UCalcinosis Cutis

Umxholo

• Iintlobo ze-calcinosis cutis
• Iimpawu ze-calcinosis cutis
• Iimbangela ze-calcinosis cutis
• Ukubalwa kweDystrophic
• Ukubalwa kweMetastatic
• Ukubalwa kwe-Idiopathic
• Ukubalwa kwe-Iatrogenic
• Calciphylaxis
• Ngokudibanisa nescleroderma
• Ukuchongwa kwecalcinosis cutis
• Unyango lwe-calcinosis cutis
• Iziyobisi
• Ugqirha
• Olunye unyango
• Umbono wecalcinosis cutis

Ushwankathelo

I-Calcinosis cutis kukuqokelelwa kweekristale zetyuwa kulusu lwakho. Iidipozithi zekhalsiyam ngamaqhuma aqinileyo anganyibiliki. Ubume kunye nobukhulu bezilonda ziyahluka.

Le yimeko enqabileyo enezizathu ezininzi ezahlukeneyo. Olu luhlu lususela kusuleleko kunye nokwenzakala kwizifo zenkqubo efana nokusilela kwezintso.

Rhoqo i-calcinosis cutis ayinazo iimpawu. Kodwa kwezinye iimeko, kunokuba buhlungu kakhulu. Unyango lukhona, kubandakanya utyando, kodwa izilonda zekhalsiyam zinokuphinda zibuye.

Iintlobo ze-calcinosis cutis

Zintlanu iindidi zecalcinosis cutis:

• Ukubalwa kweDystrophic. Olu lolona hlobo luqhelekileyo lwecalcinosis. Kuyenzeka apho ulusu lonakele okanye ludumbile. Akubandakanyi amanqanaba angaqhelekanga e-calcium okanye i-phosphorus emzimbeni.
• Ukubalwa kweMetastatic. Oku kwenzeka kubantu abanamanqanaba e-calcium kunye ne-phosphorus aphezulu kakhulu.
• Ukubalwa kwe-Idiopathic. Olu hlobo lwe-calcinosis cutis alunasizathu sibonakalayo. Ngokwesiqhelo kwenzeka kwindawo enye yomzimba kuphela.
• Ukubalwa kwe-Iatrogenic. Olu hlobo lwe-calcinosis cutis lubangelwa yinkqubo yonyango okanye unyango, ngesiqhelo ngengozi. Umzekelo, iintsana ezisandul 'ukuzalwa zinokuba nokubalwa kwe-iatrogenic kwisithende, okubangelwa zizithende zesithende zokuthatha igazi.
• Calciphylaxis. Olu hlobo lunqabileyo nolunzulu lwe-calcinosis cutis luhlala luvela kubantu abanesifo sezintso, abafumene ukufakelwa kwezintso, okanye abakwi-dialysis. Ichaphazela imithambo yegazi kulusu okanye kumaleko amanqatha.Amanqanaba e-calcium kunye ne-phosphate emzimbeni aqhelekanga.

Iimpawu ze-calcinosis cutis

Ukubonakala kunye nendawo ye-calcinosis cutis ixhomekeke kwisizathu esisisiseko. Izilonda zihlala ziba nzima, amaqhuma amhlophe-mthubi kumgangatho wolusu. Ziqala kancinci kwaye ziyahluka ngokobukhulu.

Izilonda zinokungabikho mpawu, okanye zinokuba nzima, zibe buhlungu, okanye zikhuphe into emhlophe. Kwiimeko ezinqabileyo, isilonda sinokusongela ubomi.

Nazi iindawo apho izilonda zivela khona kwi-subtypes nganye ye-calcinosis cutis:

• Ukubalwa kweDystrophic. Amaqhuma ayenzeka kwindawo yomonakalo womzimba. Iindawo eziqhelekileyo zingaphambili, iingqiniba, iminwe kunye namadolo. Nge-lupus, izilonda zenzeka ezandleni nasezinyaweni, ezinqeni, naphantsi kwezilonda zelupus.
• Ukubalwa kweMetastatic. Amaqhuma abekwe macala onke ngokudibeneyo: amadolo, iingqiniba, okanye amagxa. Banokujikeleza amalungu angaphakathi, anje ngemiphunga, izintso, imithambo yegazi, okanye isisu. Izilonda ezijikeleze amalunga zinokunciphisa ukuhamba njengoko ulusu luqina.
• Ukubalwa kwe-Idiopathic. Oku kuhlala kuchaphazela indawo enye kuphela yomzimba. Inokwenzeka ngokujikeleza kwamalungu amakhulu, isikratshi, intloko, amabele, ipeni, i-vulva, okanye izandla neenyawo. Ebantwaneni inokuba ebusweni. Izilonda zinokukhupha okumhlophe.
• Ukubalwa kwe-Iatrogenic. Isilonda sibonakala kwindawo yonyango okanye yonyango ehlaba ulusu.
• Calciphylaxis. Izilonda zolusu zihlala emilenzeni okanye esiqwini, ngakumbi iindawo ezinamanqatha ezinje ngamabele, iimpundu, kunye nesisu. Izilonda zijongeka zinamabala kwaye zibuhlungu. Zingaba zizilonda ezingapholiyo, okanye zinokuphuma ukubola. Izilonda zinokuhamba nezinye iimpawu, ezinje ngokudinwa kunye nokuba buthathaka.

Iimbangela ze-calcinosis cutis

I-calcinosis cutis inqabile kodwa inoluhlu olubanzi lwezizathu, kuxhomekeke kudidi olungezantsi:

Ukubalwa kweDystrophic

Ngokubanzi, ukonakala kwethishu kukhokelela kwiiproteni ze-phosphate ezikhutshwe ziiseli ezifa emva koko zibala, zenze iityuwa zecalcium. Umonakalo wethishu unokuvela:

• usulelo
• amathumba
• induna
• izifo zezihlunu ezinxibelelanayo ezinje nge-lupus, systemic sclerosis, okanye i-dermatomyositis

Ukubalwa kweMetastatic

Xa i-calcium phosphate yomzimba iphakame ngokungaqhelekanga, ivelisa iityuwa zekhalsiyam ezenza amaqhuqhuva kulusu. Izizathu zamanqanaba angaqhelekanga e-calcium kunye ne-phosphate zezi:

• ukusilela kwezintso okungapheliyo (esona sizathu siqhelekileyo)
• Uninzi lwevithamini D
• i-hyperparathyroidism (i-parathyroid gland eyandisiweyo ivelisa i-hormone ye-thyroid)
• I-sarcoidosis (amaqela eeseli ezitshisayo kwimiphunga, ii-lymph node, ulusu kunye namanye amalungu omzimba)
• Ubisi lwe-alkali syndrome (i-calcium eninzi evela kukutya okanye kwi-antacids)
• izifo zamathambo, ezifana nesifo sePaget

Ukubalwa kwe-Idiopathic

Ngokungafaniyo neentlobo ezimbini zokuqala ze-calcinosis cutis, ukubalwa kwe-idiopathic kwenzeka kungabikho monakalo wethishu kwaye akukho manqanaba angaqhelekanga e-calcium okanye i-phosphorus. Idiopathic ithetha ukuba "akukho sizathu saziwayo." Zintathu iintlobo:

• amaqhuqhuva osapho, ahlala evela kulutsha olusempilweni okanye kubantwana abancinci
• amaqhuqhuva e-subepidermal, abonakala nje ngezantsi kwesikhumba
• maqhuqhuva kwisingxobo samatyhalarha

Ukubalwa kwe-Iatrogenic

Unobangela we-iatrogenic calcification yinkqubo yonyango ekhokelela ngengozi kwityuwa yecalcium njengempembelelo esecaleni. Inkqubo yoku ayaziwa. Ezinye zeenkqubo ezichaphazelekayo zezi:

• ukulawulwa kwezisombululo ezine-calcium kunye ne-phosphate
• Ukunxibelelana ixesha elide kunye ne-calcium chloride electrode paste ngexesha le-electroencephalograph okanye i-electromyograph
• i-calcium gluconate efakwa emithanjeni, i-calcium chloride, kunye ne-para-aminosalicylic acid kunyango lwesifo sephepha
• isithende sinamathela kwiintsana

Calciphylaxis

Isizathu se-calciphylaxis sihlala singaqinisekanga. Kunqabile kakhulu, nangona ezinye zezinto ezinxulumene nazo ziqhelekile:

• ukusilela kwezintso okungapheliyo
• ukutyeba kakhulu
• isifo seswekile
• hyperparathyroidism

Ngokudibanisa nescleroderma

I-calcinosis cutis ihlala ivela kunye ne-systemic sclerosis (scleroderma). Ifunyenwe ngakumbi kwifom yesi sifo, eyaziwa ngokuba yi-cutaneous systemic sclerosis (CREST).

Uqikelelo lwabo bane-CREST syndrome luya kuphuhlisa i-calcinosis cutis emva.

Izilonda zihlala zibonakala zijikeleze iminwe kunye neengqiniba kwaye zinokuqhekeka zivule kwaye zivuzise izinto ezimhlophe ezimhlophe.

Ukuchongwa kwecalcinosis cutis

Ukuchonga uhlobo lwe-calcinosis cutis onayo kubalulekile ekuthatheni isigqibo ngonyango olufanelekileyo. Ugqirha wakho uyakukuvavanya kwaye athathe imbali yakho yezonyango kwaye akubuze imibuzo malunga neempawu zakho.

Ugqirha uya kuthi ayalele iimvavanyo ezininzi zaselebhu ukufumanisa unobangela wesifo sakho secalcinosis cutis:

• iimvavanyo zegazi ukubona ukuba amanqanaba akho e-calcium kunye ne-phosphate aphezulu ngokungaqhelekanga, ukujonga amanqaku e-lupus kunye namathumba, kunye nokulawula amanqanaba e-parathyroid angaqhelekanga kunye ne-vitamin D
• iimvavanyo ze-metabolic zokulawula iingxaki zezintso
• I-ray-ray, i-CT scan, okanye i-bone scans (scintigraphy) ukujonga ubungakanani bokubalwa
• i-biopsy yezilonda
• Olunye uvavanyo olukhethekileyo lokujonga i-dermatomyositis (isifo sokudumba) kunye nobisi lwealkali syndrome

Itekhnoloji entsha phantsi kophuhliso ukunceda ukuxilongwa yinkqubela phambili yokubonakalayo kokungcangcazela. Obu buchule bokuqonda isifo busebenzisa i-Fourier transform infrared (FT-IR) okanye uhlalutyo olubonakalayo lweRamadan. Ichonga ngokukhawuleza ukwenziwa kweekhemikhali kwezilonda ze-calcinosis cutis. Inokuxela kwangaphambili ukuqhubeka kwesifo.

Unyango lwe-calcinosis cutis

Unyango lwe-calcinosis cutis luxhomekeke kwisifo esisisiseko okanye unobangela.

Iziyobisi

Iindidi zamachiza zinokuzama ukunyanga izilonda, kodwa impumelelo yazo ibe nebala.

Kwizilonda ezincinci, iziyobisi ezibandakanya:

• iwarfarin
• ceftriaxone
• i-immunoglobulin efakwa ngaphakathi (IVIG)

Kwizilonda ezinkulu, iziyobisi ezibandakanya:

• mzantsi
• bisphosphonates
• zintso
• Aluminium hayidroksayidi

Uphononongo luka-2003 lwachaza ukuba idosi esezantsi ye-antibiotic minocycline yayisebenza ekuthomalaliseni iintlungu kunye nobungakanani bezilonda kubantu abane-CREST syndrome. Imixholo yesodium thiosulfate nayo inokuba luncedo.

Ugqirha

Ukuba izilonda zakho zibuhlungu, wosuleleka rhoqo, okanye uphazamise ukusebenza kwakho, ugqirha unokucebisa ukuba utyandwe. Kodwa izilonda zinokubuya emva kotyando. Kucetyiswa ukuba utyando luqale ngecandelo elincinci lesilonda.

Olunye unyango

Unyango olutsha olucetywayo yi-hematopoietic stem cell transplantation (HSCT), etshintsha iiseli zemveliso yegazi lomntu. Oku kuye kwasetyenziselwa ukunyanga ezinye izifo ezizimeleyo.

Unyango lwe-Laser kunye nomothuko we-lithotripsy (unyango lwe-ultrasound olusetyenziselwa ukwaphula amatye ezintso) lukwalunyango.

Umbono wecalcinosis cutis

Imbonakalo ye-calcinosis cutis ixhomekeke kwisifo sayo okanye unobangela, kunye nobunzima bezilonda zakho. Unyango lwangoku lunokunceda, kwaye kunyangwa iindlela ezintsha zonyango. Thetha nogqirha wakho malunga nendlela yokunciphisa iimpawu zakho kunye nokunyanga ingcambu yengxaki.