I-lupus erythematosus ebangelwa ziziyobisi

I-lupus erythematosus ebangelwa ziziyobisi kukuphazamiseka komzimba okuzenzekelayo okubangelwa kukusabela kunyango.

I-lupus erythematosus ebangelwa ziziyobisi iyafana kodwa ayifani nenkqubo ye-lupus erythematosus (SLE). Sisifo sokuzimela. Oku kuthetha ukuba umzimba wakho uhlasela izicwili ezisempilweni ngempazamo. Kubangelwa ukusabela kumayeza. Iimeko ezinxulumene noko zibangelwa sisiyobisi se-lupus kunye ne-ANCA vasculitis.

Amayeza aqhelekileyo awaziwayo abangela i-lupus erythematosus ebangelwa ngamachiza zezi:

• Isoniazid
• IHydralazine
• IProcainamide
• I-tumor-necrosis factor (TNF) i-alpha inhibitors (njenge-etanercept, infliximab kunye ne-adalimumab)
• I-minocycline
• Iquinidine

Ezinye iziyobisi ezingaqhelekanga zinokubangela imeko. Oku kunokubandakanya:

• Amayeza okuthintela ukuhlutha
• ICapoten
• Chlorpromazine
• IMethyldopa
• Isulfasalazine
• I-Levamisole, ngesiqhelo ingcoliseko lwecocaine

Umhlaza iziyobisi ze-immunotherapy ezinje nge-pembrolizumab zinokubangela iindlela ezahlukeneyo zokuziphendulela komzimba kubandakanya ne-lupus ebangelwa ziziyobisi.

Iimpawu zelupus ezibangelwa ngamachiza zihlala zenzeka emva kokuba uthathe ichiza ubuncinci iinyanga ezi-3 ukuya kwezi-6.

Iimpawu zingabandakanya:

• Ifiva
• Imvakalelo yokugula ngokubanzi (malaise)
• Intlungu edibeneyo
• Ukudumba ngokudibeneyo
• Ukuphelelwa ngumdla wokutya
• Intlungu yesifuba sePleuritic
• Ukuqubuka kolusu kwiindawo ezikhanyiswe lilanga

Umboneleli wezempilo uya kwenza uvavanyo lomzimba kwaye amamele isifuba sakho nge-stethoscope. Umboneleli unokuva isandi esibizwa ngokuba kukukhuhlana kwentliziyo okanye ukuruthana komlo.

Uvavanyo lolusu lubonisa irhashalala.

Amalungu angadumba kwaye athambe.

Uvavanyo olunokwenziwa lunokubandakanya:

• Ulwahlulo lomzimba
• Iphaneli yeantinuclear antibody (ANA)
• Iphaneli yeAntineutrophil cytoplasmic antibody (ANCA)
  
• Gcwalisa ubalo lwegazi (CBC) ngokwahluka
• Iphaneli ebanzi yekhemistri
• Uhlalutyo lomchamo

I-x-ray yesifuba ingabonisa iimpawu ze-pleuritis okanye i-pericarditis (ukudumba okujikeleze ulusu lwomphunga okanye intliziyo). I-ECG inokubonisa ukuba intliziyo ichaphazelekayo.

Uninzi lwexesha, iimpawu ziyahamba kwiintsuku ezimbalwa ukuya kwiiveki emva kokumisa iyeza elibangele imeko.

Unyango lunokubandakanya:

• Izidakamizwa ezichasayo ezichasayo (i-NSAID) zokunyanga i-arthritis kunye ne-pleurisy
• Izithambisi zeCorticosteroid ukunyanga irhashalala
• Amachiza e-Antimalarial (hydroxychloroquine) ukunyanga ulusu kunye neempawu zamathambo

Ukuba imeko ichaphazela intliziyo yakho, izintso, okanye inkqubo ye-nervous, unokumiselwa iidosi eziphezulu ze-corticosteroids (prednisone, methylprednisolone) kunye ne-immune system suppressants (azathioprine okanye cyclophosphamide). Oku kunqabile.

Xa esi sifo sisebenza, kuya kufuneka unxibe impahla ekhuselayo kunye nezibuko zelanga ukukhusela ilanga elininzi.

Uninzi lwexesha, i-lupus erythematosus eyenziwe ngamachiza ayinamandla njenge-SLE. Iimpawu zihlala ziphela kwiintsuku ezimbalwa emva kweeveki emva kokuyeka iyeza obulithatha. Ngokuqhelekileyo, ukuvutha kwezintso (nephritis) kunokukhula kunye ne-lupus ebangelwa ngamachiza ebangelwa yi-TNF inhibitors okanye nge-ANCA vasculitis ngenxa ye-hydralazine okanye i-levamisole. I-Nephritis inokufuna unyango ngamayeza e-prednisone kunye ne-immunosuppressive.

Kunqande ukuthatha ichiza elibangele impendulo kwixa elizayo. Iimpawu zinokuthi zibuye ukuba wenza njalo.

Iingxaki zinokubandakanya:

• Usulelo
• I-Thrombocytopenia purpura - ukopha kufutshane nomphezulu wolusu, ngenxa yenani eliphantsi leeplatelets egazini
• I-anemia yeHemolytic
• Isifo esinganyangekiyo
• Pericarditis
• I-Nephritis

Fowunela umnikezeli wakho ukuba:

• Uba neempawu ezintsha xa usela nawaphi na amayeza adweliswe apha ngasentla.
• Iimpawu zakho azibi bhetele emva kokuba uyekile ukuthatha iyeza elibangele imeko.

Jonga imiqondiso yokuphendula ukuba uthatha nawaphi na amachiza anokubangela le ngxaki.

I-Lupus-iziyobisi ezenziweyo

• I-Lupus, discoid-umbono wezilonda esifubeni
• Iintsholongwane

UBenfaremo D, uManfredi L, uLuchetti MM, uGabrielli A. Izifo zeMusculoskeletal kunye ne-rheumatic ezibangelwa zii-immune checkpoint inhibitors: uphononongo loncwadi. Ikhonkco leziyobisi eziKhuselekileyo. 2018; 13 (3): 150-164. IINKCUKACHA: 29745339 www.ncbi.nlm.nih.gov/pubmed/29745339.

UDooley MA. I-lupus ebangelwa ziziyobisi. Ku: Tsokos GC, ed. Inkqubo yeLupus Erythematosus. ICambridge, MA: Elsevier Academic Press; 2016: isahluko 54.

URadhakrishnan J, uPerazella MA. Izifo ezibangelwa ziziyobisi ezibangelwa ziziyobisi: ingqalelo efunekayo! Iiklinikhi J Am Soc Nephrol. 2015; 10 (7): 1287-1290. IINKCUKACHA: 25876771 www.ncbi.nlm.nih.gov/pubmed/25876771.

URichardson BC. I-lupus ebangelwa ziziyobisi. Ku: Hochberg MC, Gravallese EM, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, ii-eds. Rheumatology. Umhla wesi-7. IPhiladelphia, PA: Elsevier; I-2019: isahluko 141.

Irubin RL. I-lupus ebangelwa ziziyobisi. Ingcali Opin iziyobisi Saf. 2015; 14 (3): 361-378. IINKCUKACHA: 25554102 www.ncbi.nlm.nih.gov/pubmed/25554102.

IVaglio A, iGrayson PC, iFenaroli P, et al. I-lupus ebangelwa ziziyobisi: iikhonsepthi zemveli kunye nezintsha. Ukuzikhusela ngokuzenzekelayo Rev. 2018; 17 (9): 912-918. IINKCUKACHA: 30005854 www.ncbi.nlm.nih.gov/pubmed/30005854.