Iimpawu zeParkinson's: Amadoda ngokuchasene nabafazi

Umxholo

• Ukubonisa iimpawu
• Amandla engqondo kunye nokuhamba kwemisipha
• Ukuchaza nokutolika imvakalelo
• Umahluko wokulala
• Ukukhuselwa kwe-Estrogen
• Iingxaki zonyango
• Ukujamelana nePD

Isifo sikaParkinson kumadoda nabasetyhini

Amadoda amaninzi kunabafazi afunyaniswa ukuba unesifo sika-Parkinson's (PD) phantse nge-2 ukuya kwi-1 margin. Izifundo ezininzi zixhasa eli nani, kubandakanya nophando olukhulu kwiAmerican Journal of Epidemiology.

Ngokwesiqhelo kukho isizathu somzimba somahluko kwisifo phakathi kwamadoda nabasetyhini. Kukhusela njani ukuba ngumfazi ngokuchasene nePD? Kwaye ngaba abantu basetyhini kunye namadoda bafumana iimpawu zePD ngokwahlukileyo?

Ukubonisa iimpawu

Abasetyhini bakhulisa iPD ngokufuthi kunamadoda. Xa bephuhlisa iPD, ubudala bokuqala yiminyaka emibini kamva kunamadoda.

Xa abafazi befunyaniswa okokuqala, ukungcangcazela kuhlala kungoyena mpawu ubalaseleyo. Iimpawu zokuqala emadodeni zihlala zihamba kancinci okanye zihamba nzima (bradykinesia).

Uhlobo olonyikimayo lwe-PD lunxulunyaniswa nenkqubela phambili yesifo kunye nomgangatho wobomi.

Nangona kunjalo, abasetyhini bahlala bexela ukoneliseka okuncinci ngomgangatho wabo wobomi, nokuba kukwinqanaba elifanayo leempawu.

Amandla engqondo kunye nokuhamba kwemisipha

I-PD inokuchaphazela amandla engqondo kunye nokuziva kunye nolawulo lwemisipha.

Kukho ubungqina bokuba amadoda nabasetyhini bachaphazeleka ngokwahlukileyo. Umzekelo, amadoda abonakala egcina amandla angcono okuqonda imeko yendawo. Abafazi, kwelinye icala, bagcina ukuthetha ngokutyibilikayo.

Ezi ntlobo zezakhono azichatshazelwa ngokwesini kuphela, kodwa "nasecaleni" leempawu zePD. Icala lasekhohlo okanye icala lasekunene leempawu ezibonisa ukuqala kweliphi icala lobuchopho elinokusilela okukhulu kwe-dopamine.

Umzekelo, unokuba nobunzima ngakumbi kulawulo lwemisipha kwicala lasekhohlo lomzimba wakho ukuba unesifo se-dopamine kwicala lasekunene lengqondo yakho.

Izakhono ezahlukeneyo, ezinje ngamakhono endawo, zibalasele kwicala elithile lobuchopho.

Ukuchaza nokutolika imvakalelo

Ukuqina kwe-PD kunokubangela ukuba izihlunu zobuso "zibambe". Oku kukhokelela kwintetho efana nemaski. Ngenxa yoko, abaguli abanePD banobunzima bokuchaza iimvakalelo ngobuso babo. Banokuqalisa nokuba nobunzima ekutolikeni imbonakalo yobuso yabanye.

Olunye uphononongo lubonisa ukuba amadoda nabafazi abane-PD banokuba nobunzima ekutolikeni umsindo kunye nokothuka, kwaye amadoda kunokwenzeka ukuba aphulukane namandla okutolika uloyiko.

Nangona kunjalo, abasetyhini banokucaphuka ngakumbi kukungakwazi kwabo ukutolika iimvakalelo. Zonke izigulana zePD zinokuxhamla kwintetho kunye nonyango lomzimba ukunceda le mpawu.

Umahluko wokulala

Ingxaki yokuziphatha kwamehlo ekhawulezileyo (RBD) sisifo sokulala esenzeka ngexesha lokulala kwe-REM.

Ngokuqhelekileyo, umntu oleleyo akanayo ithoni yezihlunu kwaye akashukumi xa elele. Kwi-RBD, umntu unokuhambisa amalungu kwaye abonakale esenza amaphupha abo.

I-RBD yenzeka ngokungaqhelekanga, kodwa rhoqo kubantu abanezifo ezingenayo i-neurodeergenerative. Phantse iipesenti ezili-15 zabantu abanePD banayo i-RBD, ngokuPhononongo lwangaphakathi lwe-Psychiatry. Amadoda kunokwenzeka kakhulu ukuba abe nale meko kunabafazi.

Ukukhuselwa kwe-Estrogen

Kutheni le nto umahluko kwiimpawu zePD phakathi kwamadoda nabasetyhini? Kubonakala ngathi ukubonakaliswa kwe-estrogen kukhusela abasetyhini kwinkqubela phambili yePD.

Isifundo esapapashwa kufunyenwe ukuba owasetyhini ofumana ukuyeka ukuya exesheni, okanye onabantwana abaninzi, kunokwenzeka ukuba ulibazisile ukuqala kweempawu zePD. Zombini ezi zimpawu zokuvezwa kwe-estrogen ebomini bakhe.

Into engekacaciswa ngokupheleleyo kukuba kutheni i-estrogen inesi siphumo. Isifundo kwiAmerican Journal of Psychiatry sibonise ukuba abasetyhini bane-dopamine ekhoyo ngakumbi kwiindawo eziphambili zobuchopho. I-Estrogen inokusebenza njenge-neuroprotectant yomsebenzi we-dopamine.

Iingxaki zonyango

Abasetyhini abanePD banokuhlangabezana neengxaki ezininzi ngexesha lonyango lweempawu zabo zePD kunamadoda.

Abasetyhini bafumana utyando ngokufuthi kunamadoda, kwaye iimpawu zabo ziba nzima kakhulu ngexesha lokuhlinzwa. Kwakhona, uphuculo olufunyenwe kuqhaqho lusenokungabi lukhulu.

Iziyobisi zokunyanga iimpawu ze-PD zinokuchaphazela abantu basetyhini ngokwahlukileyo. Ngenxa yesisindo esisezantsi somzimba, abasetyhini bahlala bevezwa kumayeza aphezulu. Le ibiyingxaki nge-levodopa, lelinye lawona mayeza aqhelekileyo ePD.

Ukuvezwa okuphezulu kunokukhokelela kwinqanaba elonyukayo leziphumo ebezingalunganga, njenge-dyskinesia. IDyskinesia inzima ukwenza intshukumo yokuzithandela.

Ukujamelana nePD

Amadoda nabasetyhini bahlala bephendula ngeendlela ezahlukeneyo kumava okuphila ngePD.

Abasetyhini abanePD bahlala benamaqondo aphezulu oxinzelelo kunamadoda anePD. Bafumana amayeza oxinzelelo rhoqo.

Amadoda anokuba neengxaki zokuziphatha ngakumbi kunye nobundlongondlongo, njengomngcipheko omkhulu wokuhambahamba kunye nokuziphatha okungafanelekanga okanye okuhlukumezayo. Amadoda kunokwenzeka ukuba afumane amayeza antipsychotic ukunyanga le ndlela yokuziphatha.