Ukusebenzisana kwe-CBD kunye neziyobisi: Into ekufuneka uyazi

Umxholo

• I-CBD inokutshintsha indlela umzimba wakho owenza ngayo amayeza athile
• Imetabolism yeziyobisi kunye ne-CYP450 enzymes
• Kutheni le nto i-CYP450 ibalulekile xa kufikwa kwi-CBD kunye namayeza?
• Ukuzama i-CBD ngokukhuselekileyo ngelixa usela amayeza
• Unxibelelwano olunokubakho lweziyobisi
• Khangela isilumkiso se-grapefruit
• Iindidi zamayeza ahlala enesilumkiso seediliya
• Uphando lwangoku ngokusebenzisana phakathi kwe-CBD kunye namayeza
• Ukhuseleko kunye neziphumo ebezingalindelekanga
• Iziphumo ebezingalindelekanga ekufuneka uzilindile
• Thetha nogqirha wakho

Uyilo lukaJamie Herrmann

I-CBD inokutshintsha indlela umzimba wakho owenza ngayo amayeza athile

I-Cannabidiol (i-CBD), ifumene ingqalelo ebanzi ngokubanakho ukunciphisa iimpawu zokungalali, unxunguphalo, iintlungu ezingapheliyo kunye nezinye iimeko zempilo.

Ngelixa izifundo ziqhubeka malunga nokusebenza kwe-CBD, abantu abaninzi bayazama.

Uphando ukuza kuthi ga ngoku lubonisa ukuba i-CBD ikhuselekile ngokubanzi kwaye ineziphumo ebezingalindelekanga ezimbalwa, ukuba zikhona. Kodwa kukho enye i-caveat enkulu: i-CBD inokubanakho ukunxibelelana namanye amayeza. Inkxalabo inento yokwenza nendlela umzimba odibanisa ngayo izinto ezithile.

Ngaphambi kokuzama i-CBD, kubalulekile ukuba uthethe nogqirha wakho malunga nazo zonke iivithamini, izongezo, kunye nonyango kunye namayeza owasebenzisayo. Nantsi inkangeleko enzulu yokuba kutheni incoko ibalulekile.

Imetabolism yeziyobisi kunye ne-CYP450 enzymes

Xa uthatha iyeza okanye enye into, umzimba wakho kufuneka uyisebenzise, ​​okanye uyophule. Imetabolism yeziyobisi yenzeka kuwo wonke umzimba, njengasesiswini, kodwa isibindi senza indima enkulu yomsebenzi, nawo.

Intsapho yee-enzymes ebizwa ngokuba yenza umsebenzi obalulekileyo wokuguqula izinto zangaphandle ukuze zisuswe ngokulula emzimbeni.

Kodwa amanye amayeza okanye izinto zichaphazela i-CYP450, nokuba kungokucothisa okanye ukukhawulezisa imetabolism yeziyobisi. Olo tshintsho kumanqanaba emetabolism anokutshintsha ukuba umzimba wakho uwenza njani amayeza okanye izongezo ozithathayo-kungoko ukuhlangana kweziyobisi.

Kutheni le nto i-CYP450 ibalulekile xa kufikwa kwi-CBD kunye namayeza?

Intsapho ye-CYP450 yee-enzyme inoxanduva lokucoca ii-cannabinoids ezininzi, kubandakanya ne-CBD, iinkqubo zophando. Ngokukodwa, i-CYP3A4, i-enzyme ebalulekileyo kusapho lwe-CYP450, iyawenza lo msebenzi. Kodwa ngexesha lale nkqubo, i-CBD ikwaphazamisa i-CYP3A4.

I-enzyme ye-CYP3A4 inoxanduva lokucoca malunga neepesenti ezingama-60 zonyango olumiselweyo. Kodwa ukuba i-CBD inqanda i-CYP3A4, ayinakusebenza ngokukuko ukuphelisa amayeza kwinkqubo yakho.

Ukuchasana kwenzeka kwakhona. Amayeza amaninzi athintela i-CYP3A4. Ukuba uthatha i-CBD ngelixa usebenzisa la mayeza, umzimba wakho awunakho ukusebenza ukuze uqhubekise i-CBD ngokufanelekileyo.

Ukuba umzimba wakho ucola amayeza ngokucothayo, unokuba namayeza amaninzi kwinkqubo yakho ngexesha elinye kunokuba bekucetyiwe - nokuba unamathele kwidosi yakho yesiqhelo. Inqanaba elonyukayo lamayeza kwinkqubo yakho linokuzibaxa iziphumo zalo, kubandakanya iziphumo ezingafunekiyo okanye eziyingozi.

Ezinye izinto zikwukhawulezisa umsebenzi wosapho lwe-CYP450. Ukuba umzimba wakho uxola amayeza ngokukhawuleza kuba enye into inyanzela ii-enzymes, usenokungabi nalo ngokwaneleyo iyeza kwinkqubo yakho ngaxeshanye ukunyanga umba wezempilo.

Ukuzama i-CBD ngokukhuselekileyo ngelixa usela amayeza

Ukuba ufuna ukuzama i-CBD njengonyango olongezayo ukunciphisa iimpawu zesimo esithile, thetha nogqirha wakho malunga nayo kuqala.

Banokunceda ekumiseleni imveliso ye-CBD, idosi, kunye neshedyuli ekhuselekileyo ngamayeza akho. Kwezinye iimeko, ugqirha wakho unokufuna ukubeka esweni amanqanaba eplasma yegazi lamayeza athile owathathayo.

Sukuyeka nawaphi na amayeza akho ukuzama i-CBD, ngaphandle kokuba ugqirha wakho uthi kukhuselekile ukwenza njalo.

Gcina ukhumbula ukuba i-CBD engundaba-mlonyeni, njengothambiso, iikhrimu kunye neesalves, zisenokukhetha. Ngokungafaniyo neeoyile, izidlo, kunye nezisombululo zomphunga, ii-topicals azihlali zingene kwigazi-okoko nje ayisosisombululo se-transdermal esenzelwe ukwenza njalo.

Unxibelelwano olunokubakho lweziyobisi

Khangela isilumkiso se-grapefruit

Nangona izifundo zisaqhubeka ukumisela unxibelelwano olunokubakho phakathi kwe-CBD kunye namayeza athile, kukho umthetho omnye wesithupha onokuthi uncede abathengi okwangoku: Yiphephe i-CBD ukuba amayeza akho anesilumkiso se-grapefruit kwileyibhile.

Esi silumkiso sibonisa ukuba abantu abathatha amayeza kufuneka bakuphephe ukutya iidiliya okanye ijusi yeziqhamo.

Ngokuka, ukutya igrapefruit ngelixa elinye lala mayeza kungakhokelela kuxinzelelo oluphezulu lwamayeza egazini nakwiziphumo ebezingalindelekanga ezibi okanye nokuba libanda.

Zingaphezulu kwama-85 iziyobisi ezinxibelelana ne-grapefruit kunye nezinye iijusi ezinxulumene ngokusondeleyo- njengee-orenji zaseSeville, i-pomelos kunye ne-tangelos. Kungenxa yokuba iikhemikhali kwisiqhamo somdiliya esaziwa njenge-furanocoumarins zithintela i-CYP3A4, ngendlela efanayo ne-CBD. Isiphumo kukucothiswa kancinci kwamayeza.

Izilumkiso ze-Grapefruit zixhaphake kwiindidi ezahlukeneyo zamayeza, kodwa ayingawo onke amayeza kwicandelo aya kufuna ukuthintela iidiliya. Jonga ulwazi lweyeza lakho okanye ubuze ugqirha wakho.

Iindidi zamayeza ahlala enesilumkiso seediliya

• ii-antibiotics kunye ne-antimicrobials
• amayeza anticancer
• antihistamines
• iziyobisi ezichasene ne-antiepileptic (AEDs)
• uxinzelelo lwegazi amayeza
• abacoci gazi
• amayeza cholesterol
• icorticosteroids
• Ukungasebenzi kakuhle kwamayeza
• Amayeza e-GI, njengokunyanga i-GERD okanye isicaphucaphu
• amayeza esingqi sentliziyo
• imichiza yokucinezeleka komzimba
• amayeza emood, njengokunyanga uxinzelelo, uxinzelelo, okanye ukuphazamiseka kwemood
• amayeza entlungu
• amayeza wendlala

Uphando lwangoku ngokusebenzisana phakathi kwe-CBD kunye namayeza

Abaphandi basebenzela ukumisela unxibelelwano oluthile phakathi kwe-CBD kunye namayeza ahlukeneyo. Izifundo zenziwe kwizilwanyana zamayeza athile, kodwa kwiimeko ezininzi, izazinzulu zisamisela ukuba ezi ziphumo ziguqulela njani ebantwini.

Olunye uvavanyo lwezonyango oluncinci lwenziwe. Umzekelo, kolunye uphononongo lwabantwana abangama-25 abanesifo sokuxhuzula, abantwana be-13 banikwa zombini i-clobazam kunye ne-CBD. Abaphandi bafumana amanqanaba aphezulu e-clobazam kwaba bantwana. Banika ingxelo yokuba ukuthatha i-CBD kunye ne-clobazam kunye kukhuselekile, kodwa bacebisa ngokujonga amanqanaba amayeza ngexesha lonyango.

Kwesinye isifundo, abantu abadala abangama-39 kunye nabantwana abangama-42 abathatha ii-AED banikwa ne-CBD ngohlobo lwe-Epidiolex. Iidosi ze-CBD zonyuswe rhoqo kwiiveki ezi-2.

Abaphandi babeke esweni amanqanaba e-serum ee-AEDs kwizifundo ekuhambeni kwexesha. Ngelixa amanqanaba e-serum ahlala ngaphakathi kuluhlu lwonyango olwamkelekileyo uninzi lwazo, amayeza amabini- i-clobazam kunye ne-desmethylclobazam-yayinamanqanaba e-serum ngaphandle koluhlu lonyango.

Izifundo zokuqala zibonisa ukuba i-CBD ngokuqinisekileyo inokuphazamisa amanqanaba amayeza kwinkqubo yakho, nokuba uthatha idosi oyimiselweyo. Kodwa kufuneka uphando olungaphezulu ukumisela ubungqongqo bokunxibelelana kwe-CBD kumayeza ahlukeneyo kunye nokuphuhlisa izindululo zokuzithatha kunye ne-CBD.

Ukhuseleko kunye neziphumo ebezingalindelekanga

Phantsi kolawulo ngononophelo lukagqirha wakho, usenokukwazi ukusebenzisa i-CBD ngokukhuselekileyo ngamayeza, nkqu nalawo anesilumkiso se-grapefruit.

Ukuba kukho imfuneko, ugqirha wakho unokujonga amanqanaba e-plasma serum amayeza owasebenzisayo. Banokukhetha ukubeka iliso ekusebenzeni kwesibindi.

Ukuba uthatha i-CBD ngamayeza, kubalulekile ukuba ujonge naluphi na utshintsho olunokubakho kwindlela amayeza okanye i-CBD ekuchaphazela ngayo.

Iziphumo ebezingalindelekanga ekufuneka uzilindile

• ukwanda okanye iziphumo ezitsha zonyango, ezinje:
  • ukozela
  • ukuthomalalisa
  • isicaphucaphu
• ukwehla kokusebenza kakuhle kwamayeza, anje ngala:
  • ukuxhamla
• Iziphumo eziqhelekileyo ze-CBD okanye utshintsho kuzo, ezinje:
  • ukudinwa
  • urhudo
  • utshintsho kumdla wokutya
  • utshintsho kubunzima

Thetha nogqirha wakho

Eyona nto iphambili kukuba uhlale udibana nogqirha wakho kuqala ukuba ungathanda ukuzama i-CBD, ngakumbi ukuba unempilo kwaye uthatha amayeza. Sukuyeka ukuthatha amayeza amiselweyo ukuze uzame i-CBD, ngaphandle kokuba uye phambili kugqirha wakho.

Amayeza aza nesilumkiso segrape yeziqhamo kungenzeka ukuba asebenzisane ne-CBD. Nangona kunjalo, nokuba uthatha elinye lala mayeza, ugqirha wakho unokukwazi ukwenza isicwangciso esisebenzelayo ngokujonga kufutshane amanqanaba amayeza kwinkqubo yakho. Ngale ndlela, unokusebenzisa zombini amayeza akho kunye ne-CBD njengonyango.

Ugqirha wakho okanye usokhemesti unokukwazi ukucebisa ngemveliso esemgangathweni ye-CBD ehambelana neemfuno zakho. Unokufumana iimveliso ezinesidima ngophando oluncinci kunye nendlela yokufunda iilebheli ze-CBD.

Ngaba i-CBD isemthethweni? Iimveliso ze-CBD ezenziwe ngeHemp (ezingaphantsi kweepesenti ze-0,3 ze-THC) zisemthethweni kwinqanaba lomdibaniso, kodwa azikho semthethweni phantsi kweminye imithetho yelizwe. Iimveliso ze-CBD ezenziwe ngentsangu azikho semthethweni kwinqanaba lomanyano, kodwa zisemthethweni phantsi kwemithetho ethile karhulumente.Jonga imithetho yelizwe lakho kunye nayo nayiphi na indawo ohamba kuyo. Gcina ukhumbula ukuba iimveliso ze-CBD ezingabhaliswanga azivunyelwanga yi-FDA, kwaye zinokubhalwa ngokungachanekanga.

UJennifer Chesak yintatheli yezonyango kwiimpapasho ezininzi zesizwe, umhlohli wokubhala kunye nomhleli wencwadi ezizimeleyo. Wafumana i-Master of Science kwi-journalism evela eMedill's Northwestern's. Ukwangumhleli olawulayo kwimagazini yoncwadi, Shift. UJennifer uhlala eNashville kodwa uphuma eMantla Dakota, kwaye xa engabhali okanye encamathisa impumlo yakhe encwadini, uhlala ehamba ngemizila okanye ehamba ngegadi yakhe. Mlandele kwi-Instagram okanye kwi-Twitter.