Ivosidenib

Umxholo

• Ngaphambi kokuba uthathe ivosidenib,
• I-Ivosidenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

I-Ivosidenib inokubangela iqela elinobuzaza okanye elisongela ubomi leempawu ezibizwa ngokuba yiyantlukwano yesifo. Ugqirha wakho uya kukujonga ngononophelo ukuze abone ukuba uyayiphuhlisa na le syndrome. Ukuba unazo naziphi na kwezi mpawu zilandelayo, biza ugqirha wakho kwangoko: umkhuhlane, ukukhohlela, irhashalala, ukutyeba ngesiquphe, ukuncipha kokuchama, ukudumba kweengalo okanye imilenze, isiyezi okanye intloko ebushushwini, ukuphefumla kancinci, okanye ukuphefumla nzima. Ezi mpawu zinokubakho ukuya kwiinyanga ezi-3 emva kokuqala unyango nge-ivosidenib. Kwisibonakaliso sokuqala sokuba uhlakulela isifo sokwahlukana, ugqirha wakho uya kukunika amayeza ukunyanga isifo, kwaye unokukuxelela ukuba uyeke ukuthatha i-ivosidenib ixesha elithile.

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile ngaphambi nangexesha lonyango lwakho ukujonga impendulo yomzimba wakho kwi-ivosidenib.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-ivosidenib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) ukufumana isiKhokelo seyeza.

I-Ivosidenib isetyenziselwa ukunyanga uhlobo oluthile lwe-myeloid leukemia (AML; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) ebuyileyo okanye engaphucukanga emva konyango (lwangaphambili). I-Ivosidenib ikwasetyenziselwa ukunyanga uhlobo oluthile lwe-AML kwabanye abantu abadala abangaphezulu kweminyaka engama-75 ubudala njengonyango lokuqala. I-Ivosidenib ikwiklasi yeyeza cad IDH1 inhibitors. Isebenza ngokunciphisa okanye ukumisa ukukhula kweeseli zomhlaza.

I-Ivosidenib iza njengecwecwe lokuthatha ngomlomo. Ihlala ithathwa kunye okanye ngaphandle kokutya kube kanye yonke imihla. Yenza hayi yithathe ngesidlo esinamafutha aphezulu (njengokutya okuthosiweyo okanye ukutya okukhawulezayo). Thatha ivosidenib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-ivosidenib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-ivosidenib, ungathathi elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokunciphisa idosi okanye okwexeshana okanye ngokusisigxina uyeke unyango lwakho nge-ivosidenib kuxhomekeke kwimpendulo yakho kunyango okanye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Thetha nogqirha wakho malunga nendlela oziva ngayo ngexesha lonyango lwakho.

Buza usokhemesti okanye ugqirha wakho ngekopi yolwazi lomenzi wesigulana.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuba uthathe ivosidenib,

• xelela ugqirha wakho kunye nosokhemisti ukuba ngaba uxabisa i-ivosidenib, nawaphi na amanye amayeza, okanye naziphi na izithako kwiipilisi ze-ivosidenib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba loluphi olunye amayeza amiselweyo kunye nalawo angabhalwanga, iivithamini, izongezo zesondlo, kunye nemveliso yamayeza owathathayo okanye oceba ukuyithatha. Qiniseka ukuba ukhankanya nayiphi na kwezi zilandelayo: amiodarone (Nexterone, Pacerone), carbamazepine (Equetro, Tegretol, Teril, others), clarithromycin, diltiazem (Cardizem, Cartia, Diltzac, Tiazac, others), efavirenz (Sustiva, in Atripla, in Symfi), erythromycin (Eryc), fluconazole (Diflucan), indinavir (Crixivan), itraconazole (Onmel, Sporanox, Tolsura), ketoconazole, izinto zokucwangcisa ngomlomo ezifana ('neepilisi zokulawula ukuzalwa'), iziqwengana, kunye nemisesane yelungu lobufazi, nefazodone , nelfinavir (Viracept), nevirapine (Viramune), phenobarbital, phenytoin (Dilantin, Phenytek), pioglitazone (Actos), procainamide, quinidine (eNuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rifadin, Rifadin (ENorvir, eKaletra, eViekira), saquinavir (Fortovase, Invirase), telithromycin (Ketek), kunye neverapamil (Calan, Verelan, eTarka). Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Amanye amayeza amaninzi anokusebenzisana ne-ivosidenib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zamayeza ozithathayo, ngakumbi iSort John's Wort.
• xelela ugqirha wakho ukuba wena okanye nabani na kusapho lwakho ukhe wanethuba elide le-QT (imeko eyonyusa umngcipheko wokuba nesifo sentliziyo esingaqhelekanga esinokubangela isiqaqa okanye ukufa ngesiquphe) ukuba ukhe wabetha okanye akwabikho ukubetha kwentliziyo okanye ezinye iingxaki zentliziyo; amanqanaba egazi asezantsi e-sodium, i-potassium, okanye i-magnesium; iingxaki zenkqubo yemithambo-luvo; isifo sesibindi, kuquka i-cirrhosis; okanye ukuba ufumana unyango lwe-dialysis okanye ukuba unesifo sezintso.
• xelela ugqirha wakho ukuba ukhulelwe okanye ucwangcise ukukhulelwa, okanye uncelisa. Kuya kufuneka uyazi ukuba i-ivosidenib inokunciphisa ukusebenza kwezicwangcisi zehomoni (iipilisi zolawulo lokuzalwa, iipatches, iiringi, okanye inaliti) ngelixa uthatha eli yeza. Thetha nogqirha wakho malunga nokusebenzisa enye indlela yolawulo lokuzalwa. Ukuba ukhulelwa ngelixa uthatha i-ivosidenib, biza ugqirha ngokukhawuleza. I-Ivosidenib inokubangela ingozi kumntwana.
• xelela ugqirha wakho ukuba uncelisa. Musa ukuncancisa ngexesha lonyango lwakho kunye ne-ivosidenib kunye nenyanga e-1 emva kwedosi yakho yokugqibela.

Thetha nogqirha wakho malunga nokutya igrapefruit kunye nokusela ijusi yamagilebhisi ngelixa uthatha eli yeza.

Qinisekisa ukuba usela amanzi amaninzi okanye olunye ulwelo yonke imihla ngelixa uthatha i-ivosidenib.

Ukuba idosi yakho elandelayo ifanelekile kwiiyure ezili-12 okanye nangaphezulu, thabatha idosi ephosiweyo kwakamsinya nje ukuba uyikhumbule. Nangona kunjalo, ukuba idosi elandelayo iya kuthathwa ngaphantsi kweeyure ezili-12, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo yedosi. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

I-Ivosidenib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• intloko ebuhlungu
• ukudinwa
• intlungu edibeneyo okanye yemisipha
• urhudo
• ukuqhina
• ukugabha
• isicaphucaphu
• Ukuphelelwa ngumdla wokutya
• iintlungu zomlomo kunye nezilonda
• isisu esibuhlungu

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana naziphi na kwezi mpawu okanye ezo zidweliswe kwicandelo LESILUMKISO ELIBALULEKILEYO, tsalela umnxeba kwangoko okanye ufumane unyango olungxamisekileyo:

• utywala, intloko elula, okanye ukuphelelwa amandla
• ubuthathaka okanye ukubetha kwemilenze, iingalo, okanye umzimba ongasentla; ukuba ndindisholo kunye nentlungu kwicala elinye okanye omabini amacala omzimba; utshintsho kumandla akho okubona, ukuchukumisa, ukuva, okanye ukungcamla; ukutshisa okanye ukuhlaba; okanye ubunzima bokuphefumla
• iintlungu zesifuba

I-Ivosidenib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Ugqirha wakho uya kuyalela uvavanyo lwelebhu ngaphambi kokuba uqale unyango lwakho ukuze ubone ukuba ngaba umhlaza wakho unganyangwa na nge-ivosidenib.

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

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