Into ye-VIII yovavanyo

Into VIII kuvavanyo luvavanyo lwegazi ukulinganisa umsebenzi wenqaku VIII. Le yenye yeeproteni emzimbeni ezinceda i-clot yegazi.

Isampulu yegazi iyafuneka.

Akukho lungiselelo lukhethekileyo luyafuneka.

Xa kufakwa inaliti ukutsala igazi, abanye abantu baziva iintlungu eziphakathi. Abanye baziva behlaba okanye behlaba kuphela. Emva koko, kunokubakho ukubetha okanye ukutyumza kancinci. Oku kuya kuhamba kungekudala.

Olu vavanyo lusetyenziselwa ukufumana unobangela wokopha kakhulu (ukuncipha kwegazi). Okanye, inoku-odolwa ukuba ilungu losapho laziwa ngokuba ne-hemophilia A. Uvavanyo lungenziwa kwakhona ukuze lubone ukuba lusebenza kakuhle kangakanani unyango lwe-hemophilia A.

Ixabiso eliqhelekileyo ngama-50% ukuya kuma-200% olawulo lwelebhu okanye ixabiso lesalathiso.

Amaxabiso esiqhelo ahluka kancinci phakathi kweelebhu ezahlukeneyo. Ezinye iilebhu zisebenzisa imilinganiselo eyahlukeneyo okanye zinokuvavanya iisampulu ezahlukeneyo. Thetha nomboneleli wakho wezempilo malunga nentsingiselo yeziphumo zakho zovavanyo.

Ukuncipha komsebenzi we-VIII kunokuba ngenxa:

• IHemophilia A (isifo esophayo esibangelwa kukusilela kwegazi ekunqandeni igazi VIII)
• Ukuphazamiseka apho iiproteni ezilawula ukujiya kwegazi ziye zigqithise ukusasazeka kwe-intravascular coagulation (DIC)
• Ubukho beFactor VIII inhibitor (antibody)
• Isifo seVon Willebrand (olunye uhlobo lwesifo sokopha)

Umsebenzi owandisiweyo unokubangelwa:

• Ukwaluphala
• Seswekile
• Isifo sesibindi
• Ukudumba
• Ukukhulelwa
• Ukutyeba kakhulu

Akukho mngcipheko ubandakanyekileyo ekuthatheni igazi lakho. Imithambo kunye nemithambo iyahluka ngobukhulu ukusuka komnye umntu ukuya komnye, kwaye ukusuka kwelinye icala lomzimba ukuya kwelinye. Ukufumana isampulu yegazi kwabanye abantu kunokuba nzima ngakumbi kunabanye.

Eminye imingcipheko enxulumene nokutsalwa kwegazi incinci, kodwa inokubandakanya:

• Ukopha kakhulu
• Ukufa isiqaqa okanye ukuziva ungenantloko
• Ukugqobhoza okuninzi ukufumana imithambo
• I-Hematoma (igazi eliqokelela phantsi kwesikhumba)
• Usulelo (umngcipheko omncinci nangaliphi na ixesha ulusu lwaphukile)

Olu vavanyo luhlala lusenziwa kubantu abaneengxaki zokopha. Umngcipheko wokopha kakhulu mkhulu kancinci kubantu abaneengxaki zokopha kunabanye.

IPlasma factor VIII antigen; Into ye-Antihemophilia; I-AHF

UCarcao M, Moorehead P, uLillicrap D.Hemophilia A kunye no-B Ku: Hoffman R, Benz EJ, Silberstein LE, et al, eds. I-Hematology: Imigaqo esisiseko kunye nokuziqhelanisa. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2018: isahluko 135.

IChernecky CC, iBerger BJ. Inqaku VIII (i-antihemophilia factor, AHF) -igazi. Ku: IChernecky CC, iBerger BJ, ii-eds. Iimvavanyo zaselebhu kunye neenkqubo zokuqonda isifo. Umhla wesi-6. ISt Louis, MO: Elsevier Saunders; Ngo-2013: 504-505.

UNapolitano M, uSchmaier AH, uKessler CM. Ukuxinana kunye nefibrinolysis. Ku: McPherson RA, Pincus MR, ii-eds. Ukuchongwa kweKlinikhi kaHenry kunye noLawulo ngeendlela zeLebhu. Umhla we-23. ISt Louis, MO: Elsevier; Ngo-2017: isahluko 39.