Isifo sesifuba sikaPaget: yintoni, iimpawu kunye nonyango

Umxholo

• Iimpawu zesifo sebele sikaPaget
• Uxilongo lwenziwa njani
• Umahluko ekuchongeni
• Unyango lwezifo zesifuba sikaPaget

Isifo sikaPaget sesifuba, okanye i-DPM, luhlobo olunqabileyo lokuphazamiseka kwebele elihlala linxulumene nezinye iintlobo zomhlaza wamabele. Esi sifo kunqabile ukuba sivele kubantu basetyhini ngaphambi kweminyaka engama-40, esihlala sixilongwa phakathi kweminyaka engama-50 nama-60. Nangona kunqabile, isifo sikaPaget sesifuba sinokuvela emadodeni.

Ukuchongwa kwesifo sebele sikaPaget kwenziwa sisazinzulu ngovavanyo lokuqonda kunye nokuvavanywa kweempawu, ezinjengentlungu kwingono, ukucaphuka kunye nokususwa kwindawo kunye nentlungu kunye nokurhawuzelela kwingono.

Iimpawu zesifo sebele sikaPaget

Iimpawu zesifo sikaPaget zihlala zivela kwisifuba esinye kuphela kwaye zihlala zixhaphakile kwabasetyhini abangaphezulu kweminyaka engama-50, ezona ziphambili zezi:

• Ukucaphuka kwendawo;
• Iintlungu kwingono;
• Ukuchazwa kommandla;
• Ukutshintsha kobume bengono;
• Iintlungu kunye ukurhawuzelela kwingono;
• Ukutshisa imvakalelo kwindawo;
• Ukuqina kwe-areola;
• Ubumnyama besiza, kwiimeko ezinqabileyo.

Kwiimeko ezihambele phambili zesifo sikaPaget, kunokubakho ukubandakanyeka kolusu olujikeleze iarola, ukongeza ekurhoxiseni, ekuguqulweni nasekucingeni kwesilonda kwingono, ke ngoko kubalulekile ukuba unyango luqaliswe ngokukhawuleza.

Ugqirha ofanelekileyo wokuchonga kunye nokukhokela unyango lwesifo sePaget sesifuba sisifo seengcongconi, nangona kunjalo, ukuchongwa nokunyangwa kwesi sifo kungacetyiswa ngugqirha wesikhumba kunye nesigulana. Kubalulekile ukuba uxilongo lwenziwe ngokukhawuleza, kuba ngale ndlela kunokwenzeka ukunyanga ngokuchanekileyo, kunye neziphumo ezilungileyo.

Uxilongo lwenziwa njani

Ukuchongwa kwesifo sikaPaget sesifuba kwenziwa ngugqirha kuvavanyo lweempawu kunye neempawu zesifuba sowasetyhini, ukongeza kwiimvavanyo zokucinga, ezinje nge-ultrasound yebele kunye nemifanekiso yokujonga ngemagneti, umzekelo. Ukongeza, i-mammografi ibonakalisiwe ukuze kujongwe ubukho bezigaqa okanye i-microcalcization ebeleni enokuthi ibonakalise i-carcinoma engenayo.

Ukongeza kwiimvavanyo zokucinga, ugqirha uhlala ecela i-biopsy yengono, ukuze aqinisekise iimpawu zeeseli, ukongeza kuvavanyo lwe-immunohistochemical, oluhambelana nohlobo lovavanyo lwelabhoratri apho ubukho okanye ukungabikho kweeantigen kungqinisisiwe Esinokubonakalisa esi sifo, njenge-AE1, AE3, CEA kunye ne-EMA ezinesifo sikaPaget sesifuba.

Umahluko ekuchongeni

Ukuchongwa okwahlukileyo kwesifo sikaPaget sesifuba kwenziwa ikakhulu yi-psoriasis, i-basal cell carcinoma kunye ne-eczema, umzekelo, ngokwahlulwa kulowo wokugqibela ngenxa yokuba unilateral kunye nokurhawuzelela okuncinci. Ukuchongwa okwahlukileyo kungenziwa kuthathelwa ingqalelo impendulo kunyango, kuba kwisifo sikaPaget, unyango lwezihloko lunokuthomalalisa iimpawu kodwa alunampembelelo iqinisekileyo, ngokuphinda-phinda.

Ukongeza, isifo sesifuba sikaPaget, xa sine-pigment, kufuneka sahlulwe kwi-melanoma, kwaye oku kwenzeka ikakhulu kuvavanyo lwe-histopathological, olwenziwa ukuvavanya iiseli zebele, kunye ne-immunohistochemistry, ekukho kuyo ubukho be-HMB-45, I-MelanA kunye ne-S100 antigens kwi-melanoma kunye nokungabikho kwe-AE1, AE3, CEA kunye ne-EMA antigens, eziqhelekileyo kwisifo sePaget sesifuba, azikho.

Unyango lwezifo zesifuba sikaPaget

Unyango oluboniswe ngugqirha kwisifo sikaPaget sesifuba sihlala silandelwa sisifo se-chemotherapy okanye unyango ngemitha, kuba esi sifo sihlala sihambelana ne-carcinoma ehlaselayo. Kwiimeko ezinganabisi kangako, kunokuboniswa ukususwa ngotyando kommandla owonzakeleyo, kugcinwe lonke isifuba. Ukuchongwa kwangoko kubalulekile ukuthintela kungekuphela ukuqhubela phambili kwesifo, kodwa kunye nonyango lotyando.

Ngamanye amaxesha ugqirha unokukhetha ukwenza unyango ngaphandle kokuqinisekisa isifo, ebonisa ukuba usebenzisa amayeza asemxholweni. Ingxaki enxulumene nolu hlobo lokuziphatha kukuba la machiza anokuzinciphisa iimpawu, nangona kunjalo azithinteli ukuqhubela phambili kwesi sifo.