Sirolimus

Umxholo

• Sebenzisa iibhotile zesisombululo, landela la manyathelo:
• Ngaphambi kokuba uthathe i-sirolimus,
• I-Sirolimus inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo okanye ezo zidweliswe kwicandelo LESILumkiso ESIBALULEKILEYO, tsalela umnxeba kwangoko:

I-Sirolimus inokunyusa umngcipheko wokuba ube nosulelo okanye umhlaza, ngakumbi i-lymphoma (umhlaza wenxalenye yamajoni omzimba) okanye umhlaza wolusu. Ukunciphisa umngcipheko womhlaza wolusu, cwangcisa ukuthintela ukukhanya kwelanga ngokungeyomfuneko kunye nokunxiba impahla ekhuselayo, iiglasi zelanga kunye nescreen elangeni ngexesha lonyango lwakho. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: umkhuhlane, umqala obuhlungu, ukugodola, ukuchama rhoqo okanye ukubabuhlungu, okanye ezinye iimpawu zosulelo; izilonda ezintsha okanye utshintsho kolusu; ukubila ebusuku; amadlala adumbileyo entanyeni, emakhwapheni, okanye emhlubulweni; ukwehla kobunzima obungachazwanga; ingxaki yokuphefumla; iintlungu zesifuba; ubuthathaka okanye ukudinwa okungapheliyo; okanye iintlungu, ukudumba, okanye ukugcwala esiswini.

I-Sirolimus inokubangela iziphumo ebezingalindelekanga ezibi okanye ukufa kwizigulana ezinesibindi okanye ukufakelwa kwemiphunga. Eli yeza akufuneki linikezwe ukunqanda ukwaliwa kwesibindi okanye ukufakelwa kwemiphunga.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-sirolimus.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-sirolimus.

I-Sirolimus isetyenziswa ngokudibeneyo namanye amayeza ukunqanda ukwala ukufakelwa kwezintso. USirolimus ukwiklasi yamayeza abizwa ngokuba zii-immunosuppressants. Isebenza ngokucinezela amajoni omzimba.

I-Sirolimus iza njengecwecwe kunye nesisombululo (ulwelo) ukuthatha ngomlomo. Ihlala ithathwa kanye ngemini, nokuba kukutya rhoqo okanye ngaphandle kokutya. Ukukunceda ukhumbule ukuthatha i-sirolimus, thatha ixesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-sirolimus ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ugqirha wakho uya kuthi ahlengahlengise idosi yakho ye-sirolimus ngexesha lonyango lwakho, ihlala ingekho ngaphezulu kwesinye kwiintsuku ezisi-7 ukuya kwezi-14.

Qhubeka nokuthatha i-sirolimus nokuba uziva uphilile. Ungayeki ukuthatha i-sirolimus ngaphandle kokuthetha nogqirha wakho.

Isisombululo seSirolimus sinokukhulisa inkungu xa ifriji. Ukuba oku kuyenzeka, vumela ibhotile ime kwiqondo lokushisa kwaye uyishukumise ngobunono kude kube ngumsi. Inkungu ayithethi ukuba iyeza lonakele okanye alikhuselekanga.

Sebenzisa iibhotile zesisombululo, landela la manyathelo:

1. Vula ibhotile yesisombululo. Ekusetyenzisweni kokuqala, faka ityhubhu yeplastiki ngesiciko ngokuqinileyo kwibhotile ide ibe iphezulu kwibhotile. Sukususa kwibhotile yakufakwa.
2. Ukusetyenziswa ngakunye, faka ngokuqinileyo enye yeesirinji zerhasi evuthiweyo, kunye nesixhobo sokugibisela sityhalelwe ngaphakathi, ekuvulekeni kwityhubhu yeplastiki.
3. Zoba inani lesisombululo esichazwe ngugqirha wakho ngokukhupha ngobunono isirinji kude kube sezantsi komgca omnyama wesiponji nokuba kunophawu oluchanekileyo kwisirinji. Gcina ibhotile ime nkqo. Ukuba amaqamza enza kwisirinji, khuphela isirinji kwibhotile kwaye uphinde eli nyathelo.
4. Khuphela isirinji kwiglasi okanye kwikomityi yeplastiki ene-ounces ezi-2 ubuncinane (i-1/4 yeekomityi) zamanzi okanye incindi yeorenji. Sukusebenzisa ijusi yeapile, ijusi yeziqhamo, okanye ezinye izinto ezingamanzi. Gquba ngamandla umzuzu omnye usele kwangoko.
5. Gcwalisa indebe nge-ounces ezi-4 (i-120 milliliters [1/2 yekomityi]) yamanzi okanye yejusi yeorenji. Gquba ngamandla kwaye usele isisombululo sokususa.
6. Lahla isirinji esetyenzisiweyo.

Ukuba ufuna ukuphatha isirinji ezalisiweyo kunye nawe, qhobosha ikepusi kwisirinji uze ubeke isirinji kwityesi. Sebenzisa iyeza kwisirinji kwiiyure ezingama-24.

I-Sirolimus ikwasetyenziswa ngamanye amaxesha ukunyanga i-psoriasis. Thetha nogqirha wakho malunga neengozi zokusebenzisa la mayeza kwimeko yakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-sirolimus,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-sirolimus, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-sirolimus okanye isisombululo. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: aminoglycoside antibiotics ezifana ne-amikacin, gentamicin, kanamycin, neomycin (Neo-Fradin, Neo-Rx), streptomycin, kunye ne-tobramycin (Tobi); i-amphotericin B (i-Abelcet, i-AmBisome, i-Amphocin, i-Fungizone); i-angiotensin-converting enzyme (ACE) inhibitors enjenge benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), fosinopril (Monopril), lisinopril (Prinivil, Zestril), moexipril (Univasc), peripopril (Acropil) ), ramipril (Altace), kunye netrandolapril (Mavik); ii-antifungals ezinje nge-clotrimazole (Lotrimin), i-fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), kunye ne-voriconazole (Vfend); bromocriptine (Cycloset, Parlodel); cimetidine (iTagamet); i-cisapride (Propulsid) (ayifumaneki e-U.S.); i-clarithromycin (i-Biaxin); iDanazol (iDanocrine); I-diltiazem (iCardizem, iDilacor, iTiazac); i-erythromycin (i-EES, i-E-Mycin, i-Erythrocin); I-HIV protease inhibitors efana ne-indinavir (Crixivan) kunye ne-ritonavir (Norvir, e-Kaletra); amayeza athile e-cholesterol; amayeza okubanjwa njenge carbamazepine (Tegretol), phenobarbital (Luminal), kunye ne phenytoin (Dilantin); metoclopramide (Reglan); iNicardipine (Cardene); irifabutin (Mycobutin); irifampin (Rifadin, Rimactane); irifapentine (Priftin); telithromycin (Ketek); i-troleandomycin (TAO) (ayifumaneki e-US); Kunye neverapamil (Calan, Covera, Isoptin, Verelan). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• ukuba uthatha i-cyclosporine (Neoral) njengepilisi zejelatin ezithambileyo okanye isisombululo, zithathe iiyure ezi-4 ngaphambi kwesirolimus.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe waba ne-cholesterol ephezulu okanye i-triglycerides okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye uncancisa. Kuya kufuneka usebenzise indlela esebenzayo yolawulo lokuzalwa ngaphambi kokuqala ukuthatha i-sirolimus, ngelixa uthatha i-sirolimus, kunye neeveki ezili-12 emva kokumisa i-sirolimus. Ukuba ukhulelwa ngelixa uthatha i-sirolimus, biza ugqirha wakho.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha i-sirolimus.
• awunalo ugonyo ngaphandle kokuthetha nogqirha wakho.

Gwema ukusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Sirolimus inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isisu esibuhlungu
• intloko ebuhlungu
• ukuqhina
• urhudo
• isicaphucaphu
• intlungu edibeneyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ezi mpawu zilandelayo aziqhelekanga, kodwa ukuba ufumana enye yazo okanye ezo zidweliswe kwicandelo LESILumkiso ESIBALULEKILEYO, tsalela umnxeba kwangoko:

• ukopha okungaqhelekanga okanye ukugruzuka
• ukukhohlela
• idumbile, ibomvu, iqhekekile, isikhumba esinamaxolo
• urhwebo
• irhashalala
• ukurhawuzelela
• ubunzima bokuphefumla okanye ukugwinya
• ukudumba kobuso, umqala, ulwimi, imilebe, amehlo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• ukudinwa

I-Sirolimus inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Gcina iitafile kubushushu begumbi kwaye kude nokukhanya, ubushushu obungaphaya, kunye nokufuma (hayi kwigumbi lokuhlambela). Gcina amayeza alulwelo kwifriji, kude nokukhanya, uvalwe ngokuqinileyo, kwaye ulahle naliphi na iyeza elingasetyenziswanga kwinyanga enye emva kokuba ibhotile ivuliwe. Musa ukubanda. Ukuba kufuneka, unokugcina iibhotile ukuya kwiintsuku ezili-15 kubushushu begumbi.

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• I-Rapamune^®

• URapamycin