Isifo seZollinger-Ellison

I-Zollinger-Ellison syndrome yimeko apho umzimba uvelisa kakhulu i-hormone gastrin. Uninzi lwexesha, ithumba elincinci (gastrinoma) kwi-pancreas okanye amathumbu amancinci ngumthombo wegastrin eyongezelelweyo egazini.

I-Zollinger-Ellison syndrome ibangelwa ngamathumba. Oku kukhula kuhlala kufumaneka entlokweni yepancreas nakwisisu esincinci esingaphezulu. Amathumba abizwa ngokuba zii-gastrinomas. Amanqanaba aphezulu e-gastrin abangela ukuveliswa kwesisu esiswini kakhulu.

I-Gastrinomas yenzeka njenge-tumors enye okanye amathumba aliqela. Isiqingatha ukuya kwisibini kwisithathu se-gastrinomas enye sinomhlaza (onobungozi) tumors. Ezi zivumba zihlala zisasazeka kwisibindi nakwii-lymph node ezikufutshane.

Abantu abaninzi abane-gastrinomas banamathumba aliqela njengenxalenye yemeko ebizwa ngokuba luhlobo lwe-endocrine neoplasia yohlobo I (MEN I). Izidumbu zinokukhula kwindlala yebhinqa (ingqondo) kunye nedlala yeparathyroid (intamo) nakwiipancreas.

Iimpawu zingabandakanya:

• Intlungu zesisu
• Urhudo
• Ukuphalaza igazi (ngamanye amaxesha)
• Iimpawu ezinzima ze-esophageal reflux (GERD)

Iimpawu zibandakanya izilonda esiswini kunye namathumbu amancinci.

Uvavanyo lubandakanya:

• Ukuskena kwe-CT esiswini
• Uvavanyo lokufakwa kweCalcium
• I-endoscopic ultrasound
• Utyando lokuhlola
• Inqanaba legazi leGastrin
• Ukuskena i-Octreotide
• Uvavanyo lokukhuthaza ngasese

Amachiza abizwa ngokuba yiproton pump inhibitors (omeprazole, lansoprazole, kunye nezinye) asetyenziselwa ukunyanga le ngxaki. La machiza anciphisa ukuveliswa kweasidi sisisu. Oku kunceda izilonda esiswini kunye namathumbu amancinci aphole. La mayeza akwanokuthomalalisa iintlungu zesisu kunye norhudo.

Ugqirha lokususa i-gastrinoma inokwenziwa xa izidumbu zingasasazekanga kwamanye amalungu. Utyando esiswini (gastrectomy) ukulawula imveliso ye-asidi kunqabile ukuba lufuneke.

Inqanaba lokunyanga liphantsi, nokuba lifunyenwe kwangethuba kwaye ithumba liyasuswa. Nangona kunjalo, i-gastrinomas ikhula kancinci.Abantu abanale meko banokuphila iminyaka emininzi emva kokufunyanwa kwethumba. Amayeza acinezela i-acid asebenza kakuhle ukulawula iimpawu.

Iingxaki zinokubandakanya:

• Ukusilela ukufumana ithumba ngexesha lotyando
• Ukopha emathunjini okanye umngxunya (ukugqobhoza) kwizilonda esiswini okanye kwi-duodenum
• Urhudo olomeleleyo kunye nokwehla kobunzima
• Ukusasazeka kwethumba kwamanye amalungu

Fowunela umboneleli wakho wezempilo ukuba unentlungu ebuhlungu esiswini engahambiyo, ngakumbi ukuba iyenzeka ngorhudo.

Isifo se-ZE; Gastrinoma

• Amadlala endocrine

UJensen RT, Norton JA, Oberg K. Neuroendocrine tumors. Ku: UFeldman M, uFriedman LS, uBrandt LJ, ii-eds. Sleisenger kunye neFordtran's Gastrointestinal and Liver Disease. Ngomhla we-10. IPhiladelphia, PA: Elsevier Saunders; I-2016: isahluko 33.

UVella A. Amadlala emathunjini kunye namathumbu endocrine esiswini. Ku: Melmed S, Polonsky KS, Larsen PR, Kronenberg HM, ii-eds. Incwadi ebhaliweyo kaWilliam ye-Endocrinology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 38.