Inaliti yeArsenic Trioxide

Umxholo

• Ngaphambi kokufumana inaliti ye-arsenic trioxide,
• Inaliti ye-Arsenic trioxide inokubangela ukonyuka kweswekile esegazini. Tsalela umnxeba kwangoko ukuba unazo naziphi na kwezi mpawu zehyperglycemia (iswekile ephezulu yegazi):
• Ukuba iswekile ephezulu yegazi ayinyangwa, imeko enesongelo yobomi ebizwa ngokuba sisifo seswekile ketoacidosis inokuvela. Fumana unyango ngokukhawuleza ukuba unayo nayiphi na impawu:
• Inaliti ye-Arsenic trioxide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

I-Arsenic trioxide kufuneka inikwe kuphela phantsi kweliso likagqirha onamava ekunyangeni abantu abane-leukemia (umhlaza weeseli ezimhlophe zegazi).

I-Arsenic trioxide inokubangela iqela elinobuzaza okanye elisongela ubomi leempawu ezibizwa ngokuba yi-APL umahluko wesifo. Ugqirha wakho uya kukujonga ngononophelo ukuze abone ukuba uyayiphuhlisa na le syndrome. Ugqirha wakho unokukucela ukuba uzilinganise yonke imihla kwiiveki zokuqala zonyango lwakho kuba ukuzuza ubunzima luphawu lokwahlulahlula i-APL. Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: umkhuhlane, ukutyeba, ukuphefumla kancinci, ukuphefumla okusebenzayo, iintlungu esifubeni, okanye ukukhohlela. Kwisibonakaliso sokuqala sokuba uphuhlisa i-APL yokwahlulahlula isifo, ugqirha wakho uya kukuyalela iyeza elinye okanye nangaphezulu ukunyanga isifo.

I-Arsenic trioxide inokubangela ukwandiswa kwe-QT (izihlunu zentliziyo zithatha ixesha elide ukuphinda ziphinde ziphinde ziphinde ziphinde ziphinde zibekhona phakathi kwentsimbi ngenxa yokuphazamiseka kombane), ezinokubangela iingxaki zesingqi sentliziyo. Ngaphambi kokuba uqale unyango nge-arsenic trioxide, ugqirha wakho uya kuyala i-electrocardiogram (ECG; uvavanyo olurekhoda umsebenzi wombane wentliziyo) kunye nolunye uvavanyo ukuze ubone ukuba sele unophazamiseko lombane entliziyweni yakho okanye uphezulu kunengozi yesiqhelo ukuphuhlisa le meko. Ugqirha wakho uya kukubeka esweni ngokusondeleyo kwaye ayalele i-ECG kunye nolunye uvavanyo ngexesha lonyango lwakho nge-arsenic trioxide. Tshela ugqirha wakho ukuba unayo okanye wakha wanokwandiswa kwe-QT, ukusilela kwentliziyo, ukubetha kwentliziyo okungaqhelekanga, okanye amanqanaba asezantsi e-potassium okanye yemagniziyam egazini lakho. Xelela ugqirha wakho ukuba uthatha nawaphi na amayeza alandelayo: amiodarone (Nexterone, Pacerone), amphotericin (Abelcet, Amphotec, Fungizone), cisapride (Propulsid), disopyramide (Norpace), diuretics ('iipilisi zamanzi'), dofetilide ( Tikosyn), erythromycin (EES, E-Mycin, Erythrocin), moxifloxacin (Avelox), pimozide (Orap), procainamide (Procanbid, Pronestyl), quinidine (Quinidex), sotalol (Betapace, Betapace AF), sparfagine) (Mellaril), kunye ne-ziprasidone (Geodon). Fowunela ugqirha ngoko nangoko ukuba unentliziyo engavumelekanga okanye ekhawulezayo okanye ukuba uyaphela xa unyanga nge-arsenic trioxide.

Inaliti ye-Arsenic trioxide inokubangela i-encephalopathy (ukudideka, iingxaki zememori, kunye nobunye ubunzima obubangelwa kukungasebenzi kakuhle kwengqondo). Tshela ugqirha wakho ukuba uyasela okanye wakha wasela izixa ezikhulu zotywala, ukuba une-malabsorption syndrome (iingxaki zokufunxa ukutya), ukunqongophala kwesondlo, okanye ukuba uthatha i-furosemide (Lasix). Ukuba ufumana naziphi na kwezi mpawu zilandelayo, biza ugqirha ngoko nangoko: ukudideka; ukulahleka kwengqondo; ukuxhuzula; utshintsho lwentetho; iingxaki ngokulungelelanisa, ukulingana, okanye ukuhamba; okanye utshintsho olubonakalayo njengokunciphisa ukubonwa, iingxaki zokufunda, okanye umbono ophindwe kabini. Qiniseka ukuba usapho lwakho okanye umntu okhathalelayo uyazi ukuba zeziphi iimpawu ezinokubanzima ukuze bakwazi ukufuna unyango ukuba awukwazi ukuzibiza ngokwakho.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi nasemva kokujonga impendulo yomzimba wakho kwi-arsenic trioxide.

Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-arsenic trioxide.

I-Arsenic trioxide isetyenziswa ngokudibanisa ne-tretinoin ukunyanga i-leukemia ye-promyelocytic etsolo (i-APL; uhlobo lomhlaza apho iiseli zegazi zininzi kakhulu kwigazi kunye nomongo wethambo) kubantu abathile njengonyango lokuqala. Isetyenziselwa ukunyanga i-APL kubantu abathile abangakhange bancedwe zezinye iintlobo zekhemotherapy okanye imeko yabo ephucukileyo kodwa yaya isiba mandundu ngokulandela unyango kunye ne-retinoid kunye nezinye iintlobo zonyango lwe-chemotherapy. I-Arsenic trioxide ikwiklasi yamayeza abizwa ngokuba yi-anti-neoplastics. Isebenza ngokunciphisa okanye ukumisa ukukhula kweeseli zomhlaza.

I-Arsenic trioxide iza njengesisombululo (ulwelo) esiza kungeniswa emthanjeni ngugqirha okanye ngumongikazi kwiofisi yezonyango okanye ekliniki. I-Arsenic trioxide ihlala itofwe ngaphezulu kwe-1 ukuya kwiiyure ezi-2, kodwa inokuthi ifakwe kwisitofu kangangeeyure ezi-4 ukuba ngaba iziphumo ebezingalindelekanga zifumaneka ngexesha lokufakwa. Ihlala inikwa kube kanye ngosuku kangangexesha elithile.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokufumana inaliti ye-arsenic trioxide,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uyaliwa yi-arsenic trioxide, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-arsenic trioxide injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhaliswanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ngokukhankanya amayeza adweliswe kwicandelo LESILUMKISO ESIBALULEKILEYO. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga.
• xelela ugqirha wakho ukuba ukhe unesifo sesibindi okanye sezintso.
• xelela ugqirha wakho ukuba ukhulelwe, cwangcisa ukukhulelwa, okanye ukuba ucwangcisa ukuba notata umntwana. Ukuba ungowasetyhini, kuya kufuneka uthathe uvavanyo lokukhulelwa ngaphambi kokuqala unyango kwaye usebenzise ulawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwakho kunye neenyanga ezi-6 ubuncinci emva kwethamo lakho lokugqibela. Ukuba uyindoda, wena kunye neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa olusebenzayo ngelixa nifumana inaliti ye-arsenic trioxide kunye neenyanga ezi-3 emva kwedosi yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa usebenzisa eli yeza, biza ugqirha wakho. Thetha nogqirha wakho malunga nolawulo lokuzalwa ukuthintela ukukhulelwa ngexesha lonyango lwe-arsenic trioxide. I-Arsenic trioxide inokulimaza umbungu.
• xelela ugqirha wakho ukuba uncelisa.Ugqirha wakho uya kukuxelela ukuba ungancancisi ngexesha lonyango lwakho kunye nakwiiveki ezi-2 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga nemingcipheko yokufumana i-arsenic trioxide.
• ukuba wenza utyando, kubandakanya utyando lwamazinyo, xelela ugqirha okanye ugqirha wamazinyo ukuba ufumana i-arsenic trioxide.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inaliti ye-Arsenic trioxide inokubangela ukonyuka kweswekile esegazini. Tsalela umnxeba kwangoko ukuba unazo naziphi na kwezi mpawu zehyperglycemia (iswekile ephezulu yegazi):

• ukunxanwa okugqithisileyo
• ukuchama rhoqo
• indlala enkulu
• ubuthathaka
• ukungaboni kakuhle

Ukuba iswekile ephezulu yegazi ayinyangwa, imeko enesongelo yobomi ebizwa ngokuba sisifo seswekile ketoacidosis inokuvela. Fumana unyango ngokukhawuleza ukuba unayo nayiphi na impawu:

• umlomo owomileyo
• isicaphucaphu nokugabha
• ukuqhawukelwa ngumphefumlo
• umphefumlo onuka iziqhamo
• ukuncipha kwengqondo

Inaliti ye-Arsenic trioxide inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudinwa kakhulu
• isiyezi
• intloko ebuhlungu
• urhudo
• ukudumba kweengalo, izandla, iinyawo, amaqatha okanye imilenze esezantsi
• irhashalala
• ukurhawuzelela

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko:

• ukugruzuka okanye ukopha okungaqhelekanga
• ukugabha okunegazi okanye okujongeka njengendawo yekofu
• isitulo esimnyama kunye nokulinda okanye esinegazi elibomvu eliqaqambileyo
• ukuncipha kokuchama
• urhwebo

Inaliti ye-Arsenic trioxide inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• ukuxhuzula
• ubuthathaka bemisipha
• ukudideka

Buza ugqirha wakho okanye usokhemesti ukuba unayo nayiphi na imibuzo malunga nenaliti ye-arsenic trioxide.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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