Progressive-Progressive vs MS ukubuyisela kwakhona

Umxholo

• Yintoni i-MS ephambili yokuqhubela phambili?
• Ziziphi iimpawu eziqhelekileyo ze-PPMS?
• Ngubani ofumana iPPMS?
• Yintoni ebangela iPPMS?
• Ithini imbonakalo yePPMS?
• Zeziphi iindlela zonyango ezikhoyo ze-PPMS?
• Yintoni i-MS ebuyela umva kwakhona?
• Ziziphi iimpawu eziqhelekileyo zeRRMS?
• Ngubani ofumana iRRMS?
• Yintoni ebangela iRRMS?
• Ithini imbonakalo yeRRMS?
• Luthini unyango lweRRMS?
• Yintoni umahluko phakathi kwePPMS kunye neRRMS?
• Ubudala bokuqala
• Oonobangela
• Imbonakalo
• Izinketho zonyango

Ushwankathelo

I-Multiple sclerosis (MS) yimeko engapheliyo ebangela ukonakala kwentliziyo. Ezi ndidi zine ziphambili zeMS zezi:

• Isifo esizimele sodwa (CIS)
• Ukubuyela kwakhona kwi-MS (RRMS)
• i-MS ephambili (i-PPMS)
• Inkqubela phambili ye-MS (SPMS)

Uhlobo ngalunye lwe-MS lukhokelela kwizimo ezahlukeneyo zokuziphatha, amanqanaba obukhali, kunye neendlela zonyango. Qhubeka ufunda ukuze ufumane ukuba i-PPMS yahluke njani kwi-RRMS.

Yintoni i-MS ephambili yokuqhubela phambili?

I-PPMS yenye yeentlobo ze-MS ezinqabileyo, ezichaphazela malunga neepesenti ezili-15 zabo bonke abantu abanesifo. Ngelixa ezinye iintlobo ze-MS zibonakaliswa ngohlaselo oluqatha, olubizwa ngokuba kukuphinda ubuye, lulandelwe ngamaxesha okungenziyo, okubizwa ngokuba kukuxolelwa, i-PPMS ibangela ukuba iimpawu ziye zisiba mandundu.

I-PPMS inokutshintsha ngokuhamba kwexesha. Ixesha lokuphila nale meko linokuhlelwa njenge:

• isebenza ngokuqhubela phambili ukuba kukho iimpawu eziba mandundu okanye umsebenzi omtsha we-MRI okanye ukubuyela umva
• isebenza ngaphandle kokuqhubela phambili ukuba iimpawu okanye umsebenzi we-MRI ukhona, kodwa iimpawu azikabi nzima
• ayisebenzi ngaphandle kokuqhubela phambili ukuba akukho zimpawu okanye umsebenzi we-MRI kwaye akukho kukhubazeka kukhulayo
• ayisebenzi ngokuqhubela phambili ukuba kukho ukubuyela umva okanye umsebenzi weMRI, kwaye iimpawu ziye zaba qatha

Ziziphi iimpawu eziqhelekileyo ze-PPMS?

Iimpawu ze-PPMS zingahluka, kodwa iimpawu eziqhelekileyo zibandakanya:

• iingxaki zombono
• kunzima ukuthetha
• iingxaki zokuhamba
• ingxaki ngokulinganisela
• iintlungu ngokubanzi
• ziqinile kwaye zibuthathaka imilenze
• ingxaki ngememori
• ukudinwa
• ingxaki ngesinyi kunye namathumbu
• ukudakumba

Ngubani ofumana iPPMS?

Abantu bavame ukufumanisa i-PPMS kwiminyaka engama-40 no-50, ngelixa abo bafumanisa ukuba bane-RRMS bahlala be-20 no-30. Amadoda nabasetyhini bafumanisa ukuba bane-PPMS ngamazinga afanayo, ngokungafaniyo ne-RRMS, echaphazela uninzi lwabasetyhini.

Yintoni ebangela iPPMS?

Oonobangela beMS abaziwa. Iingcamango eziqhelekileyo zibonisa ukuba i-MS iqala njengenkqubo yokuvuvukala kwenkqubo yokuzimela komzimba eyenza umonakalo kwi-myelin sheath. Esi sisimbozo sokukhusela esingqonge imithambo-luvo yenkqubo yemithambo-luvo.

Enye inkolelo kukuba yimpendulo yomzimba yomzimba ebangelwa lusulelo lwentsholongwane. Emva kwexesha, ukonakala kwethambo okanye ukonakala kwenzeka.

Obunye ubungqina bucebisa ukuba i-MS ephambili yokuqhubela phambili iyinxalenye yeeklinikhi ezibonakalayo ze-MS kwaye ayifani nokubuyela kwi-MS kwakhona.

Ithini imbonakalo yePPMS?

I-PPMS ichaphazela wonke umntu ngokwahlukileyo. Ngenxa yokuba iPPMS iqhubeka, iimpawu zihlala zisiya zisiba mbi kunokuba ngcono. Uninzi lwabantu lunengxaki yokuhamba. Abanye abantu banengxaki yokungcangcazela kunye nokubona.

Zeziphi iindlela zonyango ezikhoyo ze-PPMS?

Unyango lwe-PPMS lunzima ngakumbi kune-RRMS. Kubandakanya ukusebenzisa unyango lwe-immunosuppressive. Banokunika ngoncedo lwethutyana kodwa banokusetyenziswa ngokukhuselekileyo kwiinyanga ezimbalwa ukuya kunyaka ngexesha.

I-Ocrelizumab (Ocevus) kuphela kwonyango oluvunyiweyo lwe-FDA lokunyanga i-PPMS.

Akukho lunyango lwe-PPMS, kodwa ungayilawula imeko.

Iziyobisi ezithile eziguqula izifo (i-DMDs) kunye nee-steroids zinokunceda ukulawula iimpawu. Ukugcina indlela yokuphila esempilweni equka ukutya ukutya okunesondlo kunye nokwenza imithambo kunokunceda. Ukubuyisela kwisimo sangaphambili ngokunyanga ngokwasemzimbeni kunye nasemsebenzini nako kunokunceda.

Yintoni i-MS ebuyela umva kwakhona?

I-RRMS lolona hlobo luqhelekileyo lwe-MS. Ichaphazela malunga neepesenti ezingama-85 zabo bonke abantu abafumene i-MS. Uninzi lwabantu baqala ukufumanisa ukuba bane-RRMS. Ukuchongwa kwesi sifo kuguquka emva kweminyaka emininzi ukuya kwikhosi eqhubela phambili.

Igama eliphindayo-elikhupha i-MS licacisa imeko yale meko. Ngokwesiqhelo kubandakanya amaxesha okubuyela umva kakhulu kunye nexesha lokuxolelwa.

Ngexesha lokuphinda ubuye, iimpawu ezintsha zinokubonisa, okanye iimpawu ezifanayo zinokuqaqamba kwaye zibe qatha. Ngexesha lokuxolelwa, abantu banokuba neempawu ezimbalwa, okanye iimpawu zinokuba nzima kangangeeveki, iinyanga, okanye iminyaka.

Ezinye iimpawu zeRRMS zinokuba sisigxina. Ezi zibizwa ngokuba ziimpawu ezishiyekileyo.

I-RRMS ihlelwa njenge:

• iyasebenza xa kukho ukubuyela umva okanye izilonda ezifumaneka kwi-MRI
• ayisebenzi xa kungekho kubuyela umva okanye umsebenzi weMRI
• iya isiba mandundu xa iimpawu ziqhubeka ngokuthe kratya emva kokubuyela umva
• ukungabi mandundu xa iimpawu zingafumani ngokuthe ngcembe ngakumbi emva kokubuyela umva

Ziziphi iimpawu eziqhelekileyo zeRRMS?

Iimpawu ziyahluka kumntu ngamnye, kodwa iimpawu eziqhelekileyo zeRRMS zibandakanya:

• iingxaki ngokulungelelanisa kunye nokulinganisela
• ukuba ndindisholo
• ukudinwa
• ukungakwazi ukucinga kakuhle
• iingxaki ngombono
• ukudakumba
• iingxaki ngokuchama
• ingxaki yokunyamezela ubushushu
• ubuthathaka bemisipha
• ingxaki yokuhamba

Ngubani ofumana iRRMS?

Uninzi lwabantu lufunyaniswa ukuba lunama-RRMS kwiminyaka engama-20 ukuya kwengama-30, emncinci kunokuchongwa kwesiqhelo kwezinye iintlobo ze-MS, ezinje nge-PPMS. Abasetyhini banamathuba aphindwe kabini okuchongwa kunamadoda.

Yintoni ebangela iRRMS?

Enye inkolelo eqhelekileyo kukuba i-RRMS yimeko engapheliyo yokuzimela komzimba eyenzekayo xa umzimba uqala ukuzihlasela. Amajoni omzimba ahlasela inkqubo yemithambo-luvo esembindini kunye neelaying zokugquma, ezibizwa ngokuba yi-myelin, ezikhusela iintsinga zemithambo-luvo.

Olu hlaselo lubangela ukudumba kwaye lwenze iindawo ezincinci zomonakalo. Lo monakalo wenza ukuba kube nzima kwimithambo-luvo ukuhambisa ulwazi emzimbeni. Iimpawu zeRRMS ziyahluka ngokuxhomekeka kwindawo yomonakalo.

Isizathu se-MS asaziwa, kodwa kunokwenzeka ukuba zibangelwe yimfuza kunye nokusingqongileyo okubangela i-MS. Enye imbono ibonisa ukuba intsholongwane, njenge-Epstein-Barr, inokubangela i-MS.

Ithini imbonakalo yeRRMS?

Le meko ichaphazela umntu ngamnye ngokwahlukileyo. Abanye abantu banokuhlala ubomi obusempilweni kunye nokubuyela umva kunqabile okungabangeli iingxaki ezibonakalayo. Abanye banokuhlaselwa rhoqo ngeempawu eziqhubela phambili eziya kuthi zikhokelele kwiingxaki ezinzima.

Luthini unyango lweRRMS?

Kukho amayeza aliqela avunyiweyo yi-FDA ukunyanga i-RRMS. La mayeza athanda ukunciphisa ukubuyela umva kunye nokuphuhliswa kwezilonda ezintsha. Bacothisa ukuqhubela phambili kweRRMS.

Yintoni umahluko phakathi kwePPMS kunye neRRMS?

Nangona i-PPMS kunye ne-RRMS zombini ezi ntlobo ze-MS, kukho umahluko ocacileyo phakathi kwabo, onje:

Ubudala bokuqala

Ukuxilongwa kwe-PPMS kwenzeka kubantu abaneminyaka engama-40 ukuya kuma-50, ngelixa i-RRMS ichaphazela abo baneminyaka engama-20 no-30.

Oonobangela

Zombini i-PPMS kunye ne-RRMS zibangelwa kukudumba kunye nokuhlaselwa kwenkqubo yomzimba yokuzikhusela kwi-myelin kunye neentsinga zemithambo-luvo. I-RRMS ithande ukuba nokudumba ngakumbi kune-PPMS.

Abo bane-PPMS banezikrakra ezingaphezulu kunye neeplathi, okanye izilonda, kwiintambo zomqolo, ngelixa abo baneRRMS benezilonda ezingakumbi kwingqondo.

Imbonakalo

I-PPMS iqhubela phambili kwaye iimpawu ziya zisiba mandundu ngokuhamba kwexesha, ngelixa i-RRMS inokubonisa njengohlaselo olubi kunye nexesha elide lokungasebenzi. I-RRMS inokukhula ibe luhlobo oluqhubekayo lwe-MS, olubizwa ngokuba yi-MS yesibini eqhubela phambili, okanye i-SPMS, emva kwexesha elithile.

Izinketho zonyango

Ngelixa i-Ocrelizumab kuphela kwonyango oluvunyiweyo lwe-FDA ukunyanga i-PPMS, zininzi izinto ezinokunceda. Kukwakho namanye amayeza asaphandwayo. I-RRMS ineendlela ezingaphezulu kweshumi ezivunyiweyo zonyango.

Izigulana ezine-PPMS kunye ne-RRMS zinokuxhamla ekuvuseleleni ngokunyanga ngokwasemzimbeni nangokomsebenzi. Kukho amayeza amaninzi anokuwasebenzisa ukunceda abantu abane-MS ukulawula iimpawu zabo.