Unyango lwe-Preterm Labour: iiCalcium Channel blockers (CCBs)

Umxholo

• Iimpawu zomsebenzi wokuqala
• Oonobangela kunye nemingcipheko
• Uvavanyo lokufumanisa ukusebenza ngaphambi kwexesha
• Zisebenza njani ii-calcium channel blocker?
• Isebenza njani i-nifedipine?
• Zeziphi iziphumo ebezingalindelekanga ezinokubakho ze-nifedipine?
• Ngaba kukho abafazi abangafanelekanga ukuthatha i-nifedipine?
• Imbonakalo

Umsebenzi wokuqala kunye ne-calcium block blockers

Ukukhulelwa okuqhelekileyo kuhlala malunga neeveki ezingama-40. Xa umfazi esiya kubeleka kwiiveki ezingama-37 okanye ngaphambili, ibizwa ngokuba yi-preterm labour kwaye usana luthiwa luzelwe ngaphambi kwexesha. Abanye abantwana abazelwe ngaphambi kwexesha bafuna ukhathalelo olukhethekileyo xa bezalwa, kwaye abanye banesiphene sexesha elide emzimbeni nasengqondweni kuba abanalo ixesha elaneleyo lokukhula ngokupheleleyo

Iicalcium channel blockers (CCBs), eziqhele ukusetyenziselwa ukunciphisa uxinzelelo lwegazi, zinokusetyenziselwa ukuphumla ukubetheka kwesibeleko kunye nokuhlehlisa ukuzalwa kwangaphambi kokubeleka. I-CCB eqhelekileyo yale njongo yi-nifedipine (Procardia).

Iimpawu zomsebenzi wokuqala

Iimpawu zomsebenzi wokuqala zinokubonakala okanye zingabonakali. Ezinye zeempawu zibandakanya:

• Ukuncipha rhoqo okanye rhoqo
• uxinzelelo lwe-pelvic
• uxinzelelo lwesisu esisezantsi
• iicampu
• ukubonwa kwilungu lobufazi
• ukopha kwilungu lobufazi
• ukuqhekeka kwamanzi
• ukukhutshwa kwilungu lobufazi
• urhudo

Jonga ugqirha wakho ukuba unazo naziphi na kwezi mpawu okanye uziva usenokuya emsebenzini kwangoko.

Oonobangela kunye nemingcipheko

Izizathu zokuya emsebenzini ngaphambi kwexesha kunzima ukuzichaza.

Ngokwe-Mayo Clinic, naliphi na ibhinqa linokuya emsebenzini kwangoko. Izinto ezinobungozi ezinxulunyaniswa nomsebenzi wokuqala ngaphambi kwexesha zezi:

• ukuzalwa ngaphambi kwexesha ngaphambi kwexesha
• ukukhulelwa amawele, okanye ezinye izinto ezininzi
• ukuba neengxaki kwisibeleko sakho, umlomo wesibeleko, okanye iplacenta
• ukuba noxinzelelo lwegazi
• unesifo seswekile
• ukuba neanemia
• ukutshaya
• ukusebenzisa iziyobisi
• ukuba nosulelo kumalungu esini
• ukutyeba okanye ukutyeba kakhulu ngaphambi kokukhulelwa
• ukuba ne-amniotic fluid eninzi, ebizwa ngokuba yi-polyhydramnios
• ukopha kwilungu lobufazi ngexesha lokukhulelwa
• ukuba nosana olungekazalwa olunesiphene sokuzalwa
• Ukuba nexesha elingaphantsi kweenyanga ezintandathu ukusukela ekukhulelweni kokugqibela
• Unononophelo oluncinci okanye awunalo kwaphela
• ukufumana amava oxinzelelo ebomini, njengokufa komntu omthandayo

Uvavanyo lokufumanisa ukusebenza ngaphambi kwexesha

Ugqirha wakho unokwenza olunye okanye ngaphezulu kwezi mvavanyo ukufumanisa umsebenzi wokuqala:

• Uvavanyo lwe-pelvic ukumisela ukuba umlomo wakho wesibeleko sele uqalile ukuvuleka kwaye umisele ubuntununtunu besibeleko sakho kunye nosana
• i-ultrasound yokulinganisa ubude bomlomo wesibeleko sakho kunye nokuchonga ubungakanani bomntwana kunye nokuma kwesibeleko sakho
• Ukubeka esweni isibeleko, ukulinganisa ubude bexesha kunye nokushiyana kweekhontrakthi zakho
• ukukhula kwe-amniocentesis, ukuvavanya i-amniotic fluid yakho ukumisela ukukhula kwemiphunga yomntwana wakho
• swab lobufazi ukuvavanya usulelo

Zisebenza njani ii-calcium channel blocker?

Oogqirha baqhele ukumisela iiCCBs ukuba zihlehlise umsebenzi ngaphambi kwexesha. Isibeleko sisihlunu esikhulu esenziwe ngamawaka eeseli zemisipha. Xa i-calcium ingena kwezi seli, izihlunu zemisipha ziyaqina kwaye ziyaqina. Xa ikhalsiyam ibuyela umva isuka kwiseli, izihlunu ziyayekelela. I-CCB isebenza ngokuthintela i-calcium ekuhambeni kwayo iye kwiiseli zemisipha zesibeleko, iyenza ukuba ingabinakho ukufikelela kwisivumelwano.

IiCCBs ziyiqela leqela leziyobisi ezibizwa ngokuba zii-tocolytics. Omnye ubonisa ukuba i-nifedipine yeyona CCB isebenzayo yokuhlehlisa umsebenzi ngaphambi kwexesha kunye nokuba isebenza ngakumbi kunezinye i-tocolytics.

Isebenza njani i-nifedipine?

I-Nifedipine inokunciphisa inani kunye nokuhamba rhoqo kokuphambana, kodwa ukusebenza kwayo kunye nokuba ihlala ixesha elingakanani iyahluka ukusuka kumfazi ukuya komnye. Njengawo onke amayeza e-tocolytic, ii-CCBs azithinteli okanye zilibazise ukuhanjiswa kwangaphambi kwexesha ixesha elibalulekileyo.

Ngokwenye, ii-CCBs zinokulibazisa ukuhanjiswa kwiintsuku ezininzi, kuxhomekeke ekubeni umgama wesibeleko sowasetyhini wanda kangakanani xa uqala amayeza. Oku kungabonakali ngathi lixesha elininzi, kodwa kunokwenza umahluko omkhulu kuphuhliso losana lwakho ukuba unikwe ii-steroids kunye neeCCB. Emva kweeyure ezingama-48, ii-steroids zinokuphucula ukusebenza kwemiphunga yosana lwakho kwaye zinciphise umngcipheko wokufa kwazo.

Zeziphi iziphumo ebezingalindelekanga ezinokubakho ze-nifedipine?

Ngokwe-Matshi ka-Dimes, i-nifedipine iyasebenza kwaye ikhuselekile noko, yiyo loo nto oogqirha beyisebenzisa kakhulu. I-Nifedipine ayinaziphumo zibi kumntwana wakho. Iziphumo ezinokubakho ezinokubandakanya:

• ukuqhina
• urhudo
• isicaphucaphu
• ndiziva ndinesiyezi
• ndiziva ndidiniwe
• intloko ebuhlungu
• uxinzelelo lwegazi oluphantsi
• ukuba bomvu kwesikhumba
• ukubetha kwentliziyo
• irhashalala

Ukuba uxinzelelo lwegazi luyehla ixesha elide, kunokuchaphazela ukuhamba kwegazi kusana lwakho.

Ngaba kukho abafazi abangafanelekanga ukuthatha i-nifedipine?

Abasetyhini abaneemeko zonyango ezinokuthi zenziwe mandundu ziziphumo ebezingalindelekanga ezichazwe apha ngasentla akufuneki bathathe iiCCB. Oku kubandakanya abasetyhini abanxinzelelo lwegazi oluphantsi, ukusilela kwentliziyo, okanye ukuphazamiseka okuchaphazela amandla emisipha.

Imbonakalo

Ukuya emsebenzini wokuqala kunokuchaphazela ukukhula komntwana wakho. IiCCB yindlela ekhuselekileyo nesebenzayo yokuhlehlisa umsebenzi ngaphambi kwexesha. IiCCB zihlehlisa umsebenzi ukuya kuthi ga kwiiyure ezingama-48. Xa usebenzisa i-CCB kunye ne-corticosteroids, la mayeza mabini anokunceda ukukhula komntwana wakho ngaphambi kokuzalwa kunye nokunceda ekuqinisekiseni ukuba unokubeleka okukhuselekileyo kunye nosana olusempilweni.