I-Lactic Acidosis: Into ekufuneka uyazi

Umxholo

• Ziintoni iimpawu?
• Yintoni unobangela?
• Isifo sentliziyo
• Usulelo olomeleleyo (sepsis)
• Intsholongwane kaGawulayo
• Umhlaza
• Isifo esifutshane samathumbu (isisu esifutshane)
• Ukusetyenziswa kwe-Acetaminophen
• Ukunxila rhoqo
• Ukuzilolonga kakhulu okanye ukwenza umthambo
• I-Lactic acidosis kunye neswekile
• Kufunyaniswa njani?
• Zithini iindlela zokhetho zonyango?
• Yintoni imbono?
• Ukuthintela i-lactic acidosis

Yintoni i-lactic acidosis?

I-Lactic acidosis luhlobo lwe-metabolic acidosis eqala xa umntu evelisa ngaphezulu okanye engasebenzisi i-lactic acid, kwaye umzimba wabo awunakho ukuziqhelanisa nolu tshintsho.

Abantu abane-lactic acidosis bane (kwaye ngamanye amaxesha izintso zabo) bayakwazi ukususa i-asidi engaphezulu emzimbeni. Ukuba i-lactic acid yakha emzimbeni ngokukhawuleza kunokuba inokususwa, amanqanaba e-asidi kulwelo lomzimba- njenge-spike yegazi.

Olu lwakhiwo lweasidi lubangela ukungalingani kwinqanaba le-pH yomzimba, ekufuneka ihlale inealkaline kancinci endaweni ye-asidi. Kukho iintlobo ezahlukeneyo zeasidi.

I-Lactic acid buildup yenzeka xa kungekho oksijini yaneleyo kwimisipha yokuphula iswekile kunye ne-glycogen. Oku kubizwa ngokuba yi-anaerobic metabolism.

Zimbini iintlobo ze-lactic acid: L-lactate kunye ne-D-lactate. Uninzi lweentlobo ze-lactic acidosis zibangelwa yi-L-lactate eninzi kakhulu.

Zimbini iintlobo ze-lactic acidosis, Uhlobo A nohlobo B:

• Uhlobo lwe-lactic acidosis kubangelwa zii-hypoperfusion zeethishu ezibangelwa yi-hypovolemia, ukusilela kwentliziyo, isifo se-sepsis, okanye ukubanjwa kwe-cardiopulmonary.
• Uhlobo lwe-lactic acidosis Kubangelwa kukungasebenzi kakuhle kwamaselula kunye neendawo ezihlala kuzo ezixineneyo.

I-Lactic acidosis inezizathu ezininzi kwaye inokunyangwa. Kodwa ukuba ayishiywanga inganyangwa, inokubusongela ubomi.

Ziintoni iimpawu?

Iimpawu ze-lactic acidosis ziqhelekile kwimicimbi yezempilo. Ukuba unazo naziphi na kwezi mpawu, kufuneka unxibelelane nodokotela ngokukhawuleza. Ugqirha wakho unokukunceda ufumane unobangela.

Iimpawu ezininzi ze-lactic acidosis zibonisa imeko yonyango engxamisekileyo:

• ukuphefumla okunuka iziqhamo (into enokubonisa ingxaki enkulu yesifo seswekile, ebizwa ngokuba yi ketoacidosis)
• ukudideka
• i-jaundice (ukutyheli kwesikhumba okanye abamhlophe bamehlo)
• Ingxaki yokuphefumla okanye ukungabi nzulu, ukuphefumla ngokukhawuleza

Ukuba uyazi okanye ukrokrela ukuba une-lactic acidosis kwaye unayo nayiphi na le mpawu, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka ngoko nangoko.

Ezinye iimpawu ze-lactic acidosis zibandakanya:

• ukudinwa okanye ukudinwa kakhulu
• izihlunu okanye iintlungu
• ubuthathaka bomzimba
• Iimvakalelo zizonke zokungonwabi komzimba
• iintlungu esiswini okanye ukungaphatheki kakuhle
• urhudo
• ukunciphisa ukutya
• intloko ebuhlungu
• ukukhawuleza kwentliziyo

Yintoni unobangela?

I-Lactic acidosis inoluhlu olubanzi lwezizathu, kubandakanya ityhefu ye-carbon monoxide, ikholera, isifo seengcongconi kunye nokudumba. Ezinye zezizathu eziqhelekileyo zibandakanya:

Isifo sentliziyo

Iimeko ezinje ngokubanjwa kwentliziyo kunye nokungaphumeleli kwentliziyo kunokunciphisa ukuhamba kwegazi kunye neoksijini kuwo wonke umzimba. Oku kunokunyusa amanqanaba e-lactic acid.

Usulelo olomeleleyo (sepsis)

Naluphi na uhlobo losulelo olunamandla lwentsholongwane okanye ibhaktiriya kunokubangela isifo sepsis. Abantu abane-sepsis banokufumana i-spike kwi-lactic acid, ebangelwa kukuncipha kokuhamba kweoksijini.

Intsholongwane kaGawulayo

Amayeza e-HIV, afana ne-nucleoside reverse transcriptase inhibitors, anokuphakamisa amanqanaba e-lactic acid. Kananjalo zinokubangela ukonakala kwesibindi. Oku kwenza ukuba kube nzima kumzimba ukwenza i-lactate.

Umhlaza

Iiseli zomhlaza zenza i-lactic acid. Olu lwakhiwo lwe-lactic acid lunokukhawulezisa njengoko umntu ephulukana nobunzima kwaye isifo siqhubeka.

Isifo esifutshane samathumbu (isisu esifutshane)

Ngelixa, abantu abanesisu esifutshane banokuba namava okwakhiwa kwe-D-lactic acid, ebangelwa kukugcwala kwebhakteria kwithumbu elincinci. Abantu abaye banesifo sokuhlinzwa esiswini banokufumana i-D-lactic acidosis.

Ukusetyenziswa kwe-Acetaminophen

Ukusetyenziswa rhoqo kwe-acetaminophen (iTylenol) kunokubangela i-lactic acidosis, nokuba ithathwa kumthamo ochanekileyo. Kungenxa yokuba inokubangela ukuqokelelwa kwe-pyroglutamic acid egazini.

Ukunxila rhoqo

Ukusela utywala ngokugqithileyo ixesha elide kunokukhokelela kwi-lactic acidosis kunye ne-ketoacidosis enxilisayo. I-ketoacidosis enxilisayo yimeko enokubulala xa ishiywe inganyangwa, kodwa inokulwa ne-intravenous (IV) hydration kunye neglucose.

Utywala bonyusa amanqanaba e-phosphate, ezichaphazela kakubi izintso. Oku kwenza i-pH yomzimba ibe neasidi eninzi. Ukuba unengxaki yokunciphisa utywala, amaqela enkxaso anokunceda.

Ukuzilolonga kakhulu okanye ukwenza umthambo

Ukwakhiwa okwethutyana kwe-lactic acid kunokubangelwa kukuzilolonga ngamandla ukuba umzimba wakho awunayo ioksijini eyaneleyo yokwaphula iswekile egazini. Oku kunokubangela imvakalelo evuthayo kumaqela emisipha owasebenzisayo. Inokubangela isicaphucaphu kunye nokuba buthathaka.

I-Lactic acidosis kunye neswekile

Udidi oluthile lwamayeza eswekile asemlonyeni, abizwa ngokuba yi-biguanides, anokubangela amanqanaba e-lactic acid.

I-Metformin (iGlucophage) yenye yezi ziyobisi. Isetyenziselwa ukunyanga isifo seswekile kwaye inokumiselwa kwezinye iimeko, ezinjengokungasebenzi kakuhle kwezintso. I-Metformin ikwasetyenziselwa ngaphandle kwelebheli ukunyanga isifo se-polycystic ovarian syndrome.

Kubantu abanesifo seswekile, i-lactic acidosis inokuba yinkxalabo ngakumbi ukuba isifo sezintso sikhona. Ukuba unesifo seswekile kunye namava e-lactic acidosis, tsalela umnxeba ku-911 okanye uye kwigumbi likaxakeka kwangoko.

Kufunyaniswa njani?

I-Lactic acidosis ifunyaniswa ngovavanyo lwegazi olukhawulezayo. Ugqirha wakho unokukuyalela ukuba ungatyi okanye usele nantoni na iiyure eziyi-8 ukuya kwezi-10 ngaphambi kokuba uthathe uvavanyo. Unokuyalelwa ukuba uthintele inqanaba lomsebenzi wakho kwiiyure ezikhokelela kuvavanyo.

Ngexesha lovavanyo, ugqirha wakho angakuxelela ukuba ungabambisi inqindi lakho, kuba oku kunokuba nakho ukwenza amanqanaba e-asidi. Ukubopha ibhanti ye-elastic ejikeleze ingalo kunokuba nesiphumo.

Ngezi zizathu, uvavanyo lwegazi lwe-lactic acidosis ngamanye amaxesha lwenziwa ngokufumana umthambo ngasemva kwesandla endaweni yengalo.

Zithini iindlela zokhetho zonyango?

Eyona ndlela yokunyanga i-lactic acidosis kukunyanga unobangela wayo. Ngenxa yeso sizathu, unyango luyahluka.

I-Lactic acidosis ngamanye amaxesha imele imeko engxamisekileyo yezonyango. Oku kufuna ukunyanga iimpawu, ngaphandle kwengcambu yazo. Ukonyusa ioksijini kwizicubu kunye nokunika ii-IV ulwelo zihlala zisetyenziselwa ukunciphisa amanqanaba e-lactic acid.

I-Lactic acidosis ebangelwa kukuzilolonga inokunyangwa ekhaya. Ukuyeka into oyenzayo ukucoca kunye nokuphumla, kuhlala kunceda. Iziphuzo zemidlalo ezibuyisela i-Electrolyte, ezinje ngeGatorade, zinceda nge-hydration, kodwa amanzi ahlala engcono.

Yintoni imbono?

Ngokusekwe kunobangela oyintloko, unyango lwe-lactic acidosis ihlala ikhokelela ekuphulukaneni ngokupheleleyo, ngakumbi ukuba unyango ngokukhawuleza. Ngamanye amaxesha, ukusilela kwezintso okanye ukusilela kokuphefumla kunokubangela. Xa ishiywe inganyangwa, i-lactic acidosis inokubulala.

Ukuthintela i-lactic acidosis

Ukuthintela i-Lactic acidosis ikwagqitywa sisizathu sayo. Ukuba unesifo seswekile, i-HIV, okanye umhlaza, xoxa ngemeko yakho kunye namayeza owafunayo nogqirha wakho.

I-Lactic acidosis evela kwimithambo inokuthintelwa ngokuhlala i-hydrated kwaye uzinike ixesha lokuphumla elide phakathi kweeseshini zokuzilolonga

Kubaluleke kakhulu ukunqanda ukusebenzisa kakubi utywala. Xoxa ngokubuyisela kwimeko yesiqhelo kunye nenkqubo yamanyathelo ali-12 kunye nogqirha okanye umcebisi wakho.