Isisombululo seCoQ10: Kufuneka uthathe malini ngosuku?

Umxholo

• Yintoni iCoQ10?
• Iingcebiso zedosi neMeko yezeMpilo
• Ukusetyenziswa kwamayeza eStatin
• Isifo sentliziyo
• Intloko ye-Migraine
• Ukwaluphala
• Seswekile
• Ukungachumi
• Ukuzivocavoca ukusebenza
• Imiphumela
• Umgca osezantsi

ICoenzyme Q10-eyaziwa ngcono njenge-CoQ10-sisixhobo esiveliswa ngumzimba wakho ngokwendalo.

Idlala iindima ezininzi ezibalulekileyo, ezinje ngemveliso yamandla kunye nokukhuselwa kumonakalo weseli we-oxidative.

Ikwathengiswa kwifom yokongeza ukunyanga iimeko ezahlukeneyo zempilo kunye nezifo.

Kuxhomekeka kwimeko yezempilo ozama ukuyiphucula okanye ukuyisombulula, izindululo zedosi yeCoQ10 zinokwahluka.

Eli nqaku liphonononge ezona dosi zibalaseleyo zeCoQ10 kuxhomekeke kwiimfuno zakho.

Yintoni iCoQ10?

ICoenzyme Q10, okanye iCoQ10, sisinyibilikisi esinyibilikayo esinamafutha esikho kuzo zonke iiseli zabantu, esineyonaxinaniso iphezulu kwimitochondria.

IMitochondria - ehlala ibizwa ngokuba yindawo yokugcina amandla ezisele - zizinto ezizodwa ezivelisa iadenosine triphosphate (ATP), owona mthombo wamandla osetyenziswa ziiseli zakho ().

Zimbini iindlela ezahlukeneyo zeCoQ10 emzimbeni wakho: ubiquinone kunye ne-ubiquinol.

I-Ubiquinone iguqulelwa kwifom yayo esebenzayo, ubiquinol, ethi emva koko ifunxwe kwaye isetyenziswe ngumzimba wakho ().

Ngaphandle kokuveliswa ngokwendalo ngumzimba wakho, iCoQ10 inokufumaneka ngokutya kubandakanya amaqanda, iintlanzi ezinamanqatha, inyama yenyama, amandongomane kunye neenkukhu ().

I-CoQ10 idlala indima ebalulekileyo kwimveliso yamandla kwaye isebenza njenge-antioxidant enamandla, inqanda isizukulwane esikhululekileyo kunye nokuthintela ukonakala kweseli ().

Nangona umzimba wakho wenza iCoQ10, izinto ezininzi zinokuwaphelisa amanqanaba ayo. Umzekelo, inqanaba lokuveliswa kwalo liyancipha kakhulu kubudala, okunxulunyaniswa nokuqala kweemeko ezinxulumene nobudala njengesifo sentliziyo kunye nokwehla kwengqondo ().

Ezinye izizathu zokupheliswa kweCoQ10 kubandakanya ukusetyenziswa kwamayeza e-statin, isifo sentliziyo, ukusilela kwezondlo, ukuguquka kwemfuza, uxinzelelo lwe-oxidative kunye nomhlaza ().

Ukuxhaswa nge-CoQ10 kubonisiwe ukungqubana nomonakalo okanye ukuphucula iimeko ezinxulumene nokusilela kwesi sixhobo sibalulekileyo.

Ukongeza, njengoko ibandakanyeka kwimveliso yamandla, izongezo zeCoQ10 zibonisiwe ukukhulisa ukusebenza kweembaleki kunye nokunciphisa ukudumba kwabantu abasempilweni abangaswelekanga ().

I-CoQ10 yinkomfa enemisebenzi emininzi ebalulekileyo emzimbeni wakho. Izinto ezahlukeneyo zinokuwaphelisa amanqanaba e-CoQ10, yiyo loo nto izongezo zinokuba yimfuneko.

Iingcebiso zedosi neMeko yezeMpilo

Nangona i-90-200 mg ye-CoQ10 ngosuku icetyiswa, iimfuno zingahluka ngokuxhomekeke kumntu nakwimeko yokunyangwa ().

Ukusetyenziswa kwamayeza eStatin

I-Statins liqela lamayeza asetyenziselwa ukuthoba amanqanaba aphezulu egazi e-cholesterol okanye i-triglycerides ukukhusela isifo sentliziyo ().

Nangona la machiza evame ukunyamezeleka, anokubangela iziphumo ebezingalindelekanga, ezinjengokwenzakala kakhulu kwemisipha kunye nokonakala kwesibindi.

Iingxelo zikwaphazamisa ukuveliswa kwe-mevalonic acid, esetyenziselwa ukwenza iCoQ10. Oku kubonisiwe ukunciphisa kakhulu amanqanaba e-CoQ10 egazini nakwizicubu zomzimba ().

Uphando lubonakalisile ukuba ukuxhasa i-CoQ10 kunciphisa iintlungu zemisipha kwabo bathatha amayeza e-statin.

Isifundo kubantu abangama-50 abathatha amayeza e-statin bafumanisa ukuba idosi eyi-100 mg ye-CoQ10 ngemini kangangeentsuku ezingama-30 inciphise ngokufanelekileyo iintlungu ezinxulumene nomzimba kwi-75% yezigulana ().

Nangona kunjalo, olunye uphononongo alubonisanga siphumo, sigxininisa isidingo sophando ngakumbi kwesi sihloko ().

Kubantu abathatha amayeza e-statin, isincomo sesiqhelo se-CoQ10 ngama-30-200 mg ngosuku ().

Isifo sentliziyo

Abo baneemeko zentliziyo, ezinje ngokusilela kwentliziyo kunye ne-angina, banokufumana inzuzo ngokuthatha isongezelelo seCoQ10.

Ukujongwa kwakhona kwezifundo ezili-13 kubantu abanesifo sentliziyo bafumanise ukuba i-100 mg ye-CoQ10 ngosuku ngeeveki ezili-12 iphucule ukuhamba kwegazi okusuka entliziyweni ().

Ukongeza, ukongezwa kubonisiwe ukunciphisa inani lotyelelo esibhedlele kunye nomngcipheko wokufa kwimicimbi enxulumene nentliziyo kubantu abanesifo sentliziyo ().

I-CoQ10 iyasebenza ekunciphiseni iintlungu ezinxulunyaniswa ne-angina, esisifo esifubeni esibangelwa yimisipha yentliziyo yakho engafumani oksijini yaneleyo ().

Ngaphezulu, isongezelelo sinokunciphisa isifo somngcipheko wesifo sentliziyo, njengokunciphisa i-cholesterol "embi" yeLDL ().

Kubantu abanesifo sentliziyo okanye i-angina, isincomo sesiqhelo se-CoQ10 ngama-60-300 mg ngosuku ().

Intloko ye-Migraine

Xa isetyenziselwa yodwa okanye idityaniswe nezinye izondlo, ezinje nge-magnesium kunye ne-riboflavin, i-CoQ10 ibonakalisiwe ukuphucula iimpawu ze-migraine.

Kufunyenwe ukuba inciphise iintloko ngokunciphisa uxinzelelo lwe-oxidative kunye nemveliso yasimahla ye-radical, enokuthi ibangele ukuba i-migraines.

I-CoQ10 inciphisa ukuvuvukala emzimbeni wakho kwaye iphucula ukusebenza kwe-mitochondrial, enceda ukunciphisa iintlungu ezinxulumene ne-migraine ().

Isifundo seenyanga ezintathu kwabasetyhini abangama-45 babonakalise ukuba abo baphathwe nge-400 mg ye-CoQ10 ngemini bafumana ukuncipha okubonakalayo kwisantya, ubukhali kunye nexesha le-migraines, xa kuthelekiswa neqela le-placebo ().

Ukunyanga i-migraines, isincomo sesiqhelo se-CoQ10 ngama-300-400 mg ngosuku ().

Ukwaluphala

Njengoko kukhankanyiwe ngasentla, amanqanaba e-CoQ10 ngokwendalo aphelela kubudala.

Ngombulelo, izongezo zinokunyusa amanqanaba akho e-CoQ10 kwaye zinokuphucula umgangatho wobomi.

Abantu abadala abadala abanamanqanaba aphezulu egazi e-CoQ10 bahlala benomdla kwaye benamanqanaba asezantsi oxinzelelo lwe-oxidative, olunokunceda ukuthintela isifo sentliziyo kunye nokwehla kwengqondo ().

Izongezo zeCoQ10 zibonisiwe ukuphucula amandla emisipha, amandla kunye nokusebenza komzimba kubantu abadala ().

Ukulwa nokupheliswa okunxulumene nobudala be-CoQ10, kuyacetyiswa ukuba uthathe i-100-200 mg ngosuku ().

Seswekile

Zombini uxinzelelo lwe-oxidative kunye nokungasebenzi kakuhle kwe-mitochondrial kunxulunyaniswe nokuqala kunye nokuqhubela phambili kwesifo seswekile kunye nengxaki enxulumene neswekile ().

Ngaphezu koko, abo banesifo seswekile banokuba namanqanaba asezantsi e-CoQ10, kwaye ezinye iziyobisi ezichasene neswekile zinokuhambisa ngakumbi iivenkile zomzimba wale nto ibalulekileyo ().

Izifundo zibonisa ukuba ukongeza kunye neCoQ10 kunceda ukunciphisa ukuveliswa kwee-radicals zasimahla, ezizezimolekyuli ezingazinzanga ezinokuthi zonakalise impilo yakho ukuba amanani abo aphezulu kakhulu.

I-CoQ10 ikwanceda ukuphucula ukunganyangeki kwe-insulin kunye nokulawula amanqanaba eswekile yegazi kubantu abanesifo seswekile.

Isifundo seeveki ezili-12 kubantu abangama-50 abanesifo seswekile bafumanise ukuba abo bafumana i-100 mg ye-CoQ10 ngosuku banonciphiso olukhulu kwiswekile yegazi, amanqaku e-oxidative uxinzelelo kunye nokumelana ne-insulin, xa kuthelekiswa neqela lolawulo ().

Imithamo ye-100-300 mg ye-CoQ10 ngosuku ibonakala iphucula iimpawu zeswekile ().

Ukungachumi

Umonakalo we-oxidative sesinye sezizathu eziphambili zokungachumi kwabesilisa nabasetyhini ngokuchaphazela kakubi isidoda kunye nomgangatho weqanda (,).

Umzekelo, uxinzelelo lwe-oxidative lunokubangela ukonakala kwi-DNA yesidoda, enokubangela ukungachumi kwendoda okanye ukulahleka kokukhulelwa okuphindaphindiweyo ().

Uphando lufumanise ukuba ii-antioxidants zokutya- kubandakanya neCoQ10- inokunceda ukunciphisa uxinzelelo lwe-oxidative kunye nokuphucula ukuchuma kokubini kwabesilisa nabasetyhini.

Ukuxhaswa nge-200-300 mg ngosuku lwe-CoQ10 kubonisiwe ukuphucula ukuxinana kwesidoda, ukuxinana kunye nokuhamba emadodeni ngokungachumi ().

Kwangokunjalo, ezi zongezo zinokuphucula ukuchuma kwabasetyhini ngokukhuthaza impendulo ye-ovari kunye nokunceda ukuguga kwe-ovari ().

Iidosi ze-CoQ10 ze-100-600 mg zibonisiwe ukunceda ukukhulisa ukuzala ().

Ukuzivocavoca ukusebenza

Njengoko i-CoQ10 ibandakanyeka kwimveliso yamandla, sisongezo esidumileyo phakathi kweembaleki kunye nabo bafuna ukukhulisa ukusebenza komzimba.

Uncedo lweCoQ10 lunceda ukunciphisa ukudumba okunxulunyaniswa nokuzilolonga okunzima kwaye kunokukhawulezisa ukubuyisela kwimeko yesiqhelo ().

Uphononongo lweeveki ezi-6 kwiimbaleki ezili-100 zaseJamani zafumanisa ukuba abo bancedisa nge-300 mg yeCoQ10 yonke imihla bafumana ukuphucuka okubonakalayo ekusebenzeni komzimba-kulinganiswa njengokukhutshwa kwamandla- xa kuthelekiswa neqela le-placebo ().

I-CoQ10 ikwabonakalisiwe ukunciphisa ukukhathala kunye nokunyusa amandla emisipha kwabangengombaleki ().

Iidosi ze-300 mg ngosuku zibonakala zisebenza kakhulu ekonyuseni ukusebenza kwezemidlalo kwizifundo zophando ().

Iingcebiso zedosi yeCoQ10 iyahluka ngokuxhomekeke kwiimfuno kunye neenjongo ezizodwa. Thetha nogqirha wakho ukumisela idosi efanelekileyo kuwe.

Imiphumela

I-CoQ10 inyamezeleka kakuhle, nokuba idosi ephezulu kakhulu ye-1,000 mg ngosuku okanye ngaphezulu ().

Nangona kunjalo, abanye abantu abanolwazelelelo kwikhompawundi banokuba neziphumo ebezingalindelekanga, ezinjengorhudo, intloko ebuhlungu, isicaphucaphu kunye nerhashalala ().

Kufuneka kuqatshelwe ukuba ukuthatha i-CoQ10 kufutshane nexesha lokulala kunokubangela ukulala kwabanye abantu, ke kungcono ukuyithatha ekuseni okanye emva kwemini ().

Izongezelelo zeCoQ10 zinokunxibelelana namanye amayeza aqhelekileyo, kubandakanya abacoci gazi, amayeza okulwa uxinzelelo kunye namayeza e-chemotherapy. Dibana nogqirha wakho ngaphambi kokuthatha i-CoQ10 eyongezelelekileyo (,).

Njengoko inyibilika ngamanqatha, abo bongeza nge-CoQ10 kufuneka bayigcine engqondweni ukuba ibhetele xa ithathwa ngesidlo okanye i-snack equlathe umthombo wamafutha.

Ukongeza, qiniseka ukuthenga izongezo ezihambisa i-CoQ10 ngohlobo lwe-ubiquinol, eyeyona ifunekayo ().

Nangona i-CoQ10 inyamezeleka kakuhle, abanye abantu banokuba neziphumo ebezingalindelekanga, isicaphucaphu, urhudo kunye neentloko, ngakumbi ukuba uthatha iidosi eziphezulu. Isongezelelo sinokusebenzisana namayeza aqhelekileyo, ke thetha nogqirha wakho kuqala.

Umgca osezantsi

ICoenzyme Q10 (CoQ10) inxulunyaniswe nokuphuculwa kokuguga, ukusebenza komzimba, impilo yentliziyo, isifo seswekile, ukuchuma kunye ne-migraine. Inokuphinda ichaphazele neziphumo ezibi zamayeza e-statin.

Ngokwesiqhelo, i-90-200 mg ye-CoQ10 ngosuku iyacetyiswa, nangona ezinye iimeko zinokufuna iidosi eziphezulu ze-300-600 mg.

I-CoQ10 sisongezelelo esinyamezelweyo nesikhuselekileyo esinokunceda abantu abaninzi abafuna indlela yendalo yokunyusa impilo.