids ezinganyangekiyo zineziphumo ebezingalindelekanga ezimbalwa. Ukuba uthatha idosi ephezulu, kwiimeko ezinqabileyo unokufumana usulelo lomngundo lomlomo obizwa ngokuba yitrush.

Isistim sokuqinisa iiseli

La mayeza asebenza ngokuthintela ukukhutshwa komxube obizwa ngokuba yi-histamine ngamaseli athile omzimba emzimbeni wakho (iiseli zemasti). Zikwasetyenziselwa ukuthintela iimpawu zesifuba, ngakumbi ebantwaneni nasebantwini abanesifuba esibangelwa kukuzilolonga.

Isistim sokuqinisa iiseli zihlala zithathwa amaxesha amabini okanye amane ngemini kwaye zineziphumo ebezingalindelekanga ezimbalwa. Iziphumo ebezingalindelekanga zixhaphakileyo ngumqala owomileyo.

Iinguqu zeLeukotriene

Iinguqu zeLeukotriene zihlobo olutsha lwamayeza esifuba. Basebenza ngokuthintela isenzo seekhompawundi ezithile, ezibizwa ngokuba zii-leukotrienes. IiLeukotrienes ngokwendalo zenzeka emzimbeni wakho kwaye zinokubangela ukuxinana kwezihlunu zomoya.

Ezi pilisi zinokuthathwa kube kanye okanye kane ngemini. Iziphumo ebezingalindelekanga zixhaphakileyo ziintloko ebuhlungu kunye nobucaphucaphu

Umgca wezantsi

I-Prednisone yicorticosteroid enikwa ngokwesiqhelo iimeko ezinobunzima besifuba. Inceda ukunciphisa ukudumba kwindlela yomoya kubantu abahlaselwa sisifo sombefu.

I-Prednisone ifunyenwe iyasebenza ekunciphiseni ukuphindaphinda kweempawu zesifuba emva kokundwendwela igumbi likaxakeka okanye isibhedlele.

Uninzi lweziphumo ebezingalindelekanga ezinxulumene ne-prednisone zenzeka ngexesha lokusetyenziswa kwexesha elide.

I-Prednisone inokusebenzisana nezinye iintlobo zamayeza. Kubaluleke kakhulu ukuxelela ugqirha wakho ngawo onke amanye amayeza owathathayo ngaphambi kokuqala kwi-prednisone.