Abaxhasi beNkqubo yokuKhusela iZifo zeSifo sikaCrohn

Umxholo

• I-Azathioprine
• Imercaptopurine
• Imethotrexate
• Izinto ekufuneka uzigcine engqondweni

Ushwankathelo

Akukho nonyango yesifo sikaCrohn, ngoko ukukhululeka kwempawu kuza ngendlela yokuxolelwa. Zininzi iindlela zonyango ezikhoyo ezinokunceda ukunciphisa iimpawu zakho. Amajoni omzimba iziyobisi eziguqula amajoni omzimba.

Kumntu oneCrohn's, oku kunokunceda ukunciphisa ukudumba okubangela iimpawu ezininzi.

Ama-Immunomodulators abandakanya iziyobisi ezenza i-immunosuppressants kunye ne-immunostimulants. Ama-immuneosuppressants athintela ukhuseleko komzimba, kodwa uxinzelelo lokuzikhusela komzimba lungabeka umzimba emngciphekweni omkhulu wezinye izifo.

Amajoni omzimba ayonyusa okanye "avuselele" amajoni omzimba, akhuthaza umzimba ukuba uqale ukulwa nezifo.

Kukho iintlobo ezahlukeneyo ze-immunomodulators, nganye ithengiswa phantsi kwegama layo lophawu. I-Azathioprine, i-mercaptopurine, kunye ne-methotrexate zezona ntlobo zintathu ziphambili.

I-Azathioprine

I-Azathioprine ihlala isetyenziswa kubantu abafumana ukufakelwa kwamalungu ukuthintela umzimba ukwala ilungu elitsha ngokucinezela amajoni omzimba. Isetyenziselwa ukunyanga isifo samathambo, yimeko apho umzimba womntu uhlasela amalungu abo.

Nangona i-azathioprine ingakhange ibonakaliswe iyasebenza ukunciphisa iimpawu zeCrohn zexesha elifutshane okanye ukufezekisa ukuxolelwa, inokunciphisa isidingo sonyango lwe-steroid. Uphando lubonisa ukuba i-azathioprine inceda ukugcina abantu bexolelwe emva kokuba iimpawu zikaCrohn ziphantsi kolawulo.

Ngesi sizathu, Ikholeji yaseMelika yeGastroenterology ixhasa ukusebenzisa i-azathioprine yabantu abaxolelweyo okanye abasenazo iimpawu ngaphandle kokusebenzisa ii-steroids.

Kukho ezinye ezinqabileyo, kodwa ezinzima, iziphumo ebezingalindelekanga ze-azathioprine. Eli chiza lenza ukuba umzimba wakho uvelise iiseli ezimhlophe zegazi ezimbalwa. Oku kunokubangela iingxaki kuba iiseli ezimhlophe zegazi zilwa nosulelo.

Abantu abathatha i-azathioprine banokufumana nokudumba kwepancreas okanye umngcipheko ophezulu wokukhula kwe-lymphoma.

Ngenxa yezi ziphumo bezingalindelekanga, i-azathioprin ihlala ichazwa kuphela kumodareyitha ukuya kumatyala amabi eCrohn's. Kuya kufuneka uthathele ingqalelo yonke ingozi ngaphambi kokuba uthathe i-azathioprine. Unokuvavanywa kwakhona ukusilela kwe-TPMT, enokuchaphazela amajoni akho omzimba.

Imercaptopurine

I-Mercaptopurine, ekwabizwa ngokuba yi-6-MP, iyaziwa ukuyeka iiseli zomhlaza ekukhuleni. Eli chiza lihlala lisetyenziselwa ukunyanga i-leukemia. Kubantu abane-Crohn's, i-mercaptopurine inokunceda ukugcina uxolelo.

I-Mercaptopurine inokunciphisa ukuveliswa kweeseli ezimhlophe ezibomvu. Ugqirha wakho uya kufuna ukuqhuba iimvavanyo zegazi rhoqo ukuqinisekisa ukuba akukho monakalo kumnkantsha wakho wethambo. Unokuvavanywa kwakhona ukusilela kwe-TPMT, enokuchaphazela amajoni akho omzimba.

Ezinye iziphumo ebezingalindelekanga ze-mercaptopurine zingabandakanya:

• izilonda zomlomo
• ifiva
• umqala obuhkungu
• igazi kumchamo okanye isitulo

Kuya kufuneka uthathele ingqalelo zonke iziphumo ebezingalindelekanga ezinokubakho ngaphambi kokuba uqale unyango.

Imethotrexate

I-Methotrexate ibhloka isetabolism yeseli, ebangela ukuba iiseli zife. Oku kukhokelele ekusetyenzisweni kwayo kwesifo sikaCrohn, umhlaza, kunye ne-psoriasis.

Ikholeji yaseMelika yeGastroenterology ixhasa ukusebenzisa i-methotrexate ukunyanga iimpawu zesifo sikaCrohn kubantu abaxhomekeke kwii-steroids. I-Methotrexate ikwanceda ukugcina abantu abane-Crohn's kuxolelo.

Nangona kunjalo, i-methotrexate ineziphumo ebezingalindelekanga ezibandakanya ubungozi besibindi okanye umongo wethambo kwaye, kwiimeko ezinqabileyo, ubuthi bemiphunga. Amadoda okanye abafazi abazama ukukhulelwa akufuneki basebenzise eli chiza. Iziphumo ebezingalindelekanga ezimbi zibandakanya:

• intloko ebuhlungu
• ukozela
• irhashalala
• isicaphucaphu nokugabha
• ukulahleka kweenwele

Izinto ekufuneka uzigcine engqondweni

Ama-Immunomodulators anokunceda ukulwa neempawu ezinxulumene nesifo sikaCrohn, kodwa ziyaphazamisa ukukwazi komzimba wakho ukulwa nosulelo. Ngelixa uthatha ii-immunomodulators, nikela ingqalelo kuyo nayiphi na imiqondiso yosulelo, enjengomkhuhlane okanye ukugodola.

Ukuba uvelisa ezi mpawu, nxibelelana nogqirha ngokukhawuleza.

Nangaliphi na ixesha uthatha ii-immunomodulators, qiniseka ukuba ugqirha wakho uvavanya igazi lakho rhoqo ngeempawu zomonakalo kumathambo akho nakwizitho zangaphakathi.

Abanye oomatshini bokuzikhusela emzimbeni bangakulunga ukuthatha ngexesha lokukhulelwa, kodwa kuya kufuneka uxoxe ngeenzuzo kunye nobubi bokuqala amayeza amatsha nogqirha wakho kuqala. Kuya kufuneka uthethe nogqirha wakho ukuba ukhulelwe okanye, nokuba uyindoda okanye umfazi, unokukhulelwa.