I-calcium pyrophosphate arthritis

I-calcium pyrophosphate dihydrate (CPPD) isifo samathambo sisifo esidibeneyo esinokubangela uhlaselo lwe-arthritis. Njenge-gout, i-crystals ifom edibeneyo. Kodwa kule samathambo, iikristali azenziwanga kwiuric acid.

Ukufakwa kwe-calcium pyrophosphate dihydrate (CPPD) kubangela le fomu ye-arthritis. Ukwakhiwa kwale khemikhali kwenza iikristali kwi-cartilage yamajoyina. Oku kukhokelela kuhlaselo lokudumba ngokudibeneyo kunye neentlungu emadolweni, ezihlahleni, emaqatheni, emagxeni nakwamanye amalungu. Ngokuchasene ne-gout, indibaniselwano yeminwe ye-metatarsal-phalangeal ayichatshazelwa.

Phakathi kwabantu abadala, i-CPPD ngunobangela oqhelekileyo we-arthritis (acute) ngesiquphe kwilungu elinye. Uhlaselo lubangelwa ngu:

• Ukwenzakalisa ilungu
• Inaliti yeHyaluronate kwilungu
• Ukugula

I-CPPD arthritis ikakhulu ichaphazela abantu abadala ngenxa yokudodobala ngokudibeneyo kunye ne-osteoarthritis iyanda ngokuguga. Lo monakalo udibeneyo ukonyusa ukutyekela kwe-CPPD. Nangona kunjalo, i-CPPD arthritis ngamanye amaxesha inokuchaphazela abantu abancinci abaneemeko ezinje:

• I-Hemochromatosis
• Isifo seParathyroid
• Ukusilela kwezintso ngokuxhomekeke kwi-Dialysis

Kwiimeko ezininzi, i-CPPD arthritis ayibangeli zimpawu. Endaweni yoko, ii-x-reyi zamalungu achaphazelekayo anje ngamadolo abonisa iidipozithi ezibonakalayo zekhalsiyam.

Abanye abantu abaneedipozithi ezingapheliyo ze-CPPD kumalungu amakhulu banokuba nezi mpawu zilandelayo:

• Intlungu
• Ukudumba
• Ubushushu
• Ubomvu

Ukuhlaselwa kwentlungu edibeneyo kunokuhlala iinyanga. Kungangabikho mpawu phakathi kokuhlaselwa.

Abanye abantu i-CPPD arthritis ibangela umonakalo omkhulu kwilungu.

I-CPPD arthritis inokubakho nasemqolo, zombini ezisezantsi neziphezulu. Uxinzelelo kwimithambo-luvo yomqolo inokubangela iintlungu ezingalweni okanye emilenzeni.

Kuba iimpawu ziyafana, i-CPPD arthritis inokubhideka ne:

• Isifo samathambo (sifo)
• Osteoarthritis
• Irheumatoid Arthritis

Uninzi lweemeko zamathambo zibonisa iimpawu ezifanayo. Ukuvavanya ngononophelo ulwelo oludibeneyo lweekristali kunokunceda ugqirha abone imeko.

Unokufumana ezi mvavanyo zilandelayo:

• Uvavanyo oluhlangeneyo lwamanzi ukubona iiseli ezimhlophe zegazi kunye neekhalsiyam zepyrophosphate crystals
• I-x-ray ezidibeneyo ukujonga umonakalo odibeneyo kunye ne-calcium deposits kwiindawo ezidibeneyo
• Olunye uvavanyo lokudibanisa ngokudibeneyo njenge-CT scan, iMRI okanye i-ultrasound, ukuba iyafuneka
• Uvavanyo lwegazi ukukhusela iimeko ezinxulunyaniswe ne-calcium pyrophosphate arthritis

Unyango lunokubandakanya ukususa ulwelo ukunciphisa uxinzelelo kwilungu. Inaliti ibekwa kumdibaniso kwaye ulwelo lunqwenelwa. Ezinye iindlela zonyango eziqhelekileyo zezi:

• Inaliti zeSteroid: ukunyanga amalungu adumbileyo
• I-Oral steroids yomlomo: ukunyanga amalungu amaninzi adumbileyo
• Amayeza angasebenziyo okulwa nokudumba (i-NSAIDs): ukunciphisa iintlungu
• IColchicine: ukunyanga uhlaselo lwe-CPPD arthritis
• Isifo esinganyangekiyo se-CPPD arthritis kumalungu amaninzi e-methotrexate okanye i-hydroxychloroquine kunokuba luncedo

Uninzi lwabantu luqhuba kakuhle ngonyango ukunciphisa iintlungu ezihlangeneyo. Iyeza elinje nge-colchicine linokunceda ukuthintela uhlaselo oluphindaphindiweyo. Akukho lunyango lokususa iikristali ze-CPPD.

Umonakalo osisigxina odibeneyo ungenzeka ngaphandle konyango.

Fowunela umboneleli wakho wokhathalelo lwempilo ukuba uhlaselwa ngokudumba ngokudibeneyo kunye nentlungu edibeneyo.

Akukho ndlela yaziwayo yokuthintela esi sifo. Nangona kunjalo, ukunyanga ezinye iingxaki ezinokubangela isifo samathambo se-CPPD kunokwenza imeko ingaphantsi.

Ukutyelelwa rhoqo kunokukunceda ukuthintela umonakalo osisigxina kumalungu achaphazelekayo.

Isifo sokufakwa kweCalcium pyrophosphate dihydrate; Isifo se-CPPD; Isifo samathambo esibuhlungu / esingapheliyo; Pseudogout; IPyrophosphate arthropathy; Chondrocalcinosis

• Ukudumba kwamagxa ngokudibeneyo
• Osteoarthritis
• Ubume bedibeneyo

UAndrés M, uSivera F, uPascual E. Unyango lwe-CPPD: ukhetho kunye nobungqina. ICurr Rheumatol Rep. 2018; 20 (6): 31. IINKCUKACHA: 29675606 pubmed.ncbi.nlm.nih.gov/29675606/.

Edwards NL. Izifo zokufaka i-Crystal. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Ngomhla wama-26. IPhiladelphia, PA: Elsevier; 2020: isahluko 257.

I-Terkeltaub R. Isifo seCalcium crystal: I-calcium pyrophosphate dihydrate kunye ne-calcium phosphate esisiseko. Ku: Firestein GS, Budd RC, Gabriel SE, McInnes IB, O'Dell JR, ii-eds. Incwadi kaKelley kunye neFirestein yeRheumatology. Ngomhla we-10. IPhiladelphia, PA: Elsevier; Ngo-2017: isahluko 96.