I-Efavirenz, iLamivudine, kunye neTenofovir

Umxholo

• Ngaphambi kokuba uthathe i-efavirenz, lamivudine, kunye ne-tenofovir,
• I-Efavirenz, lamivudine, kunye ne-tenofovir zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:
• Iimpawu libanda kungaquka oku kulandelayo:

I-Efavirenz, lamivudine kunye ne-tenofovir akufuneki zisetyenziselwe ukunyanga usulelo lwentsholongwane ye-hepatitis B (HBV; usulelo lwesibindi oluqhubekayo). Xelela ugqirha wakho ukuba unayo okanye ucinga ukuba unayo i-HBV. Ugqirha wakho angakuvavanya ukuze abone ukuba unayo i-HBV phambi kokuba uqale unyango lwakho nge-efavirenz, lamivudine kunye ne-tenofovir. Ukuba unayo i-HBV kwaye uthatha i-efavirenz, lamivudine kunye ne-tenofovir, imeko yakho inokuba mandundu mandundu xa uyeka ukuthatha i-efavirenz, lamivudine kunye ne-tenofovir. Ugqirha wakho uyakukuvavanya kwaye aodole iimvavanyo zelebhu rhoqo kwiinyanga ezininzi emva kokuba uyekile ukuthatha i-efavirenz, lamivudine kunye ne-tenofovir ukubona ukuba ngaba i-HBV yakho isibaxekile na.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-efavirenz, lamivudine, kunye ne-tenofovir.

Indibaniselwano ye-efavirenz, lamivudine, kunye ne-tenofovir isetyenziselwa ukunyanga i-HIV kubantu abadala nasebantwaneni. I-Efavirenz ikudidi lwamayeza abizwa ngokuba zii-non-nucleoside reverse transcriptase inhibitors (NNRTIs). I-Lamivudine kunye ne-tenofovir bakudidi lwamayeza abizwa ngokuba yi-nucleoside kunye ne-nucleotide reverse transcriptase inhibitors (NRTIs). Basebenza ngokunciphisa inani le-HIV emzimbeni. Nangona i-efavirenz, lamivudine kunye ne-tenofovir zingayi kuyinyanga i-HIV, la mayeza angalinciphisa ithuba lakho lokufumana isifo se-immunodeficiency syndrome (i-AIDS) kunye nezifo ezinxulumene ne-HIV ezifana nosulelo olubi okanye umhlaza. Ukuthatha la mayeza kunye nokwabelana ngesondo okukhuselekileyo nokwenza olunye utshintsho kwindlela yokuphila kunokunciphisa umngcipheko wokufumana okanye wokuhambisa intsholongwane kaGawulayo kwabanye abantu.

Indibaniselwano ye-efavirenz, lamivudine, kunye ne-tenofovir iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kanye ngemini kwisisu esingenanto (ubuncinci iyure enye ngaphambi okanye iiyure ezi-2 emva kwesidlo). Thatha i-efavirenz, lamivudine, kunye ne-tenofovir ngexesha elifanayo yonke imihla. Ukuthatha i-efavirenz, lamivudine, kunye ne-tenofovir ngexesha lokulala kunokwenza ukuba ezinye iziphumo ebezingalindelekanga zingakhathazi. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-efavirenz, lamivudine, kunye ne-tenofovir ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Qhubeka uthathe i-efavirenz, lamivudine, kunye ne-tenofovir nokuba uziva uphilile. Sukuyeka ukuthatha i-efavirenz, lamivudine, kunye ne-tenofovir ngaphandle kokuthetha nogqirha wakho. Ukuba uyayeka ukuthatha i-efavirenz, lamivudine, kunye ne-tenofovir nokuba kungexesha elifutshane, okanye ukweqa idosi, intsholongwane isenokunganyangeki kumayeza kwaye kunokuba nzima ukunyanga.

Indibaniselwano ye-efavirenz, lamivudine, kunye ne-tenofovir iyafumaneka ngamagama egama leSymfi neSymfi Lo. Ezi zinto zimbini ziqulathe izixa zamayeza ezifanayo, kwaye azinakutshintshwa enye nenye. Qiniseka ukuba ufumana kuphela uphawu lwe-efavirenz, lamivudine, kunye ne-tenofovir obumiselwe yona ngugqirha wakho. Buza usokhemesti wakho ukuba unemibuzo malunga nohlobo lwe-efavirenz, lamivudine, kunye ne-tenofovir oyinikiweyo.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe i-efavirenz, lamivudine, kunye ne-tenofovir,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabana ne-efavirenz, lamivudine, tenofovir, nawaphi na amanye amayeza, okanye nasiphi na isithako esikwipilisi ye-efavirenz, lamivudine, kunye ne-tenofovir. Buza usokhemesti wakho uluhlu lwezithako.
• Kuya kufuneka uyazi ukuba i-efavirenz, lamivudine kunye ne-tenofovir ziyafumaneka ngokwahlukeneyo ngamagama e-Sustiva, Epivir, Epivir-HBV (esetyenziselwa ukunyanga i-hepatitis B), i-Vemlidy (esetyenziselwa ukunyanga i-hepatitis B), kunye ne-Viread, ngokunjalo namanye amayeza anamagama e-Atripla, Biktarvy, Combivir, Complera, Descovy, Epzicom, Genvoya, Odefsey, Stribild, Symfi, Triumeq, Trizivir, kunye neTruvada. Tshela ugqirha wakho ukuba uthatha nawaphi na amayeza ukuze uqiniseke ukuba awufumani mayeza afanayo kabini.
• xelela ugqirha wakho ukuba uthatha i-elbasvir / grazoprevir (Zepatier). Ugqirha wakho angakuxelela ukuba ungathathi i-efavirenz, lamivudine, kunye ne-tenofovir ukuba uthatha eli yeza.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nononyango, iivithamini, izongezo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: acyclovir (Sitavig, Zovirax); i-adefovir (iHepsera); ii-aminoglycosides ezinjenge-gentamicin; artemether / lumefantine (Coartem); i-aspirin kunye nezinye iyeza ezichasayo (i-NSAIDs) ezinje nge-ibuprofen (Advil, Motrin) kunye ne-naproxen (Aleve, Naprosyn); atorvastatin (Lipitor, kwiCaduet); atovaquone / proguanil (Malarone); bupropion (Forfivo, Wellbutrin, Zyban, abanye); iicalcium block blockers ezinjenge diltiazem (Cardizem, Cartia, Diltzac, abanye), felodipine, nicardipine (Cardene), nifedipine (Adalat, Afeditab, Procardia), kunye neverapamil (Calan, Verelan, eTarka); carbamazepine (Carbatrol, Equetro, Tegretol, nabanye); cidofovir; icyclosporine (Gengraf, Neoral, Sandimmune); ganciclovir (icytovene); glecaprevir / pibrentasvir (Mavynet); itraconazole (Sporanox, Onmel); ketoconazole; I-ledipasvir / sofosbuvir (iHarvoni); ii-macrolide antibiotics ezifana ne-clarithromycin (i-Biaxin, kwi-Prevpac); imethadone (iDolophine, iMethadose); phenobarbital; phenytoin (Dilantin, kwiPhenytek); i-posaconazole (Noxafil); ipravastatin (Pravachol); irifabutin (Mycobutin); irifampin (Rimactane, eRifamate, Rifater); i-sertraline (iZoloft); isimeprevir (iOlyslo); isimvastatin (Flolopid, Zocor, eVytorin); i-sirolimus (iRapamune); isofosbuvir / velpatasvir (Epculsa); isofosbuvir / velpatasvir / voxilaprevir (Vosevi); i-sorbitol okanye amayeza anencasa nge-sorbitol; itacrolimus (Astagraf, Envarsus, Prograf); itrimethoprim (Primsol, eBactrim, Septra); i-valacyclovir (iValtrex); ivalganciclovir (iValcyte); kunye ne-warfarin (Coumadin, Jantoven). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-efavirenz, lamivudine kunye ne-tenofovir, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba unayo nayiphi na imiqathango ekhankanywe kwicandelo LESILUMKISO ESIBALULEKILEYO, okanye ukuba unethuba elide le-QT (ingxaki enqabileyo yentliziyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukutyhafa, okanye ukufa ngesiquphe), inqanaba eliphantsi i-potassium okanye i-magnesium egazini lakho, iingxaki zethambo kubandakanya i-osteoporosis (imeko apho amathambo esiba buthathaka kwaye abuthathaka kwaye aphule ngokulula) okanye ukwaphuka kwamathambo, ukuxhuzula, i-hepatitis C okanye esinye isifo sesibindi, okanye isifo sezintso.Xelela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala, wasebenzisa okanye wakha wasebenzisa iziyobisi ezitalatweni, wasebenzisa kakhulu okanye wakha wasebenzisa amayeza kagqirha, okanye wakhe wanokudakumba okanye esinye isifo sengqondo. Kubantwana abathatha la mayeza, xelela ugqirha wakho ukuba banayo okanye bakha baba ne-pancreatitis okanye bafumene unyango ngeyeza le-nucleoside analog njenge-NRTI ngaphambili.
• xelela ugqirha wakho ukuba ukhulelwe, okanye ucwangcise ukukhulelwa. Akufanele ukhulelwe ngexesha lonyango lwakho. Ukuba unokukhulelwa, kuya kufuneka ukuba ube novavanyo lokukhulelwa olubi ngaphambi kokuba uqale ukuthatha eli yeza kwaye usebenzise ulawulo lokuzalwa olusebenzayo ngexesha lonyango lwakho. I-Efavirenz, lamivudine, kunye ne-tenofovir zinokuphazamisa isenzo sezinto zokucwangcisa zehomoni (iipilisi zolawulo lokuzalwa, amabala, iiringi, ukufakelwa, okanye inaliti), ngenxa yoko akufuneki uzisebenzise njengekuphela kwendlela yolawulo lokuzalwa ngexesha lonyango. Kuya kufuneka usebenzise indlela yesithintelo yolawulo lokuzalwa kunye nayo nayiphi na enye indlela yolawulo lokuzalwa oyikhethileyo kunyango lwakho kunye nakwiiveki ezili-12 emva kwedosi yakho yokugqibela. Buza ugqirha wakho ukuba akuncede ukhethe indlela yolawulo lokuzalwa eya kukusebenzela. Ukuba uyakhulelwa ngelixa uthatha i-efavirenz, lamivudine, kunye ne-tenofovir, biza ugqirha ngoko nangoko.
• akufuneki uncelise xa wosulelwe yi-HIV okanye uthatha i-efavirenz, lamivudine, kunye ne-tenofovir.
• Kuya kufuneka wazi ukuba amanqatha omzimba wakho anganyuka okanye afudukele kwiindawo ezahlukeneyo zomzimba wakho, ezinje ngomqolo wangasentla, intamo (’’ inyathi ’), amabele, kunye nesisu sakho. Ungabona ukulahleka kwamafutha omzimba ebusweni bakho, kwimilenze nakwiingalo.
• Kuya kufuneka uyazi ukuba ngelixa uthatha amayeza ukunyanga usulelo lwe-HIV, amajoni akho omzimba angomelela kwaye aqale ukulwa nezinye izifo ezazisele zisemzimbeni wakho okanye zibangele ezinye iimeko zenzeke. Oku kunokubangela ukuba ukhule iimpawu zolo sulelo okanye iimeko. Ukuba uneempawu ezintsha okanye eziya zisiba mandundu ngexesha lonyango lwakho nge-efavirenz, lamivudine, kunye ne-tenofovir qiniseka ukuxelela ugqirha wakho.
• Kuya kufuneka uyazi ukuba i-efavirenz, lamivudine, kunye ne-tenofovir zinokukwenza ukuba ube nesiyezi, wozele, ungakwazi ukugxila, ube nengxaki yokulala okanye ukulala, ube namaphupha angaqhelekanga okanye ube nemibono (ukubona izinto okanye ukuva amazwi angekhoyo). Ezi ziphumo zihlala zihamba iiveki ezi-2 ukuya kwezi-4 emva kokuqala unyango. Ezi ziphumo zingalulanga xa usela utywala, okanye uthatha amanye amayeza afana noxinzelelo, amayeza oxinzelelo, amayeza okugula ngengqondo, amayeza okuxhuzula, amayeza okuthambisa, iipilisi zokulala, okanye iziyobisi. Musa ukuqhuba imoto okanye usebenzise oomatshini de ube uyazi indlela elikuchaphazela ngayo eli yeza.
• Kuya kufuneka uyazi ukuba i-efavirenz, lamivudine, kunye ne-tenofovir zinokubangela utshintsho kwiingcinga zakho, indlela oziphatha ngayo, okanye impilo yengqondo. Fowunela ugqirha ngoko nangoko xa uvela kwezi mpawu zilandelayo ngelixa uthatha i-efavirenz, lamivudine kunye ne-tenofovir: ukudakumba, ukucinga ngokuzibulala okanye ukucwangcisa okanye ukuzama ukwenza njalo, ukuba nomsindo okanye ukuba ndlongondlongo, ukubona izinto ezingekhoyo (ukubona izinto okanye ukuva amazwi Azikho), iingcinga ezingaqhelekanga, ukulahleka kwebala kunye nenyani, okanye ukungakwazi ukuhamba okanye ukuthetha ngesiqhelo. Qiniseka ukuba usapho lwakho luyazazi ukuba zeziphi iimpawu ezinokubanzima ukuze bakwazi ukubiza ugqirha wakho ukuba awukwazi ukuzifunela unyango ngokwakho.
• Kuya kufuneka uyazi ukuba i-efavirenz inokubangela iingxaki zesistim ezinobunzima, kubandakanya i-encephalopathy (isifo esibi nesinokubulala ingqondo) iinyanga okanye iminyaka emva kokuba uthathe i-efavirenz, lamivudine, kunye ne-tenofovir. Nangona iingxaki zenkqubo yemithambo luqala emva kokuba uthathe i-efavirenz, lamivudine, kunye ne-tenofovir kangangexesha elithile, kubalulekile kuwe nakugqirha wakho ukuba niqonde ukuba zingabangelwa yi-efavirenz. Fowunela ugqirha wakho ngoko nangoko xa unengxaki yokulingana okanye yokulungelelanisa, ukudideka, iingxaki zememori, kunye nezinye iingxaki ezibangelwa kukusebenza kwengqondo okungaqhelekanga, nangaliphi na ixesha kunyango lwakho nge-efavirenz, lamivudine, kunye ne-tenofovir. Ugqirha wakho angakuxelela ukuba uyeke ukuthatha i-efavirenz, lamivudine, kunye ne-tenofovir.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba phantse lixesha ledosi elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yethamo eqhelekileyo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Efavirenz, lamivudine, kunye ne-tenofovir zinokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• intlungu zesisu
• urhudo
• isilungulela
• isicaphucaphu
• ukugabha
• umqolo, ukudibana, okanye iintlungu zemisipha
• ukunqongophala kwamandla
• ukuhlaba, ukutshisa, okanye ukuziva kabuhlungu ezingalweni okanye emilenzeni

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zikwiCandelo LOKUQINISEKISA OKHETHEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• urhangqo, ubunzima bokuphefumla okanye ukuginya, ukudumba kobuso, umqala, ulwimi, imilebe, okanye amehlo, ukudakumba
• irhashalala, ukuxobuka okanye isikhumba esidumbileyo, ukurhawuzelela, umkhuhlane, ukudumba kobuso, izilonda emlonyeni, amehlo abomvu okanye adumbileyo
• iintlungu zemisipha engaqhelekanga, ingxaki yokuphefumla, isisu esibuhlungu, ukugabha, ukugabha, ukuziva ubanda ingakumbi ezingalweni okanye emilenzeni, uziva unesiyezi okanye unentloko elula, ukudinwa kakhulu okanye ubuthathaka, ukubetha kwentliziyo okukhawulezayo
• ubumthubi besikhumba okanye amehlo, umchamo omnyama, isitulo esikhanyayo, isicaphucaphu, ukugabha, ukuphelelwa ngumdla, iintlungu, ukuqaqanjelwa, okanye ukuthamba kwinxalenye ephezulu yesisu, isisu esidumbileyo, ukudinwa kakhulu, ubuthathaka, ukudideka
• ukuncipha kokuchama, ukudumba kwemilenze
• iintlungu zethambo, iintlungu ezingalweni okanye emilenzeni, ukwaphuka kwamathambo, iintlungu zemisipha okanye ubuthathaka, iintlungu ezidibeneyo
• ukuxhuzula
• ukuziva utyhafile, unentloko elula, okanye unesiyezi; ukubetha kwentliziyo okungaqhelekanga okanye okukhawulezayo
• iintlungu eziqhubekayo eziqala phezulu ngasekhohlo okanye embindini wesisu kodwa zisenokunwenwela ngasemva, isicaphucaphu, ukugabha

I-Efavirenz, lamivudine, kunye ne-tenofovir kunokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu libanda kungaquka oku kulandelayo:

• isiyezi
• ingxaki yokujonga
• ukozela
• ubunzima bokulala okanye ukulala
• amaphupha angaqhelekanga
• ukubona okanye ukuva izinto ezingekhoyo
• ukushukuma kwezihlunu okanye ukungcangcazela ongenakukulawula

Phambi kokuba wenze uvavanyo lwaselebhu, xelela ugqirha wakho kunye nabasebenzi baselebhu ukuba uthatha i-efavirenz, lamivudine, kunye ne-tenofovir.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Gcina isibonelelo se-efavirenz, lamivudine, kunye ne-tenofovir esandleni. Sukulinda de uphelelwe ngamayeza ukuze uphinde uzalise amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Symfi^®
• Symfi Lo^®

• EFV, 3TC kunye neTDF