UBrigatinib

Umxholo

• Ngaphambi kokuba uthathe i-brigatinib,
• I-Brigatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

I-Brigatinib isetyenziselwa ukunyanga uhlobo oluthile lomhlaza wesifo semiphunga ongekho mncinci (i-NSCLC) ethe yasasazeka kwezinye iindawo zomzimba. UBrigatinib ukwiklasi yamayeza abizwa ngokuba yi-kinase inhibitors. Isebenza ngokuthintela isenzo seprotein engaqhelekanga ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukucothisa okanye ukunqanda ukusasazeka kweeseli zomhlaza.

UBrigatinib uza njengepilisi ukuba ayithathe ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla. Thatha i-brigatinib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-brigatinib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; sukuzihlafuna okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-brigatinib, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokukuqala ngedosi esezantsi ye-brigatinib kwaye wandise idosi yakho kube kanye emva kweentsuku ezisi-7 zonyango.

Ugqirha wakho unokufuna ukumisa okwexeshana okanye ngokusisigxina unyango lwakho okanye unciphise idosi yakho ye-brigatinib okanye amanye amayeza owathathayo, kuxhomekeka kwiziphumo ozifumanayo ngexesha lonyango lwakho. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho. Ungayeki ukuthatha i-brigatinib ngaphandle kokuthetha nogqirha wakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-brigatinib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-brigatinib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-brigatinib. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya oku kulandelayo: i-antitifungals efana ne-itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, buprenorphine kunye naloxone (Suboxone), carbamazepine (Equetro, Tegretol, Teril, abanye), clarithromycin, cyclosporine (Gengraf, Neoral ), diltiazem (Cardizem, Cartia, Diltzac, abanye), efavirenz (Sustiva, eAtripla, Symfi), erythromycin (EES, Eryc, Erythrocin), indinavir (Crixivan), nefazodone, nelfinavir (Viracept), nevirapine (Virireptine) ; phenytoin (Dilantin, Phenytek), pioglitazone (Actos, in Actoplus Met, Duetact, Oseni), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifamate, eRifater), ritonavir (Norvir, e Kaletra, Technivie, sirolimus (Rapamune), tacrolimus (Astagraf, Envarsus, Prograf), okanye verapamil (Calan, Verelan, eTarka). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-brigatinib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wakha waba noxinzelelo lwegazi oluphezulu; ukubetha kwentliziyo kancinci; isifo seswekile okanye ezinye iingxaki zeswekile yegazi; okanye isifo sezintso okanye sesibindi.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ucwangcise ukuba ngutata womntwana. I-Brigatinib inokuphazamisa ukusebenza kwezicwangcisi zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, ukufakelwa, okanye inaliti), ke akufuneki ukuba uzisebenzise njengokuphela kwendlela yolawulo lokuzalwa ngexesha lonyango lwakho. Kuya kufuneka usebenzise indlela yokuzalwa engeyiyo ihomoni enje ngendlela yothintelo (isixhobo esivimba isidoda ukuba singene esibelekweni esifana nekhondom okanye uvalo). Buza ugqirha wakho ukuba akuncede ukhethe indlela yolawulo lokuzalwa eya kukusebenzela. Ukuba ungowasetyhini, kuyakufuneka usebenzise ulawulo lokuzalwa olungelulo i-hormonal ngexesha lonyango lwakho kunye neenyanga ezi-4 emva kwedosi yakho yokugqibela. Ukuba uyindoda, wena neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kwaye niqhubeke nokusebenzisa ulawulo lokuzalwa kwiinyanga ezi-3 emva kwedosi yokugqibela. I-Brigatinib inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncelise ngexesha lonyango lwakho kunye ne-brigatinib kwaye ukuya kuthi ga kwiveki e-1 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-brigatinib.

Gwema ukutya i-grapefruit kunye nokusela ijusi yegrapefruit ngelixa uthatha i-brigatinib.

Tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yokulinganisa Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

Ukuba uphoswa ukuthatha i-brigatinib kangangeentsuku ezili-14 okanye ngaphezulu, thetha nogqirha wakho ngaphambi kokuba uqale ukuyithatha kwakhona. Kuya kufuneka uphinde uqalise ukuyithatha ngedosi esezantsi.

I-Brigatinib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isicaphucaphu
• urhudo
• ukugabha
• ukuqhina
• ukudinwa
• irhashalala
• intloko ebuhlungu
• ukuba ndindisholo, iintlungu, ukurhawuzelela, okanye ukutshiswa ziinyawo okanye izandla
• umqolo okanye iintlungu ezidibeneyo
• Ukuphelelwa ngumdla wokutya
• ubunzima bokulala okanye ukulala

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba unazo naziphi na kwezi mpawu, biza ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• ukuphefumla kancinci okanye ukuphefumla nzima
• iintlungu zesifuba
• khohlela kunye okanye ngaphandle kwencindi
• ifiva
• intloko ebuhlungu, isiyezi, intloko ebuhlungu, okanye uziva utyhafile
• ukungaboni kakuhle okanye umbono ophindwe kabini
• ubona ukukhanya kokukhanya
• ukukhanya kwenzakalisa amehlo akho
• ukubona '' iisheyibhile '' okanye amachaphaza amancinci
• ukunxanwa okugqithisileyo, ukuchama rhoqo, ukulamba kakhulu, ukungaboni kakuhle, okanye ubuthathaka
• iintlungu zesisu ezinokuthi zisasazeke emqolo okanye zibe mbi ngokutya; ukuhla ukusinda; okanye isicaphucaphu
• ukubetha kwentliziyo kancinci okanye okungaqhelekanga
• iintlungu zemisipha, ukuxhamla, ukuthamba, okanye ubuthathaka

I-Brigatinib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya ku-odola uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba umhlaza wakho unganyangwa nge-brigatinib. Ugqirha wakho uya ku-odola uvavanyo oluthile lwelebhu kwaye ujonge uxinzelelo lwegazi ngaphambi kwaye ngexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-brigatinib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• IAlunbrig^®