Iyofinit

Umxholo

• Ngaphambi kokuba uthathe i-tofacitinib,
• I-Tofacitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

Ukuthatha i-tofacitinib kunokunciphisa ukubanakho kwakho ukulwa nosulelo kwaye kwandise umngcipheko wokuba ufumane usulelo olubi, kubandakanya ukungunda okunamandla, ibhaktiriya, okanye usulelo lwentsholongwane olusasazeka emzimbeni. Ezi zifo zingafuna ukunyangwa esibhedlele kwaye zingabangela ukufa. Tshela ugqirha wakho ukuba uhlala ufumana naluphi na uhlobo losulelo okanye ukuba ucinga ukuba unalo naluphi na uhlobo losulelo ngoku. Oku kubandakanya usulelo oluncinci (njengokusikwa okuvulekileyo okanye izilonda), usulelo olufikayo (olufana nezilonda ezibandayo), kunye nosulelo olungapheliyo olungapheliyo. Xelela ugqirha wakho ukuba ukhe unesifo seswekile, intsholongwane (i-HIV), ufumene isifo se-immunodeficiency syndrome (i-AIDS), isifo semiphunga, okanye enye imeko echaphazela amajoni akho Kuya kufuneka uxelele ugqirha wakho ukuba uhlala okanye wakha waphila kwiindawo ezifana ne-Ohio okanye i-Mississippi river valleys apho kukho izifo zokungunda ezixhaphakileyo. Buza ugqirha wakho ukuba awuqinisekanga ukuba ezi zifo zixhaphakile kwindawo yakho. Xelela ugqirha wakho ukuba uthatha amayeza anciphisa umsebenzi wamajoni omzimba afana nala alandelayo: abatacept (Orencia); adalimumab (Humira); anakinra (iKineret); azathioprine (Azasan, Imuran); isatifikethi (Cimzia); icyclosporine (Gengraf, Neoral, Sandimmune); etanercept (Enbrel); igolimumab (iSimponi); infliximab (Remicade); imethotrexate (Otrexup, Rasuvo, Trexall); rituximab (Rituxan); i-steroids kubandakanya i-dexamethasone, i-methylprednisolone (Medrol), i-prednisolone (i-Prelone), kunye ne-prednisone (iRayos); itacrolimus (Astagraf, Envarsus XR, Prograf); kunye ne-tocilizumab (Actemra).

Ugqirha wakho uya kukubeka esweni ngeempawu zosulelo ngexesha nasemva konyango lwakho. Ukuba unazo naziphi na kwezi mpawu zilandelayo ngaphambi kokuba uqale unyango lwakho okanye ukuba unazo naziphi na kwezi mpawu zilandelayo okanye emva nje konyango lwakho, tsalela umnxeba kwangoko: fiva; ukubila; Ukugodola; iintlungu zemisipha; ukuginya kabuhlungu okanye kunzima; ukukhohlela; ukuqhawukelwa ngumphefumlo; ukuhla ukusinda; ulusu olufudumeleyo, olubomvu, okanye olubuhlungu; irhashalala elibuhlungu; intloko ebuhlungu, ubuntununtunu ekukhanyeni, ukuqina kwentamo, ukudideka; rhoqo, ebuhlungu, okanye evuthayo xa uchama; isisu esibuhlungu; urhudo; okanye ukudinwa okugqithisileyo.

Usenokuba sele wosulelwe sisifo sephepha (i-TB; isifo esibuhlungu semiphunga) kodwa ungabi nazimpawu zesi sifo. Kule meko, ukusebenzisa i-tofacitinib kunokwenza usulelo lwakho lube lubi kakhulu kwaye kubangele ukuba ube neempawu. Ugqirha wakho uza kwenza uvavanyo lolusu ukuze abone ukuba unesifo se-TB esingasebenziyo phambi kokuba uqale unyango lwakho nge-tofacitinib. Ukuba kukho imfuneko, ugqirha wakho uya kukunika amayeza ukunyanga esi sifo phambi kokuba uqale usebenzise i-tofacitinib. Xelela ugqirha wakho ukuba ukhe wakha okanye wakha wanayo na i-TB, ukuba ngaba wakhe wahlala okanye watyelela ilizwe apho ixhaphake kakhulu i-TB, okanye ukuba wakhe wakunye nomntu one-TB. Ukuba unazo naziphi na kwezi mpawu zilandelayo ze-TB, okanye ukuba uvela kwezi mpawu ngexesha lonyango lwakho, tsalela umnxeba kwangoko: ukukhohlela, ukukhohlela umchamo wegazi, ukwehla kobunzima, ukulahleka kwethoni yezihlunu, okanye umkhuhlane.

Ukuthatha i-tofacitinib kwindawo enkulu kuneedosi ekucetyiswayo kunokubangela iingxaki zentliziyo okanye ezisongela ubomi ngexesha lonyango lwakho. Xelela ugqirha wakho ukuba uneminyaka engama-50 ubudala okanye ngaphezulu okanye ukuba uyatshaya, kwaye ukuba une-cholesterol ephezulu, uxinzelelo lwegazi oluphezulu, okanye isifo seswekile. Thatha i-tofacitinib ngokuchanekileyo njengoko kuyalelwe. Sukuyithatha ngaphezulu okanye uyithathe rhoqo kunokuyalelwa ngugqirha.

Ukuthatha i-tofacitinib kunokunyusa umngcipheko wokuba ube ne-lymphoma (umhlaza oqala kwiiseli zegazi ezilwa nosulelo) okanye ezinye iintlobo zomhlaza, kubandakanya nomhlaza wolusu. Abanye abantu abathathe i-tofacitinib namanye amayeza emva kokuba befakelwe izintso bakhulisa imeko ebangele ukuba imizimba yabo ivelise iiseli ezimhlophe zegazi ezininzi kakhulu. Xelela ugqirha wakho ukuba wakhe wanalo naluphi na uhlobo lomhlaza okanye wakha wafakelwa izintso.

Ukuthatha i-tofacitinib kwindawo enkulu kuneedosi ezicetyiswayo kunokunyusa umngcipheko wamahlwili egazi asongela ubomi. Tshela ugqirha wakho ukuba uneminyaka engama-50 ubudala okanye ngaphezulu kwaye usengozini yesifo sentliziyo okanye segazi. Kwakhona, xelela ugqirha wakho ukuba wakhe waba negazi emilenzeni, ezingalweni, okanye emiphungeni, okanye kwimithambo. Thatha i-tofacitinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho. Ukuba ufumana naziphi na kwezi mpawu zilandelayo yeka ukuthatha i-tofacitinib kwaye ubize ugqirha ngoko nangoko: ukuphefumla ngokukhawuleza okanye ukuphefumla nzima, iintlungu zesifuba, ukudumba komlenze okanye ingalo, iintlungu zomlenze, ubomvu, ukujika kombala, okanye ukufudumala emilenzeni okanye kwiingalo .

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-tofacitinib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Tofacitinib isetyenziswa yodwa okanye namanye amayeza ukunyanga isifo samathambo (imeko apho umzimba uhlasela amalungu ayo ubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) kubantu abangaphendulanga kwimethotrexate (Otrexup, Rasuvo, Trexall). Ikwasetyenziswa kunye ne-methotrexate, sulfasalazine (Azulfidine), okanye i-leflunomide (Arava) yokunyanga i-psoriatic arthritis (imeko ebangela iintlungu ezidibeneyo kunye nokudumba kunye nezikali kulusu) kubantu abangaphendulanga kula mayeza kuphela. I-Tofacitinib isetyenziselwa ukunyanga i-ulcerative colitis (imeko ebangela ukudumba kunye nezilonda kumngxunya wekholoni [amathumbu amakhulu] kunye ne-rectum) kubantu abangakwaziyo ukuthatha okanye abangaphendulanga kwi-tumor necrosis factor (TNF) ye-inhibitor iyeza. Isetyenziselwa ukunyanga i-polyarticular juvenile idiopathic arthritis (PJIA; uhlobo lwesifo samathambo ebuntwaneni esichaphazela amalunga amahlanu okanye nangaphezulu kwiinyanga ezintandathu zokuqala kwimeko, kubangela iintlungu, ukudumba, kunye nokuphulukana nomsebenzi) kubantwana abaneminyaka emi-2 nangaphezulu. UTofacitinib ukwiklasi yamayeza abizwa ngokuba yiJanus kinase (JAK) inhibitors. Isebenza ngokunciphisa umsebenzi wamajoni omzimba.

I-Tofacitinib iza njengecwecwe, ukukhutshwa okwandisiweyo (ukusebenza ixesha elide), kunye nesisombululo somlomo (ulwelo) ukuthatha ngomlomo. Unyango lwe-ulcerative colitis, i-rheumatoid arthritis, okanye i-psoriatic arthritis, ithebhulethi ihlala ithathwa kabini yonke imihla kunye okanye ngaphandle kokutya kwaye ithebhulethi ekhutshiweyo ihlala ithathwa kube kanye yonke imihla kunye okanye ngaphandle kokutya. Ukunyanga ikhosi ye-polyarticular yolutsha lwe-idiopathic arthritis, ithebhulethi okanye isisombululo somlomo sihlala sithathwa kabini yonke imihla kunye okanye ngaphandle kokutya. Thatha i-tofacitinib malunga namaxesha afanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-tofacitinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi zokukhululwa ezandisiweyo; ungahluleli, ungahlaleli, okanye uzityumze.

Njalo sebenzisa isirinji yomlomo oza kunye nesisombululo se-tofacitinib ukulinganisa umthamo wakho. Thetha nogqirha wakho okanye usokhemesti ukuba unemibuzo malunga nendlela yokulinganisa idosi yakho yesisombululo se-tofacitinib.

Ukuba wena okanye umntwana wakho uthatha isisombululo somlomo se-tofacitinib, cela usokhemesti okanye ugqirha wakho ikopi yemiyalelo yokusetyenziswa komenzi. Funda ngononophelo le miyalelo.

Ugqirha wakho unokufuna ukunciphisa idosi okanye ayeke unyango lwakho ukuba uneziphumo ebezingalindelekanga. Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-tofacitinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-tofacitinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-tofacitinib, iipilisi zokukhululwa ezandisiweyo, okanye isisombululo somlomo. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO kunye nokunye oku kulandelayo: amayeza athile okubulala anje nge-fluconazole (Diflucan), itraconazole (Onmel, Sporanox), kunye ne ketoconazole; i-aspirin kunye nezinye iyeza ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Naprosyn, Aleve); carbamazepine (Carbatrol, Tegretol, Equetro, nabanye); i-clarithromycin (i-Biaxin, kwi-Prevpac); amayeza athile e-HIV kubandakanya i-indinavir (Crixivan), nelfinavir (Viracept), kunye ne-ritonavir (Norvir, e-Kaletra); nefazodone; phenobarbital; phenytoin (iDilantin, iPhenytek); irifabutin (Mycobutin); kunye nerifampin (Rifadin, Rimactane, eRifamate, eRifater). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unentlungu esiswini engakhange ifunyanwe kwaye ukuba unaso okanye wakha waba nezilonda (izilonda kumngxunya wesisu sakho okanye amathumbu), i-diverticulitis (ukudumba kwenwebu yamathumbu amakhulu), isifo sesibindi kubandakanya nehepatitis B okanye hepatitis C, umhlaza, ianemia (inani elisezantsi kuneliqhelekileyo leeseli ezibomvu zegazi), idialysis (unyango lwezamayeza lokucoca igazi xa izintso zingasebenzi kakuhle), okanye isifo sezintso. Ukuba uthatha iipilisi ezikhutshiweyo, xelela ugqirha wakho ukuba unciphile okanye uvalekile kwinkqubo yakho yokwetyisa.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngelixa uthatha i-tofacitinib. Ukuba ukhulelwa ngelixa uthatha i-tofacitinib, biza ugqirha wakho.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngelixa uthatha iipilisi ze-tofacitinib okanye isisombululo somlomo kunye neeyure ezili-18 ubuncinci emva kwethamo lokugqibela lethebhulethi okanye ubuncinci iiyure ezingama-36 emva kwedosi yokugqibela yethebhulethi ekhulisiweyo.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma kubafazi. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-tofacitinib.
• xelela ugqirha wakho ukuba usandula ukufumana okanye ucwangciselwe ukufumana naluphi na ugonyo. Ukuba ufuna naluphi na ugonyo, kungafuneka ufumane ugonyo kwaye ulinde ixesha elithile ngaphambi kokuba uqale unyango lwakho nge-tofacitinib. Awunalo ugonyo ngexesha lonyango ngaphandle kokuthetha nogqirha wakho.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Tofacitinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• urhudo
• intloko ebuhlungu
• impumlo egobileyo okanye egobayo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• imihlathi, ukudumba kobuso, amehlo, imilebe, okanye umqala, kunzima ukugwinya okanye ukuphefumla
• isisu esibuhlungu, ngakumbi ukuba siza kunye nomkhuhlane kunye norhudo okanye ukuqhina
• mthubi ulusu okanye amehlo
• Ukuphelelwa ngumdla wokutya
• umchamo omnyama
• intshukumo yombala wodongwe
• ukugabha
• irhashalala
• ulusu oluthuthu
• ukuqhawukelwa ngumphefumlo

I-Tofacitinib inokubangela ukwanda kwamanqanaba egazi egazini. Ugqirha wakho uya kuyalela iimvavanyo zokujonga amanqanaba akho e-cholesterol ngexesha lonyango lwakho nge-tofacitinib. Thetha nogqirha wakho malunga nemingcipheko yokuthatha la mayeza.

I-Tofacitinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela). Lahla nasiphi na isisombululo esingasetyenziswanga kwiintsuku ezingama-60 emva kokuvula ibhotile.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zebhu ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-tofacitinib.

Ukuba uthatha iipilisi ezikhutshiweyo unokuthi uqaphele into ebonakala ngathi ithebhulethi xa ushukuma. Le yigobolondo elingenanto lethebhulethi, kwaye oku akuthethi ukuba awufumananga idosi epheleleyo yamayeza.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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