Ukusilela kovavanyo

Ukungaphumeleli kwamatyhalarha kwenzeka xa amasende engenako ukuvelisa amadlozi okanye iihomoni zesilisa, ezinje nge testosterone.

Ukungaphumeleli kovavanyo akuqhelekanga. Izizathu zibandakanya:

• Amayeza athile, kubandakanya i-glucocorticoids, i-ketoconazole, i-chemotherapy, kunye neyeza leentlungu ze-opioid
• Izifo ezichaphazela ityhalarha, kubandakanya i-hemochromatosis, uqwilikana, i-orchitis, umhlaza wamatyhalarha, ityhalarha, kunye ne-varicocele
• Ukwenzakala okanye ukwenzakala kumatyhalarha
• Ukutyeba kakhulu
• Izifo zemfuza, ezinje ngesifo seKlinefelter okanye iPrader-Willi syndrome
• Ezinye izifo, ezinje ngecystic fibrosis

Oku kulandelayo kunokunyusa umngcipheko wokusilela kwamatyhalarha:

• Imisebenzi ebangela ukwenzakala okungagungqiyo, kwinqanaba eliphantsi kwisingxobo samatyhalarha, njengokukhwela isithuthuthu okanye ibhayisekile
• Ukusetyenziswa rhoqo kunye nobunzima bentsangu
• Amatyhalarha angalungiswanga ekuzalweni

Iimpawu zixhomekeke kubudala xa ukusilela kwamatyhalarha kukhula, nokuba ngaphambi okanye emva kokufikisa.

Iimpawu zingabandakanya:

• Nciphisa ukuphakama
• Ukwandiswa kwamabele (gynecomastia)
• Ukungachumi
• Ukuphulukana nobunzima bemisipha
• Ukungabikho kokuqhuba ngesondo (libido)
• Ukuphulukana nekhwapha kunye neenwele zasesidlangalaleni
• Ukukhula kancinci okanye ukunqongophala kweempawu zesini sesibini (ukukhula kweenwele, ukwandiswa kwesototum, ukwandiswa kwepenisi, ukutshintsha kwelizwi)

Amadoda anokuqaphela ukuba akukho mfuneko yokuba achebe rhoqo.

Uvavanyo lomzimba lunokubonisa:

• Izitho zangasese ezingabonakali ngokucacileyo ukuba yindoda okanye ibhinqa (zihlala zifumaneka ebusaneni)
• Amancinci amancinci ngokungaqhelekanga
• Ithumba okanye ubunzima obungaqhelekanga kwitestende okanye kwisingxobo samatyhalarha

Olunye uvavanyo lunokubonisa ukuxinana kwethambo kunye nokuqhekeka. Uvavanyo lwegazi lunokubonisa inqanaba eliphantsi le testosterone kunye namanqanaba aphezulu eprolactin, FSH, kunye ne-LH (ichonga ukuba ingxaki iphambili okanye yesibini).

Ukuba inkxalabo yakho kukuchuma, umboneleli wakho wokhathalelo lwempilo unokuyalela uhlalutyo lobudoda ukuvavanya inani lesidoda esisempilweni olivelisayo.

Ngamanye amaxesha, i-ultrasound yamatyhalarha iya kuyalelwa.

Ukungaphumeleli kovavanyo kunye nenqanaba eliphantsi le testosterone kunokuba nzima ukufumanisa isifo kumadoda amadala kuba inqanaba le testosterone ngesiqhelo liyancipha kancinci ngobudala.

Izongezo zehomoni yamadoda zinokunyanga ezinye iindlela zokusilela kwamatyhalarha. Olu nyango lubizwa ngokuba lonyango lwe testosterone olutshintshayo (TRT). I-TRT inokunikwa njengejeli, isiziba, inaliti, okanye ukufakelwa.

Ukuthintela iyeza okanye umsebenzi obangela ingxaki kunokubuyisa umsebenzi wamatyhalarha ubuyele esiqhelweni.

Iindlela ezininzi zokusilela kwamatyhalarha azinakubuyiselwa umva. I-TRT inokunceda ukuguqula iimpawu, nangona isenokungayibuyisi inzala.

Amadoda ane-chemotherapy enokubangela ukusilela kwamatyhalarha kufuneka axoxe ngeesampulu zesidoda ngaphambi kwexesha lonyango.

Ukusilela kwamatyhalarha okuqala ngaphambi kokufikisa kuya kumisa ukukhula komzimba okuqhelekileyo. Inokuthintela iimpawu zabantu abadala (ezinjengezwi elinzulu kunye neendevu) ekuphuhliseni. Oku kunganyangwa nge-TRT.

Amadoda akwi-TRT kufuneka ajongwe ngononophelo ngugqirha. I-TRT inokubangela oku kulandelayo:

• Iprostate eyandisiweyo, ekhokelela kubunzima bokuchama
• Amahlwili egazi
• Utshintsho ekulaleni nasekudleni

Tsalela umnxeba kwindibano kunye nomboneleli wakho ukuba uneempawu zokusilela kwamatyhalarha.

Biza umnikezeli wakho ukuba uku-TRT kwaye ucinga ukuba uneziphumo ebezingalindelekanga kunyango.

Gwema imisebenzi enobungozi obuphezulu xa kunokwenzeka.

I-hypogonadism yaseprayimari-eyindoda

• I-anatomy yovavanyo
• I-anatomy yokuzala eyindoda

UAllan CA, uMcLachlan RI. Ukuphazamiseka kweAndrogen. Ku: Jameson JL, De Groot LJ, de Kretser DM, et al, ii-eds. Endocrinology: Abantu abadala kunye nabantwana. Umhla wesi-7. IPhiladelphia, PA: Elsevier Saunders; 2016: isahluko 139.

Umthengisi weMorgenter A, uZitzmann M, u-AM owonzakeleyo, et al. Iikhonsepthi ezisisiseko ngokubhekisele kunqongophala kwe-testosterone kunye nonyango: izigqibo zesivumelwano seengcali zamanye amazwe. Ikliniki yaseMayo. Ngo-2016; 91 (7): 881-896. IINKCUKACHA: 27313122 www.ncbi.nlm.nih.gov/pubmed/27313122.

Iwebhusayithi yoLawulo lwezoKutya kunye nokuSebenzisa iziyobisi. Unxibelelwano ngokhuseleko lweziyobisi lwe-FDA: I-FDA iyalumkisa malunga nokusebenzisa iimveliso ze testosterone ze testosterone esezantsi ngenxa yokuguga; Ifuna ukutshintsha iilebheli ukwazisa ngobungozi obunokubakho bokuhlaselwa sisifo sentliziyo kunye nokubetha ngokusetyenziswa. www.fda.gov/Drugs/DrugSafety/ucm436259.htm. Ukuhlaziywa ngoFebruwari 26, 2018. Kufikeleleke ngoMeyi 20, 2019.