IPanobinostat

Umxholo

• Ngaphambi kokuba uthathe i-panobinostat,
• I-Panobinostat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Panobinostat inokubangela urhudo oluqatha kunye nolunye ulusu olunzima (GI; echaphazela isisu okanye amathumbu) iziphumo ebezingalindelekanga. Ukuba ufumana naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: isisu; izitulo ezikhululekileyo; urhudo; ukugabha; okanye umlomo owomileyo, umchamo omnyama, ukwehla kokubila, ulusu olomileyo, kunye neminye imiqondiso yokuphelelwa ngamanzi emzimbeni. Thetha nogqirha wakho malunga nento ekufuneka uyenzile ukuba ukhula urhudo ngexesha lonyango lwakho nge-panobinostat. Thetha nogqirha wakho ngaphambi kokuba uthathe naziphi na i-laxatives okanye i-stool softeners ngelixa uthatha eli yeza.

I-Panobinostat inokubangela iingxaki zentliziyo okanye ezisongela ubomi ngexesha lonyango lwakho. Tshela ugqirha wakho ukuba usandula ukuba nesifo sentliziyo okanye ukuba une-QT syndrome (imeko eyonyusa umngcipheko wokuba nesifo sentliziyo esingaqhelekanga esinokubangela ukuba utyhafile okanye usweleke ngesiquphe), i-angina (iintlungu esifubeni), okanye ezinye iingxaki zentliziyo. Ugqirha wakho uya kuyalela iimvavanyo ezinje nge-electrocardiogram (ECG; uvavanyo olurekhoda umsebenzi wombane wentliziyo) ngaphambi kwaye ngexesha lonyango lwakho ukubona ukuba kukhuselekile na kuwe ukuthatha ipanobinostat. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: iintlungu zesifuba, ukukhawuleza, ukubetha, okanye ukubetha kwentliziyo okungahambelaniyo, ukuba krwada, ukuziva utyhafile, isiyezi, imilebe enemibala eluhlaza okwesibhakabhaka, ukuphefumla kancinci, okanye ukudumba kwezandla, iingalo, iinyawo, amaqatha, okanye imilenze esezantsi.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ukujonga impendulo yomzimba wakho kwi-panobinostat.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-panobinostat kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

Thetha nogqirha wakho malunga nomngcipheko wokuthatha ipanobinostat.

I-Panobinostat isetyenziswa ngokudibeneyo ne-bortezomib (Velcade) kunye ne-dexamethasone ukunyanga abantu abane-myeloma (uhlobo lomhlaza womongo wethambo) esele baphathwa ngamanye amayeza amabini, kubandakanya i-bortezomib (Velcade). I-Panobinostat ikudidi lwamayeza abizwa ngokuba yi-histone deacetylase (HDAC) inhibitors. Isebenza ngokubulala iiseli zomhlaza.

I-Panobinostat iza njengepilisi yokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye ngeentsuku ezithile zomjikelo weentsuku ezingama-21. Umjikelo unokuphindaphindwa ukuya kuthi ga kwi-16 imijikelezo. Thatha i-panobinostat malunga nexesha elifanayo ngosuku ngalunye olucwangcisiweyo. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-panobinostat ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Gwinya zonke njengezingxobo ngeglasi yamanzi; sukuzityumza, uzihlafune, okanye uzivule. Phatha iifomsile kancinci kangangoko kunokwenzeka. Ukuba uchukumisa i-panobinostat capsule eyaphukileyo okanye iyeza elikwi-capsule, hlamba loo ndawo yomzimba wakho ngesepha namanzi. Ukuba iyeza elikwipilisi lingena emlonyeni, empumlweni, okanye emehlweni, lihlanze ngamanzi amaninzi.

Ukuba uyagabha emva kokuthatha ipanobinostat, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Qiniseka ukuba uxelela ugqirha wakho indlela oziva ngayo ngexesha lonyango lwakho. Ugqirha wakho unokunciphisa idosi yakho ye-panobinostat okanye ayeke unyango lwakho okwethutyana okanye ngokusisigxina, ukuba ufumana iziphumo ebezingalindelekanga zonyango.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-panobinostat,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-panobinostat, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-panobinostat Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: amiodarone (Cordarone, Nexterone, Pacerone); izinto zokubulala ezinje nge-itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), posaconazole (Noxafil), kunye ne-voriconazole (Vfend); iatomoxetine (iStrattera); i-bepridil (iVascor; ayisafumaneki e-US); I-boceprevir (iVictrelis); carbamazepine (Carbatrol, Tegretol, Teril, nabanye); chloroquine (Aralen); i-clarithromycin (i-Biaxin, kwi-PrevPac); ikhonkco (Vaprisol); desipramine (Norpramin); dextromethorphan; iDisopyramide (iNorpace); idolasetron (Anzemet); amayeza athile e-HIV afana ne-indinavir (Crixivan), lopinavir / ritonavir (Kaletra), nelfinavir (Viracept), ritonavir (Norvir, eKaletra, eViekira Pak), saquinavir (Invirase); imethadone (iDolophine, iMethadose); iMetoprolol (iLopressor, iTrolrol-XL); moxifloxacin (Avelox); nebivolol (Bystolic); nefazodone; I-ondansetron (iZofran, iZuplenz); iperphenazine; ipimozide (Orap); phenobarbital; phenytoin (iDilantin, iPhenytek); ukuvelisa; quinidine (kwiNuedexta); irifampin (Rifadin, Rimactane, eRifamate, eRifater); i-sotalol (iBetapace, iSorine, iSotylize); I-telaprevir (Incivek; ayisafumaneki e-U.S.); telithromycin (Ketek); thioridazine; itolterodine (Detrol); kunye ne-venlafaxine (Effexor). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unentsholongwane okanye ukhe wanengxaki yokopha okanye isifo sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. I-Panobinostat inokulimaza umbungu. Sebenzisa ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho nge-panobinostat kwaye ubuncinci kwinyanga enye emva kwethamo lokugqibela. Ukuba uyindoda kwaye iqabane lakho lingakhulelwa, kuya kufuneka usebenzise ikhondom ngelixa uthatha eli yeza kunye neentsuku ezingama-90 emva kokuba unyango lwakho lugqityiwe. Buza ugqirha wakho ukuba unemibuzo malunga nohlobo lolawulo lokuzalwa oluza kukusebenzela. Ukuba ukhulelwa ngelixa uthatha ipanobinostat, tsalela umnxeba kwangoko.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngelixa uthatha ipanobinostat.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba uthatha ipanobinostat.

Sukuyitya ipomegranate, iidiliya okanye isiqhamo seenkwenkwezi okanye usele iziqhamo zomdiliya okanye irharnate xa usela la mayeza.

Ukuba bekuziiyure ezili-12 okanye ngaphantsi ukusukela oko wawucwangciselwe ukuthatha idosi, thatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule. Ukuba sele ngaphezulu kweeyure ezili-12 ukusukela kwidosi oyicwangcisileyo, tsiba idosi kwaye uqhubeke neshedyuli yakho yesiqhelo. Musa ukuthatha idosi ephindwe kabini ukwenza okuphosiweyo.

I-Panobinostat inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukuhla ukusinda
• intloko ebuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• emnyama, ilindile, okanye ilindle eligazi
• ukugabha kwegazi okanye into egabileyo ebonakala ngathi yindawo yekhofi
• ukugruzuka okanye ukopha okungaqhelekanga
• umchamo opinki okanye omdaka
• igazi kwi-phlegm
• ukudideka
• utshintsho kwintetho yakho
• umkhuhlane, ukukhohlela, ukugodola, ukubila okanye ezinye iimpawu zosulelo
• ulusu oluthuthu
• isicaphucaphu, ukugabha, ukungabi namdla wokutya, umchamo omnyama, iintlungu zesisu, ukudinwa kakhulu, ukungabi namandla, okanye ukuba tyheli kolusu okanye amehlo amhlophe

I-Panobinostat inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nokukhanya, ubushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• urhudo
• isicaphucaphu
• ukugabha
• ukunciphisa ukutya

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• UFarydak^®