Isisu seStromal Tumors: Iimpawu, oonobangela, kunye nezinto ezinobungozi

Umxholo

• Iimpawu
• Oonobangela
• Imiba yomngcipheko
• Ubudala
• Imfuza

Izisu zesisu zesisu (GISTs) zizidumba, okanye izihloko zeeseli ezigqithileyo, kwithumbu lesisu (GI). Iimpawu zamathumba e-GIST zibandakanya:

• ilindle elinegazi
• iintlungu okanye ukungaphatheki kakuhle esiswini
• isicaphucaphu nokugabha
• isithintelo samathumbu
• ubunzima esiswini ukuba ungaziva
• ukudinwa okanye ukuziva udiniwe kakhulu
• ndiziva ndihluthi emva kokutya izixa ezincinci
• intlungu okanye ubunzima xa uginya

Iphecana le-GI yinkqubo enoxanduva lokwetyisa kunye nokufunxa ukutya kunye nezondlo. Ibandakanya umqala, isisu, ithumbu elincinci kunye nekholoni.

Ii-GIST ziqala kwiiseli ezizodwa eziyinxalenye yenkqubo ye-autonomic nervous system. Ezi seli zibekwe eludongeni lwe-GI tract, kwaye zilawula intshukumo yemisipha yokwetyisa.

Uninzi lweefom ze-GIST esiswini. Ngamanye amaxesha enza emathunjini amancinci, kodwa ii-GISTs ezikwikholoni, umqala kunye nomqolo ziqhelekile kakhulu. Ii-GISTs zinokuba zezibi kunye nomhlaza okanye ezinobungozi kwaye zingabi nomhlaza.

Iimpawu

Iimpawu zixhomekeke kubungakanani be-tumor nalapho ikhoyo. Ngenxa yoku, bahlala behluka ngokobunzima kwaye ukusuka komnye umntu ukuya komnye. Iimpawu ezinje ngeentlungu zesisu, isicaphucaphu, kunye nokudinwa kuyangqubana nezinye iimeko kunye nezifo.

Ukuba ufumana enye yezi okanye ezinye iimpawu ezingaqhelekanga, kuya kufuneka uthethe nogqirha wakho. Baza kukunceda baqonde unobangela weempawu zakho.

Ukuba unayo nayiphi na imingcipheko ye-GIST okanye nayiphi na enye imeko enokubangela ezi mpawu, qiniseka ukuyikhankanya kugqirha wakho.

Oonobangela

Oyena nobangela wee-GISTs awaziwa, nangona kubonakala ngathi kukho unxibelelwano notshintsho ekubonakalisweni kweprotein ye-KIT. Umhlaza ukhula xa iiseli ziqala ukukhula ngaphandle kolawulo. Njengoko iiseli ziqhubeka nokukhula ngokungalawulekiyo, ziyakha zenze ubunzima obubizwa ngokuba yithumba.

Ii-GIST ziqala kwiphecana le-GI kwaye zinokukhula ziye ngaphandle ziye kwizakhiwo ezikufuphi okanye kumalungu. Bahlala besasazeka kwisibindi kunye ne-peritoneum (i-membranous lining of the esiswini) kodwa kunqabile kwii-lymph node ezikufutshane.

Imiba yomngcipheko

Zimbalwa kuphela izinto ezaziwayo zomngcipheko kwii-GIST:

Ubudala

Eyona minyaka ixhaphakileyo yokuphuhlisa i-GIST iphakathi kwama-50 nama-80.

Imfuza

Uninzi lwee-GISTs lwenzeka ngokungacwangciswanga kwaye akukho sizathu sicacileyo. Nangona kunjalo, abanye abantu bazalwa benokutshintsha kwemfuza okunokukhokelela kwii-GISTs.

Ezinye zofuzo kunye neemeko ezinxulumene nee-GISTs zibandakanya:

I-Neurofibromatosis 1: Esi sifo semfuza, esikwabizwa ngokuba sisifo iVon Recklinghausen's (VRD), sibangelwa sisiphene kwi I-NF1 Uhlobo. Imeko inokudluliselwa isuka kumzali iye emntwaneni kodwa ayisoloko izuzwa njengelifa. Abantu abanale meko basemngciphekweni okhulayo wokukhula kwezidumbu ezinobungozi kwiimbilini besebancinci. Ezi tumors zinokubangela amabala amnyama kulusu kunye ne-freckling kwi-groin okanye underarms. Le meko ikwandisa umngcipheko wokuphuhlisa i-GIST.

Usapho oluqhelekileyo lwesisu esisisu se-tumor syndrome: Esi sifo sibangelwa rhoqo yimfuza engaqhelekanga yeKIT edluliselwe ukusuka kumzali kuye emntwaneni. Le meko inqabileyo inyusa umngcipheko we-GISTs. Ezi GISTs zinokubumba zisemncinci kunabantu ngokubanzi. Abantu abakule meko banokuba nee-GIST ezininzi ngexesha lokuphila kwabo.

Utshintsho kuhlobo lwe-succinate dehydrogenase (SDH): Abantu abazalwa benokutshintsha kweempawu ze-SDHB kunye ne-SDHC basemngciphekweni owandayo wokuphuhlisa ii-GIST. Bakwasemngciphekweni owandayo wokuphuhlisa uhlobo lwethumba lemithambo-luvo elibizwa ngokuba yiparaganglioma.