I-R-CHOP Chemotherapy: Iziphumo ebezingalindelekanga, idosi kunye nokunye

Umxholo

• Yintoni i-R-CHOP ephatha ngayo?
• Isebenza njani i-R-CHOP?
• IRituximab (Rituxan)
• ICyclophosphamide (iCytoxan)
• I-Doxorubicin hydrochloride (Adriamycin, iRubex)
• UVincristine (uOncovin, uVincasar PFS, uVincrex)
• IPrednisolone
• Inikwa njani?
• Zeziphi iziphumo ezinokubakho?
• Yintoni ekufuneka uyazi ngaphambi kokuba uqale unyango?
• Yintoni enye ekufuneka uyazi?

Yintoni i-R-CHOP chemotherapy?

Amachiza e-Chemotherapy anganciphisa amathumba okanye abulale iiseli zomhlaza ezilahlekileyo ezishiyeke ngasemva kotyando okanye ngemitha. Ikwayinkqubo yonyango, oko kuthetha ukuba injongo yayo kukubulala iiseli zomhlaza emzimbeni wakho wonke.

Onke amayeza e-chemotherapy asebenza ukubulala iiseli zomhlaza, kodwa azenza ngeendlela ezahlukeneyo. Kungenxa yoko le nto oncologists bahlala bekhetha indibaniselwano yamachiza. Basekela ukhetho lwabo kwizinto ezinje ngohlobo lomhlaza onawo, ukuba sele isasazeke kangakanani, kunye nempilo yakho iyonke.

I-R-CHOP ibandakanya amayeza amahlanu e-chemotherapy:

• rituximab (Rituxan)
• cyclophosphamide
• doxorubicin hydrochloride
• iincincine (iOncovin, iVincasar PFS)
• yingca

Unokufumana i-R-CHOP kunye okanye ngaphandle kwezinye iindlela zonyango ezinje ngokuhlinzwa kunye nonyango lwemitha.

Yintoni i-R-CHOP ephatha ngayo?

Oogqirha ikakhulu basebenzisa i-R-CHOP ukunyanga i-non-Hodgkin lymphoma (NHL) kunye nezinye ii-lymphomas. I-Lymphoma ngumhlaza oqala kwinkqubo ye-lymphatic.

I-R-CHOP inokunyanga nezinye iintlobo zomhlaza.

Isebenza njani i-R-CHOP?

Amachiza amathathu kwi-R-CHOP anamandla e-cytotoxics, oko kuthetha ukuba abulala iiseli. Olunye luhlobo lwe-immunotherapy kwaye eyokugqibela yi-steroid, ebonakalise ukuba ineziphumo ze-anticancer.

IRituximab (Rituxan)

I-Rituximab isetyenziselwa ukunyanga i-NHL. Yintsholongwane yomntu omnye. Ijolise kwiprotein ebizwa ngokuba yiCD20 kumphezulu weeseli ezimhlophe zegazi ezibizwa ngokuba zii “B cells. Nje ukuba ichiza linamathele kwiiseli ze-B, amajoni akho omzimba ahlasela kwaye abulale.

ICyclophosphamide (iCytoxan)

Eli chiza linokunyanga iintlobo ezahlukeneyo zomhlaza, kubandakanya i-lymphoma kunye nomhlaza webele kunye nomphunga. I-Cyclophosphamide ijolise kwi-DNA yeeseli zomhlaza kwaye ibonakalise ukuba ziyeke ukwahlulahlula.

I-Doxorubicin hydrochloride (Adriamycin, iRubex)

Eli yeza liyi-anthracycline enokunyanga iintlobo ezininzi zomhlaza, kubandakanya ibele, imiphunga kunye nomhlaza we-ovari. Iibhloko ze-Doxorubicin ezinesifo somhlaza se-enzyme kufuneka zikhule kwaye zivelise. Umbala oqaqambileyo obomvu uye wawufumana igama lesidlaliso "umtyholi obomvu."

UVincristine (uOncovin, uVincasar PFS, uVincrex)

I-Vincristine yi-alkaloid enokunyanga iintlobo ezininzi zomhlaza, kubandakanya nomhlaza webele ophambili, i-lymphomas, kunye neleukemia. Iphazamisana nemfuza ukuwayeka angaphindeki. Eli chiza linqabileyo, oko kuthetha ukuba linokonakalisa izicwili kunye neenqanawa.

IPrednisolone

Eli chiza yi-corticosteroid ekhoyo phantsi kwegama lophawu. Ngokungafaniyo nabanye, eli liyeza lonyango. Isebenza kunye namajoni akho omzimba ukunceda ukunciphisa:

• ukudumba
• isicaphucaphu
• ukugabha
• negazi lakho
• amanqanaba eeplatelet asezantsi, okanye thrombocytopenia
• amanqanaba aphezulu e-calcium, okanye i-hypercalcemia

Ngokudibeneyo, la machiza enza i-cocktail yokulwa nomhlaza.

Inikwa njani?

Umthamo omiselweyo usekwe kubude kunye nobunzima. Ugqirha wakho uya kuqwalasela nayiphi na eminye imeko yezempilo onayo, ubudala bakho, kunye nendlela abakulindele ngayo ukuba uyinyamezele amayeza xa usenza isigqibo sokulinganisa kunye nenani lemijikelezo.

Abantu ngokubanzi bafumana la machiza rhoqo emva kweeveki ezimbini ukuya kwezintathu. Ngokwesiqhelo, oogqirha banika iyonke iidosi okanye imijikelezo ubuncinci. Unyango luya kuthatha iiveki ezili-18 okanye ngaphezulu ukuba unemijikelezo eyongezelelweyo.

Phambi konyango ngalunye, uyakufuna uvavanyo lwegazi ukukhangela ukubalwa kwegazi kunye nokufumanisa ukuba isibindi sakho kunye nezintso zisebenza ngokwaneleyo. Ukuba azikho, ugqirha wakho unokufuna ukulibazisa unyango lwakho okanye ukunciphisa umthamo wakho.

Unyango lomntu ngamnye lunokuthatha iiyure ezininzi, kwaye umboneleli wezempilo uya kukunyanga amayeza ngokufaka ngaphakathi, okuthetha ngomthambo engalweni yakho. Unokuyifumana kwizibuko ugqirha anokulifaka esifubeni sakho. Kuya kufuneka uhlale esibhedlele ukuze ufumane unyango lwakho, kodwa abantu banokulufumana kwiziko lokumnika abagulayo ngaphandle.

Uya kuhlala ujongisiswe. Ngexesha lonyango lokuqala, ababoneleli ngezempilo baya kukujonga ngononophelo kuyo nayiphi na imiqondiso yokuphendula komzimba okanye enye into esongela ubomi kunyango lomhlaza ekuthiwa yi-tumor lysis syndrome.

I-Prednisolone sisiyobisi somlomo osithatha ekhaya iintsuku ezimbalwa emva kokufumana amanye amayeza.

Zeziphi iziphumo ezinokubakho?

Amachiza e-Chemotherapy ahlasela iiseli zomhlaza. Banokonakalisa iiseli ezisempilweni kwinkqubo. Kungenxa yoko le nto kukho iziphumo ebezingalindelekanga ezininzi ezinokubakho. Akunakulindeleka ukuba ube nazo zonke.

I-Chemotherapy ichaphazela wonke umntu ngokwahlukileyo. Iziphumo ebezingalindelekanga zinokutshintsha ukuba ukule mithi ixesha elide, kodwa zihlala zisesikhashana. Iqela lakho lokhathalelo lwempilo linokubonelela ngolwazi ngendlela yokujongana nazo.

Iziphumo ebezingalindelekanga zixhaphakileyo zezi:

• Ukucaphuka malunga nendawo efakwa ngaphakathi okanye efrijini
• umchamo obomvu okanye opinki iintsuku ezimbalwa ngenxa ye-doxorubicin
• utshintsho lokutya
• utshintsho lobunzima
• ukuqunjelwa
• isicaphucaphu
• ukugabha
• ukudinwa
• ubunzima bokulala
• ubalo lwegazi olusezantsi
• ianemia
• ukuphuma kwempumlo
• impumlo esibalekayo
• iintsini ezophayo
• izilonda zomlomo
• izilonda zomlomo
• ukulahleka kweenwele
• ukulahleka kokuya esikhathini, okanye i-amenorrhea
• ukulahleka kokuchuma
• ukuya exesheni kwangoko
• ubuntununtunu besikhumba
• iingxaki zemithambo-luvo, okanye i-neuropathy

Iziphumo eziqhelekileyo ezichaphazelekayo zingabandakanya:

• irhashalala ngenxa yolusu
• ukutshisa okanye ukuqaqanjelwa ngumchamo
• utshintsho kwincasa
• utshintsho kwiminwe kunye neenzwane
• utshintsho kwimisipha yentliziyo
• urhudo

Iziphumo ebezingalindelekanga ezinqabileyo zibandakanya utshintsho kwizicubu zemiphunga kunye nokuphuhlisa olunye uhlobo lomhlaza kwixesha elizayo.

Yintoni ekufuneka uyazi ngaphambi kokuba uqale unyango?

Ngaphambi kokuba uqale i-chemotherapy, uya kudibana ne-oncologist yakho. Eli lixesha lokubuza imibuzo malunga nento onokuyilindela ngexesha nasemva konyango. Landela ezi ngcebiso:

• Tshela ugqirha wakho ukuba uthatha iipilisi zokulawula ukuzalwa, amanye amayeza, okanye izongezo zokutya. Ezinye zezi mveliso, nkqu nezo zingaphaya kwekhawuntara, zinokubangela unxibelelwano olubi.
• Ukuba okwangoku uncancisa, kuya kufuneka uyeke kuba la machiza anokugqitha kubisi lwebele usana lwakho.
• Tshela ugqirha wakho ukuba ucinga ukuba unokukhulelwa. La machiza anokulimaza usana lwakho kwaye abangele iziphene zokuzalwa.
• Amachiza e-Chemotherapy anokuchaphazela ukuchuma kwakho kunye nokuya exesheni kwangoko. Ukuba ucwangcisa usapho, thetha nogqirha wakho malunga nokukhetha ucwangciso losapho kunye nokudibana nengcali yezokuzala xa kukho imfuneko ngaphambi konyango lwakho lokuqala.
• Amachiza e-Chemotherapy achaphazela amajoni akho omzimba. Musa ukufumana naluphi na ugonyo ngexesha le-chemotherapy, kwaye ubuze ugqirha wakho ukuba kuya kukhuseleka nini ukwenza njalo.
• Iziphumo ebezingalindelekanga ezivela kwikhemotherapy kulindeleke, kodwa zinokulawulwa ngamayeza, amayeza ekhaya, kunye nonyango olongezelelekileyo. Unganqikazi ukuthetha nodokotela wakho malunga nemiphumo emibi.

Yintoni enye ekufuneka uyazi?

Njengoko iiveki zihamba, uya kuziqhelanisa neshedyuli yonyango, kodwa iziphumo ebezingalindelekanga zinokuqhubeka. Usenokudinwa ngakumbi. Ingcinga efanelekileyo yokuba nomnye umntu akuqhubele ukuya nokubuya kwikhemotherapy kwaye akuxhase ngezinye iindlela ngexesha lonyango.

Ezi ngcebiso zinokukunceda ukuba ube ne-chemotherapy ukhululeke ngakumbi kwaye ungabi noxinzelelo:

• Nxiba iimpahla ezintle kwaye uze nejezi okanye ingubo. Abanye abantu bade beze nomqamelo abawuthandayo okanye iisiliphu.
• Yiza nezinto zokufunda okanye imidlalo ukuhambisa ixesha.
• Ukuba udiniwe, zivumele ukuba ukhe ulale ngexesha lonyango.
• Xelela umongikazi okanye ugqirha wakho ukuba unempawu ezingaqhelekanga.

Ngaphandle kwekhemotherapy, kubalulekile ukwenza oku kulandelayo:

• Qhubeka nokutya ukutya okunesondlo, nokuba awunamdla wokutya.
• Sela amanzi amaninzi kwaye uhlale unamanzi.
• Phumla ngokwaneleyo.
• Thatha inxaxheba kwimisebenzi yomzimba xa unakho.
• Funa uncedo ngemisebenzi yasekhaya kunye nakwezinye izinto.
• Kuphephe ukuba phakathi kwabantu abanezifo ezosulelayo kuba amajoni akho omzimba aya kuba buthathaka.
• Hlala ubandakanyeka ekuhlaleni kunye nosapho kunye nabahlobo, kodwa zithathe ixesha lakho xa ufuna ukwenza njalo.