IGlasdegib

Umxholo

• Ngaphambi kokuthatha i-glasdegib,
• IGlasdegib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:
• Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:
• Iimpawu zokudlula ngaphezulu zinokubandakanya:

IGlasdegib akufuneki ithathwe zizigulana ezikhulelweyo okanye ezinokukhulelwa. Kukho umngcipheko ophezulu wokuba i-glasdegib iya kubangela iziphene zokuzalwa ezinzima (iingxaki zomzimba ezikhoyo ekuzalweni) okanye ukusweleka kosana olungekazalwa.

Ukuba ungumfazi onokukhulelwa, kuya kufuneka ube novavanyo lokukhulelwa olungelulo kwiintsuku ezisi-7 ngaphambi kokuba uqale unyango nge-glasdegib. Uya kudinga ukusebenzisa ulawulo lokuzalwa olusebenzayo ngexesha lonyango nge-glasdegib kwaye ubuncinci iintsuku ezingama-30 emva kwedosi yakho yokugqibela. Thetha nogqirha wakho malunga neenketho zolawulo lokuzalwa oluza kukusebenzela.

Ukuba uyindoda enomlingane ongumfazi onokukhulelwa okanye okhulelweyo, kuya kufuneka uyazi ukuba i-glasdegib inokubakho kwisidoda kwaye inokubangela ingozi kumntwana ongekazalwa. Sebenzisa ikhondom ngexesha lonyango lwakho nge-glasdegib kwaye ubuncinci iintsuku ezingama-30 emva kwethamo lokugqibela nokuba une-vasectomy (utyando ukunqanda isidoda ukuba singashiyi umzimba wakho kwaye sibangele ukukhulelwa). Musa ukunikela ngamadlozi ngexesha lonyango lwakho kwaye ubuncinci kwiintsuku ezingama-30 emva kwedosi yakho yokugqibela.

Ukuba uye wabelana ngesondo ngokungakhuselekanga, cinga ukuba ulawulo lwakho lokuzalwa aluphumelelanga, okanye ucinga ukuba wena okanye iqabane lakho labasetyhini unokukhulelwa biza ugqirha wakho kwangoko.

Musa ukunikela ngegazi okanye iimveliso zegazi ngexesha lonyango lwakho nge-glasdegib kwaye ubuncinci iintsuku ezingama-30 emva kwedosi yakho yokugqibela.

Ugqirha wakho okanye usokhemesti uya kukunika uxwebhu lolwazi lwesigulana lomenzi (Isikhokelo seyeza) xa uqala unyango nge-glasdegib kwaye ngalo lonke ixesha ugcwalisa amayeza akho. Funda ulwazi ngononophelo kwaye ubuze ugqirha okanye usokhemesti ukuba unayo nayiphi na imibuzo. Ungandwendwela noLawulo lwezoKutya noLawulo lweziyobisi (FDA) iwebhusayithi (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) okanye iwebhusayithi yomenzi ukufumana isiKhokelo seMithi.

I-Glasdegib isetyenziswa kunye ne-cytarabine njengonyango lokuqala lwe-myeloid leukemia (AML; uhlobo lomhlaza oqala kwiiseli ezimhlophe zegazi) kubantu abangaphezulu kweminyaka engama-75 ubudala, okanye kubantu abadala abanezinye iimeko zonyango kwaye abanakunyangwa namanye amayeza e-chemotherapy. IGlasdegib ikwiklasi yamayeza abizwa ngokuba yihedgehog pathway inhibitors. Isebenza ngokuthintela isenzo seprotini ebonisa iiseli zomhlaza ukuba zande. Oku kunceda ukumisa okanye ukucothisa ukusasazeka kweeseli zomhlaza.

IGlasdegib iza njengecwecwe lokuthatha ngomlomo. Ihlala inikwa kunye okanye ngaphandle kokutya kube kanye ngosuku kangangeenyanga ezi-6, okanye ukuba ugqirha ucebisa unyango. Thatha i-glasdegib malunga nexesha elifanayo yonke imihla. Landela izikhokelo kwileyibhile yakho yonyango ngononophelo, kwaye ubuze ugqirha wakho okanye usokhemesti ukuba achaze nayiphi na indawo ongayiqondiyo. Thatha i-glasdegib ngokuchanekileyo njengoko kuyalelwe. Musa ukuthatha ngaphezulu okanye ngaphantsi kwayo okanye uthathe rhoqo kunokuba umiselwe ngugqirha wakho.

Ginya iipilisi ngokupheleleyo; ungahluleli, ungahlaleli, okanye uzityumze.

Ukuba uyagabha emva kokuthatha i-glasdegib, musa ukuthatha elinye idosi. Qhubeka neshedyuli yakho yesiqhelo.

Ugqirha wakho unokufuna ukuphazamisa unyango lwakho, ukunciphisa idosi yakho, okanye uyeke unyango lwakho ngokuxhomekeke kwimpendulo yakho kunyango kunye naziphi na iziphumo ebezingalindelekanga ohlangabezana nazo. Qiniseka ukuba uxelela ugqirha wakho ukuba uziva njani ngexesha lonyango lwakho nge-glasdegib.

Eli yeza linokumiselwa ezinye izinto; buza ugqirha wakho okanye usokhemesti ngolwazi oluthe kratya.

Ngaphambi kokuthatha i-glasdegib,

• xelela ugqirha wakho kunye nosokhemesti ukuba ngaba uxabisa i-glasdegib, nawaphi na amanye amayeza, okanye nasiphi na isithako kwiipilisi ze-glasdegib. Buza usokhemesti wakho okanye ujonge isiKhokelo seyeza ukuze ufumane uluhlu lwezithako.
• xelela ugqirha wakho kunye nosokhemesti ukuba yeyiphi na amayeza kagqirha kunye nalawo angabhalwanga, iivithamini, kunye nezongezelelo zesondlo ozithathayo okanye oceba ukuzithatha. Qiniseka ukuba ukhankanya oku kulandelayo: amiodarone (Nexterone, Pacerone), carbamazepine (Carbatrol, Equetro, Tegretol, abanye), chlorpromazine, cilostazol, citalopram (Celexa), clarithromycin, disopyramide (Norpace), dofetilide, donepezil dronedarone (Multaq), efavirenz (Sustiva, eAtripla, Symfi), escitalopram (Lexapro), flecainide (Tambocor), fluconazole (Diflucan), haloperidol (Haldol), ibutilide (Corvert), indinavir (Crixivan), iStraconaz ), ketaconazole, methadone (Dolophine, Methadose), nefazodone, nelfinavir (Viracept), nevirapine (Viramune), ondansetron (Zofran, Zuplenz), phenobarbital, phenytoin (Dilantin, Phenytek), pimozide (Orap), Actogosit , Duetact, Actoplus Met), procainamide, quinidine (eNuedexta), rifabutin (Mycobutin), rifampin (Rifadin, Rimactane, eRifater, Rifamate), ritonavir (Norvir, eViekira Pak, Kaletra, Technivie), iSotalol (Betapace). , Sotylize), kunye ne-thioridazine. Ugqirha wakho unokufuna ukutshintsha amayeza akho okanye akubeke esweni ngononophelo kwiziphumo ebezingalindelekanga. Uninzi lwamanye amayeza anokusebenzisana ne-glasdegib, ke qiniseka ukuxelela ugqirha wakho ngawo onke amayeza owathathayo, nkqu nalawo angaveli kolu luhlu.
• xelela ugqirha wakho ukuba zeziphi iimveliso zemithi ozithathayo, ngakumbi iSt John's wort.
• xelela ugqirha wakho ukuba ukhe wanethuba elide le-QT (ingxaki yentliziyo enqabileyo enokubangela ukubetha kwentliziyo ngokungaqhelekanga, ukuphelelwa ngamandla, okanye ukufa ngesiquphe), ukusilela kwentliziyo (imeko apho intliziyo ingakwazi ukumpompa igazi elaneleyo kwamanye amalungu omzimba) , okanye amanqanaba asezantsi e-magnesium okanye i-potassium egazini lakho.
• xelela ugqirha wakho ukuba uncelisa. Akufanele uncancise ibele ngexesha lonyango lwakho nge-glasdegib kwaye ubuncinci kwiintsuku ezingama-30 emva kwedosi yakho yokugqibela.
• Kuya kufuneka uyazi ukuba eli yeza linciphisa ukuzala emadodeni. Thetha nogqirha wakho malunga nemingcipheko yokuthatha i-glasdegib.

Ngaphandle kokuba ugqirha wakho akuxelele ngenye indlela, qhubeka nokutya okuqhelekileyo.

Thatha idosi ephosiweyo ngokukhawuleza nje ukuba uyikhumbule. Nangona kunjalo, ukuba ingaphantsi kweeyure ezili-12 kude kufike idosi yakho elandelayo, tsiba idosi ephosiweyo kwaye uqhubeke neshedyuli yakho yesiqhelo. Sukuthatha idosi ephindwe kabini ukwenza eyilahlekileyo.

IGlasdegib inokubangela iziphumo ebezingalindelekanga. Tshela ugqirha wakho ukuba ngaba ezinye zeempawu zinzima okanye azihambi:

• ukudumba kwezihlunu
• iintlungu zemisipha, zethambo okanye zamalungu
• ukudinwa kakhulu
• isicaphucaphu
• ukugabha
• intlungu zesisu
• ukuqhina
• iintlungu okanye izilonda emlonyeni okanye emqaleni
• ukunciphisa ukutya
• utshintsho kwindlela izinto ezingcamla ngayo
• ukuhla ukusinda
• intloko ebuhlungu
• irhashalala
• ukudumba kwezandla okanye imilenze
• ukulahleka kweenwele
• Lizinyo

Ezinye iziphumo ebezingalindelekanga zinokuba nzulu. Ukuba ufumana nayiphi na le mpawu, biza ugqirha wakho ngokukhawuleza:

• ukuziva utyhafile, unentloko elula, okanye unesiyezi; ukukhawuleza kwentliziyo okanye okungaqhelekanga
• ukugruzuka okanye ukopha okungaqhelekanga
• umkhuhlane wedwa okanye kunye nokubanda, ubuthathaka. okanye ezinye iimpawu zosulelo
• ukuncipha kokuchama
• iintlungu zesifuba

IGlasdegib inokubangela ezinye iziphumo ebezingalindelekanga. Biza ugqirha wakho ukuba unengxaki engaqhelekanga ngelixa uthatha eli yeza.

Ukuba uhlangabezana neziphumo ebezingalindelekanga ezimandundu, wena okanye ugqirha wakho ungathumela ingxelo kwiNkqubo yoKutya kunye nezoLawulo (i-FDA) yeMedWatch yeNkqubo yokuNgxelo ngezeMeko eziGwenxa kwi-Intanethi (http://www.fda.gov/Safety/MedWatch) okanye ngomnxeba ( 1-800-332-1088).

Gcina eli yeza kwisikhongozeli lifikile, livalekile, kwaye alifumaneki ebantwaneni. Yigcine kubushushu begumbi kwaye kude nobushushu obuninzi kunye nokufuma (hayi kwigumbi lokuhlambela).

Kubalulekile ukugcina onke amayeza ngaphandle kwamehlo kunye nokufikelela kwabantwana njengezikhongozeli ezininzi (ezinje ngeeveki zeepilisi zeveki kunye nezo zamehlo, iikhrim, iipatches, kunye ne-inhalers) azinyangeki kwaye abantwana abancinci banokuzivula ngokulula. Ukukhusela abantwana abancinci kwiityhefu, soloko ukhiya iminqwazi yokhuseleko kwaye ubeke amayeza kwindawo ekhuselekileyo-leyo iphakame kwaye iphakame kwaye ingabonakali kubo kwaye ifikelele kuyo. http://www.upandaway.org

Amayeza angafunekiyo kufuneka achithwe ngeendlela ezizodwa zokuqinisekisa ukuba izilwanyana zasekhaya, abantwana kunye nabanye abantu abanakuzisebenzisa. Nangona kunjalo, akufuneki uligungxule eli yeza kwindlu yangasese. Endaweni yoko, eyona ndlela yokulahla amayeza akho yinkqubo yokubuyisa amayeza. Thetha kumayeza wakho okanye unxibelelane nesebe lakho lenkunkuma / lokurisayikilisha ukuze ufunde malunga neenkqubo zokubuyisa kwindawo ohlala kuyo. Jonga i-FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) ngolwazi oluthe kratya ukuba awunakho ukufikelela kwinkqubo yokubuyisa.

Kwimeko yokugqithisa, fowunela umnxeba wolawulo lwetyhefu kwi-1-800-222-1222. Ulwazi lukwafumaneka kwi-Intanethi kwi-https: //www.poisonhelp.org/help. Ukuba ixhoba liye lawa, laxhuzula, linengxaki yokuphefumla, okanye alikwazi ukuvuswa, ngoko nangoko lifowunele iinkonzo zongxamiseko ngo-911.

Iimpawu zokudlula ngaphezulu zinokubandakanya:

• isicaphucaphu
• ukugabha
• ukudinwa kakhulu
• isiyezi

Gcina lonke ixesha lokudibana nogqirha wakho kunye nelabhoratri. Ugqirha wakho uya kuyalela iimvavanyo ezithile zelebhu ezinje nge-electrocardiograms (EKG, uvavanyo olurekhoda umsebenzi wombane wentliziyo) kunye novavanyo lwegazi ngaphambi kunye nangexesha lonyango ukuze uqiniseke ukuba kukhuselekile ukuba ungathatha i-glasdegib kwaye ujonge impendulo yomzimba wakho kunyango .

Musa ukuvumela nabani na ukuba athathe amayeza akho. Buza usokhemesti wakho nayiphi na imibuzo onayo malunga nokuzalisa amayeza akho.

Kubalulekile ukuba ugcine uluhlu olubhaliweyo lwawo onke amayeza owasebenzisayo amayeza owasebenzisayo, kunye nezinye iimveliso ezinjengeevithamini, iiminerali, okanye ezinye izongezo zokutya. Kuya kufuneka uze nolu luhlu qho xa undwendwela ugqirha okanye ungeniswe esibhedlele. Kukwabalulekile ulwazi ukuba uphathe nawe xa kukho imeko kaxakeka.

• Daurismo^®