Rituxan yeMS

Umxholo

• Malunga nokusetyenziswa kweziyobisi ezingekho kwilebula
• Ngaba i-Rituxan ikhuselekile kwaye iyasebenza ekunyangeni i-MS?
• Ngaba iyasebenza?
• Ngaba ikhuselekile?
• Uthini umahluko phakathi kweRituxan kunye ne-Ocrevus?
• Ukuthatha

Ushwankathelo

I-Rituxan (igama eliqhelekileyo elithi rituximab) liyeza elijolise kwiprotein ebizwa ngokuba yi-CD20 kumaseli eB immune system. Ivunyiwe yiU.S.Ukutya kunye noLawulo lweDrug (i-FDA) yokunyanga izifo ezinje nge-Non-Hodgkin's lymphoma kunye ne-rheumatoid arthritis (RA).

Ngamanye amaxesha oogqirha bamisela i-Rituxan yokunyanga i-multiple sclerosis (MS), nangona i-FDA ingayamkelanga le nto. Oku kubizwa ngokuba kukusetyenziswa kweziyobisi “ngaphandle kwelebheli”

Malunga nokusetyenziswa kweziyobisi ezingekho kwilebula

Ukusetyenziswa kweziyobisi ngaphandle kwelebheli kuthetha ukuba ichiza elivunyiweyo yi-FDA ngenjongo enye lisetyenziselwa injongo eyahlukileyo engavunyelwanga.

Nangona kunjalo, ugqirha usenokulisebenzisa iyeza ukulungiselela loo njongo. Kungenxa yokuba i-FDA ilawula ukuvavanywa kunye nokuvunywa kwamachiza, kodwa hayi indlela abagqirha abazisebenzisa ngayo iziyobisi ukunyanga izigulana zabo. Ke ugqirha wakho unokuyalela ichiza kodwa bacinga ukuba yeyona nto ilungileyo ukuba unyamekele. Funda ngakumbi malunga nokusetyenziswa kwelebheli emiselweyo

Ukuba ugqirha wakho ukumisela iyeza ukuba ulisebenzise ngaphandle kwelebheli, kuya kufuneka uzive ukhululekile ukubuza nayiphi na imibuzo onokuba unayo. Unelungelo lokubandakanyeka kuso nasiphi na isigqibo malunga nokukhathalelwa kwakho.

Imizekelo yemibuzo onokuyibuza ibandakanya:

• Kutheni le nto umisele ukusetyenziswa kwesiyobisi ngaphandle kwelebheli?
• Ngaba zikhona ezinye iziyobisi ezivunyiweyo ezinokwenza into efanayo?
• Ngaba i-inshurensi yam yezempilo iya kuyigubungela le nto ingasetyenziswanga kwilebula?
• Ngaba uyazi ukuba zeziphi iziphumo ebezingalindelekanga ezinokuba nazo kweli chiza?

Ngaba i-Rituxan ikhuselekile kwaye iyasebenza ekunyangeni i-MS?

Akukho sivumelwano malunga nokuba ikhuselekile kwaye isebenza njani i-Rituxan yokunyanga i-MS, kodwa izifundo zibonisa ukuba ibonisa isithembiso.

Ngaba iyasebenza?

Nangona kungakhange kubekho ngokwaneleyo kwizifundo zokwenziwa kwehlabathi lokwenyani ukugweba ngokugqibeleleyo iRituxan njengonyango olusebenzayo lwe-MS, iimpawu ezintle zibonisa ukuba kunokuba njalo.

Isifundo kwirejista ye-MS MS yaseSweden ngokuthelekisa iRituxan kunye nesifo sokuqala sendabuko esiguqula ukhetho lonyango olunje

• I-Tecfidera (i-dimethyl fumarate)
• IGilenya (fingolimod)
• ITysabri (natalizumab)

Ngokupheliswa kweziyobisi kunye nokusebenza kweeklinikhi ekubuyiseleni kwakhona ukuphindaphinda i-sclerosis (i-RRMS), i-Rituxan yayingelilo kuphela ukhetho olukhokelayo kunyango lokuqala, kodwa ikwabonisa iziphumo ezilungileyo.

Ngaba ikhuselekile?

I-Rituxan isebenza njenge-B-cell depleting agent. Ngokuka, ukupheliswa kwexesha elide kweeseli B zomda ngeRituxan kubonakala kukhuselekile, kodwa kufuneka isifundo ngakumbi.

Imiphumo emibi yeRituxan ingabandakanya:

• ukumnika iimpendulo njengokukhawuleza, ukurhawuzelela, kunye nokudumba
• iingxaki zentliziyo ezinje ngokubetha kwentliziyo okungaqhelekanga
• iingxaki zezintso
• iintsini ezophayo
• isisu esibuhlungu
• ifiva
• Ukugodola
• usulelo
• iintlungu zomzimba
• isicaphucaphu
• irhashalala
• ukudinwa
• iiseli zegazi ezimhlophe ezisezantsi
• ingxaki yokulala
• ukudumba ulwimi

Iiprofayili zokhuseleko zezinye iindlela zonyango ezinje ngeGilenya kunye neTysabri yabantu abane-MS banamaxwebhu abanzi ngakumbi kuneRituxan.

Uthini umahluko phakathi kweRituxan kunye ne-Ocrevus?

I-Ocrevus (ocrelizumab) sisiyobisi esivunyiweyo se-FDA esisetyenziselwa unyango lwe-RRMS kunye nesiseko se-multiple sclerosis (PPMS).

Abanye abantu bakholelwa ukuba i-Ocrevus yinguqulelo eyabhalwa ngokutsha yeRituxan. Zombini zisebenza ngokujolisa kwiiseli ze-B ngeemolekyuli zeCD20 kumphezulu wazo.

UGenentech-umphuhlisi wawo omabini la machiza-uthi kukho iyantlukwano kwiimolekyuli kwaye ichiza ngalinye linxibelelana nenkqubo yomzimba ngokwahlukileyo.

Umahluko omkhulu kukuba izicwangciso zeinshurensi yezempilo zigubungela i-Ocrevus yonyango lwe-MS kuneRituxan.

Ukuthatha

Ukuba wena-okanye umntu osondeleyo kuwe-une-MS kwaye uziva ukuba i-Rituxan inokuba lolunye unyango, xoxa ngale ndlela kunye nogqirha wakho. Ugqirha wakho unokunika ukuqonda ngeendlela ezahlukeneyo zonyango kunye nendlela abaza kusebenza ngayo kwimeko ethile.