Ukusilela kweFactor XII (Hageman factor)

Ukusilela kweFactor XII sisifo esizuze ilifa esichaphazela iprotein (factor XII) ebandakanyeka ekunqandeni igazi.

Xa usopha, uthotho lweempendulo zenzeka emzimbeni onceda amahlwili egazi. Le nkqubo ibizwa ngokuba yi-coagulation cascade. Ibandakanya iiproteni ezikhethekileyo ezibizwa ngokuba yi-coagulation okanye i-clotting factor. Unokuba nethuba eliphezulu lokuphuma kwegazi kakhulu ukuba enye okanye ezingaphezulu kwezi zinto zilahlekile okanye azisebenzi njengoko kufanelekile.

Inqaku XII yenye yezinto ezinjalo. Ukusilela kwale nto akubangeli ukuba wophe ngokungaqhelekanga. Kodwa, igazi lithatha ixesha elide kuneliqhelekileyo ukunxiba kwityhubhu yovavanyo.

Ukusilela kweFactor XII sisifo esinqabileyo esivela kwilifa.

Ngokuqhelekileyo akukho zimpawu.

Ukusilela kwefactor XII kudla ngokufumaneka xa kuvavanywa iimvavanyo zokuhlola rhoqo.

Uvavanyo lunokubandakanya:

• Inqaku XII kuvavanyo lokulinganisa umsebenzi we-XII
• Ixesha le-thromboplastin ekhethekileyo (i-PTT) yokujonga ukuba kuthatha ixesha elingakanani ukuba igazi lijiye
• Ukuxubusha isifundo, uvavanyo olukhethekileyo lwe-PTT ukuqinisekisa ukusilela kwe-XII

Unyango alufuneki.

Ezi zixhobo zinokubonelela ngolwazi ngakumbi malunga nokusilela kwe-XII:

• Isiseko seSizwe seHemophilia - www.hemophilia.org/Bleeding-Disorder/Type-of-Beeding-Disorder/Other-Factor-Deficiency/Factor-XII
• Umbutho weSizwe weengxaki zoRare- rarediseases.org/rare-diseases/factor-xii-deficiency
• IZiko loLwazi lweZifo zeMvelo zeNiH kunye neRare-rarediseases.info.nih.gov/diseases/6558/factor-xii-deficiency

Isiphumo kulindeleke ukuba sibe ntle ngaphandle konyango.

Ngokuqhelekileyo akukho ngxaki.

Umboneleli wezempilo uhlala efumanisa le meko xa eqhuba ezinye iimvavanyo zelebhu.

Esi sisifo esizuzwe njengelifa. Akukho ndlela yaziwayo yokuthintela.

Ukusilela kwe-F12; Ukusilela kwento yeHageman; Uphawu lweHageman; Ukusilela kwe-HAF

• Amahlwili egazi

UGailani D, Wheeler AP, Neff AT. Ukunqongophala kwezinto ezinqabileyo. Ku: Hoffman R, Benz EJ, Silberstein LE, et al, ii-eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 137.

Iholo JE. I-Hemostasis kunye nokuqina kwegazi. Ku: Iholo JE, ed. Incwadi kaGuyton kunye neHolo yePhysical Physiology. Umhla we-13. IPhiladelphia, PA: Elsevier; 2016: isahluko 37.

Ragni MV. Ukuphazamiseka kwento eyophayo: ukungabikho kwento ekunqandeni. Ku: IGoldman L, iSchafer AI, ii-eds. Amayeza eGoldman-Cecil. Umhla wama-25. IPhiladelphia, PA: Elsevier Saunders; Ngo-2016: isahluko 174.