Unyango lwepsoriasis: amafutha kunye neepilisi

Umxholo

• Unyango lwezihloko (iikhrim kunye namafutha okuthambisa)
• 1. IiCorticoids
• 2. ICalcipotriol
• 3. Izinto zokuthambisa kunye nezinto ezikhuthazayo
• Unyango lwendlela yokusebenza (iipilisi)
• 1. Acitretin
• 2. IMethotrexate
• 3. ICyclosporine
• 4. Iiarhente zebhayoloji

I-Psoriasis sisifo esinganyangekiyo kwaye asinyangeki, nangona kunjalo, kunokwenzeka ukunciphisa iimpawu kunye nokwandisa ukuxolelwa kwesi sifo ixesha elide lonyango olufanelekileyo.

Unyango lwe-psoriasis luxhomekeke kuhlobo, indawo kunye nobungakanani bezilonda, kwaye lunokwenziwa ngeekhrim okanye ngamafutha nge-corticosteroids kunye ne-retinoids okanye amayeza omlomo, njenge-cyclosporine, methotrexate okanye i-acitretin, umzekelo, kwingcebiso kagqirha.

Ukongeza kunyango lwe-pharmacological, kubalulekile ukuthambisa ulusu yonke imihla, ngakumbi imimandla echaphazelekayo, kunye nokuthintela iimveliso ezirhabaxa kakhulu ezibangela ukucaphuka kolusu kunye nokoma okugqithileyo.

Amanye amayeza aqhele ukumiselwa ngugqirha kunyango lwe-psoriasis zezi:

Unyango lwezihloko (iikhrim kunye namafutha okuthambisa)

1. IiCorticoids

Izihloko ze-corticosteroids ziyasebenza ekunyangeni iimpawu, ngakumbi xa isifo sinqunyelwe kummandla omncinci, kwaye sinokudityaniswa ne-calcipotriol kunye neziyobisi zenkqubo.

Eminye imizekelo ye-corticosteroids yamahloko esetyenziswa kunyango lwe-psoriasis yi-clobetasol cream okanye i-0.05% isisombululo se-capillary kunye ne-dexamethasone cream 0.1%, umzekelo.

Ngubani ongafanele asebenzise: abantu abane-hypersensitivity to the components, abanezilonda zolusu ezibangelwa ziintsholongwane, ukungunda okanye iintsholongwane, abantu abane-rosacea okanye i-perioral dermatitis engalawulwayo.

Iziphumo ebezingalindelekanga ezinokwenzeka: ukurhawuzelela, iintlungu kunye nokutsha eluswini.

2. ICalcipotriol

I-Calcipotriol yi-analogue ye-vitamin D, ekujoliswe kuyo kwi-0.005% ibonakaliswe kunyango lwe-psoriasis, kuba inegalelo ekunciphiseni ukubunjwa kwamacwecwe e-psoriatic. Kwiimeko ezininzi, i-calcipotriol isetyenziswa ngokudibanisa ne-corticosteroid.

Ngubani ongafanele asebenzise: abantu abane-hypersensitivity to the components kunye ne-hyperkalaemia.

Iziphumo ebezingalindelekanga ezinokwenzeka: isikhumba, irhashalala, ukurhawuzelela, keratosis, ukurhawuzelela, erythema kunye contact dermatitis.

3. Izinto zokuthambisa kunye nezinto ezikhuthazayo

Izithambiso ezinamafutha kunye neoyile kufuneka zisetyenziswe yonke imihla, ngakumbi njengonyango lokugcina emva kokusetyenziswa kwe-corticosteroids, enceda ukuthintela ukubuyela kwakhona kubantu abane-psoriasis ethambileyo.

Ezi zithambiso kunye neoyile kufuneka ziqulathe i-urea kwizingxube ezinokwahluka phakathi kwe-5% ukuya kwi-20% kunye / okanye i-salicylic acid kugxina phakathi kwe-3% kunye ne-6%, ngohlobo lolusu kunye nenani lezikali.

Unyango lwendlela yokusebenza (iipilisi)

1. Acitretin

I-Acitretin yi-retinoid ihlala iboniswa ukunyanga iindlela ezinzima ze-psoriasis xa kufanelekile ukunqanda ukunyanzelwa komzimba kwaye iyafumaneka ngeedosi ze-10 mg okanye i-25 mg.

Ngubani ongafanele asebenzise: abantu abane-hypersensitivity to the components, abasetyhini abakhulelweyo kunye nabasetyhini abanqwenela ukukhulelwa kule minyaka izayo, abafazi abancancisayo kunye nabantu abanesibindi esibi okanye ukusilela kwezintso

Iziphumo ebezingalindelekanga ezinokwenzeka: intloko ebuhlungu, ukoma kunye nokudumba kwenwebu yangaphakathi, umlomo owomileyo, unxano, itrush, ukuphazamiseka kwamathumbu, i-cheilitis, ukurhawuzelela, ukulahleka kweenwele, ukubhabha kuwo wonke umzimba, iintlungu zemisipha, ukwanda kwe-cholesterol yegazi kunye ne-triglycerides kunye ne-edema ngokubanzi.

2. IMethotrexate

I-Methotrexate ibonakalisiwe kunyango lwe-psoriasis eqatha, njengoko inciphisa ukwanda kunye nokudumba kweeseli zolusu. Esi sixhobo siyafumaneka kwiipilisi ze-2.5 mg okanye kwi-50 mg / 2mL ampoules.

Ngubani ongafanele asebenzise: Abantu abane-hypersensitivity to the components, abafazi abakhulelweyo nabancancisayo, abantu abane-cirrhosis, isifo se-ethyl, i-hepatitis esebenzayo, ukusilela kwesibindi, usulelo olubi, i-immunodeficiency syndromes, i-aplasia okanye i-hypoplasia yomqolo, i-thrombocytopenia okanye i-anemia efanelekileyo kunye ne-gastric ulcer.

Iziphumo ebezingalindelekanga ezinokwenzeka: intloko ebuhlungu, ukuqina kwentamo, ukugabha, umkhuhlane, ukuba bomvu kwesikhumba, ukonyusa i-uric acid, ukunciphisa ukubala kwesidoda emadodeni, i-thrush, ukudumba kolwimi kunye neentsini, urhudo, ukunciphisa iiseli ezimhlophe zegazi kunye neplatelet count, ukusilela kwezintso kunye ne-pharyngitis.

3. ICyclosporine

ICyclosporine lunyango olungena emzimbeni kwaye lubonakalise ukunyanga i-psoriasis ngokuphakathi, kwaye akufuneki ukuba idlule kwiminyaka emi-2 yonyango.

Ngubani ongafanele asebenzise: abantu abane-hypersensitivity to the components, uxinzelelo lwegazi, ukungazinzi nokungalawuleki ngamachiza, izifo ezisebenzayo kunye nomhlaza.

Iziphumo ebezingalindelekanga ezinokwenzeka: ukuphazamiseka kwezintso, uxinzelelo lwegazi kunye namandla omzimba.

4. Iiarhente zebhayoloji

Kwiminyaka yakutshanje, umdla ekuphuhliseni iiarhente zebhayoloji ezineempawu zokuzikhusela komzimba ezikhethwe ngakumbi kune-cyclosporine inyukile ukwenzela ukuphucula iprofayili yokhuseleko lwamachiza e-psoriasis.

Eminye imizekelo yeearhente zebhayiloji ezisandula ukwenziwa kunyango lwe-psoriasis zezi:

• UAdalimumab;
• Etanercept;
• Infliximab;
• Ustecinumab;
• Ukhuseleko.

Olu didi lutsha lwamachiza luqukethe iiproteni okanye ii-antibodies ze-monoclonal eziveliswa zizinto eziphilayo, kusetyenziswa i-recombinant biotechnology, ebonakalise ukuphucuka kwezilonda kunye nokwehliswa kokongezwa kwazo.

Ngubani ongafanele asebenzise: Abantu abane-hypersensitivity to the components, ukungaphumeleli kwentliziyo, isifo esihambisa isifo, imbali yakutshanje ye-neoplasia, usulelo olusebenzayo, ukusetyenziswa kwezitofu zokucutha komzimba kunye nokukhulelwa okukhulelweyo.

Iziphumo ebezingalindelekanga ezinokwenzeka: ukusabela kwendawo yenaliti, ukusuleleka, isifo sephepha, ukusabela kolusu, neoplasms, ukudambisa izifo, intloko ebuhlungu, isiyezi, urhudo, ukurhawuzelela, iintlungu zemisipha nokudinwa.