Inotuzumab Ozogamicin Inaliti

Umxholo

• Ngaphambi kokusebenzisa inaliti ye-inotuzumab ozogamicin,
• Inotuzumab ozogamicin inaliti inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe KWISILUMKISO ESIBALULEKILEYO okanye INDLELA yamacandelo, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

Inotuzumab ozogamicin inaliti inokubangela ukonakala okanye ukusongela ubomi kwesibindi, kubandakanya isifo se-hepatic veno-occlusive isifo (VOD; imithambo yegazi evaliweyo ngaphakathi kwesibindi). Xelela ugqirha wakho ukuba ukhe unesifo sesibindi okanye ukhe wafakelwa i-hematopoietic stem-cell transplant (HSCT; inkqubo apho iiseli ezithile zegazi zisuswe emzimbeni zize zibuyele emzimbeni). Ukuba unazo naziphi na kwezi mpawu zilandelayo, tsalela umnxeba kwangoko: ukutyeba ngokukhawuleza, iintlungu okanye ukudumba kwinxalenye ephezulu yesisu, ukuba tyheli kolusu okanye amehlo, isicaphucaphu, ukugabha, umchamo omnyama, okanye ukudinwa okugqithisileyo.

Inotuzumab ozogamicin inaliti inokubangela umngcipheko wokufa, hayi ngenxa yokubuya kwe-leukemia, emva kokufumana i-HSCT. Ukuba uhlangabezana naziphi na kwezi mpawu zilandelayo emva kwe-HSCT ngelixa ufumana inaliti ye-inotuzumab ozogamicin, tsalela umnxeba kwangoko: umkhuhlane, ukukhwehlela, umqala obuhlungu, ukubola, okanye ezinye iimpawu zosulelo ukukhawuleza ukutyeba, okanye iintlungu okanye ukudumba kwinxalenye ephezulu yesisu.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi, ngexesha, nasemva konyango lwakho ukujonga impendulo yomzimba wakho kwi-inotuzumab ozogamicin.

Inotuzumab ozogamicin injection is used to treat some acute lymphoblastic leukemia (BONKE; uhlobo lomhlaza oluqala kwiiseli ezimhlophe zegazi) kubantu abadala abangaphendulanga kunyango lomhlaza lwangaphambili. Inotuzumab ozogamicin inaliti ikwiklasi yamayeza abizwa ngokuba ngamachiza omzimba. Isebenza ngokwenza amajoni omzimba atshabalalise iiseli zomhlaza.

Inotuzumab ozogamicin inaliti iza njengomgubo oxutywe nolwelo ukuze ifakwe ngaphakathi ngaphakathi (emthanjeni) ngugqirha okanye ngumongikazi esibhedlele okanye kwiziko lonyango. Ihlala itofwe ngeentsuku zoku-1, 8, kunye ne-15 kumjikelo weeveki ezi-3 ukuya kwezi-4. Umjikelo unokuphindwa rhoqo kwiiveki ezi-4 njengoko kucetyiswa ngugqirha wakho. Ubude bonyango lwakho buxhomekeke kwindlela ophendula ngayo emzimbeni wakho kunyango nakwiziphumo ebezingalindelekanga ohlangabezana nazo.

Ugqirha wakho unokufuna ukuphazamisa okanye ukuyeka unyango lwakho, ukunciphisa umthamo wakho, okanye ukunyanga ngamayeza angaphezulu, kuxhomekeke kwimpendulo yakho kwi-inotuzumab ozogamicin kunye nayiphi na imiphumo emibi ohlangabezana nayo. Uya kufumana amayeza athile ukunceda ukuthintela impendulo ngaphambi kokuba ufumane idosi nganye ye-inotuzumab ozogamicin. Xelela ugqirha wakho okanye umongikazi ukuba unazo naziphi na kwezi mpawu zilandelayo kwaye ubuncinci iyure enye emva kokuphela kokufakwa: umkhuhlane, Ukugodola, irhashalala, ukuphefumla kancinci, okanye ukuphefumla nzima. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha nasemva konyango lwakho.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokusebenzisa inaliti ye-inotuzumab ozogamicin,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-inotuzumab ozogamicin, nawaphi na amanye amayeza, okanye naziphi na izithako kwi-inotuzumab ozogamicin injection. Buza usokhemesti wakho uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zinto zilandelayo: amiodarone (Pacerone, Nexterone); chloroquine (Aralen); i-clarithromycin (i-Biaxin, kwi-Prevpac); iDisopyramide (iNorpace); i-erythromycin (EES, E-Mycin, PCE, abanye); haloperidol; imethadone (iDolophine, iMethadose); nefazodone; ipimozide (Orap); ukuvelisa; quinidine (kwiNuedexta); i-sotalol (iBetapace, iBetapace AF, iSorine); kunye ne-thioridazine. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-inotuzumab ozogamicin, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho unethuba elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe). Kwakhona xelela ugqirha wakho ukuba ubukhe wanayo inqanaba eliphantsi le potassium okanye wemagniziyam egazini lakho okanye isifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa. Ukuba ungumfazi, akufanele ukhulelwe ngelixa ufumana i-inotuzumab ozogamicin kunye neenyanga ezili-8 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neendlela zokulawula ukuzalwa eziza kukusebenzela. Ukuba uyindoda, wena neqabane lakho labasetyhini kufuneka nisebenzise ulawulo lokuzalwa ngexesha lonyango kwaye niqhubeke nokusebenzisa ulawulo lokuzalwa ubuncinci iinyanga ezintlanu emva kwedosi yokugqibela. Ukuba wena okanye iqabane lakho ukhulelwe ngelixa ufumana i-inotuzumab ozogamicin, tsalela ugqirha wakho. Inotuzumab ozogamicin inokwenzakalisa umntwana ongekazalwa.
• xelela ugqirha wakho ukuba uncelisa. Ugqirha wakho unokukuxelela ukuba ungancancisi ngexesha lonyango lwakho ngenaliti ye-inotuzumab ozogamicin kwaye ubuncinci iinyanga ezi-2 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuchuma emadodeni nakwabasetyhini. Thetha nogqirha wakho malunga neengozi zokufumana i-inotuzumab ozogamicin.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Inotuzumab ozogamicin inaliti inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• isiyezi
• intloko elula

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe KWISILUMKISO ESIBALULEKILEYO okanye INDLELA yamacandelo, tsalela ugqirha ngokukhawuleza okanye ufumane unyango olungxamisekileyo:

• umkhuhlane, ukugodola, ukukhohlela, okanye ezinye iimpawu zosulelo
• ukopha okungaqhelekanga okanye ukugruzuka
• izitulo ezimnyama kunye nokulinda
• Igazi elibomvu ilindle
• ulusu oluthuthu
• ukudinwa

Inotuzumab ozogamicin inaliti inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unayo nayiphi na ingxaki engaqhelekanga ngelixa ufumana eliyeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nenaliti ye-inotuzumab ozogamicin.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Besponsa^®