Thalidomide

Umxholo

• Ixabiso
• Iimpawu
• Kusetyenziswa kwanjani
• Imiphumela
• Ukungqinelana

I-Thalidomide liyeza elisetyenziselwa ukunyanga iqhenqa esisifo esibangelwa yintsholongwane echaphazela ulusu kunye nemithambo-luvo, ebangela ukulahleka kwemvakalelo, ubuthathaka bemisipha kunye nokukhubazeka. Ukongeza, kuyacetyiswa kwizigulana ezine-HIV kunye ne-lupus.

Eli yeza lokusetyenziswa ngomlomo, ngohlobo lwamacwecwe, linokusetyenziswa kuphela ngcebiso kagqirha kwaye iyaphikiswa ngokupheleleyo ekukhulelweni kwaye ayivumelekanga kubafazi abakwiminyaka yokuzala, phakathi kokuya exesheni kunye nokuyeka ukuya exesheni, njengoko kukhokelela kulusu olubi lomntwana, njengokungabikho kwemilebe, iingalo kunye nemilenze, ukwanda kwenani leminwe, ihydrocephalus okanye ukungasebenzi kakuhle kwentliziyo, amathumbu nezintso, umzekelo. Ngesi sizathu, kwimeko yokusebenzisa eli yeza ukubonisa unyango, ixesha loxanduva kufuneka lisayinwe.

Ixabiso

Eli yeza lithintelwe ekusetyenzisweni kwesibhedlele kwaye linikezelwa simahla ngurhulumente kwaye, ke ngoko, alithengiswa ezikhemesti.

Iimpawu

Ukusetyenziswa kweThalidomide kubonisiwe kunyango:

• Iqhenqa, eluphendulo lwesifo soqhenqa uhlobo II okanye uhlobo lwe-erythema nodosum;
• UGawulayo, kuba kunciphisa umkhuhlane, isifo kunye nokuqina kobuthathaka:
• ILupus, isifo se-graft-versus-host, kuba ukudumba kuyancipha.

Ukuqala kwamanyathelo onyango kunokuhluka phakathi kweentsuku ezi-2 ukuya kwiinyanga ezi-3, kuxhomekeke kwisizathu sonyango kwaye kunokusetyenziswa kuphela ngabafazi abangafikanga kubudala bokuzala kunye nabantwana abangaphezulu kweminyaka eli-12 ubudala.

Kusetyenziswa kwanjani

Ukusetyenziswa kweli iyeza emacwecweni kunokuqaliswa kuphela ngengcebiso kagqirha nasemva kokulandela umthetho othile wokusetyenziswa kweli yeza elifuna ukuba isigulana sisayine ifom yemvume. Ngokubanzi, ugqirha ucebisa ukuba:

• Unyango lokuphendula kweqhenqa uhlobo lweqhina okanye uhlobo II phakathi kwe-100 ukuya kwi-300 mg, kanye ngemini, ngexesha lokulala okanye ubuncinci, iyure e-1 emva kwesidlo sangokuhlwa;
• Unyango lwe-eI-leema enesiqholo se-nodular, Qalisa ukuya kuthi ga kwi-400 mg ngosuku, kwaye unciphise idosi iiveki ezi-2, de ube ufikelele kwidosi yesondlo, ephakathi kwe-50 kunye ne-100 mg ngosuku.
• Ukuphelisa isifo, ehambelana ne-HIV: 100 ukuya ku-200 mg kanye ngemini ngexesha lokulala okanye iyure e-1 emva kwesidlo sokugqibela.

Ngexesha lonyango umntu akufuneki abenonxibelelwano olusondeleyo kwaye ukuba kuyenzeka, iindlela ezimbini zokuthintela ukukhulelwa kufuneka zisetyenziswe ngaxeshanye, njengepilisi yokuthintela ukukhulelwa, inaliti okanye ukufakelwa kunye nekhondom okanye uvalo. Ukongeza, kufuneka uqale ukukhusela ukukhulelwa malunga nenyanga enye ngaphambi kokuqala unyango kunye nezinye iiveki ezi-4 emva kokupheliswa.

Kwimeko yamadoda abelana ngesondo nabasetyhini abakwiminyaka yokuzala, kufuneka basebenzise iikhondom kulo naluphi na uhlobo lonxibelelwano olusenyongweni.

Imiphumela

Iziphumo ebezingalindelekanga eziqhelekileyo zokusebenzisa eli yeza ukuba ngaba lisetyenziswa ngumfazi okhulelweyo, oko kukhokelela kukungalunganga kosana. Ukongeza, kunokukhokelela ekubanjweni, iintlungu ezandleni, iinyawo kunye neuropathy.

Ukunganyamezelani emathunjini, ukozela, ukuba nesiyezi, i-anemia, i-leukopenia, i-leukemia, i-purpura, isifo samathambo, iintlungu zomqolo, uxinzelelo lwegazi, i-vein thrombosis, i-angina, isifo sentliziyo, ukuphazamiseka, uvalo, i-sinusitis, ukukhohlela, iintlungu zesisu, urhudo, okanye ijele Isibeleko, isihlanganisi, ulusu olomileyo.

Ukungqinelana

Ukusetyenziswa kweli chiza kuyaphikiswa kwaphela ekukhulelweni kuba kubangela ukungalungi kosana, njengokungabikho kwemilenze, iingalo, imilebe okanye iindlebe, ukongeza ekusebenzeni kwentliziyo, izintso, amathumbu kunye nesibeleko, umzekelo.

Ukongeza, iipesenti ezingama-40 zeentsana ziyafa kwakamsinya emva kokuzalwa kwaye ziyaphikiswa ngexesha lokuncancisa, kuba isiphumo salo asaziwa. Ayinakusetyenziswa kwimeko yokungabikho komzimba kwi-Thalidomide okanye nayiphi na into yayo.